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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
activin like kinase 5 (ALK5)
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "activin like kinase 5 (ALK5)" in MCE Product Catalog:
23
23 Publications Verification
Synonyms: E-616452; SJN 2511
Target:
Research Areas:
RepSox (E-616452) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox can be used for the research of obesity and associated metabolic diseases such as type 2 diabetes .
13
Target:
Research Areas:
Vactosertib (EW-7197) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM. Vactosertib also inhibits ALK2 and ALK4 (IC50 of 17.3 nM) at nanomolar concentrations. Vactosertib has potently antimetastatic activity and anticancer effect .
13
13 Cited Publications
Cat. No.: HY-19928A
CAS No.: 1352610-25-3
Synonyms: EW-7197 Hydrochloride; TEW-7197 Hydrochloride
Target:
Research Areas:
Vactosertib Hydrochloride (EW-7197 Hydrochloride) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM. Vactosertib Hydrochloride also inhibits ALK2 and ALK4 (IC50 of 17.3 nM) at nanomolar concentrations. Vactosertib Hydrochloride has potently antimetastatic activity and anticancer effect .
2
2 Cited Publications
Cat. No.: HY-P72454
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein kinase Receptor R4; Prev. ESS1; activin Receptor-like kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; Transforming Growth Factor-Beta Receptor Type I; Multiple Self-Healing Squamous Epithelioma; TGF-Beta Recepto
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P78525
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein kinase Receptor R4; Prev. ESS1; activin Receptor-like kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; Transforming Growth Factor-Beta Receptor Type I; Multiple Self-Healing Squamous Epithelioma; TGF-Beta Recepto
Species:
Human
Source:
HEK293
Target:
Research Areas:
TP-008, a chemical probe, is a potent, selective and orally active (Activin-Like Kinase 5) ALK5 inhibitor with pIC50 and pEC50 values of 7.6 and 6.63, respectively. TGFβRI-IN-2 can produce observed cardiac toxicity in vivo at high dose .
Cat. No.: HY-13012R
CAS No.: 446859-33-2
Synonyms: E-616452 (Standard); SJN 2511 (Standard)
Research Areas:
RepSox (Standard) is the analytical standard of RepSox. This product is intended for research and analytical applications. RepSox (E-616452) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox can be used for the research of obesity and associated metabolic diseases such as type 2 diabetes .
Cat. No.: HY-W707119
CAS No.: 2319939-07-4
Synonyms: E-616452 hydrochloride; SJN 2511 hydrochloride
Research Areas:
RepSox hydrochloride is a potent and selective inhibitor of transforming growth factor-β receptor I/activin-like kinase 5 (TGF-β-RI/ALK5). RepSox hydrochloride inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox hydrochloride can be used in the study of obesity and related metabolic diseases such as type 2 diabetes.
Cat. No.: HY-149403
CAS No.: 2374772-60-6
Target:
Research Areas:
J-1048 is an activin receptor-like kinase 5 (ALK5) inhibitor. J-1048 can inhibit TAA-induced liver fibrosis in mice by explicitly blocking the TGF-β/Smad signaling pathway .
Cat. No.: HY-162902
CAS No.: 3001361-04-9
Target:
Research Areas:
ALK5-IN-82 is a potent and selective inhibitor against activin receptor-like kinase 5 (ALK5) with an IC50 value of 9.1 nM. ALK5-IN-82 inhibits the protein expression of α-smooth muscle actin (α-SMA), collagen I and tissue inhibitor of metalloproteinase 1 (TIMP-1)/matrix metalloproteinase 13 (MMP-13) in transforming growth factor-β-induced human umbilical vein endothelial cells. ALK5-IN-82 is promising for research of cardiac fibrosis .
Cat. No.: HY-P74522
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein kinase Receptor R4; Prev. ESS1; activin Receptor-like kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; Transforming Growth Factor-Beta Receptor Type I; Multiple Self-Healing Squamous Epithelioma; TGF-Beta Recepto
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P74523
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein kinase Receptor R4; Prev. ESS1; activin Receptor-like kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; Transforming Growth Factor-Beta Receptor Type I; Multiple Self-Healing Squamous Epithelioma; TGF-Beta Recepto
Species:
Human
Source:
HEK293
Cat. No.: HY-P704918
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein kinase Receptor R4; Prev. ESS1; activin Receptor-like kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; Transforming Growth Factor-Beta Receptor Type I; Multiple Self-Healing Squamous Epithelioma; TGF-Beta Recepto
Species:
Human
Source:
HEK293
Cat. No.: HY-13012S
Synonyms: E-616452-d5; SJN 2511-d5
Cat. No.: HY-19928R
CAS No.: 1352608-82-2
Synonyms: EW-7197 (Standard); TEW-7197 (Standard)
Target:
Research Areas:
Vactosertib (Standard) is the analytical standard of Vactosertib (HY-19928). This product is intended for research and analytical applications. Vactosertib (EW-7197) is a potent, orally active and ATP-competitive activin receptor-like Kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM. Vactosertib also inhibits ALK2 and ALK4 (IC50 of 17.3 nM) at nanomolar concentrations. Vactosertib has potently antimetastatic activity and anticancer effect .
Cat. No.: HY-P72453
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein kinase Receptor R4; Prev. ESS1; activin Receptor-like kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; Transforming Growth Factor-Beta Receptor Type I; Multiple Self-Healing Squamous Epithelioma; TGF-Beta Receptor Type-1; TGF-Beta Type I Receptor; ACVRLK4; TGF-Beta Receptor Type I; TBR-I; LDS1A; TBRI; LDS2A; activin A Receptor Type II-like Protein kinase Of 53kD; AAT5; Mutant Transforming Growth Factor Beta Receptor I; LDS1; activin A Receptor Type II-like kinase, 53kDa; Transforming Growth Factor Beta Receptor 1; Transforming Growth Factor Beta Receptor I
Species:
Human
Source:
HEK293
Cat. No.: HY-P706225
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TGFBR1; Serine/Threonine-Protein kinase Receptor R4; Prev. ESS1; activin Receptor-like kinase 5; Prev. MSSE; TbetaR-I; ALK-5; TGFR-1; ALK5; SKR4; Transforming Growth Factor-Beta Receptor Type I; Multiple Self-Healing Squamous Epithelioma; TGF-Beta Receptor Type-1; TGF-Beta Type I Receptor; ACVRLK4; TGF-Beta Receptor Type I; TBR-I; LDS1A; TBRI; LDS2A; activin A Receptor Type II-like Protein kinase Of 53kD; AAT5; Mutant Transforming Growth Factor Beta Receptor I; LDS1; activin A Receptor Type II-like kinase, 53kDa; Transforming Growth Factor Beta Receptor 1; Transforming Growth Factor Beta Receptor I
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
