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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
VcMMAE
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "VcMMAE" in MCE Product Catalog:
97
97 Publications Verification
Synonyms: MC-Val-Cit-PAB-MMAE; mc-vc-PAB-MMAE; Vedotin
Domaines de recherche:
VcMMAE (mc-vc-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
2
2 Cited Publications
Synonyms: CDX-011; CR011-VcMMAE
Domaines de recherche:
Glembatumumab vedotin (CDX-011) is an ADC comprising a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB) and conjugated to the potent tubulinbinding cytotoxic agent MMAE via a protease-sensitive vc linker. Glembatumumab vedotin has potent anticancer effects .
1
1 Cited Publications
Cat. No.: HY-P99016B
CAS No.: 1346452-25-2
Domaines de recherche:
1
1 Cited Publications
Cat. No.: HY-P99107A
CAS No.: 914088-09-8
Domaines de recherche:
Brentuximab vedotin (solution) (cAC10-vcMMAE) is an antibody-drug conjugate (ADC) comprising an anti-CD30 antibody and the cytotoxic agent Monomethyl auristatin E (MMAE). The antibody portion is Brentuximab (HY-P99151), and the drug-linker conjugate for ADC is VcMMAE (HY-15575). Brentuximab vedotin (solution) inhibits CD30-positive cells with an IC50 of 2.5 ng/mL. Brentuximab vedotin (solution) can be used for the research of relapsed and refractory Hodgkin lymphoma .
1
1 Cited Publications
Cat. No.: HY-P99016A
CAS No.: 1346452-25-2
1
1 Cited Publications
Domaines de recherche:
1
1 Cited Publications
Cat. No.: HY-78738
CAS No.: 159857-80-4
Target:
Domaines de recherche:
MC-Val-Cit-PAB is a cleavable ADC Linker that forms part of VcMMAE (HY-15575). VcMMAE is Drug-Linker Conjugates for ADCs. The ADC Cytotoxin in VcMMAE is MMAE, a tubulin polymerization inhibitor.
Cat. No.: HY-164153
Domaines de recherche:
Target:
Domaines de recherche:
Tisotumab vedotin is an antibody drug conjugate (ADC) targeting tissue factor (TF), formed by covalently linking a fully human monoclonal antibody (TF-011) against TF with the microtubule disruptor Monomethyll Auristatin E (MMAE) (HY-15162), and the drug-linker conjugate for ADC is VcMMAE (HY-15575). Tisotumab vedotin has immunomodulatory and anti-tumor activities, and can be used in the study of advanced or metastatic solid tumors such as cervical cancer .
Cat. No.: HY-15575G
CAS No.: 646502-53-6
Synonyms: MC-Val-Cit-PAB-MMAE (GMP); mc-vc-PAB-MMAE (GMP)
Cat. No.: HY-171265
Synonyms: MRG003
Cat. No.: HY-171821
Synonyms: SGN-PDL1V
Cat. No.: HY-164835
CAS No.: 2760408-75-9
Synonyms: VcMMAE-(PAB-GGFG-AMAA)Exatecan; SMP-54418
Domaines de recherche:
VcMMAE-Deruxtecan (VcMMAE-(PAB-GGFG-AMAA)Exatecan; SMP-54418) is a drug-linker conjugate for ADC, composed of linker-payload molecule conjugate VcMMAE (HY-15575) and linker-payload molecule conjugate Deruxtecan (PAB-GGFG-AMAA)Exatecan) (HY-13631E). VcMMAE-Deruxtecan can be used in the synthesis of ADCs.
Cat. No.: HY-15575S
Pureté: 97.56%
Synonyms: MC-Val-Cit-PAB-MMAE-d8; mc-vc-PAB-MMAE-d8
Cat. No.: HY-145627
CAS No.: 2460400-11-5
Synonyms: BA3021; Anti-ROR2 ADC; CAB-ROR2-ADC
Domaines de recherche:
Cat. No.: HY-P99595
CAS No.: 1824663-83-3
Synonyms: AGS15E; ASG-15ME; 1VcMMAE
Target:
Domaines de recherche:
Sirtratumab vedotin (ASG15-ME) is an ADC composed of a SLITRK6-specific human gamma 2 antibody (Igγ2) conjugated to a small molecule microtubule disrupting agent, monomethyl auristatin E (MMAE) via a protease-cleavable linker .
Cat. No.: HY-15575R
CAS No.: 646502-53-6
Synonyms: MC-Val-Cit-PAB-MMAE (Standard); mc-vc-PAB-MMAE (Standard); Vedotin (Standard)
Domaines de recherche:
VcMMAE (Standard) is the analytical standard of VcMMAE. This product is intended for research and analytical applications.
Synonyms: anti-CD22-vc-MMAE; DCDT2980S
Domaines de recherche:
Pinatuzumab vedotin, an antibody-drug conjugate (ADC), is a CD22 humanized monoclonal antibody Pinatuzumab (HY-P99230) conjugated to VcMMAE (HY-15575). Pinatuzumab vedotin has antitumor activities .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
