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Swiss Albino Mice

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Acetolactate Synthase (ALS) (1) Akt (1) Amyloid-β (1) Apoptosis (7) Autophagy (1) Bacterial (5) Bcl-2 Family (1) Beta-lactamase (1) Beta-secretase (1) Biochemical Assay Reagents (1) Caspase (3) Cholinesterase (ChE) (3) ClpP (1) COX (1) DNA Alkylator/Crosslinker (1) Drug Derivative (1) Drug Metabolite (1) EGFR (1) Environmental Pollutants (3) Flavivirus (1) Fungal (2) Herbicide (1) IFNAR (1) Interleukin Related (1) Keap1-Nrf2 (1) MDM-2/p53 (1) Mitochondrial Metabolism (1) MMP (3) NF-κB (4) Parasite (2) PARP (3) PPAR (2) PROTACs (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) SARS-CoV (1) SOD (1) Survivin (1) TNF Receptor (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Infection (8) Inflammation/Immunology (8) Metabolic Disease (3) Neurological Disease (7)

By Targets:

5-HT Receptor (1)

Acetolactate Synthase (ALS) (1)

Akt (1)

Amyloid-β (1)

Apoptosis (7)

Autophagy (1)

Bacterial (5)

Bcl-2 Family (1)

Beta-lactamase (1)

Beta-secretase (1)

Biochemical Assay Reagents (1)

Caspase (3)

Cholinesterase (ChE) (3)

ClpP (1)

COX (1)

DNA Alkylator/Crosslinker (1)

Drug Derivative (1)

Drug Metabolite (1)

EGFR (1)

Environmental Pollutants (3)

Flavivirus (1)

Fungal (2)

Herbicide (1)

IFNAR (1)

Interleukin Related (1)

Keap1-Nrf2 (1)

MDM-2/p53 (1)

Mitochondrial Metabolism (1)

MMP (3)

NF-κB (4)

Parasite (2)

PARP (3)

PPAR (2)

PROTACs (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (1)

SARS-CoV (1)

SOD (1)

Survivin (1)

TNF Receptor (1)

By Research Areas:

Cancer (9)

Cardiovascular Disease (1)

Infection (8)

Inflammation/Immunology (8)

Metabolic Disease (3)

Neurological Disease (7)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0021

Palonosetron hydrochloride 1 Publications Verification	5-HT Receptor Flavivirus	Infection Cardiovascular Disease Neurological Disease
Palonosetron hydrochloride is a 5-HT3 antagonist primarily used to prevent acute, delayed, and overall chemotherapy-induced nausea and vomiting. In addition, Palonosetron hydrochloride exhibits moderate anti-flavivirus activity and potent anti-Zika virus activity in mammalian cells. Palonosetron hydrochloride also possesses antidepressant activity .

HY-N11908

α-Santalol cis-α-Santalol	Akt Survivin Apoptosis Caspase PARP	Metabolic Disease Cancer
α-Santalol (cis-α-Santalol), a naturally occurring sesquiterpene, is an orally active anticancer agent and apoptosis inducer. α-Santalol activates caspase-3 to drive apoptotic processes. >α-Santalol induces apoptosis, decreases cell viability, and causes PARP cleavage in human prostate cancer cells. α-santalol inhibits Akt/Survivin pathway to induce cell death. α-Santalol can be used for the research of prostate cancer and diabetes mellitus .

HY-B0900

Anethole 2 Publications Verification Anise camphor; p-Propenylanisole; Isoestragole	Environmental Pollutants Apoptosis NF-κB Fungal Bacterial MMP	Infection Neurological Disease Inflammation/Immunology Cancer
Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .

HY-B1206

Neostigmine (methyl sulfate) 1 Publications Verification	Cholinesterase (ChE)	Infection Neurological Disease
Neostigmine methyl sulfate is an AchE inhibitor. Neostigmine methyl sulfate increases endogenous acetylcholine levels, mediates antinociceptive effects, and alleviates heat-induced pain. Neostigmine methyl sulfate can be used in studies related to postoperative pain and sepsis .

HY-B1847

Terbuthylazine 1 Publications Verification	Environmental Pollutants Acetolactate Synthase (ALS) Herbicide	Others
Terbuthylazine is an inhibitor of acetolactate syntase (ALS), is a selective herbicide. Terbuthylazine blocks electron transport in photosystem II via interaction with the D1-protein .

HY-157581

MS39	EGFR PROTACs	Cancer
MS39 (compound 6) is a PROTAC targeting EGFR. MS39 reduces the expression of EGFR and downstream signaling in HCC-827 and H3255 cells. MS39 inhibits the proliferation of H3255 cells .

HY-N8210

Homoeriodictyol	Drug Metabolite Autophagy Apoptosis Reactive Oxygen Species (ROS) Keap1-Nrf2 MMP Caspase PARP MDM-2/p53	Neurological Disease Inflammation/Immunology Cancer
Homoeriodictyol is an orally active, bitter-tasting flavanone that can penetrate the blood-brain barrier. Homoeriodictyol enhances synaptic-related protein expression through NCOA4-mediated ferritin autophagy. Homoeriodictyol improves memory impairment in mice by inhibiting the NLRP3 inflammasome. Homoeriodictyol protects human endothelial cells from oxidative damage by activating Nrf2 and inhibiting mitochondrial dysfunction. Homoeriodictyol enhances ROS activity and induces apoptosis, exhibiting anticancer effects. Homoeriodictyol inhibits the survival and migration of androgen-resistant prostate cancer cells in vitro. Homoeriodictyol exerts antinociceptive activity in mice in vivo .

HY-W013762

Tributyl citrate	Environmental Pollutants Biochemical Assay Reagents	Others
Tributyl citrate is a low-toxicity and orally active citrate ester with no genotoxicity or skin sensitizing activity. Tributyl citrate also acts as a plasticizer, solvent, FDA-approved indirect food additive, and topical anesthetic, among other uses. Tributyl citrate induces a needle-prick insensitivity response that lasts for more than 2 hours, and a 5% suspension of it temporarily eliminates the corneal reflex in rabbits. Tributyl citrate causes no significant systemic toxicity in rats and cats at most tested doses, and only may cause growth retardation and gastrointestinal reactions such as diarrhea and nausea at high doses or with repeated oral administration .

HY-156277

SP4f	PPAR	Metabolic Disease
SP4f is an activator ofPPAR-γ, with the EC₅₀ of 826 nM in HK-2 cells. SP4f reduces the blood glucose levels and lipid peroxidation, and increases glutathione levels and catalase activityin the Swiss albino mice .

HY-178749

MS6076	ClpP Mitochondrial Metabolism Apoptosis Caspase PARP	Cancer
MS6076 is a mitochondrial protease ClpP agonist. MS6076 specifically activates the ClpP protease in the mitochondrial matrix, significantly disrupting mitochondrial Electron Transport Chain (ETC) function by accelerating the degradation of unfolded proteins. MS6076 exhibits potent cytotoxicity against a variety of cancer cell lines. MS6076 induces cell apoptosis, increasing cleavage of caspase 3 and PARP. MS6076 can be used for the research of breast cancer .

HY-156276

SP4e	PPAR	Metabolic Disease
SP4e is an activator of PPAR-γ, with the EC₅₀ of 739 nM in HK-2 cells. SP4e reduces the blood glucose levels and lipid peroxidation, and increases glutathione levels and catalase activityin the Swiss albino mice .

HY-176519

ANT2681	Beta-lactamase Bacterial	Infection
ANT2681 is a potent NDM inhibitor with a K_i value of 0.04 μM against NDM-1. ANT2681 also inhibits other MBLs, such as VIM-1 and IMP-1 with K_i values of 0.63 μM and 3.81 μM, respectively. ANT2681 can be used in combination with Meropenem (HY-13678) to inhibit infections caused by NDM-producing Enterobacteriaceae .

HY-B0900R

Anethole (Standard) Anise camphor (Standard); p-Propenylanisole (Standard); Isoestragole (Standard)	Apoptosis Fungal Bacterial MMP NF-κB Reference Standards	Infection Neurological Disease Inflammation/Immunology Cancer
Anethole (Standard) is the analytical standard of Anethole. This product is intended for research and analytical applications. Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .

HY-108281

Enfenamic acid Tromaril; RH 8	Others	Inflammation/Immunology
Enfenamic acid is a nonsteroidal anti-inflammatory agent and a prostaglandin synthetase inhibitor, inhibiting hepatic gluconeogenesis in Swiss albino mice. Enfenamic acid suppresses wound healing .

HY-161243

AChE-IN-56	Cholinesterase (ChE)	Neurological Disease
AChe-IN-56 is an orally active inhibitor for acetylcholinesterase enzyme (AChE) with neuroprotective efficacy .

HY-158261

AChE-IN-63	Cholinesterase (ChE) Amyloid-β Beta-secretase	Neurological Disease
AChE-IN-63 (Compound 5AD) is a selective inhibitor of hAChE (IC₅₀=0.103 μM). AChE-IN-63 also inhibits hBChE and hBACE-1 (IC₅₀= 10 μM (hBChE); 1.342 μM (hBACE-1)). AChE-IN-63 inhibits Aβ aggregation, preventing the formation and deposition of Aβ1-42. AChE-IN-63 can effectively penetrate the blood-brain barrier and is orally effective. It is primarily used in Alzheimer's disease research .

HY-162761

COX-1/2-IN-9	Bacterial COX	Inflammation/Immunology
COX-1/2-IN-9 (Compound 3n) is a potent and selective inhibitor of COX-1/2, with IC₅₀ values of 0.031 µM and 0.01 µM, respectively. COX-1/2-IN-9 possesses both antibacterial and anti-inflammatory activities, effectively inhibiting MRSA 1478 (MIC=50 μg/mL) and multidrug-resistant S. lentus (MIC=50 μg/mL). COX-1/2-IN-9 holds significant potential to alleviate MRSA-induced pneumonia in immunocompromised states .

HY-152169

BIHC	Interleukin Related Apoptosis TNF Receptor IFNAR NF-κB Bcl-2 Family	Inflammation/Immunology
BIHC is a TNF blocker with anti-inflammatory activity. BIHC can significantly inhibit the proliferation of hepatocellular carcinoma (HCC) cells and exhibits potent cytotoxicity against the HepG2 cell line, capable of inducing cell apoptosis , while demonstrating relatively low toxicity towards normal hepatocytes. Additionally, BIHC can be used for research on inflammatory bowel disease (IBD) .

HY-182065

SARS-CoV-2 Mpro-IN-56	SARS-CoV	Infection
SARS-CoV-2 Mpro-IN-56 is an orally active SARS-CoV-2 Mpro inhibitor with an IC₅₀ of 0.026 μM. SARS-CoV-2 Mpro-IN-56 can be used for the research of COVID-19 .

HY-N16926

Chingchengenamide A	Drug Derivative	Others
Chingchengenamide A is a natural alkaloid.

HY-N19628

Dianellin	Parasite	Infection
Dianellin is an orally active anti-malarial agent found in Kniphofia foliosa. Dianellin binds to Plasmodium falciparum plasmepsin II and shows anti-malarial activity in mice. Dianellin can be used for the research of malaria .

HY-182403

GR-891	Apoptosis	Others Cancer
GR-891 is an acyclic nucleoside 5-Fluorouracil (HY-90006) derivative. GR-891 exerts antiproliferative activity in human cancer cells and inhibits proliferation of human rhabdomyosarcoma cells. GR-891 induces terminal myogenic differentiation in human rhabdomyosarcoma cells, including modulation of desmin and vimentin expression. GR-891 is phosphorylated by kinases, incorporated into RNA, and releases acrolein. GR-891 can be used for the research of cancer and rhabdomyosarcoma .

HY-N18080

Parthenin	Parasite DNA Alkylator/Crosslinker Bacterial	Infection Inflammation/Immunology Cancer
Parthenin is a pseudoguaianolide-type sesquiterpene lactone present in Parthenium hysterophorus L. Parthenin induces chromosomal aberrations, mainly chromatid breaks, in human peripheral blood lymphocytes. Parthenin exhibits toxicity against Salmonella typhimurium and Escherichia coli strains, with reduced toxicity in the presence of a metabolic activation system (S9). Parthenin acts as an antifeedant against the 6th instar larvae of the tobacco cutworm (Spodoptera litura). Parthenin shows insecticidal activity against adult cowpea weevils (Callosobruchus maculatus). Parthenin inhibits seed germination and seedling growth of sicklepod (Cassia tora). Parthenin possesses nematicidal activity against the 2nd instar larvae of the southern root-knot nematode (Meloidogyne incognita). Parthenin serves as a research agent for studies related to cancer, malaria, amoebiasis, inflammatory diseases, and bacterial infections .

HY-N19717

Bartogenic acid	NF-κB SOD	Inflammation/Immunology Cancer
Bartogenic acid is an orally active NF-κB inhibitor, found in Barringtonia racemosa fruits. Bartogenic acid increases catalase, superoxide dismutase (SOD), and glutathione levels. Bartogenic acid inhibits lipid peroxidation and suppresses inflammation markers. Bartogenic acid can be used for the research of ovarian cancer, skin cancer, and inflammatory conditions .

α-Santalol cis-α-Santalol	Structural Classification Santalum album Linn. Terpenoids Sesquiterpenes Plants Source Classification Santalaceae	Akt Survivin Apoptosis Caspase PARP
α-Santalol (cis-α-Santalol), a naturally occurring sesquiterpene, is an orally active anticancer agent and apoptosis inducer. α-Santalol activates caspase-3 to drive apoptotic processes. >α-Santalol induces apoptosis, decreases cell viability, and causes PARP cleavage in human prostate cancer cells. α-santalol inhibits Akt/Survivin pathway to induce cell death. α-Santalol can be used for the research of prostate cancer and diabetes mellitus .

Anethole 2 Publications Verification Anise camphor; p-Propenylanisole; Isoestragole	Structural Classification Classification of Application Fields Simple Phenylpropanols Leguminosae Phenylpropanoids Umbelliferae Plants Vernonia Schreb. Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification Cancer	Environmental Pollutants Apoptosis NF-κB Fungal Bacterial MMP
Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .

Homoeriodictyol	Flavonoids other families Classification of Application Fields Flavonones Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Drug Metabolite Autophagy Apoptosis Reactive Oxygen Species (ROS) Keap1-Nrf2 MMP Caspase PARP MDM-2/p53
Homoeriodictyol is an orally active, bitter-tasting flavanone that can penetrate the blood-brain barrier. Homoeriodictyol enhances synaptic-related protein expression through NCOA4-mediated ferritin autophagy. Homoeriodictyol improves memory impairment in mice by inhibiting the NLRP3 inflammasome. Homoeriodictyol protects human endothelial cells from oxidative damage by activating Nrf2 and inhibiting mitochondrial dysfunction. Homoeriodictyol enhances ROS activity and induces apoptosis, exhibiting anticancer effects. Homoeriodictyol inhibits the survival and migration of androgen-resistant prostate cancer cells in vitro. Homoeriodictyol exerts antinociceptive activity in mice in vivo .

Anethole (Standard) Anise camphor (Standard); p-Propenylanisole (Standard); Isoestragole (Standard)	Structural Classification Simple Phenylpropanols Leguminosae Phenylpropanoids Umbelliferae Plants Vernonia Schreb. Glycyrrhiza uralensis Fisch. Source Classification	Apoptosis Fungal Bacterial MMP NF-κB Reference Standards
Anethole (Standard) is the analytical standard of Anethole. This product is intended for research and analytical applications. Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .

Chingchengenamide A	Structural Classification Natural Products Piperaceae Plants Piper kadsura (Choisy) Ohwi Source Classification	Drug Derivative
Chingchengenamide A is a natural alkaloid.

Dianellin	Structural Classification Monophenols Phenols Plants Asphodelaceae Kniphofia foliosa Hochst. Source Classification	Parasite
Dianellin is an orally active anti-malarial agent found in Kniphofia foliosa. Dianellin binds to Plasmodium falciparum plasmepsin II and shows anti-malarial activity in mice. Dianellin can be used for the research of malaria .

Parthenin	Structural Classification Terpenoids Sesquiterpenes Antheroporum pierrei Gagnep. Plants Compositae Source Classification	Parasite DNA Alkylator/Crosslinker Bacterial
Parthenin is a pseudoguaianolide-type sesquiterpene lactone present in Parthenium hysterophorus L. Parthenin induces chromosomal aberrations, mainly chromatid breaks, in human peripheral blood lymphocytes. Parthenin exhibits toxicity against Salmonella typhimurium and Escherichia coli strains, with reduced toxicity in the presence of a metabolic activation system (S9). Parthenin acts as an antifeedant against the 6th instar larvae of the tobacco cutworm (Spodoptera litura). Parthenin shows insecticidal activity against adult cowpea weevils (Callosobruchus maculatus). Parthenin inhibits seed germination and seedling growth of sicklepod (Cassia tora). Parthenin possesses nematicidal activity against the 2nd instar larvae of the southern root-knot nematode (Meloidogyne incognita). Parthenin serves as a research agent for studies related to cancer, malaria, amoebiasis, inflammatory diseases, and bacterial infections .

Bartogenic acid	Triterpenes Structural Classification Terpenoids Plants Fagaceae Quercus aliena Blume Source Classification	NF-κB SOD
Bartogenic acid is an orally active NF-κB inhibitor, found in Barringtonia racemosa fruits. Bartogenic acid increases catalase, superoxide dismutase (SOD), and glutathione levels. Bartogenic acid inhibits lipid peroxidation and suppresses inflammation markers. Bartogenic acid can be used for the research of ovarian cancer, skin cancer, and inflammatory conditions .

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Swiss Albino Mice

Inhibitors & Agonists

NaturalProducts

Natural
Products