Zaltenibart
Based on 1 Customer Validation
Zaltenibart (OMS906) is an IgG4 humanized monoclonal antibody and MASP-3 inhibitor. By inhibiting MASP-3, Zaltenibart achieves upstream inhibition of the alternative complement pathway. MASP-3 is an upstream activator of Factor D (Factor D), a key enzyme in the alternative complement pathway. Zaltenibart prevents both intravascular hemolysis and extravascular hemolysis. Zaltenibart is applicable to research related to paroxysmal nocturnal hemoglobinuria.
For research use only. We do not sell to patients.
- Purity: 99%
- CAS No.: 2527079-60-1
- Molecular Weight:144.437 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
MASP3
In Vitro
Zaltenibart can safely and effectively significantly increase and maintain hemoglobin levels while controlling hemolysis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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IgG4-kappa
Application
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 2527079-60-1
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Appearance Liquid
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Molecular Weight 144.437 kDa
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Color Colorless to light yellow
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SMILES
[Zaltenibart]
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Synonyms
OMS906
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Keywords
- Zaltenibart
- 2527079-60-1
- OMS906
- OMS 906
- OMS-906
- Ser/Thr Protease
- Complement System
- MASP-3
- absolute reticulocyte count
- intravascular hemolysis
- mannan-binding lectin-associated serine protease-3
- IgG4 humanized monoclonal antibody
- alternative complement pathway
- hemoglobin
- paroxysmal nocturnal hemoglobinuria
- Factor D
- extravascular hemolysis
- Inhibitor
- inhibitor
- inhibit