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Results for "

Sesquiterpene Lactone

" in MedChemExpress (MCE) Product Catalog:

91

Inhibitors & Agonists

87

Natural
Products

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0141
    Parthenolide
    Maximum Cited Publications
    39 Publications Verification

    (-)-Parthenolide

    		 NF-κB Autophagy Mitophagy Apoptosis IKK Cancer
    Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.
    Parthenolide
  • HY-B0094
    Artemisinin
    30+ Cited Publications

    Qinghaosu; NSC 369397

    		 HCV Parasite Akt Ferroptosis Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
    Artemisinin
  • HY-N0036
    Costunolide
    5+ Cited Publications

    (+)-Costunolide; Costus Lactone

    		 Apoptosis Endogenous Metabolite Cancer
    Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells .
    Costunolide
  • HY-N0847
    Micheliolide
    5+ Cited Publications

    		 NF-κB PI3K Akt TGF-beta/Smad Inflammation/Immunology Cancer
    Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .
    Micheliolide
  • HY-N0591
    Dehydrocostus Lactone
    2 Publications Verification

    (-)-Dehydrocostus Lactone; Epiligulyl oxide

    		 Bacterial Apoptosis p38 MAPK NF-κB MAPKAPK2 (MK2) Akt NO Synthase Interleukin Related Caspase Infection Inflammation/Immunology Cancer
    Dehydrocostus Lactone ((-)-Dehydrocostus lactone) is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells .
    Dehydrocostus Lactone
  • HY-119970
    Helenalin
    5+ Cited Publications

    		 NF-κB Inflammation/Immunology Cancer
    Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .
    Helenalin
  • HY-N8290
    Lactupicrin

    Lactucopicrin

    		 LOX-1 NF-κB Cholinesterase (ChE) Parasite Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
    Lactupicrin (Lactucopicrin) exhibits analgesic, sedative, antimalarial activities and atheroprotective effect. Lactupicrin inhibits acetylcholinesterase (AChE) with an IC50 of 150.3 μM. Lactupicrin is an orally active characteristic bitter sesquiterpene lactone .
    Lactupicrin
  • HY-114519
    Helenalin acetate
    2 Publications Verification

    		 Histone Demethylase NF-κB Inflammation/Immunology Cancer
    Helenalin acetate, a natural NF-κB inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities .
    Helenalin acetate
  • HY-N6843
    Arnicolide D
    2 Publications Verification

    		 Caspase PI3K Akt mTOR STAT Apoptosis NF-κB Reactive Oxygen Species (ROS) Cancer
    Arnicolide D is a sesquiterpene lactone that can be isolated from Centipeda minima. Arnicolide D is cytotoxic to tumor cells and can induce cell cycle arrest, apoptosis, and oncosis in tumor cells. Arnicolide D has anti-tumor activity .
    Arnicolide D
  • HY-N2491
    Deoxyelephantopin
    1 Publications Verification

    		 NF-κB Cancer
    Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling .
    Deoxyelephantopin
  • HY-N2350
    Cynaropicrin

    		MMP NF-κB TNF Receptor Cancer
    Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.
    Cynaropicrin
  • HY-116506
    Bigelovin

    		RAR/RXR Reactive Oxygen Species (ROS) Apoptosis Autophagy Cancer
    Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation .
    Bigelovin
  • HY-Y0949
    Methyl 2-furoate
    1 Publications Verification

    Methyl furan-2-carboxylate

    		 Endogenous Metabolite Others
    Methyl 2-furoate (Methyl furan-2-carboxylate) can be used to synthesize cis-fused 5-oxofuro[2,3-b]furans. Methyl 2-furoate is also used in the preparation of sesquiterpene lactones .
    Methyl 2-furoate
  • HY-N0781
    Linderalactone
    2 Publications Verification

    		 Apoptosis Cancer
    Linderalactone is an important sesquiterpene lactone isolated from Lindera aggregata. Linderalactone inhibits cancer growth by modulating the expression of apoptosis-related proteins and inhibition of JAK/STAT signalling pathway. Linderalactone also inhibits the proliferation of the lung cancer A-549 cells with an IC50 of 15 µM .
    Linderalactone
  • HY-B0094R
    Artemisinin (Standard)

    Qinghaosu (Standard); NSC 369397 (Standard)

    		 Reference Standards HCV Parasite Akt Ferroptosis Infection Neurological Disease Cancer
    Artemisinin (Standard) is the analytical standard of Artemisinin. This product is intended for research and analytical applications. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
    Artemisinin (Standard)
  • HY-N9357
    Granilin

    		Bacterial Fungal Infection
    Granilin, a sesquiterpene lactone, can be found in the flower buds of Carpesium triste. Granilin can be used as the bactericide and fungicide .
    Granilin
  • HY-137984
    Cnicin

    		SARS-CoV Apoptosis Cancer
    Cnicin is an orally bioavailable sesquiterpene lactone. Cnicin has antibacterial and antiproliferative properties and induces apoptosis in primary myeloma cells. Cnicin also exhibits activity against SARS-CoV-2. Cnicin inhibits the viral replication of SARS CoV-2 with an IC50 of 1.18 μg/mL. Cnicin can promote functional nerve regeneration .
    Cnicin
  • HY-N8187
    Eupalinolide O

    		Apoptosis Cancer
    Eupalinolide O is a sesquiterpene lactone with anticancer activities. Eupalinolide O induces cell apoptosis in human MDA-MB-468 breast cancer cells .
    Eupalinolide O
  • HY-N10483
    Telekin

    		Apoptosis Cancer
    Telekin is an eucalyptus-type sesquiterpene lactone compound found in Carpesium divaricatum. Telekin can activate mitochondria-mediated cell apoptosis and has anticancer activity .
    Telekin
  • HY-122295
    Dehydroleucodine

    		Apoptosis Inflammation/Immunology Cancer
    Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects .
    Dehydroleucodine
  • HY-N7293
    Bakkenolide D

    		Histamine Receptor Inflammation/Immunology
    Bakkenolide D is a sesquiterpene lactone. Bakkenolide D is the major component of Bakkenolides in Petasites tricholobus. Bakkenolide D exhibits anti-allergic and antihistamine activities, and can be used in studies related to allergic rhinitis .
    Bakkenolide D
  • HY-N7595
    Microhelenin C

    		Others Cancer
    Microhelenin C is a sesquiterpene lactone that can be isolated from Helenium microcephalum, with antitumor activity .
    Microhelenin C
  • HY-N1247
    Scabertopin

    		Others Cancer
    Scabertopin is a sesquiterpene lactone. Scabertopin has been found to be prominent anticancer constituents .
    Scabertopin
  • HY-N0141R
    Parthenolide (Standard)

    (-)-Parthenolide (Standard)

    		 Reference Standards NF-κB Autophagy Mitophagy Apoptosis Cancer
    Parthenolide (Standard) is the analytical standard of Parthenolide. This product is intended for research and analytical applications. Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.
    Parthenolide (Standard)
  • HY-N2240
    Eupalinolide K

    		STAT Cancer
    Eupalinolide K, a sesquiterpene lactones compound from Eupatorium lindleyanum, is a STAT3 inhibitor. Eupalinolide K is a Michael reaction acceptor (MRA) .
    Eupalinolide K
  • HY-N0036R
    Costunolide (Standard)

    (+)-Costunolide (Standard); Costus Lactone (Standard)

    		 Reference Standards Apoptosis Endogenous Metabolite Cancer
    Costunolide (Standard) is the analytical standard of Costunolide. This product is intended for research and analytical applications. Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells .
    Costunolide (Standard)
  • HY-N1326
    Santamarine

    Santamarin; Balchanin

    		 JNK p38 MAPK MMP NF-κB COX TNF Receptor Interleukin Related Reactive Oxygen Species (ROS) Apoptosis Mitochondrial Metabolism DNA/RNA Synthesis Keap1-Nrf2 Bcl-2 Family Caspase PARP TGF-beta/Smad Metabolic Disease Inflammation/Immunology Cancer
    Santamarine (Santamarin; Balchanin) is a sesquiterpene lactone found in Artemisia scoparia. Santamarine shows anti-inflammatory, antioxidant, anticancer and anti-photoaging activities. Santamarine suppresses UVA-induced phosphorylation of JNK and p38 MAPK, nuclear translocation of phosphorylated c-Fos and c-Jun, and AP-1-mediated MMP-1 transcription and secretion. Santamarine suppresses NF-κB signaling, iNOS, COX-2, TNF-α, and IL-1β production. Santamarine inhibits thioredoxin reductase activity, induces ROS production, mitochondrial apoptosis, G2/M cell cycle arrest, and DNA damage, and reduces cancer cell growth. Santamarine can be used for the photoaging, inflammatory diseases and cancer .
    Santamarine
  • HY-N6955
    Eupalinilide B

    		Others Cancer
    Eupalinilide B is a guaiane type sesquiterpene lactone that can be found in Eupatorium lindleyanum. Eupalinilide B shows potent cytotoxicity against P-388 and A-549 tumor cell lines .
    Eupalinilide B
  • HY-N8619
    Minimolide F
    1 Publications Verification

    		 Others Cancer
    Minimolide F is a sesquiterpene lactone. Minimolide F has inhibitory activity against human nasopharyngeal cancer cells. Minimolide F can be used for the research of cancer .
    Minimolide F
  • HY-N10073
    Eupahualin C

    		Others Cancer
    Eupahualin C is a sesquiterpene lactone that can be isolated from Eupatorium hualienense. Eupahualin C shows cytotoxicity to K562 and U2OS cancer cells .
    Eupahualin C
  • HY-N10912
    Shizukanolide

    		Others Infection
    Shizukanolide, a sesquiterpene lactone, can be isolated from Chloranthus japonicus (Chloranthaceae). The dehydro-compound of Shizukanolide, shows moderate antifungal activity .
    Shizukanolide
  • HY-N2585
    Isodeoxyelephantopin
    1 Publications Verification

    		 Reactive Oxygen Species (ROS) NF-κB Autophagy Cancer
    Isodeoxyelephantopin is a sesquiterpene lactone isolated from Elephantopus scaber. Isodeoxyelephantopin induces ROS generation, suppresses NF-κB activation. Isodeoxyelephantopin also modulates LncRNA expression and exhibit activities against breast cancer .
    Isodeoxyelephantopin
  • HY-N10847
    1-O-Acetyl-6beta-O-Isobutyrylbritannilactone

    		Others Cancer
    1-O-Acetyl-6beta-O-Isobutyrylbritannilactone (compound 5), a sesquiterpene lactone, can be isolated from the flowers of Inula britannica. 1-O-Acetyl-6beta-O-Isobutyrylbritannilactone shows significant cytotoxicity to tumor cells .
    1-O-Acetyl-6beta-O-Isobutyrylbritannilactone
  • HY-N16658
    Asperilin

    NSC 85238

    		 Glutathione Peroxidase Inflammation/Immunology
    Asperilin (NSC 85238) is an orally active sesquiterpene lactone. Asperilin is an effective hydroxyl radical scavenger. Asperilin significantly enhance the lipid peroxidation levels of liver microsomes in various systems. Asperilin leads to a significant decrease in liver glutathione (GSH) levels and an increase in glutathione peroxidase (GPx) activity. Asperilin can be used for research on inflammatory conditions .
    Asperilin
  • HY-B0094S
    Artemisinin-d3

    Qinghaosu-d3; NSC 369397-d3

    		 Akt Ferroptosis HCV Parasite Infection Neurological Disease Cancer
    Artemisinin-d3 is the deuterium labeled Artemisinin. Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
    Artemisinin-d3
  • HY-122915
    Zedoarondiol

    		Reactive Oxygen Species (ROS) Cardiovascular Disease
    Zedoarondiol, a sesquiterpene lactone compound, with antioxidant and anti-inflammatory activity. Zedoarondiol can be used for atherosclerosis research .
    Zedoarondiol
  • HY-N8149
    Eupalinolide H

    		Others Inflammation/Immunology
    Eupalinolide H, a sesquiterpene lactone, has the potential to be used as natural anti-inflammatory agent .
    Eupalinolide H
  • HY-126156
    Leucodin

    Desacetoxymatricarin

    		 Bacterial Cancer
    Leucodin is a sesquiterpene lactone derived from Gynoxys verrucosa. Leucodin has cytotoxic activity on human leukemia cells .
    Leucodin
  • HY-118019
    Scandenolide

    		Platelet-activating Factor Receptor (PAFR) Cardiovascular Disease
    Scandenolide is a sesquiterpene lactone that can be found in Philippines medicinal plant Mikania cordata. Scandenolide inhibits leukotriene and platelet activating factor synthesis in leukocytes .
    Scandenolide
  • HY-N11800
    Transilin

    		Others Others
    Transilin is a sesquiterpene lactone. Transilin can be isolated from the whole plant of Lepisorus contortus (Christ) Ching .
    Transilin
  • HY-N6842
    ArnicolideC

    		Others Infection Cancer
    ArnicolideC is a sesquiterpene lactone isolated Centipeda minima . ArnicolideC exertes a cytotoxic effect on the panel of Nasopharyngeal carcinoma (NPC) cells, significantly inhibiting cell growth in a dose- and time- dependent manner. ArnicolideC also exhibits inhibitory effects on NPC proliferation .
    ArnicolideC
  • HY-N3579
    Chlorantholide C

    		Others Others
    Chlorantholide C, an eudesmane-type sesquiterpene lactone, can be isolated from Chloranthus elatior .
    Chlorantholide C
  • HY-N15590
    Solstitialin A

    Solstitialin

    		 Others Endocrinology
    Solstitialin A is a guaianolide-type sesquiterpene lactone. Solstitialin A can be isolated from Centaurea solstitialis L. ssp. Solstitialis. A mixture of solstitialin A and 13-acetyl solstitialin A has an inhibitory effect on ethanol- and Indomethacin (HY-14397)-induced ulcers. Solstitialin A can be used in research related to peptic ulcers .
    Solstitialin A
  • HY-N8290R
    Lactupicrin (Standard)

    Lactucopicrin (Standard)

    		 Autophagy NF-κB AMPK Reference Standards Neurological Disease Metabolic Disease
    Lactupicrin (Standard) is the analytical standard of Lactupicrin. This product is intended for research and analytical applications. Lactupicrin (Lactucopicrin) exhibits analgesic, sedative, antimalarial activities and atheroprotective effect. Lactupicrin inhibits acetylcholinesterase (AChE) with an IC50 of 150.3 μM. Lactupicrin is an orally active characteristic bitter sesquiterpene lactone .
    Lactupicrin (Standard)
  • HY-N8485
    Pungiolide A

    		Others Others
    Pungiolide A is a sesquiterpene lactones that can be isolated from Xanthium sibiricum .
    Pungiolide A
  • HY-N12210
    Notrilobolide

    		Histamine Receptor Inflammation/Immunology
    Notrilobolide is a sesquiterpene lactone. Notrilobolide induces a potent histamine release from peritoneal rat mast cells .
    Notrilobolide
  • HY-N9263
    Diacetylpiptocarphol

    		Others Infection
    Diacetylpiptocarphol (compound 4) is a sesquiterpene lactone compound. Diacetylpiptocarphol has anti-leishmaniasis activity .
    Diacetylpiptocarphol
  • HY-N10967
    Isoatriplicolide tiglate

    		Others Neurological Disease
    Isoatriplicolide tiglate is a bioactive sesquiterpene lactone. Isoatriplicolide tiglate can be isolated from Paulownia coreana. Isoatriplicolide tiglate has neuroprotective effect .
    Isoatriplicolide tiglate
  • HY-N9121
    8β-(4-Acetoxy-5-hydroxytigloyloxy)costunolide

    		Others Others
    8β-(4-Acetoxy-5-hydroxytigloyloxy)costunolide (compound 5) is a sesquiterpene lactone that can be isolated from Stevia alpina var. glutinosa .
    8β-(4-Acetoxy-5-hydroxytigloyloxy)costunolide
  • HY-N10959
    4,15-Isoatriplicolide methylacrylate

    		Others Cancer
    4,15-Isoatriplicolide methylacrylate is a germacrane-type sesquiterpene lactone. 4,15-Isoatriplicolide methylacrylate also is a cytotoxic agent. 4,15-Isoatriplicolide methylacrylate has cytotoxic activity for MCF-7 human breast cancer cell line .
    4,15-Isoatriplicolide methylacrylate

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