25 Results for "

carbon tetrachloride

" in MedChemExpress (MCE) Product Catalog:
Products (25)

25 Results for "carbon tetrachloride" in MCE Product Catalog:

6
Lithospermic acid
Lithospermic acid
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6 Publications Verification
Cat. No.: HY-N0823
CAS No.: 28831-65-4
Synonyms: (+)-Lithospermic acid
Category:  

Labiatae Samanea saman (Jacq.) Merr. Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology

Target:  

NO Synthase AMPK Keap1-Nrf2 Xanthine Oxidase Apoptosis

Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo .
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3
Dimethyl 2-oxoglutarate
Dimethyl 2-oxoglutarate
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3 Cited Publications
Cat. No.: HY-44134
CAS No.: 13192-04-6
Synonyms: Dimethyl α-ketoglutarate
Category:  

Natural Products Other Diseases Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite Drug Derivative Autophagy Mitochondrial Metabolism Reactive Oxygen Species (ROS)

Dimethyl 2-oxoglutarate (Dimethyl α-ketoglutarate) is a cell-permeable derivative of 2-oxoglutarate and tricarboxylic acid cycle metabolite with antioxidant properties. Dimethyl 2-oxoglutarate inhibits Autophagy. Dimethyl 2-oxoglutarate prevents mitochondrial damage and reduces ROS production. Dimethyl 2-oxoglutarate alleviates Carbon tetrachloride (HY-Y0298)-induced liver fibrosis. Dimethyl-2-oxoglutaric acid can be used in the research of diseases such as Alzheimer's disease, diabetes, and cardiomyopathy .
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1
Swertiamarin
Swertiamarin
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1 Cited Publications
Cat. No.: HY-N0807
CAS No.: 17388-39-5
Category:  

other families Monophenols Metabolic Disease Phenols Zanthoxylum chiloperone var. angustifolium Plants Disease Research Fields Cancer

Target:  

MMP NF-κB JAK Keap1-Nrf2

Swertiamarin is an orally active natural product with hypoglycemic, lipid-lowering, anti-rheumatic, and antioxidant activities. Swertiamarin can regulate the levels of pro-inflammatory cytokines, MMP, and NF-κB, and promote osteoblast proliferation. Swertiamarin has antioxidant and hepatoprotective effects against carbon tetrachloride induced rat liver toxicity through the Nrf2/HO-1 pathway. Swertiamarin can attenuate inflammatory mediators by regulating JAK2/STAT3 transcription factors in adjuvant induced arthritis rats. Swertiamarin can be used in the research of diabetes and arthritis .
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1
Gigantol
Gigantol
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1 Cited Publications
Cat. No.: HY-N10549
CAS No.: 83088-28-2
Category:  

Orchidaceae Other Diseases Phenols Polyphenols Glucosinolates Plants Disease Research Fields Dendrobium nobile Lindl.

Target:  

Ferroptosis c-Myc Glutathione Peroxidase JNK Reactive Oxygen Species (ROS) GSK-3

Gigantol is an orally active bibenzyl compound. Gigantol targets MYC to promote its ubiquitin-proteasomal degradation and inhibit the growth of lung cancer cells. Gigantol exerts anti-lung cancer activity by inducing ferroptosis (Ferroptosis) via the SLC7A11-GPX4 axis. Gigantol restores the sensitivity of mcr-harboring multidrug-resistant bacteria to colistin. Gigantol ameliorates carbon tetrachloride-induced liver injury by inhibiting the activation of the JNK/cPLA2/12-LOX inflammatory pathway. Gigantol promotes cholesterol metabolism and progesterone biosynthesis in Leydig cells. Gigantol can be used in studies related to diseases such as lung cancer, multidrug-resistant Gram-negative bacterial infections, and acute liver injury .
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Isorhamnetin 3-O-galactoside
Isorhamnetin 3-O-galactoside
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1 Cited Publications
Cat. No.: HY-N2082
CAS No.: 6743-92-6
Synonyms: Cacticin
Category:  

Cardiovascular Disease Flavonols Flavonoids Typhaceae Typha angustifolia L. Phenols Polyphenols Plants Disease Research Fields

Target:  

Thrombin COX ERK JNK Factor Xa

Isorhamnetin 3-O-galactoside (Cacticin) is a flavonoid glycoside that can be isolated from Oenanthe javanica, with antithrombotic and profibrinolytic activities. Isorhamnetin 3-O-galactoside inhibits the activities of thrombin and factor Xa (FXa) and reduces thrombin-catalyzed fibrin polymerization maximum rate. Isorhamnetin 3-O-galactoside suppresses TNF-α-induced PAI-1 secretion, decreases the PAI-1/tissue-type plasminogen activator (t-PA) ratio, and inhibits FXa production and FVa/FXa-mediated thrombin generation. Isorhamnetin 3-O-galactoside exerts protective effects against Carbon tetrachloride (CCl4) (HY-Y0298)-induced hepatic injury in mice. Isorhamnetin 3-O-galactoside can be used for the study of liver injury-related diseases and thrombotic vascular diseases .
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1
Celosin I
Celosin I
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1 Cited Publications
Cat. No.: HY-N7026
CAS No.: 1807732-38-2
Category:  

Celosia argentea Linn. Triterpenes Terpenoids Metabolic Disease Amaranthaceae Plants Disease Research Fields

Target:  

Others

Celosin I, an oleanane-type triterpenoid saponin isolated from the seeds of Celosia argentea L, could be used as chemical markers for the quality control of C. argentea seeds. Celosin I exhibits significant hepatoprotective effect on carbon tetrachloride-induced and N,N-dimethylformamide-induced hepatotoxicity in mice .
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Rubiadin
Rubiadin
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Cat. No.: HY-N0444
CAS No.: 117-02-2
Category:  

Quinones Anthraquinones Rubiaceae Phenols Polyphenols Plants Morinda officinalis How Disease Research Fields Inflammation/Immunology

Target:  

Free Radical Scavengers Reactive Oxygen Species (ROS) NF-κB HBV Apoptosis Bacterial Fungal Parasite

Rubiadin is an orally active free radical scavenger that inhibits the activation of the NF-κB pathway. Rubiadin inhibits osteoclast formation, bone resorption, lipid peroxidation, HBV DNA replication and cancer cell proliferation; reduces pro-inflammatory cytokine levels; induces cancer cell apoptosis; and possesses antifungal, antimalarial, antibacterial and anticonvulsant activities. Rubiadin can be used in the research of osteoporosis, acute inflammation, chronic inflammation, carbon tetrachloride-induced liver injury, Alzheimer's disease, breast cancer, iron overload disorders, hepatitis B virus infection, colon cancer, liver cancer, T-lymphocytic leukemia, cervical cancer, diabetic nephropathy, epileptic seizures, fungal infections, malaria and bacterial infections .
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Chitobiose dihydrochloride
Chitobiose dihydrochloride
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Cat. No.: HY-N7697B
CAS No.: 115350-24-8
Category:  

Microorganisms Other Diseases Disease Research Fields Saccharides

Target:  

Others

Chitobiose dihydrochloride is an orally active chitosan oligosaccharide (degree of polymerization 2). Chitobiose dihydrochloride shows hepatoprotective activity and counteracts CCl4-induced elevation of plasma aspartate transaminase and alanine transaminase activities in rats. Chitobiose dihydrochloride can be used for the research of carbon tetrachloride-induced acute hepatotoxicity .
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Ochnaflavone
Ochnaflavone
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Cat. No.: HY-N7327
CAS No.: 50276-96-5
Category:  

Flavonoids Ochna atropurpurea DC. Plants Biflavones

Target:  

Phospholipase

Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2 (sPLA2-IIA) with an IC50 of 3.45 µM. Ochnaflavone exhibits significant anti-inflammatory and liver-protective effects, capable of inhibiting the degradation of phosphatidylethanolamine (PE) and lipid peroxidation induced by carbon tetrachloride (CCl4) in rat liver, with an IC50 of 7.16 µM for lipid peroxidation. Ochnaflavone can be used in research on liver damage and inflammatory diseases .
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Chitobiose
Chitobiose
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Cat. No.: HY-N7697F
CAS No.: 577-76-4
Category:  

Polysaccharides Microorganisms Animals Other Diseases Disease Research Fields Saccharides

Target:  

Others

Chitobiose is an orally active chitosan oligosaccharide (degree of polymerization 2). Chitobiose shows hepatoprotective activity and counteracts CCl4-induced elevation of plasma aspartate transaminase and alanine transaminase activities in rats. Chitobiose can be used for the research of carbon tetrachloride-induced acute hepatotoxicity .
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3,4-Didehydroglabridin
3,4-Didehydroglabridin
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Cat. No.: HY-142101
CAS No.: 214283-58-6
Category:  

Natural Products Leguminosae Plants Glycyrrhiza uralensis Fisch.

Target:  

Others

3,4-Didehydroglabridin is a natural product that can be found in licorice. 3,4-Didehydroglabridin exhibits protective activities against carbon tetrachloride-induced HepG2 cells injury. 3,4-Didehydroglabridin has the potential for the research of liver injury .
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Rubiadin (Standard)
Rubiadin (Standard)
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Cat. No.: HY-N0444R
CAS No.: 117-02-2
Category:  

Quinones Anthraquinones Rubiaceae Phenols Polyphenols Plants Morinda officinalis How

Target:  

Reference Standards Reactive Oxygen Species (ROS) Apoptosis Fungal Parasite NF-κB HBV Bacterial

Rubiadin (Standard) is the analytical standard of Rubiadin (HY-N0444). This product is intended for research and analytical applications. Rubiadin is an orally active free radical scavenger that inhibits the activation of the NF-κB pathway. Rubiadin inhibits osteoclast formation, bone resorption, lipid peroxidation, HBV DNA replication and cancer cell proliferation; reduces pro-inflammatory cytokine levels; induces cancer cell apoptosis; and possesses antifungal, antimalarial, antibacterial and anticonvulsant activities. Rubiadin can be used in the research of osteoporosis, acute inflammation, chronic inflammation, carbon tetrachloride-induced liver injury, Alzheimer's disease, breast cancer, iron overload disorders, hepatitis B virus infection, colon cancer, liver cancer, T-lymphocytic leukemia, cervical cancer, diabetic nephropathy, epileptic seizures, fungal infections, malaria and bacterial infections.
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Goodyeroside A
Goodyeroside A
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Cat. No.: HY-N13159
CAS No.: 211107-44-7
Category:  

Crocus sativus Linn. Iridaceae Plants Saccharides Monosaccharides

Target:  

Others

Goodyeroside A is a glycoside compound derived from the plant Goodyera that exhibits significant hepatoprotective activity. It can inhibit liver damage induced by carbon tetrachloride (HY-Y0298) in primary cultured rat hepatocytes .
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Lithospermic acid (Standard)
Lithospermic acid (Standard)
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Cat. No.: HY-N0823R
CAS No.: 28831-65-4
Synonyms: (+)-Lithospermic acid (Standard)
Category:  

Labiatae Samanea saman (Jacq.) Merr. Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants

Target:  

Reference Standards NO Synthase AMPK Keap1-Nrf2 Xanthine Oxidase Apoptosis

Lithospermic acid (Standard) is the analytical standard of Lithospermic acid. This product is intended for research and analytical applications. Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo .
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Andrographiside
Andrographiside
0 Images
Cat. No.: HY-N2867
CAS No.: 82209-76-5
Category:  

Acanthaceae Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants

Target:  

Bacterial

Andrographiside is a labdane diterpenoid glucoside that can be isolated from the leaves of Andrographis paniculata Nees. Andrographiside has antihepatotoxic and antioxidative effects. Andrographiside shows protective effects on mice with hepatotoxicity induced by carbon tetrachloride or tert-butylhydroperoxide (tBHP) . Andrographiside is a novel biofilm inhibitor of Pseudomonas aeruginosa PAO1 by modulating quorum-sensing proteins .
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Vitexin 7-O-β-D-glucopyranoside
Vitexin 7-O-β-D-glucopyranoside
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Cat. No.: HY-N15155
CAS No.: 35109-95-6
Synonyms: Vitexin 7-glucoside
Category:  

Flavonoids Flavones Amaranthaceae Plants Beta vulgaris var. cicla L. Saccharides Monosaccharides

Target:  

Others

Vitexin 7-O-β-D-glucopyranoside (Vitexin 7-glucoside) is a flavone glycoside found in Beta vulgaris var. cicla. Vitexin 7-O-β-D-glucopyranoside shows a hepatoprotective activity in primary cultured rat hepatocytes with Carbon tetrachloride (CCl4) (HY-Y0298)-induced cell toxicity .
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ABP/PPAR modulator 1
ABP/PPAR modulator 1
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Cat. No.: HY-172883
CAS No.: 3104894-76-7
Target:  

FABP PPAR

Research Areas:  

Metabolic Disease Inflammation/Immunology

ABP/PPAR modulator 1 is an orally active FABP and PPAR multiple modulator (IC50s of 0.65  μM and 1.08  μM for FABP1 and FABP4, EC50 s of 9.19  μM, 2.20  μM and 1.58 μM for PPARα, PPARγ and PPARδ). ABP/PPAR modulator 1 has potent anti-metabolic dysfunction-associated steatohepatitis (MASH) activity. ABP/PPAR modulator 1 dose-dependently ameliorates multiple pathological characteristics of fatty liver in WD + Carbon tetrachloride-induced MASH mice model .
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(E/Z)-ABP/PPAR modulator 1
(E/Z)-ABP/PPAR modulator 1
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Cat. No.: HY-172883A
Target:  

FABP PPAR

Research Areas:  

Metabolic Disease Inflammation/Immunology

(E/Z)-ABP/PPAR modulator 1 is a mixture of the E and Z isomers of ABP/PPAR modulator 1 (HY-172883). ABP/PPAR modulator 1 is an orally active FABP and PPAR multiple modulator (IC50s of 0.65  μM and 1.08  μM for FABP1 and FABP4, EC50 s of 9.19  μM, 2.20  μM and 1.58 μM for PPARα, PPARγ and PPARδ). ABP/PPAR modulator 1 has potent anti-metabolic dysfunction-associated steatohepatitis (MASH) activity. ABP/PPAR modulator 1 dose-dependently ameliorates multiple pathological characteristics of fatty liver in WD + Carbon tetrachloride-induced MASH mice model .
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Licoagrochalcone A
Licoagrochalcone A
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Cat. No.: HY-N18297
CAS No.: 202815-28-9
Category:  

Flavonoids Chalcones Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch.

Target:  

Phosphatase

Licoagrochalcone A is a PTP1B inhibitor. Licoagrochalcone A exerts protective effects against liver cell injury induced by carbon tetrachloride and Acetaminophen (HY-66005). Licoagrochalcone A is applicable to the research of type 2 diabetes, obesity and liver injury .
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Antifibrotic agent 3
Antifibrotic agent 3
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Cat. No.: HY-184738
CAS No.: 2103516-38-5
Target:  

Collagen

Research Areas:  

Metabolic Disease

Antifibrotic agent 3 is an orally active antifibrotic agent. Antifibrotic agent 3 reduces hepatic stellate cell activation by downregulating the expression of Collagen I and α-SMA. Antifibrotic agent 3 inhibits liver fibrosis in bile duct ligation and carbon tetrachloride-induced liver fibrosis models. Antifibrotic agent 3 can be used for the research of liver fibrosis .
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