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Results for "

TACC3

" in MedChemExpress (MCE) Product Catalog:

22

Inhibitors & Agonists

1

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-135960
    BO-264
    1 Publications Verification

    		 FGFR Apoptosis Cancer
    BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC50 of 188 nM and a Kd of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis. BO-264 has broad-spectrum antitumor activity .
    BO-264
  • HY-120087
    KG-548

    		MOFs HIF/HIF Prolyl-Hydroxylase Cancer
    KG-548 is an ARNT/TACC3 disruptor and a HIF-1α inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as HIF-β .
    KG-548
  • HY-10996A
    KHS101 hydrochloride
    1 Publications Verification

    		 Autophagy HSP Apoptosis Aurora Kinase Microtubule/Tubulin Polo-like Kinase (PLK) Neurological Disease Cancer
    KHS101 is a blood-brain barrier-penetrant anticancer agent that primarily functions by inhibiting HSPD1 (IC50 = 14.4 μM) and TACC3 across different cellular backgrounds. KHS101 promotes the aggregation of HSPD1 with client proteins, destabilizes TACC3, and reduces the levels of TACC3, Aurora A and PLK1. KHS101 induces autophagy, apoptosis, cell cycle exit and neuronal differentiation; it suppresses cancer cell growth, motility, EMT and stemness; it also impairs mitochondrial bioenergetics and glycolysis in glioblastoma cells. KHS101 can be used in research related to glioblastoma multiforme and breast cancer [3].
    KHS101 hydrochloride
  • HY-111876
    SNIPER(TACC3)-1

    		SNIPERs Cancer
    SNIPER(TACC3)-1 targets the TACC3 protein for degradation via the ubiquitin-proteasome pathway based on IAP ligand. SNIPER(TACC3)-1 induces cancer cell death .
    SNIPER(TACC3)-1
  • HY-172158
    ALKBH5-IN-5
    1 Publications Verification

    		 Anaplastic lymphoma kinase (ALK) Caspase Cancer
    ALKBH5-IN-5 is a highly selective ALKBH5 (IC50 = 0.62 μM, Kd = 804 nM). ALKBH5-IN-5 disrupts ALKBH5 binding to m 6A-RNA and 6mA-DNA substrates. ALKBH5-IN-5 promotes differentiation, induces apoptosis, cause G2-M phase arrest and exerts strong antiproliferative effects in cancer cells. ALKBH5-IN-5 reduces TACC3 and MYC protein levels and increases cleaved caspase-3 levels. ALKBH5-IN-5 exerts antitumor activity in tumor xenograft mice models. ALKBH5-IN-5 can be used for the research of acute myeloid leukemia .
    ALKBH5-IN-5
  • HY-111877
    SNIPER(TACC3)-2

    		SNIPERs Cancer
    SNIPER(TACC3)-2 targets the TACC3 protein for degradation via the ubiquitin-proteasome pathway based on IAP ligand. SNIPER(TACC3)-2 induces cancer cell death .
    SNIPER(TACC3)-2
  • HY-145895
    SNIPER(TACC3)-11

    		FGFR SNIPERs Cancer
    SNIPER(TACC3)-11 is a potent FGFR3-TACC3 degrader. SNIPER(TACC3)-11 reduces FGFR3-TACC3 protein levels and suppressed the growth of FGFR3-TACC3 positive cancer cells .
    SNIPER(TACC3)-11
  • HY-151985
    TACC3 inhibitor 1

    		Apoptosis Cancer
    TACC3 inhibitor 1 is a potent and cross the blood-brain barrier TACC3 inhibitor. TACC3 inhibitor 1 induces Apoptosis and cell cycle arrest at G2/M phase. TACC3 inhibitor 1 induces the generation of intracellular ROS. TACC3 inhibitor 1 shows antiproliferative and anti-tumor activity .
    TACC3 inhibitor 1
  • HY-170960
    TACC3 inhibitor 2

    		Microtubule/Tubulin Apoptosis Cancer
    TACC3 inhibitor 2 (Compound 13b) is a TACC3 inhibitor with an IC50 of 200 nM. TACC3 inhibitor 2 can induce mitotic arrest, cell apoptosis (Apoptosis), and DNA damage. TACC3 inhibitor 2 can be used for cancer research .
    TACC3 inhibitor 2
  • HY-RS23373
    Tacc3 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Tacc3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tacc3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Tacc3 Rat Pre-designed siRNA Set A
    Tacc3 Rat Pre-designed siRNA Set A
  • HY-RS14141
    TACC3 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TACC3 Human Pre-designed siRNA Set A contains three designed siRNAs for TACC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TACC3 Human Pre-designed siRNA Set A
    TACC3 Human Pre-designed siRNA Set A
  • HY-RS16930
    Tacc3 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Tacc3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tacc3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Tacc3 Mouse Pre-designed siRNA Set A
    Tacc3 Mouse Pre-designed siRNA Set A
  • HY-10996
    KHS101

    		HSP Microtubule/Tubulin Aurora Kinase Polo-like Kinase (PLK) Autophagy Apoptosis Neurological Disease Cancer
    KHS101 is a blood-brain barrier-penetrant anticancer agent that primarily functions by inhibiting HSPD1 (IC50 = 14.4 μM) and TACC3 across different cellular backgrounds. KHS101 promotes the aggregation of HSPD1 with client proteins, destabilizes TACC3, and reduces the levels of TACC3, Aurora A and PLK1. KHS101 induces autophagy, apoptosis, cell cycle exit and neuronal differentiation; it suppresses cancer cell growth, motility, EMT and stemness; it also impairs mitochondrial bioenergetics and glycolysis in glioblastoma cells. KHS101 can be used in research related to glioblastoma multiforme and breast cancer [3].
    KHS101
  • HY-111877A
    SNIPER(TACC3)-2 hydrochloride

    		SNIPERs Cancer
    SNIPER(TACC3)-2 hydrochloride targets the TACC3 protein for degradation via the ubiquitin-proteasome pathway based on IAP ligand. SNIPER(TACC3)-2 hydrochloride induces cancer cell death .
    SNIPER(TACC3)-2 hydrochloride
  • HY-W012248
    KG-655

    		FGFR Cancer
    KG-655 is a ligand that specifically binds to the ARNT PAS-B domain. KG-655 binds to the internal cavity of ARNT PAS-B to restrict its variable folded conformation, disrupts the interaction between ARNT PAS-B and the transcriptional coactivator TACC3, and promotes the homodimerization of ARNT PAS-B. KG-655 is widely applicable to cancer-related research .
    KG-655
  • HY-174981
    LC-MF-4

    		PROTACs FGFR ATP Synthase Cancer
    LC-MF-4 is a selective FGFR3 PROTAC degrader with a DC50 of 30.89 nM in KMS-11 cells. LC-MF-4 inhibits the metabolic function of FGFR3-TACC3 fusion positive cancers with reduction of ATP synthesis and inhibition of mitochondrial biogenesis genes. LC-MF-4 has potent antitumor activity in the Ba/F3-FGFR3-TACC3 xenograft mice model. LC-MF-4 can be used for FGFR3-altered cancers like bladder cancer and urothelial carcinoma (UC) research . Pink: FGFR3 ligand (HY-175414); Blue: VHL ligase ligand (HY-125905); Black: linker (HY-Y1224)
    LC-MF-4
  • HY-186210
    TACC3-IN-5

    		Aurora Kinase Cancer
    TACC3-IN-5 (Compound 35) is a TACC3 inhibitor. TACC3 is a scaffold protein that is highly expressed in various tumors and regulates microtubule/centrosome stability via phosphorylation by Aurora A. TACC3-IN-5 inhibits the proliferation of triple-negative breast cancer cells. TACC3-IN-5 is applicable for triple-negative breast cancer research .
    TACC3-IN-5
  • HY-111886
    KHS108-MV1

    		SNIPERs IAP Cancer
    KHS108-MV1 is a conjugate of KHS108 and MV1. KHS108 is a ligand for TACC3. MV1 is an IAP antagonist that binds to cIAP1, cIAP2, and XIAP. KHS108-MV1 can be used in the research of breast cancer and fibrosarcoma .
    KHS108-MV1
  • HY-186209
    TACC3-IN-4

    		Aurora Kinase Cancer
    TACC3-IN-4 is a TACC3 inhibitor. TACC3 is a scaffold protein that is highly expressed in various tumors and regulates microtubule/centrosome stability via phosphorylation by Aurora A. TACC3-IN-4 inhibits the proliferation of triple-negative breast cancer cells. TACC3-IN-4 can be used for triple-negative breast cancer research .
    TACC3-IN-4
  • HY-111876A
    SNIPER(TACC3)-1 hydrochloride

    		SNIPERs Cancer
    SNIPERTACC3-1 hydrochloride targets the TACC3 protein for degradation via the ubiquitin-proteasome pathway based on IAP ligand. SNIPERTACC3-1 hydrochloride induces cancer cell death .
    SNIPER(TACC3)-1 hydrochloride
  • HY-186208
    TACC3-IN-3

    		Aurora Kinase Cancer
    TACC3-IN-3 is a TACC3 inhibitor. TACC3 is a scaffold protein that is highly expressed in various tumors and regulates microtubule/centrosome stability via phosphorylation by Aurora A. TACC3-IN-3 inhibits the proliferation of triple-negative breast cancer cells. TACC3-IN-3 is applicable to triple-negative breast cancer research .\n
    TACC3-IN-3
  • HY-112500
    Spindlactone B

    SPL-B

    		 Microtubule/Tubulin Neurological Disease
    Spindlactone B (SPL-B) is a TACC3 inhibitor. Spindlactone B reduces the level of acetylated Microtubules. Spindlactone B can be used in the research of neurological diseases .
    Spindlactone B

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