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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
WNK1
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "WNK1" in MCE Product Catalog:
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20 Publications Verification
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WNK463 is an orally bioavailable pan-With-No-Lysine (K) (WNK)-kinase inhibitor with IC50s of 5 nM, 1 nM, 6 nM, and 9 nM for WNK1, WNK2, WNK3, and WNK4, respectively [1].
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4 Cited Publications
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WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1.
1
1 Cited Publications
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WNK1-IN-1 is a selective inhibitor of WNK1 with an IC50 value of 1.6 μM. WNK1-IN-1 inhibits OSR1 phosphorylation with an IC50 value of 4.3 μM. WNK1-IN-1 can be used for the research of blood pressure regulation and cancer [1].
1
1 Cited Publications
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
SB-699551 is a selective and brain penetrant 5-HT5A receptor antagonist with a pKi of 8.2 nM. SB-699551 shows high selectivity over most other 5-HT receptor subtypes, dopamine receptors, and α1B adrenoceptor. SB-699551 disrupts Gαi/o-coupled and PI3K/AKT/mTOR signaling pathways, alters CREB, ATF1, AKT, PRAS40, S6K, and FOXO1 phosphorylation in breast tumor cells. SB-699551 can be used for the research of anxiety, breast cancer, and Alzheimer's disease [1] .
Cat. No.: HY-RS15823
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WNK1 Human Pre-designed siRNA Set A contains three designed siRNAs for WNK1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS16969
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Wnk1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Wnk1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23412
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Wnk1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Wnk1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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STOCK2S-26016 is a WNK signalling inhibitors. STOCK2S-26016 inhibits WNK4 and WNK1 with IC50s of 16 μM and 34.4 μM, respectively. STOCK2S-26016 has potential for antihypertensive research [1].
Cat. No.: HY-E70806
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WNK1 is a WNK kinase that is involved in embryonic angiogenesis and tumor-induced angiogenesis. Biotin-WNK1 Recombinant Human Active Protein Kinase is obtained by expressing WNK1 proteins and is biotinylated [1].
Cat. No.: HY-101959A
CAS No.: 118409-60-2
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Tyrphostin 47 is a nonspecific inhibitor of WNK1. Tyrphostin 47 is a protein tyrosine kinase inhibitor. Tyrphostin 47 inhibits smooth-muscle cell proliferation [1]
Cat. No.: HY-P82468
Synonyms: WNK1; HSN2; KDP; KIAA0344; PRKWNK1; Serine/threonine-protein kinase WNK1; Erythrocyte 65 kDa protein; p65; Kinase deficient protein; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; hWNK1
Cat. No.: HY-P706114
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Serine/threonine-protein kinase WNK1; Erythrocyte 65 kDa protein; p65; Kinase deficient protein; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; hWNK1; HSN2; KDP; KIAA0344; PRKWNK1
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Cat. No.: HY-P703072
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Erythrocyte 65 kDa protein; p65; Kinase deficient protein; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; HSN2; KDP, KIAA0344; PRKWNK1
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Source:
Cat. No.: HY-111286
CAS No.: 853298-47-2
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WNK-IN-2 is an ATP-competitive WNK kinase inhibitor with low kinase selectivity [1].
Cat. No.: HY-103100R
CAS No.: 864741-95-7
Target:
Reference Standards 5-HT Receptor Epigenetic Reader Domain Akt Ribosomal S6 Kinase (RSK) FOXO
Research Areas:
SB-699551 (Standard) is the analytical standard of SB-699551 (HY-103100). This product is intended for research and analytical applications. SB-699551 is a potent and selective 5-HT5A antagonist with a Ki value of 5.1 μM. SB-699551 increases the phosphorylation levels of CREB and ATF1, and decreases the phosphorylation levels of AKT, PRAS40, P70S6K, FOXO1, and S6RP. SB-699551 improves drug-induced cognitive deficits. SB-699551 improves social withdrawal and forgetfulness. SB-699551 inhibits breast cancer.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
