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Results for "

carbon tetrachloride

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldehyde Dehydrogenase (ALDH) (1) AMPK (2) Apoptosis (2) Autophagy (1) Bacterial (2) c-Myc (1) Collagen (1) COX (1) Drug Derivative (2) Endogenous Metabolite (1) ERK (1) FABP (2) Factor Xa (1) Ferroptosis (1) Glutathione Peroxidase (1) GSK-3 (1) JAK (1) JNK (2) Keap1-Nrf2 (3) Mitochondrial Metabolism (1) MMP (1) NF-κB (1) NO Synthase (2) Phosphatase (1) Phospholipase (1) PPAR (2) Reactive Oxygen Species (ROS) (3) Reference Standards (1) Thrombin (1) Xanthine Oxidase (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (4) Infection (1) Inflammation/Immunology (12) Metabolic Disease (12) Neurological Disease (1)

By Targets:

Aldehyde Dehydrogenase (ALDH) (1)

AMPK (2)

Apoptosis (2)

Autophagy (1)

Bacterial (2)

c-Myc (1)

Collagen (1)

COX (1)

Drug Derivative (2)

Endogenous Metabolite (1)

ERK (1)

FABP (2)

Factor Xa (1)

Ferroptosis (1)

Glutathione Peroxidase (1)

GSK-3 (1)

JAK (1)

JNK (2)

Keap1-Nrf2 (3)

Mitochondrial Metabolism (1)

MMP (1)

NF-κB (1)

NO Synthase (2)

Phosphatase (1)

Phospholipase (1)

PPAR (2)

Reactive Oxygen Species (ROS) (3)

Reference Standards (1)

Thrombin (1)

Xanthine Oxidase (2)

By Research Areas:

Cancer (3)

Cardiovascular Disease (4)

Infection (1)

Inflammation/Immunology (12)

Metabolic Disease (12)

Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-44134

Dimethyl 2-oxoglutarate 1 Publications Verification Dimethyl α-ketoglutarate	Endogenous Metabolite Drug Derivative Autophagy Mitochondrial Metabolism Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Metabolic Disease
Dimethyl 2-oxoglutarate (Dimethyl α-ketoglutarate) is a cell-permeable derivative of 2-oxoglutarate and tricarboxylic acid cycle metabolite with antioxidant properties. Dimethyl 2-oxoglutarate inhibits Autophagy. Dimethyl 2-oxoglutarate prevents mitochondrial damage and reduces ROS production. Dimethyl 2-oxoglutarate alleviates Carbon tetrachloride (HY-Y0298)-induced liver fibrosis. Dimethyl-2-oxoglutaric acid can be used in the research of diseases such as Alzheimer's disease, diabetes, and cardiomyopathy .

HY-N0823

Lithospermic acid Maximum Cited Publications 6 Publications Verification (+)-Lithospermic acid	NO Synthase AMPK Keap1-Nrf2 Xanthine Oxidase Apoptosis	Cardiovascular Disease Inflammation/Immunology
Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl₄)-induced acute liver damage in vitro and in vivo .

HY-N0807

Swertiamarin 1 Publications Verification	MMP NF-κB JAK Keap1-Nrf2	Metabolic Disease Inflammation/Immunology Cancer
Swertiamarin is an orally active natural product with hypoglycemic, lipid-lowering, anti-rheumatic, and antioxidant activities. Swertiamarin can regulate the levels of pro-inflammatory cytokines, MMP, and NF-κB, and promote osteoblast proliferation. Swertiamarin has antioxidant and hepatoprotective effects against carbon tetrachloride induced rat liver toxicity through the Nrf2/HO-1 pathway. Swertiamarin can attenuate inflammatory mediators by regulating JAK2/STAT3 transcription factors in adjuvant induced arthritis rats. Swertiamarin can be used in the research of diabetes and arthritis .

HY-N0444

Rubiadin	Reactive Oxygen Species (ROS)	Inflammation/Immunology
Rubiadin is an orally active polyketide-derived compound and free radical scavenger that inhibits the activation of the NF-κB pathway. Rubiadin inhibits osteoclast formation, bone resorption, lipid peroxidation, HBV DNA replication and cancer cell proliferation; reduces pro-inflammatory cytokine levels; induces cancer cell apoptosis; and possesses antifungal, antimalarial, antibacterial and anticonvulsant activities. Rubiadin can be used in the research of osteoporosis, acute inflammation, chronic inflammation, carbon tetrachloride-induced liver injury, Alzheimer's disease, breast cancer, iron overload disorders, hepatitis B virus infection, colon cancer, liver cancer, T-lymphocytic leukemia, cervical cancer, diabetic nephropathy, epileptic seizures, fungal infections, malaria and bacterial infections .

HY-N10549

Gigantol 1 Publications Verification	Ferroptosis c-Myc Glutathione Peroxidase JNK Reactive Oxygen Species (ROS) GSK-3	Infection Metabolic Disease Cancer
Gigantol is an orally active bibenzyl compound. Gigantol targets MYC to promote its ubiquitin-proteasomal degradation and inhibit the growth of lung cancer cells. Gigantol exerts anti-lung cancer activity by inducing ferroptosis (Ferroptosis) via the SLC7A11-GPX4 axis. Gigantol restores the sensitivity of mcr-harboring multidrug-resistant bacteria to colistin. Gigantol ameliorates carbon tetrachloride-induced liver injury by inhibiting the activation of the JNK/cPLA2/12-LOX inflammatory pathway. Gigantol promotes cholesterol metabolism and progesterone biosynthesis in Leydig cells. Gigantol can be used in studies related to diseases such as lung cancer, multidrug-resistant Gram-negative bacterial infections, and acute liver injury .

HY-N7697B

Chitobiose dihydrochloride	Others	Others
Chitobiose dihydrochloride is an orally active chitosan oligosaccharide (degree of polymerization 2). Chitobiose dihydrochloride shows hepatoprotective activity and counteracts CCl₄-induced elevation of plasma aspartate transaminase and alanine transaminase activities in rats. Chitobiose dihydrochloride can be used for the research of carbon tetrachloride-induced acute hepatotoxicity .

HY-N7327

Ochnaflavone	Phospholipase	Inflammation/Immunology
Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2 (sPLA2-IIA) with an IC₅₀ of 3.45 µM. Ochnaflavone exhibits significant anti-inflammatory and liver-protective effects, capable of inhibiting the degradation of phosphatidylethanolamine (PE) and lipid peroxidation induced by carbon tetrachloride (CCl4) in rat liver, with an IC₅₀ of 7.16 µM for lipid peroxidation. Ochnaflavone can be used in research on liver damage and inflammatory diseases .

HY-N7697F

Chitobiose	Others	Metabolic Disease
Chitobiose is an orally active chitosan oligosaccharide (degree of polymerization 2). Chitobiose shows hepatoprotective activity and counteracts CCl₄-induced elevation of plasma aspartate transaminase and alanine transaminase activities in rats. Chitobiose can be used for the research of carbon tetrachloride-induced acute hepatotoxicity .

HY-N2082

Isorhamnetin 3-O-galactoside 1 Publications Verification Cacticin	Thrombin COX ERK JNK Factor Xa	Cardiovascular Disease Inflammation/Immunology
Isorhamnetin 3-O-galactoside (Cacticin) is a flavonoid glycoside that can be isolated from Oenanthe javanica, with antithrombotic and profibrinolytic activities. Isorhamnetin 3-O-galactoside inhibits the activities of thrombin and factor Xa (FXa) and reduces thrombin-catalyzed fibrin polymerization maximum rate. Isorhamnetin 3-O-galactoside suppresses TNF-α-induced PAI-1 secretion, decreases the PAI-1/tissue-type plasminogen activator (t-PA) ratio, and inhibits FXa production and FVa/FXa-mediated thrombin generation. Isorhamnetin 3-O-galactoside exerts protective effects against Carbon tetrachloride (CCl4) (HY-Y0298)-induced hepatic injury in mice. Isorhamnetin 3-O-galactoside can be used for the study of liver injury-related diseases and thrombotic vascular diseases .

HY-N7026

Celosin I 1 Publications Verification	Others	Metabolic Disease
Celosin I, an oleanane-type triterpenoid saponin isolated from the seeds of Celosia argentea L, could be used as chemical markers for the quality control of C. argentea seeds. Celosin I exhibits significant hepatoprotective effect on carbon tetrachloride-induced and N,N-dimethylformamide-induced hepatotoxicity in mice .

HY-142101

3,4-Didehydroglabridin	Others	Inflammation/Immunology
3,4-Didehydroglabridin is a natural product that can be found in licorice. 3,4-Didehydroglabridin exhibits protective activities against carbon tetrachloride-induced HepG2 cells injury. 3,4-Didehydroglabridin has the potential for the research of liver injury .

HY-N13159

Goodyeroside A	Others	Inflammation/Immunology
Goodyeroside A is a glycoside compound derived from the plant Goodyera that exhibits significant hepatoprotective activity. It can inhibit liver damage induced by carbon tetrachloride (HY-Y0298) in primary cultured rat hepatocytes .

HY-N0823R

Lithospermic acid (Standard) (+)-Lithospermic acid (Standard)	Reference Standards NO Synthase AMPK Keap1-Nrf2 Xanthine Oxidase Apoptosis	Cardiovascular Disease Inflammation/Immunology
Lithospermic acid (Standard) is the analytical standard of Lithospermic acid. This product is intended for research and analytical applications. Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo .

HY-N2867

Andrographiside	Bacterial	Cancer
Andrographiside is a labdane diterpenoid glucoside that can be isolated from the leaves of Andrographis paniculata Nees. Andrographiside has antihepatotoxic and antioxidative effects. Andrographiside shows protective effects on mice with hepatotoxicity induced by carbon tetrachloride or tert-butylhydroperoxide (tBHP) . Andrographiside is a novel biofilm inhibitor of Pseudomonas aeruginosa PAO1 by modulating quorum-sensing proteins .

HY-N15155

Vitexin 7-O-β-D-glucopyranoside Vitexin 7-glucoside	Others	Metabolic Disease
Vitexin 7-O-β-D-glucopyranoside (Vitexin 7-glucoside) is a flavone glycoside found in Beta vulgaris var. cicla. Vitexin 7-O-β-D-glucopyranoside shows a hepatoprotective activity in primary cultured rat hepatocytes with Carbon tetrachloride (CCl4) (HY-Y0298)-induced cell toxicity .

HY-172883

ABP/PPAR modulator 1	FABP PPAR	Metabolic Disease Inflammation/Immunology
ABP/PPAR modulator 1 is an orally active FABP and PPAR multiple modulator (IC₅₀s of 0.65  μM and 1.08  μM for FABP1 and FABP4, EC₅₀s of 9.19  μM, 2.20  μM and 1.58 μM for PPARα, PPARγ and PPARδ). ABP/PPAR modulator 1 has potent anti-metabolic dysfunction-associated steatohepatitis (MASH) activity. ABP/PPAR modulator 1 dose-dependently ameliorates multiple pathological characteristics of fatty liver in WD + Carbon tetrachloride-induced MASH mice model .

HY-172883A

(E/Z)-ABP/PPAR modulator 1	FABP PPAR	Metabolic Disease Inflammation/Immunology
(E/Z)-ABP/PPAR modulator 1 is a mixture of the E and Z isomers of ABP/PPAR modulator 1 (HY-172883). ABP/PPAR modulator 1 is an orally active FABP and PPAR multiple modulator (IC₅₀s of 0.65  μM and 1.08  μM for FABP1 and FABP4, EC₅₀s of 9.19  μM, 2.20  μM and 1.58 μM for PPARα, PPARγ and PPARδ). ABP/PPAR modulator 1 has potent anti-metabolic dysfunction-associated steatohepatitis (MASH) activity. ABP/PPAR modulator 1 dose-dependently ameliorates multiple pathological characteristics of fatty liver in WD + Carbon tetrachloride-induced MASH mice model .

HY-N18297

Licoagrochalcone A	Phosphatase	Metabolic Disease
Licoagrochalcone A is a PTP1B inhibitor. Licoagrochalcone A exerts protective effects against liver cell injury induced by carbon tetrachloride and Acetaminophen (HY-66005). Licoagrochalcone A is applicable to the research of type 2 diabetes, obesity and liver injury .

HY-N13285

(-)-Epigallocatechin-4'-O-methylether (-)-EGC-4'-O-ME	Drug Derivative	Metabolic Disease Inflammation/Immunology
(-)-Epigallocatechin-4'-O-methylether ((-)-EGC-4'-O-ME) is an orally active natural phenolic catechin with antioxidant, free radical-scavenging and hepatoprotective activities. (-)-Epigallocatechin-4'-O-methylether interferes with radiation-induced free radical formation, scavenges DPPH free radicals, inhibits carbon tetrachloride-induced increases in serum GOT and GPT, suppresses carbon tetrachloride-induced TBA-RS formation, and counteracts carbon tetrachloride-induced hepatocyte toxicity. (-)-Epigallocatechin-4'-O-methylether binds specifically to human serum albumin. (-)-Epigallocatechin-4'-O-methylether can be used in studies related to liver injury .

HY-N15464

Antihepatotoxic agent-1	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
Antihepatotoxic agent-1 is a cerebroside present in Lycium chinense Fruits with antihepatotoxic activity. Antihepatotoxic agent-1 exerts a protective effect by blocking the release of alanine aminotransferase and sorbitol dehydrogenase from primary cultured rat hepatocytes intoxicated with carbon tetrachloride. Antihepatotoxic agent-1 can be used in studies related to liver injury .

HY-N11736

12-O-Tiglyl-phorbol 13-dodecanoate	Collagen	Metabolic Disease
12-O-Tiglyl-phorbol 13-dodecanoate (TD13) is a potential inhibitor with anti-hepatic fibrosis activity, and it belongs to a series of derivatives of oral APOL2 inhibitors and anti-hepatic fibrosis agents. It shows no obvious toxicity in preclinical models. Compounds of the 12-O-Tiglyl-phorbol 13-dodecanoate series inhibit the expression of fibronectin, type I collagen and α-smooth muscle actin in hepatic stellate cells. 12-O-Tiglyl-phorbol 13-dodecanoate can be isolated from the Euphorbiaceae plant Euphorbia fischeriana, and it is applicable to the research of hepatic fibrosis .

HY-N19083

Tecomella undulata extract	Bacterial	Inflammation/Immunology
Tecomella undulata Extract, also known as Rohida extract, is a valuable botanical extract derived from the bark and leaves of the Tecomella undulata plant native to the Indian Thar Desert and is rich in bioactive compounds such as flavonoids, quinones, triterpenoids, and other phytochemicals that contribute to its diverse therapeutic properties. This extract is widely recognized for its hepatoprotective effects demonstrated through its ability to protect against liver damage induced by toxins such as paracetamol and carbon tetrachloride by normalizing elevated liver enzyme levels reducing oxidative stress and improving liver function. Additionally, it exhibits significant anti-inflammatory activity comparable to standard drugs like indomethacin and has been used to treat conditions like ascites and hepatosplenomegaly while also showing immunomodulatory effects by enhancing both humoral and cell-mediated immune responses and possessing antimicrobial properties that make it effective against various pathogens. Recent research suggests that Tecomella undulata may have potential in managing nonalcoholic steatohepatitis (NASH) by reducing body weight insulin resistance and improving liver function markers making it a versatile natural remedy with significant applications in hepatoprotection anti-inflammation and immune support.

Cat. No.	Product Name	Type

HY-44134

Dimethyl 2-oxoglutarate 1 Publications Verification Dimethyl α-ketoglutarate	Biochemical Assay Reagents
Dimethyl 2-oxoglutarate (Dimethyl α-ketoglutarate) is a cell-permeable derivative of 2-oxoglutarate and tricarboxylic acid cycle metabolite with antioxidant properties. Dimethyl 2-oxoglutarate inhibits Autophagy. Dimethyl 2-oxoglutarate prevents mitochondrial damage and reduces ROS production. Dimethyl 2-oxoglutarate alleviates Carbon tetrachloride (HY-Y0298)-induced liver fibrosis. Dimethyl-2-oxoglutaric acid can be used in the research of diseases such as Alzheimer's disease, diabetes, and cardiomyopathy .

Dimethyl 2-oxoglutarate

1 Publications Verification

Dimethyl α-ketoglutarate

Biochemical Assay Reagents

Dimethyl 2-oxoglutarate (Dimethyl α-ketoglutarate) is a cell-permeable derivative of 2-oxoglutarate and tricarboxylic acid cycle metabolite with antioxidant properties. Dimethyl 2-oxoglutarate inhibits Autophagy. Dimethyl 2-oxoglutarate prevents mitochondrial damage and reduces ROS production. Dimethyl 2-oxoglutarate alleviates Carbon tetrachloride (HY-Y0298)-induced liver fibrosis. Dimethyl-2-oxoglutaric acid can be used in the research of diseases such as Alzheimer's disease, diabetes, and cardiomyopathy .

Dimethyl 2-oxoglutarate 1 Publications Verification Dimethyl α-ketoglutarate	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Drug Derivative Autophagy Mitochondrial Metabolism Reactive Oxygen Species (ROS)
Dimethyl 2-oxoglutarate (Dimethyl α-ketoglutarate) is a cell-permeable derivative of 2-oxoglutarate and tricarboxylic acid cycle metabolite with antioxidant properties. Dimethyl 2-oxoglutarate inhibits Autophagy. Dimethyl 2-oxoglutarate prevents mitochondrial damage and reduces ROS production. Dimethyl 2-oxoglutarate alleviates Carbon tetrachloride (HY-Y0298)-induced liver fibrosis. Dimethyl-2-oxoglutaric acid can be used in the research of diseases such as Alzheimer's disease, diabetes, and cardiomyopathy .

Lithospermic acid Maximum Cited Publications 6 Publications Verification (+)-Lithospermic acid	Classification of Application Fields Labiatae Samanea saman (Jacq.) Merr. Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	NO Synthase AMPK Keap1-Nrf2 Xanthine Oxidase Apoptosis
Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl₄)-induced acute liver damage in vitro and in vivo .

Swertiamarin 1 Publications Verification	Monophenols other families Classification of Application Fields Phenols Zanthoxylum chiloperone var. angustifolium Metabolic Disease Plants Disease Research Fields Cancer	MMP NF-κB JAK Keap1-Nrf2
Swertiamarin is an orally active natural product with hypoglycemic, lipid-lowering, anti-rheumatic, and antioxidant activities. Swertiamarin can regulate the levels of pro-inflammatory cytokines, MMP, and NF-κB, and promote osteoblast proliferation. Swertiamarin has antioxidant and hepatoprotective effects against carbon tetrachloride induced rat liver toxicity through the Nrf2/HO-1 pathway. Swertiamarin can attenuate inflammatory mediators by regulating JAK2/STAT3 transcription factors in adjuvant induced arthritis rats. Swertiamarin can be used in the research of diabetes and arthritis .

Rubiadin	Quinones Structural Classification Classification of Application Fields Anthraquinones Rubiaceae Phenols Polyphenols Plants Morinda officinalis How Inflammation/Immunology Disease Research Fields Source Classification	Reactive Oxygen Species (ROS)
Rubiadin is an orally active polyketide-derived compound and free radical scavenger that inhibits the activation of the NF-κB pathway. Rubiadin inhibits osteoclast formation, bone resorption, lipid peroxidation, HBV DNA replication and cancer cell proliferation; reduces pro-inflammatory cytokine levels; induces cancer cell apoptosis; and possesses antifungal, antimalarial, antibacterial and anticonvulsant activities. Rubiadin can be used in the research of osteoporosis, acute inflammation, chronic inflammation, carbon tetrachloride-induced liver injury, Alzheimer's disease, breast cancer, iron overload disorders, hepatitis B virus infection, colon cancer, liver cancer, T-lymphocytic leukemia, cervical cancer, diabetic nephropathy, epileptic seizures, fungal infections, malaria and bacterial infections .

Gigantol 1 Publications Verification	Structural Classification Classification of Application Fields Orchidaceae Other Diseases Phenols Polyphenols Glucosinolates Plants Disease Research Fields Dendrobium nobile Lindl.	Ferroptosis c-Myc Glutathione Peroxidase JNK Reactive Oxygen Species (ROS) GSK-3
Gigantol is an orally active bibenzyl compound. Gigantol targets MYC to promote its ubiquitin-proteasomal degradation and inhibit the growth of lung cancer cells. Gigantol exerts anti-lung cancer activity by inducing ferroptosis (Ferroptosis) via the SLC7A11-GPX4 axis. Gigantol restores the sensitivity of mcr-harboring multidrug-resistant bacteria to colistin. Gigantol ameliorates carbon tetrachloride-induced liver injury by inhibiting the activation of the JNK/cPLA2/12-LOX inflammatory pathway. Gigantol promotes cholesterol metabolism and progesterone biosynthesis in Leydig cells. Gigantol can be used in studies related to diseases such as lung cancer, multidrug-resistant Gram-negative bacterial infections, and acute liver injury .

Chitobiose dihydrochloride	Structural Classification Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Saccharides Source Classification	Others
Chitobiose dihydrochloride is an orally active chitosan oligosaccharide (degree of polymerization 2). Chitobiose dihydrochloride shows hepatoprotective activity and counteracts CCl₄-induced elevation of plasma aspartate transaminase and alanine transaminase activities in rats. Chitobiose dihydrochloride can be used for the research of carbon tetrachloride-induced acute hepatotoxicity .

Ochnaflavone	Structural Classification Flavonoids Ochna atropurpurea DC. Plants Biflavones Source Classification	Phospholipase
Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2 (sPLA2-IIA) with an IC₅₀ of 3.45 µM. Ochnaflavone exhibits significant anti-inflammatory and liver-protective effects, capable of inhibiting the degradation of phosphatidylethanolamine (PE) and lipid peroxidation induced by carbon tetrachloride (CCl4) in rat liver, with an IC₅₀ of 7.16 µM for lipid peroxidation. Ochnaflavone can be used in research on liver damage and inflammatory diseases .

Chitobiose	Polysaccharides Microorganisms Animals Classification of Application Fields Other Diseases Disease Research Fields Saccharides Source Classification	Others
Chitobiose is an orally active chitosan oligosaccharide (degree of polymerization 2). Chitobiose shows hepatoprotective activity and counteracts CCl₄-induced elevation of plasma aspartate transaminase and alanine transaminase activities in rats. Chitobiose can be used for the research of carbon tetrachloride-induced acute hepatotoxicity .

Isorhamnetin 3-O-galactoside 1 Publications Verification Cacticin	Cardiovascular Disease Flavonols Flavonoids Typhaceae Classification of Application Fields Typha angustifolia L. Phenols Polyphenols Plants Disease Research Fields Source Classification	Thrombin COX ERK JNK Factor Xa
Isorhamnetin 3-O-galactoside (Cacticin) is a flavonoid glycoside that can be isolated from Oenanthe javanica, with antithrombotic and profibrinolytic activities. Isorhamnetin 3-O-galactoside inhibits the activities of thrombin and factor Xa (FXa) and reduces thrombin-catalyzed fibrin polymerization maximum rate. Isorhamnetin 3-O-galactoside suppresses TNF-α-induced PAI-1 secretion, decreases the PAI-1/tissue-type plasminogen activator (t-PA) ratio, and inhibits FXa production and FVa/FXa-mediated thrombin generation. Isorhamnetin 3-O-galactoside exerts protective effects against Carbon tetrachloride (CCl4) (HY-Y0298)-induced hepatic injury in mice. Isorhamnetin 3-O-galactoside can be used for the study of liver injury-related diseases and thrombotic vascular diseases .

Celosin I 1 Publications Verification	Triterpenes Structural Classification Celosia argentea Linn. Classification of Application Fields Terpenoids Metabolic Disease Amaranthaceae Plants Disease Research Fields Source Classification	Others
Celosin I, an oleanane-type triterpenoid saponin isolated from the seeds of Celosia argentea L, could be used as chemical markers for the quality control of C. argentea seeds. Celosin I exhibits significant hepatoprotective effect on carbon tetrachloride-induced and N,N-dimethylformamide-induced hepatotoxicity in mice .

3,4-Didehydroglabridin	Natural Products Leguminosae Plants Glycyrrhiza uralensis Fisch. Source Classification	Others
3,4-Didehydroglabridin is a natural product that can be found in licorice. 3,4-Didehydroglabridin exhibits protective activities against carbon tetrachloride-induced HepG2 cells injury. 3,4-Didehydroglabridin has the potential for the research of liver injury .

Goodyeroside A	Crocus sativus Linn. Iridaceae Plants Saccharides Monosaccharides Source Classification	Others
Goodyeroside A is a glycoside compound derived from the plant Goodyera that exhibits significant hepatoprotective activity. It can inhibit liver damage induced by carbon tetrachloride (HY-Y0298) in primary cultured rat hepatocytes .

Lithospermic acid (Standard) (+)-Lithospermic acid (Standard)	Structural Classification Labiatae Samanea saman (Jacq.) Merr. Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants Source Classification	Reference Standards NO Synthase AMPK Keap1-Nrf2 Xanthine Oxidase Apoptosis
Lithospermic acid (Standard) is the analytical standard of Lithospermic acid. This product is intended for research and analytical applications. Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo .

Andrographiside	Structural Classification Acanthaceae Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Source Classification	Bacterial
Andrographiside is a labdane diterpenoid glucoside that can be isolated from the leaves of Andrographis paniculata Nees. Andrographiside has antihepatotoxic and antioxidative effects. Andrographiside shows protective effects on mice with hepatotoxicity induced by carbon tetrachloride or tert-butylhydroperoxide (tBHP) . Andrographiside is a novel biofilm inhibitor of Pseudomonas aeruginosa PAO1 by modulating quorum-sensing proteins .

Vitexin 7-O-β-D-glucopyranoside Vitexin 7-glucoside	Flavonoids Flavones Amaranthaceae Plants Beta vulgaris var. cicla L. Saccharides Monosaccharides Source Classification	Others
Vitexin 7-O-β-D-glucopyranoside (Vitexin 7-glucoside) is a flavone glycoside found in Beta vulgaris var. cicla. Vitexin 7-O-β-D-glucopyranoside shows a hepatoprotective activity in primary cultured rat hepatocytes with Carbon tetrachloride (CCl4) (HY-Y0298)-induced cell toxicity .

Licoagrochalcone A	Structural Classification Chalcones Flavonoids Leguminosae Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Source Classification	Phosphatase
Licoagrochalcone A is a PTP1B inhibitor. Licoagrochalcone A exerts protective effects against liver cell injury induced by carbon tetrachloride and Acetaminophen (HY-66005). Licoagrochalcone A is applicable to the research of type 2 diabetes, obesity and liver injury .

(-)-Epigallocatechin-4'-O-methylether (-)-EGC-4'-O-ME	Structural Classification Ouratea Aubl. Phenols Polyphenols Plants Source Classification	Drug Derivative
(-)-Epigallocatechin-4'-O-methylether ((-)-EGC-4'-O-ME) is an orally active natural phenolic catechin with antioxidant, free radical-scavenging and hepatoprotective activities. (-)-Epigallocatechin-4'-O-methylether interferes with radiation-induced free radical formation, scavenges DPPH free radicals, inhibits carbon tetrachloride-induced increases in serum GOT and GPT, suppresses carbon tetrachloride-induced TBA-RS formation, and counteracts carbon tetrachloride-induced hepatocyte toxicity. (-)-Epigallocatechin-4'-O-methylether binds specifically to human serum albumin. (-)-Epigallocatechin-4'-O-methylether can be used in studies related to liver injury .

Antihepatotoxic agent-1	Structural Classification Solanaceae Plants Lycium chinense Miller Saccharides Monosaccharides Source Classification	Aldehyde Dehydrogenase (ALDH)
Antihepatotoxic agent-1 is a cerebroside present in Lycium chinense Fruits with antihepatotoxic activity. Antihepatotoxic agent-1 exerts a protective effect by blocking the release of alanine aminotransferase and sorbitol dehydrogenase from primary cultured rat hepatocytes intoxicated with carbon tetrachloride. Antihepatotoxic agent-1 can be used in studies related to liver injury .

12-O-Tiglyl-phorbol 13-dodecanoate	Structural Classification Natural Products Euphorbia fischeriana Steud. Euphorbiaceae Plants Source Classification	Collagen
12-O-Tiglyl-phorbol 13-dodecanoate (TD13) is a potential inhibitor with anti-hepatic fibrosis activity, and it belongs to a series of derivatives of oral APOL2 inhibitors and anti-hepatic fibrosis agents. It shows no obvious toxicity in preclinical models. Compounds of the 12-O-Tiglyl-phorbol 13-dodecanoate series inhibit the expression of fibronectin, type I collagen and α-smooth muscle actin in hepatic stellate cells. 12-O-Tiglyl-phorbol 13-dodecanoate can be isolated from the Euphorbiaceae plant Euphorbia fischeriana, and it is applicable to the research of hepatic fibrosis .

Tecomella undulata extract	Structural Classification Extract	Bacterial
Tecomella undulata Extract, also known as Rohida extract, is a valuable botanical extract derived from the bark and leaves of the Tecomella undulata plant native to the Indian Thar Desert and is rich in bioactive compounds such as flavonoids, quinones, triterpenoids, and other phytochemicals that contribute to its diverse therapeutic properties. This extract is widely recognized for its hepatoprotective effects demonstrated through its ability to protect against liver damage induced by toxins such as paracetamol and carbon tetrachloride by normalizing elevated liver enzyme levels reducing oxidative stress and improving liver function. Additionally, it exhibits significant anti-inflammatory activity comparable to standard drugs like indomethacin and has been used to treat conditions like ascites and hepatosplenomegaly while also showing immunomodulatory effects by enhancing both humoral and cell-mediated immune responses and possessing antimicrobial properties that make it effective against various pathogens. Recent research suggests that Tecomella undulata may have potential in managing nonalcoholic steatohepatitis (NASH) by reducing body weight insulin resistance and improving liver function markers making it a versatile natural remedy with significant applications in hepatoprotection anti-inflammation and immune support.

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carbon tetrachloride

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