24 Results for "

Tacrolimus

" in MedChemExpress (MCE) Product Catalog:
Products (24)

24 Results for "Tacrolimus" in MCE Product Catalog:

106
106 Publications Verification
Cat. No.: HY-13756
CAS No.: 104987-11-3
Purity:  99.93%
Synonyms: FK506; Fujimycin; FR900506
Tacrolimus (FK506), a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
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106
106 Publications Verification
Cat. No.: HY-13756A
CAS No.: 109581-93-3
Purity:  99.67%
Synonyms: FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate
Tacrolimus (FK506) monohydrate, a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus monohydrate inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
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6
6 Cited Publications
Cat. No.: HY-13557
CAS No.: 104987-12-4
Purity:  ≥98.0%
Synonyms: Immunomycin; FR-900520; FK520
Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research .
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1
1 Cited Publications
Cat. No.: HY-13756S
CAS No.: 1356841-89-8
Purity:  98.36%
Synonyms: FK506-13C,d2; Fujimycin-13C,d2; FR900506-13C,d2
Tacrolimus- 13C,d2 (FK506- 13C,d2) is the 13C, deuterated-labeled Tacrolimus (HY-13756). Tacrolimus (FK506), a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
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Cat. No.: HY-13756R
CAS No.: 104987-11-3
Synonyms: FK506 (Standard); Fujimycin (Standard); FR900506 (Standard)
Tacrolimus (Standard) (FK506 (Standard); Fujimycin (Standard); FR900506 (Standard)) is the analytical standard of Tacrolimus (HY-13756). This product is intended for research and analytical applications. Tacrolimus (FK506), a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
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Cat. No.: HY-161560
Tacrolimus/BSA is the antigen-adjuvant conjugate formed by the conjugation of Tacrolimus (HY-13756) with Bovine Serum Albumin (BSA). By conjugating the antigen with a protein adjuvant, it can enhance the production of antigen-specific antibodies in vaccine models. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
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Cat. No.: HY-13756S2
Synonyms: FK506-d3; Fujimycin-d3; FR900506-d3
Tacrolimus-d3 (FK506-d3) is the deuterated-labeled Tacrolimus (HY-13756). Tacrolimus (FK506), a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
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Cat. No.: HY-Z8754
CAS No.: 129212-35-7
Synonyms: Tacrolimus EP impurity D; 8-epi-Tacrolimus
Target:  

Phosphatase

Research Areas:  

Inflammation/Immunology

Tacrolimus anhydrous 8-epimer (Tacrolimus EP impurity D) is a l-pipecolic acid macrolide lactone, an important immunosuppressive agent that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2 .
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Cat. No.: HY-W585886
CAS No.: 131944-48-4
Synonyms: FK506-A
Target:  

Drug Intermediate

Research Areas:  

Others

(E/Z)-FK-506 26,28-Allylic ester rearrangement impurity (FK506-A) is a Tacrolimus (HY-13756) impurity.
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Cat. No.: HY-13557R
CAS No.: 104987-12-4
Synonyms: Immunomycin (Standard); FR-900520 (Standard); FK520 (Standard)
Ascomycin (Standard) is the analytical standard of Ascomycin. This product is intended for research and analytical applications. Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research[1][2].
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Cat. No.: HY-154916
CAS No.: 139958-51-3
Synonyms: 13-DMT; 13-O-Demethyl FK 506
Target:  

Drug Derivative

13-O-Desmethyl tacrolimus (13-DMT; 13-O-Demethyl FK 506) is the main metabolite of Tacrolimus (HY-13756). 13-O-Desmethyl tacrolimus has a weak immunosuppressive activity. 13-O-Desmethyl tacrolimus is mainly used in the research on monitoring Tacrolimus (HY-13756) by monitoring the ratio of 13-DMT/Tacrolimus .
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Cat. No.: HY-129664
CAS No.: 132172-14-6
Target:  

FKBP

Research Areas:  

Inflammation/Immunology

L 683519, one of the impurities of tacrolimus, is an immunosuppressant. L 683519 can inhibit the activity of FK-506 binding protein .
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Cat. No.: HY-123121
CAS No.: 70695-02-2
Nargenicin A1 is an antibiotic agent against various Gram-positive bacteria. Nargenicin A1 shows anti-inflammatory activity. Nargenicin A1 protects HINAE cells against Tacrolimus (HY-13756)-induced DNA damage and apoptosis. Nargenicin A1 can also be used for the research of acute myeloid leukemia .
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Cat. No.: HY-13644
CAS No.: 98629-43-7
Synonyms: 15-Deoxyspergualin
Target:  

Others

Research Areas:  

Others

Gusperimus is a fully synthetic racemate that has a novel mechanism of action by binding to the intracellular heat shock protein hsp70 and interfering with intracellular signal transduction. This mechanism of action can enhance the effect of immunosuppressive therapy. Gusperimus can inhibit the differentiation of T cells into cytotoxic T cells, reduce the expression of IL-2 receptors on CD4 and CD8 cells, and inhibit IFN-γ-induced B cell maturation. In addition, when used with cyclosporine, tacrolimus or mycophenolate mofetil, Gusperimus can enhance the immunosuppressive effect and prevent allogeneic transplant rejection.
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Cat. No.: HY-144920S
CAS No.: 1356352-20-9
Tacrolimus impurity 16- 13C,d2 is the deuterium labeled and 13C-labeled 24,32-Bis-O-(tert-butyldimethylsilyl)-FK-506 (HY-W777541).
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Cat. No.: HY-Z13410
CAS No.: 1700657-83-5
Synonyms: Tacrolimus hydroxy acid
Target:  

Drug Intermediate

Research Areas:  

Others

Tacrolimus impurity 2 (Tacrolimus hydroxy acid) is an impurity of Tacrolimus.
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Cat. No.: HY-W587684
CAS No.: 134590-88-8
Target:  

Drug Intermediate

Research Areas:  

Others

Tacrolimus impurity 6 is an impurity of Tacrolimus.
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Cat. No.: HY-W587785
CAS No.: 123719-19-7
Target:  

Drug Intermediate

Research Areas:  

Others

Tacrolimus impurity 7 is an impurity of Tacrolimus.
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Cat. No.: HY-W706508
CAS No.: 109466-74-2
Target:  

Drug Intermediate

Research Areas:  

Others

Tacrolimus impurity 9 is an impurity of Tacrolimus.
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Cat. No.: HY-Z12774
CAS No.: 144432-23-5
Target:  

Drug Intermediate

Research Areas:  

Others

Tacrolimus impurity 5 is an impurity of Tacrolimus.
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