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Results for "

Withanolide

" in MedChemExpress (MCE) Product Catalog:

38

Inhibitors & Agonists

2

Peptides

35

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N7028
    Withanolide A

    		Notch Apoptosis Neurological Disease Inflammation/Immunology Cancer
    Withanolide A is an orally active extract from the Indian herb Ashwagandha. Withanolide A can induce apoptosis. Withanolide A has anti-inflammatory and antitumor activity. Withanolide A can be used in the study of neurodegenerative diseases .
    Withanolide A
  • HY-129566
    Withanolide B

    		ERK Wnt β-catenin RUNX Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .
    Withanolide B
  • HY-N10889
    Sominone

    		Drug Metabolite RET Neurological Disease
    Sominone is the active metabolite of Withanoside IV (HY-N8693). Sominone enhances neuronal morphological plasticity by activating the RET pathway. Sominone can also induce axon/dendrite regeneration and synaptic reconstruction, thereby improving spatial memory. Sominone can be used in the research of neurodegenerative diseases such as Alzheimer's disease .
    Sominone
  • HY-N11011
    Withaphysalin A

    		NF-κB STAT PERK JNK p38 MAPK PGE synthase Interleukin Related TNF Receptor COX Inflammation/Immunology Cancer
    Withaphysalin A is a withanolide compound with anti-inflammatory and antioxidant activities. Withaphysalin A inhibits LPS (HY-D1056)-induced nuclear translocation of NF-κB p65, as well as phosphorylation of STAT3, ERK, JNK and p38 MAPK. Withaphysalin A upregulates the expression of HO-1. Withaphysalin A inhibits LPS-induced production of NO, PGE2, IL-1β, IL-6 and TNF-α. Withaphysalin A downregulates LPS-induced expression of iNOS and COX-2. Withaphysalin A interacts with B-cell activating factor protein (BAFF) to exert inhibitory effects. Withaphysalin A exhibits ELOVL6 inhibitory activity. Withaphysalin A can be used in the research of inflammatory diseases, nephrotic syndrome and chronic myeloid leukemia .
    Withaphysalin A
  • HY-N5069
    2,3-Didehydrosomnifericin

    		Bacterial Others
    2,3-Didehydrosomnifericin is one of withanolides found in Withania somnifera .
    2,3-Didehydrosomnifericin
  • HY-N5120
    Dihydrowithaferin A

    2,3-Dihydrowithaferin A

    		 Cholinesterase (ChE) Cancer
    Dihydrowithaferin A (2, 3-dihydrowithaferin A) is a withanolide isolated from Withania somnifera. Dihydrowithaferin A is active against acetylcholinesterase (AChE) .
    Dihydrowithaferin A
  • HY-N8671
    Withanoside V

    		Amyloid-β Apoptosis Reactive Oxygen Species (ROS) SARS-CoV Infection Neurological Disease
    Withanoside V is a blood-brain barrier-permeable withanolide derivative . Withanoside V binds strongly to Sudlow I (domain IIA) of human serum albumin (HSA) to form a stable complex and alter the secondary structure of albumin, thereby increasing helix content and reducing β-sheet and random coil. Withanoside V binds to Aβ (1-42) to block the interaction between monomers and subsequent aggregation. Withanoside V inhibits the viability of neuroblastoma cells, reduces the number of apoptotic cells induced by Aβ (1-42), and decreases ROS production. Withanoside V inhibits SARS-CoV-2 Mpro. Withanoside V can be used for research on Alzheimer's disease and coronavirus disease 2019 .
    Withanoside V
  • HY-N9942
    Physalin A
    1 Publications Verification

    		 Apoptosis Autophagy NF-κB p38 MAPK PI3K Akt mTOR STAT JAK Inflammation/Immunology Cancer
    Physalin A is a biologically active withanolide. Physalin A shows anti-inflammatory, antifibrotic and ameliorative effects on autophagy in models of disc degeneration. Physalin A has antitumor activity and can induce apoptosis, ROS production and G2/M phase cell cycle arrest. Besides. Physalin A can significantly increase the activity of quinone reductase and increase the expression of detoxifying enzymesc .
    Physalin A
  • HY-P11032
    Mp-4D7-pF2

    		SARS-CoV Virus Protease Infection
    Mp-4D7-pF2, a cell-penetrating bicyclic peptide, is a noncovalent SARS-CoV-2 main protease inhibitor with an IC50 of 4.51 μM. Mp-4D7-pF2 has an antiviral activity against SARS-CoV-2 with no cytotoxicity. Mp-4D7-pF2 can used for COVID-19 infections research .
    Mp-4D7-pF2
  • HY-N9061
    Withanolide S

    		Others Others
    Withanolide S is isolated from the natural Physalis cinerascens .
    Withanolide S
  • HY-N5131
    3β-Methoxy-2,3-dihydrowithaferin A

    Quresimin A

    		 Others Others
    3β-Methoxy-2,3-dihydrowithaferin A is one of withanolides found in Withania somnifera .
    3β-Methoxy-2,3-dihydrowithaferin A
  • HY-N7028R
    Withanolide A (Standard)

    		Reference Standards Notch Apoptosis Neurological Disease Inflammation/Immunology Cancer
    Withanolide A (Standard) is the analytical standard of Withanolide A. This product is intended for research and analytical applications. Withanolide A is an orally active extract from the Indian herb Ashwagandha. Withanolide A can induce apoptosis. Withanolide A has anti-inflammatory and antitumor activity. Withanolide A can be used in the study of neurodegenerative diseases .
    Withanolide A (Standard)
  • HY-N16626
    Chantriolide B

    		Others Inflammation/Immunology
    Chantriolide B is a new withanolide glucoside. Chantriolide B can be isolated from the rhizomes of Tacca chantrieri. Chantriolide B does not inhibit NO in cells .
    Chantriolide B
  • HY-N8693
    Withanoside IV

    		COX Amyloid-β Sirtuin Reactive Oxygen Species (ROS) Apoptosis SARS-CoV Infection Neurological Disease
    Withanoside IV is an orally active, blood-brain barrier-permeable withanolide derivative. Withanoside IV specifically binds to the Sudlow I site of HSA, induces secondary structural changes in HSA, and forms stable HSA complexes. Withanoside IV inhibits the enzymatic activity of COX-2. Withanoside IV induces axonal regeneration, peripheral nervous system myelination and increased axonal density in spinal cord tissue, reduces reactive gliosis-related changes, and improves hindlimb motor function. Withanoside IV binds to amyloid-β 1-42 to inhibit its aggregation, induces neurite outgrowth and synapse reconstruction, repairs damaged axons and dendrites, enhances mitochondrial biogenesis, exerts neuroprotective effects via the BDNF and SIRT1 signaling pathways, reduces ROS production and neuronal apoptosis, and ameliorates memory deficits. Withanoside IV inhibits the activity of the SARS-CoV-2 main protease. Withanoside IV can be used in research related to spinal cord injury, Alzheimer's disease, and coronavirus disease 2019 (COVID-19) .
    Withanoside IV
  • HY-129566R
    Withanolide B (Standard)

    		Reference Standards ERK Wnt β-catenin RUNX Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Withanolide B (Standard) is the analytical standard of Withanolide B. This product is intended for research and analytical applications. Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .
    Withanolide B (Standard)
  • HY-N10884
    Withasomniferolide A

    		Others Others
    Withasomniferolide A is a withanolide, isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera .
    Withasomniferolide A
  • HY-N5113
    6α-Chloro-5β-hydroxywithaferin A

    		Bacterial Others
    6α-Chloro-5β-hydroxywithaferin A is a withanolide that can be isolated from W. somnifera. W. somnifera has antioxidant, anti-inflammatory, immunomodulatory, anticarcinogenic, antibacterial antiparkinsonism and antistress properties .
    6α-Chloro-5β-hydroxywithaferin A
  • HY-N10887
    Withasomniferolide B

    		GABA Receptor Neurological Disease
    Withasomniferolide B is a withanolide. Withasomniferolide B can be isolated from a GABAA receptor positive activator methanol extract of the roots of Withania somnifera .
    Withasomniferolide B
  • HY-N10356
    4,27-Dimethyl withaferin A

    		Others Neurological Disease
    4,27-Dimethyl withaferin A is a synthetic analog of withanolide natural products. 4,27-Dimethyl withaferin A has the potential for the research of neurodegenerative diseases (extracted from patent WO2015077780A1) .
    4,27-Dimethyl withaferin A
  • HY-138146
    4-Dehydrowithaferin A

    4-oxo Withaferin A

    		 Drug Derivative Cancer
    4-Dehydrowithaferin A is the analogue of withaferin A. Withaferin A is a withanolide isolated from Withania somnifera. 4-Dehydrowithaferin A has the potential for the research of multiple myeloma .
    4-Dehydrowithaferin A
  • HY-N8671R
    Withanoside V (Standard)

    		Reference Standards Others Neurological Disease
    Withanoside V (Standard) is the analytical standard of Withanoside V. This product is intended for research and analytical applications. Withanoside V, a withanolide glycoside, exhibits inhibitory activity for tachyphylaxis to Clonidine in isolated guinea-pig ileum .
    Withanoside V (Standard)
  • HY-N11015
    Withaphysalin R

    		Others Infection Inflammation/Immunology Cancer
    Withaphysalin R (compound 5) is a Withanolide that can be isolated from the Solanaceae. Withanolide is a steroid ester with an ergosterol skeleton, and some of these compounds have some significant activities, including cytotoxic and immunosuppressive, antitumor, anti-inflammatory, anticonvulsive, and antioxidant .
    Withaphysalin R
  • HY-N8870
    Physapruin A

    		Others Others
    Physapruin A is a withanolide that can be found in Physalis pruinosa .
    Physapruin A
  • HY-163139
    Physagulide Y

    		GLUT Cancer
    Physagulide Y (2), a withanolide with anticancer activity, is a GLUT1 inhibitor .
    Physagulide Y
  • HY-161798
    Orpinolide

    		Others Cancer
    Orpinolide is a withanolide analog that has anti-leukemia properties. It disrupts the internal balance of the Golgi apparatus, which is related to signaling through inositol 4-phosphate at the interface of the endoplasmic reticulum and Golgi membrane .
    Orpinolide
  • HY-N15635
    Withacoagin

    (+)-Withacoagin

    		 HIV Infection Metabolic Disease Inflammation/Immunology
    Withacoagin is a withanolide that can be isolated from the roots of Withania coagulans. Withacoagin has various biological activites such as adaptogenic, anti-inflammatory, and antioxidant properties. Withacoagin regulates the activity of various enzymes and pathways related to oxidative stress and inflammation. Withacoagin can attenuates HIV-1 infection .
    Withacoagin
  • HY-N10351
    27-O-(tert-Butyldimethylsilyl)withaferin A

    		Apoptosis Cancer
    27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a), a natural withanolide, is an apoptosis inducer. 27-O-(tert-Butyldimethylsilyl)withaferin A shows antiproliferative activity against HeLa, A-549 and MCF-7 human cancer cell lines, and against normal Vero cells .
    27-O-(tert-Butyldimethylsilyl)withaferin A
  • HY-N17756
    Withanolide D

    		HSP Cancer
    Withanolide D (Compound 2) is a steroidal ester found in Withania somnifera (L.) Dunal, with anticancer activity. Withanolide D can activate the heat-shock factor 1 (HSF1)-dependent stress response. Withanolide D can be used for the research of cancer such as lymphoma .
    Withanolide D
  • HY-N16663
    Plantagiolide C

    		Others Neurological Disease Inflammation/Immunology
    Plantagiolide C is a withanolide found in Tacca plantaginea. Tacca plantaginea has analgesic, antipyretic and anti-inflammatory effects .
    Plantagiolide C
  • HY-N16664
    Chantriolide C

    		Others Inflammation/Immunology
    Chantriolide C is a withanolide glucoside found in Tacca chantrieri. Tacca chantrieri has anti-inflammatory and gastrointestinal mucosa protection effects .
    Chantriolide C
  • HY-N7340
    Withaperuvin C

    		Others Cancer
    Withaperuvin C is a withanolide that can be isolated from Physalis Minima. Withaperuvin C has moderate cytotoxicity against cancer cells such as HepG2, SK-LU-1, and MCF7 cells (IC50: 19.5, 14.65, 11.74 μg/mL) .
    Withaperuvin C
  • HY-N10949
    Viscosalactone B

    		Others Cancer
    Viscosalactone B is a withanolide found in Withania somnifera. Viscosalactone B shows potent inhibitory activities to NCI-H460, HCT-116, MCF-7 and SF-268 cancer cells with IC50 values of 0.32, 0.47, 0.4 and 0.45 μg/mL. Viscosalactone B can be used for the research of cancer .
    Viscosalactone B
  • HY-N16631
    Chantriolide A

    		Others Others
    Chantriolide A is a withanolide glucoside that can be isolated from the whole plant of Tacca plantaginea .
    Chantriolide A
  • HY-N17739
    Nicandrenone

    Nic-1

    		 Others Others
    Nicandrenone (Nic-1) (Compound 11) is a withanolide found in Physalis hispida .
    Nicandrenone
  • HY-N11008
    Physagulide J

    		Others Inflammation/Immunology Cancer
    Physagulide J is a kind of withanolides compound that can be isolated from Physalis angulata L.. Many kinds of active ingredients of Physalis angulata L. shows anti-inflammatory and anti-tumor activity .
    Physagulide J
  • HY-P3252AS
    Pegcetacoplan-13C3,15N TFA

    		Isotope-Labeled Compounds Complement System Inflammation/Immunology
    Pegcetacoplan- 13C3, 15N TFA is the 13C- and 15N-labeled Pegcetacoplan TFA. Pegcetacoplan is a pegylated complement C3/C3b inhibitor. Pegcetacoplan acts by specifically binding to and inhibiting C3 and C3b, thereby suppressing the complement cascade at its proximal stage. Pegcetacoplan is not a known inhibitor or inducer of CYP450 isoenzymes. Pegcetacoplan can be used for the research of complement-mediated diseases, including paroxysmal nocturnal hemoglobinuria (PNH) and age-related macular degeneration (AMD).
    Pegcetacoplan-13C3,15N TFA
  • HY-N16869
    Plantagiolide B

    		Drug Derivative Others
    Plantagiolide B is a natural steroid.
    Plantagiolide B
  • HY-N3691
    Daturataturin A aglycone

    		Drug Derivative Others
    Daturataturin A aglycone is a natural steroid.
    Daturataturin A aglycone

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