1 Result for "

disintegrin-like modules

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "disintegrin-like modules" in MCE Product Catalog:

Cat. No.: HY-P992358

Target:  

ADAMTS

Research Areas:  

Cardiovascular Disease

GSK2394002 is an antibody inhibitor targeting ADAMTS-4 and ADAMTS-5, with cartilage-penetrating ability following systemic administration. GSK2394002 inhibits the release of aggrecan-derived neoepitopes and reduces cartilage degradation, exhibiting the potential to relieve pain, alleviate hyperalgesia and inhibit the progression of joint damage. GSK2394002 also induces potentially irreversible cardiovascular effects such as increased mean arterial pressure and myocardial ischemia in cynomolgus monkeys .
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