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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
alternative complement pathway
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "alternative complement pathway" in MCE Product Catalog:
6
6 Cited Publications
Synonyms: ACH-4471
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Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) .
Synonyms: BCX9930
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Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D with an IC50 value of 14.3 nM. Pelecopan can target factor D to prevent both intravascular and extravascular hemolysis in PNH. Pelecopan also be used for other alternative pathway (AP) mediated diseases .
Art. -Nr.: HY-P99965
CAS. Nr.: 1917321-26-6
Synonyms: SKY59; RO7112689; RG-6107
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Art. -Nr.: HY-P990952
CAS. Nr.: 2527079-60-1
Synonyms: OMS906
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FD-IN-1 (Compound 12) is an orally bioavailable and selective factor D (FD) inhibitor with an IC50 of 12 nM. Complement FD, a highly specific S1 serine protease, plays a central role in the alternative complement pathway of the innate immune system. FD-IN-1 also inhibits factor XIa (FXIa) and Tryptase β2 with IC50s of 7.7 and 6.5 µM, respectively .
Art. -Nr.: HY-P99298
CAS. Nr.: 1278466-20-8
Synonyms: RG 7417; TNX 234; Anti-CFD Recombinant Antibody
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Complement factor D-IN-2 is an inhibitor of complement factor D extracted from patent WO2015130838A1, compound 190. Complement factor D-IN-2 targets factor D and inhibits the complement cascade at an early and essential point in the alternative complement pathway. Complement factor D-IN-2 can be used for the research of autoimmune diseases .
Art. -Nr.: HY-N12265
CAS. Nr.: 108885-62-7
Category:
Human Gut Microbiota Metabolites Plant Terpenoids Sesquiterpenes Violaceae Extract Viola philippica Cav. Extract Endogenous metabolite
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Art. -Nr.: HY-P992456
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SAR-443809 is a monoclonal antibody targeting complement factor Bb that inhibits the alternative complement pathway. SAR-443809 blocks the cleavage of C3 and factor B via selective binding to the activated form factor Bb, with a KD of 7.3 nM for human factor Bb. SAR-443809 inhibits the amplification loop of the alternative complement pathway and C3 activation, reduces C3b deposition, and blocks the activation of pathways associated with intravascular and extravascular hemolysis. SAR-443809 can be used for research on hematological and renal disorders mediated by abnormal alternative complement pathway activity .
Art. -Nr.: HY-P992463
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Art. -Nr.: HY-P991022
CAS. Nr.: 2842046-67-5
Synonyms: NM8074
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Art. -Nr.: HY-P992539
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LP-005 is a bifunctional anti-C5 antibody fusion protein with pH-dependent C5 binding properties. LP-005 can simultaneously inhibit activation of the terminal complement pathway and the alternative pathway. LP-005 can be used for research on paroxysmal nocturnal hemoglobinuria (PNH) .
Art. -Nr.: HY-N21519
CAS. Nr.: 2193052-99-0
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
