1. Immunology/Inflammation
  2. Complement System
  3. Pelecopan

Pelecopan  (Synonyms: BCX9930)

Cat. No.: HY-147297
Handling Instructions

Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D with an IC50 value of 14.3 nM. Pelecopan can target factor D to prevent both intravascular and extravascular hemolysis in PNH. Pelecopan also be used for other alternative pathway (AP) mediated diseases.

For research use only. We do not sell to patients.

Pelecopan Chemical Structure

Pelecopan Chemical Structure

CAS No. : 2378380-49-3

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Description

Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D with an IC50 value of 14.3 nM. Pelecopan can target factor D to prevent both intravascular and extravascular hemolysis in PNH. Pelecopan also be used for other alternative pathway (AP) mediated diseases[1][2][3].

IC50 & Target

IC50: 14.3 nM (complement factor D)[1]

In Vitro

Pelecopan has a potent, highly specific inhibitory activity for purified human factor D with an IC50 value of 14.3 nM and also inhibits its proteolytic activity against factor B bound to C3b with an IC50 of 28.1 nM[1].
Pelecopan completely blocks hemolysis of PNH cells in vitro (with an IC50 value of 29.5 nM in rabbit erythrocytes) and suppresses the accumulation of C3 fragments on PNH erythrocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

406.41

Formula

C23H19FN2O4

CAS No.
SMILES

O=C(CC1=C(OCC2=CC3=C(C(C4=C(F)C(CN)=NC=C4)=C2)OC=C3)C=CC=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Pelecopan
Cat. No.:
HY-147297
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