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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
VARS1
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "VARS1" in MCE Product Catalog:
1
1 Cited Publications
Art. -Nr.: HY-N3857
CAS. Nr.: 63807-85-2
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Art. -Nr.: HY-RS15604
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Forschungsgebiete:
VARS1 Human Pre-designed siRNA Set A contains three designed siRNAs for VARS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-N7345
CAS. Nr.: 71222-06-5
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Art. -Nr.: HY-180996
CAS. Nr.: 667914-07-0
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Forschungsgebiete:
VARS1-IN-2 (Compound 2901) is a VARS1 inhibitor with a Kd of 0.014 µM. VARS1-IN-2 does not alter VARS1 expression either at mRNA or protein level. VARS1-IN-2 exerts anti-prostate cancer effects mainly through interfering VARS1’s tRNA aminoacylation activity but not its expression [1].
Art. -Nr.: HY-179557
CAS. Nr.: 2463893-46-9
Forschungsgebiete:
iMQT_020 is a selective allosteric SLC1A5_var inhibitor. iMQT_020 disrupts the trimeric assembly of SLC1A5_var, causing metabolic crisis in cancer cells and selectively suppressing their growth. iMQT_020 reduces glutamine anaplerosis and oxidative phosphorylation, resulting in a broad disruption of cancer metabolism. iMQT_020 reduces GSH levels and increases cellular ROS and mitochondrial ROS. iMQT_020 induces apoptosis and ferroptosis. iMQT_020 can epigenetically upregulate PD-L1 expression. iMQT_020 can be used for the study of pancreatic cancer, lung cancer, and colon cancer [1].
Art. -Nr.: HY-180995
CAS. Nr.: 428830-84-6
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Forschungsgebiete:
VARS1-IN-1 is a valyl-tRNA synthetase (VARS1) inhibitor with a Kd of 0.213 μM. VARS1-IN-1 suppresses VARS1’s tRNA aminoacylation activity, reduces charged levels of valine tRNAs and redues total protein synthesis rate. VARS1-IN-1 suppresses aggressive tumor growth and cell proliferation in PC3 prostate cancer xenograft models. VARS1-IN-1 can be used for the research of prostate cancer [1].
Art. -Nr.: HY-126655
CAS. Nr.: 139713-81-8
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Art. -Nr.: HY-121691
CAS. Nr.: 41743-57-1
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Nanhaia speciosa (Champ. ex Benth.) J. Compton & Schrire Terpenoids Diterpenoids Plants Compositae
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Art. -Nr.: HY-N7359
CAS. Nr.: 13861-71-7
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Art. -Nr.: HY-N9177
CAS. Nr.: 1392307-42-4
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Art. -Nr.: HY-N9697
CAS. Nr.: 51652-39-2
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
