2. Immunology/Inflammation
  3. Complement System
  4. Ruxoprubart

Ruxoprubart  (Synonyms: NM8074)

Cat. No.: HY-P991022 Purity: 95.541%
COA
SDS
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Ruxoprubart (NM8074) is an inhibitor of complement factor B (Bb subunit). Ruxoprubart selectively binds to active Bb to inhibit the alternative complement pathway without affecting the classical complement pathway. By blocking the activities of AP C3 and C5 convertases, Ruxoprubart effectively inhibits red blood cell hemolysis and reduces C3b deposition, thereby preventing intravascular and extravascular hemolysis. Ruxoprubart can be used in research related to paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, C3 glomerulopathy, and IgA nephropathy.

For research use only. We do not sell to patients.

CAS No. : 2842046-67-5

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Based on 1 publication(s) in Google Scholar

Ruxoprubart Related Antibodies

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Description

Ruxoprubart (NM8074) is an inhibitor of complement factor B (Bb subunit). Ruxoprubart selectively binds to active Bb to inhibit the alternative complement pathway without affecting the classical complement pathway. By blocking the activities of AP C3 and C5 convertases, Ruxoprubart effectively inhibits red blood cell hemolysis and reduces C3b deposition, thereby preventing intravascular and extravascular hemolysis. Ruxoprubart can be used in research related to paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, C3 glomerulopathy, and IgA nephropathy[1][2][3].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

CFB
In Vivo

In healthy subject tests, Ruxoprubart exhibits favorable safety and tolerability at all tested doses[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Gene ID

629  [NCBI]

Accession

AAH04143.1
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ruxoprubart]
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • IgG1-kappa
Biological Activity
  • Immobilized Complement Factor B/CFB Protein, Human (HEK293, His, HY-P7813) can bind Ruxoprubart. The EC50 for this effect is 24.9 ng/mL.
Purity & Documentation
References
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Ruxoprubart Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ruxoprubart2842046-67-5NM8074NM 8074NM-8074Complement SystemC5 convertaseBb subunitC3b depositionclassical complement pathwayAP C3 convertasealternative complement pathwaycomplement Factor Batypical hemolytic uremic syndromeparoxysmal nocturnal hemoglobinuriared blood cell hemolysisInhibitorinhibitorinhibit

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