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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
Tempo
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "Tempo" in MCE Product Catalog:
16
16 Cited Publications
Cat. No.: HY-W001187
CAS No.: 2564-83-2
Research Areas:
Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells .
186
186 Publications Verification
Mito-TEMPO is a mitochondria-targeted antioxidant. Mito-TEMPO induces mitophagy by activating the PINK1/Parkin pathway, inhibits NLRP3 inflammasome activation, restores mitochondrial membrane potential, and improves renal function and podocyte injury. Mito-TEMPO regulates Ca 2+ homeostasis, inhibits Bnip3 overexpression, shortens action potential duration, and exerts antiarrhythmic effects. Mito-TEMPO reverses premature senescence, reduces trabecular bone loss, and decreases cell apoptosis. Mito-TEMPO can be used in studies of chronic kidney disease, age-related cardiac dysfunction, postmenopausal osteoporosis, and ischemic stroke .
29
29 Cited Publications
Synonyms: 4-Hydroxy-Tempo; MBM-02
Research Areas:
Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS).
2
2 Cited Publications
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Research Areas:
N3-TEMPO is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
Cat. No.: HY-W002004
CAS No.: 14691-88-4
Synonyms: 4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl
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Research Areas:
Tempone (4-Oxo-Tempo) is a nitroxide radical spin label and ROS scavenger. Tempone induces cytotoxicity in lymphoma cells. Tempone serves as a substrate for intracellular reduction to hydroxylamine, rapidly equilibrates between intracellular and extracellular compartments, reduces nitroxide radical spin labels at the ubiquinol site of the respiratory chain, and acts as an alternative terminal electron acceptor when electron flow to oxygen is blocked. Tempone serves as a superoxide sensor, a T2-weighted MRI contrast agent, and a dynamic nuclear polarization polarizing agent for 13C. Tempone inhibits superoxide and peroxynitrite, hydroxyl radical generation, nitrotyrosine formation, and poly (ADP-ribose) formation, and alleviates renal dysfunction and injury in ischemia/reperfusion and hydrogen peroxide-induced injury. Tempone can be used for research on ischemia-reperfusion injury, acute renal failure, and lymphoma .
Cat. No.: HY-W001187S
CAS No.: 205679-68-1
Cat. No.: HY-129242S
CAS No.: 80404-14-4
Synonyms: 4-Oxo-Tempo-15N,d16
Tempone- 15N,d16 (4-Oxo-Tempo 15N,D16) is the deuterated, 15N-labeled Tempone (HY-129242). Tempone (4-Oxo-Tempo) is a nitroxide radical spin label and ROS scavenger. Tempone induces cytotoxicity in lymphoma cells. Tempone serves as a substrate for intracellular reduction to hydroxylamine, rapidly equilibrates between intracellular and extracellular compartments, reduces nitroxide radical spin labels at the ubiquinol site of the respiratory chain, and acts as an alternative terminal electron acceptor when electron flow to oxygen is blocked. Tempone serves as a superoxide sensor, a T2-weighted MRI contrast agent, and a dynamic nuclear polarization polarizing agent for 13C. Tempone inhibits superoxide and peroxynitrite, hydroxyl radical generation, nitrotyrosine formation, and poly (ADP-ribose) formation, and alleviates renal dysfunction and injury in ischemia/reperfusion and hydrogen peroxide-induced injury. Tempone can be used for research on ischemia-reperfusion injury, acute renal failure, and lymphoma .
Cat. No.: HY-W001187R
CAS No.: 2564-83-2
Target:
Mitochondrial Metabolism DNA/RNA Synthesis Reactive Oxygen Species (ROS) Reference Standards
Research Areas:
Tempo (Standard) is the analytical standard of Tempo. This product is intended for research and analytical applications. Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells [4].
Cat. No.: HY-100561S
CAS No.: 90429-66-6
Synonyms: 4-Hydroxy-Tempo-d17,15N; MBM-02-d17,15N
Research Areas:
Tempol-d17, 15N is the deuterium labeled Tempol . Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS) .
Cat. No.: HY-140512
CAS No.: 2055040-79-2
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Acid-PEG5-TEMPO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
Cat. No.: HY-W002004S1
CAS No.: 70588-04-4
Synonyms: 4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl-d17
Cat. No.: HY-100561R
CAS No.: 2226-96-2
Synonyms: 4-Hydroxy-Tempo (Standard); MBM-02 (Standard)
Research Areas:
Tempol (Standard) is the analytical standard of Tempol. This product is intended for research and analytical applications. Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS).
Cat. No.: HY-W777072
CAS No.: 88418-69-3
4-isocyanato TEMPO is a spin labeling reagent used to label the 2’-position in RNA. It has been used to study HIV-1 transactivation response RNA and hammerhead ribosome dynamics by electron paramagnetic resonance (EPR) spectroscopy.
Cat. No.: HY-W002004S
CAS No.: 97461-87-5
Synonyms: 4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl-d17,15N
Cat. No.: HY-129242S1
CAS No.: 36763-53-8
Synonyms: 4-Oxo-Tempo-d16
Tempone-d16 (4-Oxo-Tempo-d16) is the deuterated-labeled Tempone (HY-129242). Tempone (4-Oxo-Tempo) is a nitroxide radical spin label and ROS scavenger. Tempone induces cytotoxicity in lymphoma cells. Tempone serves as a substrate for intracellular reduction to hydroxylamine, rapidly equilibrates between intracellular and extracellular compartments, reduces nitroxide radical spin labels at the ubiquinol site of the respiratory chain, and acts as an alternative terminal electron acceptor when electron flow to oxygen is blocked. Tempone serves as a superoxide sensor, a T2-weighted MRI contrast agent, and a dynamic nuclear polarization polarizing agent for 13C. Tempone inhibits superoxide and peroxynitrite, hydroxyl radical generation, nitrotyrosine formation, and poly (ADP-ribose) formation, and alleviates renal dysfunction and injury in ischemia/reperfusion and hydrogen peroxide-induced injury. Tempone can be used for research on ischemia-reperfusion injury, acute renal failure, and lymphoma .
Cat. No.: HY-100561S1
CAS No.: 100326-46-3
Synonyms: 4-Hydroxy-Tempo-d17; MBM-02-d17
Research Areas:
Tempol-d17 is the deuterium labeled Tempol . Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS) .
Cat. No.: HY-112879R
CAS No.: 1334850-99-5
Mito-TEMPO (Standard) is the analytical standard of Mito-TEMPO (HY-112879). This product is intended for research and analytical applications. Mito-TEMPO is a mitochondria-targeted antioxidant. Mito-TEMPO induces mitophagy by activating the PINK1/ParKin pathway, inhibits NLRP3 inflammasome activation, restores mitochondrial membrane potential, and improves renal function and podocyte injury. Mito-TEMPO regulates Ca 2+ homeostasis, inhibits Bnip3 overexpression, shortens action potential duration, and exerts antiarrhythmic effects. Mito-TEMPO reverses premature senescence, reduces trabecular bone loss, and decreases cell apoptosis. Mito-TEMPO can be used in studies of chronic Kidney disease, age-related cardiac dysfunction, postmenopausal osteoporosis, and ischemic stroke .
Cat. No.: HY-179762
CAS No.: 63658-52-6
16:0 Tempo PC is a phosphocholine with a TEMPO group. (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) is commonly used as a spin-label for lipid membrane studies. TEMPO alwayss acts as a spin probe are in electron resonance spectroscopy, as a paramagnetic contrast agent in NMR, and as oxygen-sensitive probes in biological systems.
Cat. No.: HY-W705452
CAS No.: 22977-65-7
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4-Palmitamido-TEMPO is an aliphatic derivative of TEMPO. It is incorporated into vesicles and cell membranes and has been used to study the entrapment of molecules in phosphatidylcholine vesicles.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
