Zaltenibart  (Synonyms: OMS906)

Zaltenibart (OMS906) is an IgG4 humanized monoclonal antibody and MASP-3 inhibitor. By inhibiting MASP-3, Zaltenibart achieves upstream inhibition of the alternative complement pathway. MASP-3 is an upstream activator of Factor D (Factor D), a key enzyme in the alternative complement pathway. Zaltenibart prevents both intravascular hemolysis and extravascular hemolysis. Zaltenibart is applicable to research related to paroxysmal nocturnal hemoglobinuria^[1][2].

Human IgG4 kappa

Human IgG4 (S228P) kappa, Isotype Control

Human

MASP3

Zaltenibart can safely and effectively significantly increase and maintain hemoglobin levels while controlling hemolysis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5648  [NCBI]

P48740

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

144.437 kDa

2527079-60-1

Liquid

Colorless to light yellow

[Zaltenibart]

Shipping with dry ice.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  IgG4-kappa

• [1]. Griffin M, et al. Monotherapy treatment with Zaltenibart (OMS906), an alternative pathway Masp-3 inhibitor, improved key hematologic parameters in patients with PNH with a suboptimal response to Ravulizumab: Interim results from a phase 2 proof-of-concept study. Blood. 2024 Nov 5;144:4072.
  

  [2]. Kelly RJ, et al. Pharmacological Therapies in Paroxysmal Nocturnal Haemoglobinuria: Focus on Complement Inhibition. Drugs. 2025;85(11):1413-1428.