4569-86-2
4569-86-2
Chemical Structure
Methylene Violet 3RAX
- CAS No.: 4569-86-2
- Formula:C22H23ClN4
- Molecular Weight:378.90
IUPAC Name: 3-amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride
InChIKey: MOVNSGGBTSIUGX-UHFFFAOYSA-N
SMILES: [Cl-].N=1C=2C=CC(N)=CC2[N+](C=3C=CC=CC3)=C4C=C(C=CC14)N(CC)CC
Biological Activity: Methylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells. Methylene Violet 3RAX can change the molecular structure of DNA, undermine the module of DNA, and induce the generation of the reactive singlet oxygen. Methylene Violet 3RAX shows inhibition for human erythrocyte AChE and human plasma BChE with an Kis of 1.58, 0.51 μM, respectively. Methylene Violet 3RAX has the potential for the research of potential photosensitizers for mitochondrial targeting action in PDT (photodynamic therapy)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Methylene Violet 3RAX | 97.24% | Methylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells. Methylene Violet 3RAX can change the molecular structure of DNA, undermine the module of DNA, and induce the generation of the reactive singlet oxygen. Methylene Violet 3RAX shows inhibition for human erythrocyte AChE and human plasma BChE with an Kis of 1.58, 0.51 μM, respectively. Methylene Violet 3RAX has the potential for the research of potential photosensitizers for mitochondrial targeting action in PDT (photodynamic therapy). | ||||||||||||||||||||
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(BHQ-3)-OSu hexafluorophosphate | (BHQ-3)-OSu hexafluorophosphate is used for fluorescent labeling of protease substrates. | |||||||||||||||||||||
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HP1328 | HP1328 is a potent inhibitor of FLT3 receptor tyrosine kinase (FLT3/ITD mutation). HP1328 is a benzoimidazole scaffold-based compound. HP1328 significantly reduces the leukemia burden and prolongs the survival of mice with FLT3/ITD leukemia. | |||||||||||||||||||||
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HP1142 | HP1142 is a potent and selective inhibitor of FLT3 receptor tyrosine kinase (FLT3/ITD mutation). HP1142 is a benzoimidazole scaffold-based compound. HP1142 has the potential for the research of FLT3/ITD leukemia. | |||||||||||||||||||||
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Safranin | Safranin (Safranin T) is an important and classical phenazinium dye. Safranin has been extensively used in the academic field as a spectroscopic probe and indicator. Safranin possesses a planar structure and cationic charge. Safranin can readily intercalate into biological macromolecules, including DNA and proteins. Safranin has antibacterial effects against gram-positive bacteria (S. aureus). Safranin can be used as a redox indicator in the determination of metal ion concentration. | |||||||||||||||||||||
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Indoine blue | Indoine blue is a basic dye. | |||||||||||||||||||||
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Janus green B | 98.75% | Janus green B is a supravital stain. Janus green B staining reaction is oxygen dependent, and is reversibly inhibited by cyanide. Janus Green B has been used to stain structures such as peripheral nerves in living insects, rabbit lymphatic vessels, mitochondria, and mast cells. | ||||||||||||||||||||
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Janus green | Janus green is a basic dye. | |||||||||||||||||||||
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Nile Blue A perchlorate | Nile Blue A perchlorate is a cationic oxazine dye and a laser dye for pulsed and continuous-wave operations (Ex/Em = 365/660 nm). Nile Blue A perchlorate exhibits strong solvent coloration properties and is highly sensitive to environmental polarity and pH values. | |||||||||||||||||||||
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Phenosafranine | 90.77% | Phenosafranine is a phenazine dye. Phenosafranine exhibits higher binding affinity for triple-stranded RNA than for double-stranded RNA, and binds to both types of RNA via intercalation. Phenosafranine interacts with hemoglobin. Phenosafranine can be used for plant cell staining, as well as the detection of hemoglobin, dopamine, serotonin, etc. | ||||||||||||||||||||
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Nile blue chloride | Nile blue chloride is a highly fluorescent and photostable organic dye. Nile blue chloride and fluorescein isothiocyanate (FITC) can be used to construct a ratiometric pH sensitive probe for tracking the pH of the extracellular fluid between cancer cells in realtime. Nile Blue chloride has the potential for the research of nonlinear optics. | |||||||||||||||||||||
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References
- [1]. Si Yao, et al. Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study. RSC Advances. 2022,12, 21004-21013.
- [2]. Onder S, et al. The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by methylene violet 3RAX. Chem Biol Interact. 2019 Dec 1;314:108845. [Content Brief]
