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Withania

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (2) Cholinesterase (ChE) (1) Complement System (1) Drug Derivative (1) Drug Metabolite (1) Ferroptosis (2) GABA Receptor (1) HIV (1) HSP (1) iGluR (2) Isotope-Labeled Compounds (1) NF-κB (2) Reference Standards (3) RET (1) SARS-CoV (1) Virus Protease (1)
By Research Areas:	Cancer (8) Infection (2) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (6)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2065

Withaferin A 10+ Cited Publications	NF-κB Ferroptosis	Inflammation/Immunology Cancer
Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

HY-N10889

Sominone	Drug Metabolite RET	Neurological Disease
Sominone is the active metabolite of Withanoside IV (HY-N8693). Sominone enhances neuronal morphological plasticity by activating the RET pathway. Sominone can also induce axon/dendrite regeneration and synaptic reconstruction, thereby improving spatial memory. Sominone can be used in the research of neurodegenerative diseases such as Alzheimer's disease .

HY-129692

Withanone 1 Publications Verification	iGluR	Neurological Disease Cancer
Withanone is an active ingredient from the roots of Withania somnifera and a GRP75 inhibitor. Withanone has multifunctional neuroprotective effects in alleviating cognitive dysfunction. In neuron-like cells, Withanone can inhibit NMDA-induced excitotoxicity. Withanone can inhibit white adipose tissue browning by blocking the formation of the GRP75-ANT2-UCP1 complex, thereby alleviating cancer-related cachexia. Withanone can be used in the research of tumors and nervous system diseases .

HY-N2065R

Withaferin A (Standard)	Reference Standards NF-κB Ferroptosis	Inflammation/Immunology Cancer
Withaferin A (Standard) is the analytical standard of Withaferin A. This product is intended for research and analytical applications. Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

HY-N5069

2,3-Didehydrosomnifericin	Bacterial	Others
2,3-Didehydrosomnifericin is one of withanolides found in Withania somnifera .

HY-N5120

Dihydrowithaferin A 2,3-Dihydrowithaferin A	Cholinesterase (ChE)	Cancer
Dihydrowithaferin A (2, 3-dihydrowithaferin A) is a withanolide isolated from Withania somnifera. Dihydrowithaferin A is active against acetylcholinesterase (AChE) .

HY-P11032

Mp-4D7-pF2	SARS-CoV Virus Protease	Infection
Mp-4D7-pF2, a cell-penetrating bicyclic peptide, is a noncovalent SARS-CoV-2 main protease inhibitor with an IC₅₀ of 4.51 μM. Mp-4D7-pF2 has an antiviral activity against SARS-CoV-2 with no cytotoxicity. Mp-4D7-pF2 can used for COVID-19 infections research .

HY-N5131

3β-Methoxy-2,3-dihydrowithaferin A Quresimin A	Others	Others
3β-Methoxy-2,3-dihydrowithaferin A is one of withanolides found in Withania somnifera .

HY-N10884

Withasomniferolide A	Others	Others
Withasomniferolide A is a withanolide, isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera .

HY-N10887

Withasomniferolide B	GABA Receptor	Neurological Disease
Withasomniferolide B is a withanolide. Withasomniferolide B can be isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera .

HY-138146

4-Dehydrowithaferin A 4-oxo Withaferin A	Drug Derivative	Cancer
4-Dehydrowithaferin A is the analogue of withaferin A. Withaferin A is a withanolide isolated from Withania somnifera. 4-Dehydrowithaferin A has the potential for the research of multiple myeloma .

HY-N5046

27-O-Acetyl-withaferin A	Others	Inflammation/Immunology
27-O-Acetyl-withaferin A is found in Withania aristata .

HY-N5113

6α-Chloro-5β-hydroxywithaferin A	Bacterial	Others
6α-Chloro-5β-hydroxywithaferin A is a withanolide that can be isolated from W. somnifera. W. somnifera has antioxidant, anti-inflammatory, immunomodulatory, anticarcinogenic, antibacterial antiparkinsonism and antistress properties .

HY-N11702

Kaempferol-3-O-robinoside-7-O-glucoside	Others	Others
Kaempferol-3-O-robinoside-7-Oglucoside is a double-chain flavonol triglycoside can be extracted from Withania somnifera .

HY-N15635

Withacoagin (+)-Withacoagin	HIV	Infection Metabolic Disease Inflammation/Immunology
Withacoagin is a withanolide that can be isolated from the roots of Withania coagulans. Withacoagin has various biological activites such as adaptogenic, anti-inflammatory, and antioxidant properties. Withacoagin regulates the activity of various enzymes and pathways related to oxidative stress and inflammation. Withacoagin can attenuates HIV-1 infection .

HY-N8671R

Withanoside V (Standard)	Reference Standards Others	Neurological Disease
Withanoside V (Standard) is the analytical standard of Withanoside V. This product is intended for research and analytical applications. Withanoside V, a withanolide glycoside, exhibits inhibitory activity for tachyphylaxis to Clonidine in isolated guinea-pig ileum .

HY-N18728

Withania somnifera extract	Others	Neurological Disease
Withania somnifera extract, derived from the roots and leaves of the South African ashwagandha (Withania somnifera), contains a variety of bioactive components, including solanolactones (such as solanolactone A, solanolactone D, and solanine A), solanosin (such as solanosin IV and solanosin VI), alkaloids (such as isopretiline and anaflin), β-sitosterol, benzoic acid, and tropane alkaloids. Withania somnifera extract has been extensively studied for its benefits in stress management, anxiety relief, improved physical function, and overall health.

HY-129692R

Withanone (Standard)	Reference Standards iGluR	Neurological Disease Cancer
Withanone (Standard) is the analytical standard of Withanone (HY-129692). This product is intended for research and analytical applications. Withanone is an active ingredient from the roots of Withania somnifera and a GRP75 inhibitor. Withanone has multifunctional neuroprotective effects in alleviating cognitive dysfunction. In neuron-like cells, Withanone can inhibit NMDA-induced excitotoxicity. Withanone can inhibit white adipose tissue browning by blocking the formation of the GRP75-ANT2-UCP1 complex, thereby alleviating cancer-related cachexia. Withanone can be used in the research of tumors and nervous system diseases .

HY-N10949

Viscosalactone B	Others	Cancer
Viscosalactone B is a withanolide found in Withania somnifera. Viscosalactone B shows potent inhibitory activities to NCI-H460, HCT-116, MCF-7 and SF-268 cancer cells with IC₅₀ values of 0.32, 0.47, 0.4 and 0.45 μg/mL. Viscosalactone B can be used for the research of cancer .

HY-N17756

Withanolide D	HSP	Cancer
Withanolide D (Compound 2) is a steroidal ester found in Withania somnifera (L.) Dunal, with anticancer activity. Withanolide D can activate the heat-shock factor 1 (HSF1)-dependent stress response. Withanolide D can be used for the research of cancer such as lymphoma .

HY-P3252AS

Pegcetacoplan-13C3,15N TFA	Isotope-Labeled Compounds Complement System	Inflammation/Immunology
Pegcetacoplan- ¹³C₃, ¹⁵N TFA is the ¹³C- and ¹⁵N-labeled Pegcetacoplan TFA. Pegcetacoplan is a pegylated complement C3/C3b inhibitor. Pegcetacoplan acts by specifically binding to and inhibiting C3 and C3b, thereby suppressing the complement cascade at its proximal stage. Pegcetacoplan is not a known inhibitor or inducer of CYP450 isoenzymes. Pegcetacoplan can be used for the research of complement-mediated diseases, including paroxysmal nocturnal hemoglobinuria (PNH) and age-related macular degeneration (AMD).

Cat. No.	Product Name	Target	Research Area

HY-P11032

Mp-4D7-pF2	SARS-CoV Virus Protease	Infection
Mp-4D7-pF2, a cell-penetrating bicyclic peptide, is a noncovalent SARS-CoV-2 main protease inhibitor with an IC₅₀ of 4.51 μM. Mp-4D7-pF2 has an antiviral activity against SARS-CoV-2 with no cytotoxicity. Mp-4D7-pF2 can used for COVID-19 infections research .

HY-P3252AS

Pegcetacoplan-13C3,15N TFA	Isotope-Labeled Compounds Complement System	Inflammation/Immunology
Pegcetacoplan- ¹³C₃, ¹⁵N TFA is the ¹³C- and ¹⁵N-labeled Pegcetacoplan TFA. Pegcetacoplan is a pegylated complement C3/C3b inhibitor. Pegcetacoplan acts by specifically binding to and inhibiting C3 and C3b, thereby suppressing the complement cascade at its proximal stage. Pegcetacoplan is not a known inhibitor or inducer of CYP450 isoenzymes. Pegcetacoplan can be used for the research of complement-mediated diseases, including paroxysmal nocturnal hemoglobinuria (PNH) and age-related macular degeneration (AMD).

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2065

Withaferin A 10+ Cited Publications	Structural Classification other families Classification of Application Fields Withania somnifera Solanaceae Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	NF-κB Ferroptosis
Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

HY-N10889

Sominone	Withania somnifera Solanaceae Plants Steroids Source Classification	Drug Metabolite RET
Sominone is the active metabolite of Withanoside IV (HY-N8693). Sominone enhances neuronal morphological plasticity by activating the RET pathway. Sominone can also induce axon/dendrite regeneration and synaptic reconstruction, thereby improving spatial memory. Sominone can be used in the research of neurodegenerative diseases such as Alzheimer's disease .

HY-129692

Withanone 1 Publications Verification	Withania somnifera Solanaceae Plants Steroids Source Classification	iGluR
Withanone is an active ingredient from the roots of Withania somnifera and a GRP75 inhibitor. Withanone has multifunctional neuroprotective effects in alleviating cognitive dysfunction. In neuron-like cells, Withanone can inhibit NMDA-induced excitotoxicity. Withanone can inhibit white adipose tissue browning by blocking the formation of the GRP75-ANT2-UCP1 complex, thereby alleviating cancer-related cachexia. Withanone can be used in the research of tumors and nervous system diseases .

HY-N2065R

Withaferin A (Standard)	Structural Classification other families Withania somnifera Solanaceae Plants Steroids Source Classification	Reference Standards NF-κB Ferroptosis
Withaferin A (Standard) is the analytical standard of Withaferin A. This product is intended for research and analytical applications. Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding.

HY-N5069

2,3-Didehydrosomnifericin	other families Classification of Application Fields Other Diseases Plants Disease Research Fields Steroids Source Classification	Bacterial
2,3-Didehydrosomnifericin is one of withanolides found in Withania somnifera .

HY-N5120

Dihydrowithaferin A 2,3-Dihydrowithaferin A	Classification of Application Fields Withania somnifera Plants Solanaceae Disease Research Fields Steroids Cancer Source Classification	Cholinesterase (ChE)
Dihydrowithaferin A (2, 3-dihydrowithaferin A) is a withanolide isolated from Withania somnifera. Dihydrowithaferin A is active against acetylcholinesterase (AChE) .

HY-N5131

3β-Methoxy-2,3-dihydrowithaferin A Quresimin A	other families Classification of Application Fields Other Diseases Plants Disease Research Fields Steroids Source Classification	Others
3β-Methoxy-2,3-dihydrowithaferin A is one of withanolides found in Withania somnifera .

HY-N10884

Withasomniferolide A	Withania somnifera Plants Solanaceae Steroids Source Classification	Others
Withasomniferolide A is a withanolide, isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera .

HY-N10887

Withasomniferolide B	Withania somnifera Plants Solanaceae Steroids Source Classification	GABA Receptor
Withasomniferolide B is a withanolide. Withasomniferolide B can be isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera .

HY-138146

4-Dehydrowithaferin A 4-oxo Withaferin A	Quinones Classification of Application Fields Benzene Quinones Withania somnifera Solanaceae Plants Disease Research Fields Source Classification Cancer	Drug Derivative
4-Dehydrowithaferin A is the analogue of withaferin A. Withaferin A is a withanolide isolated from Withania somnifera. 4-Dehydrowithaferin A has the potential for the research of multiple myeloma .

HY-N5046

27-O-Acetyl-withaferin A	other families Classification of Application Fields Plants Disease Research Fields Inflammation/Immunology Steroids Source Classification	Others
27-O-Acetyl-withaferin A is found in Withania aristata .

HY-N5113

6α-Chloro-5β-hydroxywithaferin A	Structural Classification Classification of Application Fields Other Diseases Withania somnifera Solanaceae Plants Disease Research Fields Steroids Source Classification	Bacterial
6α-Chloro-5β-hydroxywithaferin A is a withanolide that can be isolated from W. somnifera. W. somnifera has antioxidant, anti-inflammatory, immunomodulatory, anticarcinogenic, antibacterial antiparkinsonism and antistress properties .

HY-N11702

Kaempferol-3-O-robinoside-7-O-glucoside	Flavonoids Flavones Withania somnifera Plants Solanaceae Source Classification	Others
Kaempferol-3-O-robinoside-7-Oglucoside is a double-chain flavonol triglycoside can be extracted from Withania somnifera .

HY-N15635

Withacoagin (+)-Withacoagin	Structural Classification Solanaceae Plants Withania coagulans (Stocks) Dunal Steroids Source Classification	HIV
Withacoagin is a withanolide that can be isolated from the roots of Withania coagulans. Withacoagin has various biological activites such as adaptogenic, anti-inflammatory, and antioxidant properties. Withacoagin regulates the activity of various enzymes and pathways related to oxidative stress and inflammation. Withacoagin can attenuates HIV-1 infection .

HY-N8671R

Withanoside V (Standard)	Withania somnifera Solanaceae Plants Steroids Source Classification	Reference Standards Others
Withanoside V (Standard) is the analytical standard of Withanoside V. This product is intended for research and analytical applications. Withanoside V, a withanolide glycoside, exhibits inhibitory activity for tachyphylaxis to Clonidine in isolated guinea-pig ileum .

HY-N18728

Withania somnifera extract	Structural Classification Extract	Others
Withania somnifera extract, derived from the roots and leaves of the South African ashwagandha (Withania somnifera), contains a variety of bioactive components, including solanolactones (such as solanolactone A, solanolactone D, and solanine A), solanosin (such as solanosin IV and solanosin VI), alkaloids (such as isopretiline and anaflin), β-sitosterol, benzoic acid, and tropane alkaloids. Withania somnifera extract has been extensively studied for its benefits in stress management, anxiety relief, improved physical function, and overall health.

HY-129692R

Withanone (Standard)	Withania somnifera Solanaceae Plants Steroids Source Classification	Reference Standards iGluR
Withanone (Standard) is the analytical standard of Withanone (HY-129692). This product is intended for research and analytical applications. Withanone is an active ingredient from the roots of Withania somnifera and a GRP75 inhibitor. Withanone has multifunctional neuroprotective effects in alleviating cognitive dysfunction. In neuron-like cells, Withanone can inhibit NMDA-induced excitotoxicity. Withanone can inhibit white adipose tissue browning by blocking the formation of the GRP75-ANT2-UCP1 complex, thereby alleviating cancer-related cachexia. Withanone can be used in the research of tumors and nervous system diseases .

HY-N10949

Viscosalactone B	Structural Classification Withania somnifera Solanaceae Plants Steroids Source Classification	Others
Viscosalactone B is a withanolide found in Withania somnifera. Viscosalactone B shows potent inhibitory activities to NCI-H460, HCT-116, MCF-7 and SF-268 cancer cells with IC₅₀ values of 0.32, 0.47, 0.4 and 0.45 μg/mL. Viscosalactone B can be used for the research of cancer .

HY-N17756

Withanolide D	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	HSP
Withanolide D (Compound 2) is a steroidal ester found in Withania somnifera (L.) Dunal, with anticancer activity. Withanolide D can activate the heat-shock factor 1 (HSF1)-dependent stress response. Withanolide D can be used for the research of cancer such as lymphoma .

Cat. No.	Product Name	Chemical Structure

HY-P3252AS

Pegcetacoplan-13C3,15N TFA
Pegcetacoplan- ¹³C₃, ¹⁵N TFA is the ¹³C- and ¹⁵N-labeled Pegcetacoplan TFA. Pegcetacoplan is a pegylated complement C3/C3b inhibitor. Pegcetacoplan acts by specifically binding to and inhibiting C3 and C3b, thereby suppressing the complement cascade at its proximal stage. Pegcetacoplan is not a known inhibitor or inducer of CYP450 isoenzymes. Pegcetacoplan can be used for the research of complement-mediated diseases, including paroxysmal nocturnal hemoglobinuria (PNH) and age-related macular degeneration (AMD).

Pegcetacoplan-13C3,15N TFA

Pegcetacoplan- ¹³C₃, ¹⁵N TFA is the ¹³C- and ¹⁵N-labeled Pegcetacoplan TFA. Pegcetacoplan is a pegylated complement C3/C3b inhibitor. Pegcetacoplan acts by specifically binding to and inhibiting C3 and C3b, thereby suppressing the complement cascade at its proximal stage. Pegcetacoplan is not a known inhibitor or inducer of CYP450 isoenzymes. Pegcetacoplan can be used for the research of complement-mediated diseases, including paroxysmal nocturnal hemoglobinuria (PNH) and age-related macular degeneration (AMD).

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Withania

Inhibitors & Agonists

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