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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
acid ceramidase (AC)
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "acid ceramidase (AC)" in MCE Product Catalog:
1
1 Cited Publications
Target:
Research Areas:
Acid Ceramidase-IN-1 is orally active and blood-brain barrier penetrant acid ceramidase (AC, ASAH-1) inhibitor (hAC IC50=0.166 μM). Acid Ceramidase-IN-1 reduces AC activity, accumulates ceramide species (Cer (d18:0/16:0), Cer (d18:1/16:0)), and decreases sphingosine levels. Acid Ceramidase-IN-1 can be used for the study of severe neurological lysosomal storage diseases (LSDs) such as Gaucher’s disease (GD) and Krabbe’s disease (KD) .
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Research Areas:
SACLAC, a Ceramide analog, is a potent and covalent acid ceramidase (ASAH1; AC) inhibitor with a Ki of 97.1 nM. SACLAC effectively blocks AC activity and induces a decrease in sphingosine 1-phosphate (S1P) and total ceramide levels. SACLAC reduces the levels of splicing factor SF3B1 and alternative Mcl-1 mRNA splicing, increases pro-apoptotic Mcl-1S levels to induce apoptosis in acute myeloid leukemia (AML) cells. SACLAC reduces the leukemic burden in human AML xenograft mouse models .
Cat. No.: HY-163106
CAS No.: 853598-55-7
Target:
Research Areas:
W000113414_I13 is an acid ceramidase (AC) inhibitor. W000113414_I13 exhibits dose-dependent inhibition of AC with an IC50 value of 6.6?μM. W000113414_I13 can be used for the research of cancer .
Cat. No.: HY-N15826
CAS No.: 3077081-47-8
Target:
Research Areas:
RBM1-151, a 1-deoxy derivative and vinilog of RBM14-C12 (HY-150163), as a fluorogenic substrate of Amidases (HY-P2736) (Ex/Em). RBM1-151 is hydrolyzed by acid ceramidase (AC) (( appKm = 7.0 μM; appVmax = 99.3 nM/min), N-acylethanolamine-hydrolyzing acid amidase ( appKm = 0.73 μM; appVmax = 0.24 nM/min), and fatty Acid amide hydrolase (FAAH) ( appKm = 3.6 μM; appVmax = 7.6 nM/min) but not by other ceramidases. RBM1-151 is applicable for basic biological studies of lipid amidase function, as well as potential diagnostic/prognostic evaluations of diseases involving dysregulated AC, NAAA, or FAAH (Farber disease, cancer) .
Cat. No.: HY-P71541
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ASAH1; Putative 32 KDa Heart Protein; Prev. ASAH; acid CDase; Acylsphingosine Deacylase; FLJ21558; acid ceramidase; N-Acylsphingosine Amidohydrolase (acid ceramidase) 1; ACDase; N-Acylsphingosine Amidohydrolase (acid ceramidase); PHP32; ceramidase; AC; SM
Species:
Human
Source:
E. coli
Cat. No.: HY-P87336
Synonyms: AC antibody; ACDase antibody; acid CDase antibody; acid ceramidase antibody; acid ceramidase precursor antibody; acid ceramidase subunit beta antibody; Acylsphingosine deacylase antibody; ASAH 1 antibody; ASAH antibody; ASAH1 antibody
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
