Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
VAV1
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "VAV1" in MCE Product Catalog:
Cat. No.: HY-168625
CAS No.: 3050683-38-7
Synonyms: VAV1 degrader-3
Target:
Research Areas:
MRT-6160 (Example 185) is an orally active VAV1 molecular glue degrader (DC50: 7 nM). MRT-6160 reduces immune cell activation, immune cell proliferation and the production of various cytokines. MRT-6160 can be used for research of inflammatory or autoimmune disorder. MRT-6160 inhibits disease progression in experimntal autoimmune encephalomyelitis (EAE) mouse model, Collagen-induced arthritis (CIA) mouse model, etc. [1].
Cat. No.: HY-168624
CAS No.: 3050683-29-6
Target:
Research Areas:
VAV1 degrader-2 is a molecular glue degrader based on targeting Vav guanine nucleotide exchange factor 1 (VAV 1) with a DC50 of 4.41 nM. VAV1 degrader-2 can be used in the study of inflammatory and autoimmune diseases [1].
Cat. No.: HY-175453
CAS No.: 3050683-03-6
Target:
Research Areas:
MRT-23227 is a CRBN-recruiting molecular glue degrader targeting VAV1. MRT-23227 binds to the tryptophan triad pocket of CRBN, forms a ternary complex with the SH3c domain of VAV1, and induces proteasomal degradation of VAV1 through hydrogen-bond interactions between CRBN residues and the RT loop and side chains of VAV1. MRT-23227 can be used in the research of T-cell leukemia and lymphoma [1].
Cat. No.: HY-131598C
Synonyms: 6-Thioguanosine-5'-triphosphate tetrasodium
Target:
Research Areas:
6-Thio-GTP (tetrasodium) is a Vav1-Rac inhibitor. 6-Thio-GTP (tetrasodium) inhibits TCR-stimulated T cell proliferation and CD28-mediated T cell survival. 6-Thio-GTP (tetrasodium) has an immunosuppressive effect in a mouse cardiac allograft transplant model and prolongs cardiac allograft survival [1].
Cat. No.: HY-RS15612
Target:
Research Areas:
VAV1 Human Pre-designed siRNA Set A contains three designed siRNAs for VAV1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS20834
Target:
Research Areas:
Vav1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vav1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-182765
CAS No.: 3119457-09-6
Target:
Research Areas:
VAV1 degrader-4 is a VAV1 molecular glue degrader with a DC50 value of 3.93 nM for VAV1 in Jurkat cells. VAV1 degrader-4 can dose-dependently inhibit the production of IL-2. VAV1 degrader-4 can be used for research on autoimmune diseases [1].
Cat. No.: HY-RS27348
Target:
Research Areas:
Vav1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Vav1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P702995
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Proto-oncogene VAV; VAV1; VAV
Cat. No.: HY-P704096
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: VAV
Cat. No.: HY-P810787
Synonyms: VAV, VAV1, Proto-oncogene VAV
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
