22 Results for "

Val-Val

" in MedChemExpress (MCE) Product Catalog:
Products (22)

22 Results for "Val-Val" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-103265
CAS No.: 1021868-83-6
Purity:  99.94%
Synonyms: FPL 67156 trisodium
Target:  

NTPDase

ARL67156 (FPL 67156) trisodium is a selective small molecular inhibitor, targeting to ecto-ATPase, CD39, and CD73. ARL67156 trisodium is also a competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12?μM, respectively. ARL67156 trisodium can be used in the research of calcific aortic valve disease, asthma .
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3
3 Cited Publications
Cat. No.: HY-103265D
Synonyms: FPL 67156 triethylamine
Target:  

NTPDase

ARL67156 (FPL 67156) triethylamine is a selective small is a selective samll molecular inhibitor, targeting to ecto-ATPase, CD39, and CD73. ARL67156 triethylamine is also a competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively. ARL67156 triethylamine can be used in the research of disease like calcific aortic valve disease, asthma .
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2
2 Cited Publications
Cat. No.: HY-16513
CAS No.: 23261-20-3
Synonyms: Dianhydrodulcitol; Dianhydrogalactitol
Research Areas:  

Cancer

VAL-083 is an alkylating agent that creates N7 methylation on DNA, with antitumor activity.
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Cat. No.: HY-126584
CAS No.: 3918-94-3
Purity:  ≥99.0%
Synonyms: Val-Val
Research Areas:  

Others

H-Val-Val-OH (Val-Val) is a stereochemistry-dependent substrate and inhibitor of apical oligopeptide transporters. H-Val-Val-OH undergoes apical intracellular accumulation in human intestinal cells via carrier-mediated transport, and inhibits the uptake of Cephalexin (HY-B0200) through interaction with transporters. Substitution of L-valine with D-valine in H-Val-Val-OH abolishes its binding ability to apical oligopeptide transporters .
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Cat. No.: HY-W250408
CAS No.: 1352202-13-1
Research Areas:  

Cancer

Fmoc-NMe-Val-Val-Dil-Dap-OH is an intermediate for preparing drug-linker conjugate MC-MMAF, which can be used for synthesis of ADC molecule .
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Cat. No.: HY-160795
CAS No.: 1369426-99-2
Target:  

ADC Linkers

Research Areas:  

Cancer

Boc-NMe-Val-Val-Dil-Dap-OH is a linker, that can be used for ADC synthesis.
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Cat. No.: HY-137367
CAS No.: 124485-41-2
Purity:  99.77%
Target:  

Cathepsin

Research Areas:  

Infection

Z-Val-Val-Arg-AMC is a fluorescent peptide substrate that can be used to test the activity of cathepsins .
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Cat. No.: HY-103265B
Purity:  99.94%
Synonyms: FPL 67156 trisodium hydrate
Target:  

NTPDase

ARL67156 (FPL 67156) trisodium hydrate is a selective small is a selective samll molecular inhibitor, targeting to ecto-ATPase, CD39, and CD73. ARL67156 trisodium hydrate is also a competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with Kis of 11, 18 and 12 μM, respectively. ARL67156 trisodium hydrate can be used in the research of disease like calcific aortic valve disease, asthma .
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Cat. No.: HY-158424
CAS No.: 2565657-20-5
Purity:  99.62%
Target:  

LDLR

Research Areas:  

Cardiovascular Disease

LSN3353871 is an orally active inhibitor of lipoprotein (a) (Lp (a)) formation, with Kd values of 756 nM (apo (a) KIV8), 605 nM (apo (a) KIV7-8), and 423 nM (apo (a) KIV5-8), respectively, and an IC50 of 1.69 μM against apo (a) KIV5-8. LSN3353871 reduces circulating Lp (a) levels in transgenic mice and cynomolgus monkeys. LSN3353871 can be used in the research of atherosclerotic cardiovascular disease and calcific aortic valve disease .
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Cat. No.: HY-P5898
CAS No.: 155026-49-6
Synonyms: Z-Val-Val-Nle-CHN2
Target:  

Cathepsin MHC

Research Areas:  

Inflammation/Immunology

Z-Val-Val-Nle-diazomethylketone is a cathepsin S (CATS) inhibitor. Z-Val-Val-Nle-diazomethylketone significantly inhibits the IFNg-induced upregulation of the MHCII molecules HLA-DR and Ii-p33/35 with an increase of Ii-p10 protein level. Z-Val-Val-Nle-diazomethylketone can be used for dermatological diseases like psoriasis, atopic dermatitis and actinic keratosis research .
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Cat. No.: HY-112499S
CAS No.: 1233937-31-9
Synonyms: Vitamin K2-7-d7; Vitamin K2(35)-d7; Vitamin MK-7-d7
Menaquinone-7-d7 is the deuterium labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors . Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins . Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS) .
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Cat. No.: HY-P4019
CAS No.: 121822-32-0
Target:  

HIV Protease

Research Areas:  

Others

Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 is a substrato peptídico of HIV-1 protease. Ac-Ser-Gln-Asn-Tyr-Pro-Val-Val-NH2 acts as the variable substrate in a peptidolytic assay to quantify the inhibition of the protease .
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Cat. No.: HY-126584S
Synonyms: Val-Val-13C10,15N2
H-Val-Val-OH- 13C10, 15N2 TFA (Val-val- 13C10, 15N2) is the 13C- and 15N-labeled H-Val-Val-OH (HY-126584). H-VAL-VAL-OH (Val-val) is a dipeptide in which two valine (Val) residues are linked by an amide bond. H-VAL-VAL-OH can be used for the synthesis of some important compounds such as Poststatin (HY-125432) .
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Cat. No.: HY-P4026
CAS No.: 396679-25-7
Target:  

Peptides

Research Areas:  

Others

K(biotinyl)-KEDVV-Abu-CS-Abu-SYKK-NH2 is a peptide that the primary structure is: Lys(biotinyl)-Lys-Glu-Asp-Val-Val-Abu-Cys-Ser-Abu-Ser-Tyr-Lys-Lys-NH2.
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Cat. No.: HY-P3972
CAS No.: 149234-05-9
Target:  

TGF-β Receptor

Research Areas:  

Cancer

H-ILE-ARG-VAL-VAL-MET-OH is a pentapeptide from C7 with a domain that supports cell attachment. H-ILE-ARG-VAL-VAL-MET-OH is also the sequence fragment that binds to the thrombospondin-1 (TS1) receptor .
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Cat. No.: HY-116307
CAS No.: 35763-29-2
Target:  

P2Y Receptor

Research Areas:  

Cardiovascular Disease

2-Thio-UTP is a selective P2Y2 inhibitor with an EC50 value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) .
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Cat. No.: HY-112499S1
Purity:  ≥96.0%
Synonyms: Vitamin K2-7-13C6; Vitamin K2(35)-13C6; Vitamin MK-7-13C6
Menaquinone-7- 13C6 is the 13C-labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors . Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins . Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS) .
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Cat. No.: HY-16513R
CAS No.: 23261-20-3
Synonyms: Dianhydrodulcitol (Standard); Dianhydrogalactitol (Standard)
Research Areas:  

Cancer

VAL-083 (Standard) is the analytical standard of VAL-083. This product is intended for research and analytical applications. VAL-083 is an alkylating agent that creates N7 methylation on DNA, with antitumor activity.
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Cat. No.: HY-P99803
CAS No.: 2145123-44-8
Synonyms: Val-1221

Target:  

Glycosidase

Research Areas:  

Others

Clervonafusp alfa (VAL-1221) is a fusion protein targeting both cytosolic and lysosomal glycogen. Clervonafusp alfa is comprised of the Fab portion of a cell-penetrating antibody and recombinant human acid alpha glucosidase (rhGAA), the former utilizing the nucleoside transporter ENT-2 to gain access to the cytosol, and the latter enters lysosomes via mannose-6-phosphate receptors (M6PRs). Clervonafusp alfa can be used for late-onset Pompe disease research .
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Cat. No.: HY-174671
Target:  

mRNA

Research Areas:  

Cardiovascular Disease

Human HBEGF mRNA encodes the human heparin binding EGF like growth factor (HBEGF) protein, a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. HBEGF may be involved in normal cardiac valve formation and normal heart function.
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