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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
enterocyte
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "enterocyte" in MCE Product Catalog:
3
3 Cited Publications
Target:
Research Areas:
DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo .
2
2 Cited Publications
Cat. No.: HY-W092043
CAS No.: 1159408-54-4
Research Areas:
TLR4-IN-C34-C2-COO is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34-C2-COOH can be used in the research of inflammation and acute myocardial injury. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis .
2
2 Cited Publications
Target:
Research Areas:
DBIBB is a specific nonlipid agonist of the type 2 G protein coupled receptor for lysophosphatidic acid (LPA2). DBIBB mitigates the gastrointestinal radiation syndrome, increases intestinal crypt survival and enterocyte proliferation, and reduces apoptosis. DBIBB represents a agent candidate capable of mitigating acute radiation syndrome caused by high-dose γ-radiation to the hematopoietic and gastrointestinal system .
Target:
Research Areas:
Enteropeptidase (TMPRSS15), a type II transmembrane serine protease and a physiological activator of trypsinogen. Enteropeptidase is associated with the brush border membrane (BBM) of the enterocytes in the upper small intestine. Trypsinogen is the primary substrate for Enteropeptidase. Enteropeptidase is involved in digestion in humans and animals .
Cat. No.: HY-B0819
CAS No.: 14816-18-3
Target:
Insecticide Cholinesterase (ChE) Cytochrome P450 Autophagy Reactive Oxygen Species (ROS) Apoptosis Bcl-2 Family Caspase COX Keap1-Nrf2 TNF Receptor Interleukin Related Bacterial
Research Areas:
Phoxim is an organophosphorus pesticide and an orally active inhibitor of cholinesterase and CYP3A, which induces neurotoxicity in Caenorhabditis elegans and causes nephrotoxicity characterized by glomerular atrophy and interstitial fibrosis. Phoxim induces inhibition of the autophagy pathway. Phoxim induces dopaminergic neuron degeneration and exacerbates Aβ-induced paralysis. Phoxim damages enterocytes and disrupts intestinal barrier integrity. Phoxim induces ROS accumulation. Phoxim induces mitochondrial apoptosis, involving upregulation of Bad, Bax, caspase-3, and caspase-9 and downregulation of Bcl-2. Phoxim inhibits mitochondrial functional enzymes (COX, Ca 2+-Mg 2+-ATPase, SDH). Phoxim upregulates Nrf2 mRNA expression in the jejunal mucosa. Phoxim increases TNF-α and decreases IL-6 and IL-8 in the intestinal mucosa. Phoxim alters gut microbial composition by increasing total bacteria and Escherichia coli and reducing Lactobacillus. Phoxim enhances energy metabolism in silver carp by upregulating key glycolytic and gluconeogenic enzymes. Phoxim is used in research on neurodegenerative diseases, nephrotoxicity, intestinal oxidative stress and barrier dysfunction, and bacterial sepsis .
Cat. No.: HY-P1841
CAS No.: 89750-15-2
Target:
Cat. No.: HY-145245
Purity: 99.62%
Research Areas:
TLR4-IN-C34-C2-amide-C6-OH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis .
Cat. No.: HY-145253
Research Areas:
Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis .
Cat. No.: HY-145255
Research Areas:
Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis .
Cat. No.: HY-145254
Target:
Research Areas:
Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis .
Cat. No.: HY-W758414
Phoxim-d5 (phenyl-d5) (mixture of isomers) is the deuterated-labeled Phoxim (HY-B0819). Phoxim is an organophosphorus pesticide and an orally active inhibitor of cholinesterase and CYP3A, which induces neurotoxicity in Caenorhabditis elegans and causes nephrotoxicity characterized by glomerular atrophy and interstitial fibrosis. Phoxim induces inhibition of the autophagy pathway. Phoxim induces dopaminergic neuron degeneration and exacerbates Aβ-induced paralysis. Phoxim damages enterocytes and disrupts intestinal barrier integrity. Phoxim induces ROS accumulation. Phoxim induces mitochondrial apoptosis, involving upregulation of Bad, Bax, caspase-3, and caspase-9 and downregulation of Bcl-2. Phoxim inhibits mitochondrial functional enzymes (COX, Ca 2+-Mg 2+-ATPase, SDH). Phoxim upregulates Nrf2 mRNA expression in the jejunal mucosa. Phoxim increases TNF-α and decreases IL-6 and IL-8 in the intestinal mucosa. Phoxim alters gut microbial composition by increasing total bacteria and Escherichia coli and reducing Lactobacillus. Phoxim enhances energy metabolism in silver carp by upregulating key glycolytic and gluconeogenic enzymes. Phoxim is used in research on neurodegenerative diseases, nephrotoxicity, intestinal oxidative stress and barrier dysfunction, and bacterial sepsis .
Cat. No.: HY-P704083
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: UBE2V2; Ubiquitin Conjugating Enzyme E2 V2; Ubiquitin-Conjugating Enzyme E2 Variant 2; EDPF-1; EDAF-1; MMS2; UEV2; DDVit-1; DDVIT1; UEV-2; EDPF1; enterocyte Differentiation-Associated Factor 1; enterocyte Differentiation-Promoting Factor 1; Vitamin D3-Inducible Protein; MMS2 Homolog; DDVit 1; CDNA,FLJ93989,Homo Sapiens Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2),MRNA; Methyl Methanesulfonate Sensitive 2,S.Cerevisiae,Homolog Of; Ubiquitin-Conjugating Enzyme E2 Variant 2,Isoform CRA_a; enterocyte Differentiation-Associated Factor EDAF-1; enterocyte Differentiation Promoting Factor 1 Alpha,25-Dihydroxyvitamin D3-Inducible
Species:
Human
Source:
E. coli
Cat. No.: HY-P704084
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: UBE2V2; Ubiquitin Conjugating Enzyme E2 V2; Ubiquitin-Conjugating Enzyme E2 Variant 2; EDPF-1; EDAF-1; MMS2; UEV2; DDVit-1; DDVIT1; UEV-2; EDPF1; enterocyte Differentiation-Associated Factor 1; enterocyte Differentiation-Promoting Factor 1; Vitamin D3-Inducible Protein; MMS2 Homolog; DDVit 1; CDNA,FLJ93989,Homo Sapiens Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2),MRNA; Methyl Methanesulfonate Sensitive 2,S.Cerevisiae,Homolog Of; Ubiquitin-Conjugating Enzyme E2 Variant 2,Isoform CRA_a; enterocyte Differentiation-Associated Factor EDAF-1; enterocyte Differentiation Promoting Factor 1 Alpha,25-Dihydroxyvitamin D3-Inducible
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P71411
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2V2; Ubiquitin Conjugating Enzyme E2 V2; Ubiquitin-Conjugating Enzyme E2 Variant 2; EDPF-1; EDAF-1; MMS2; UEV2; DDVit-1; DDVIT1; UEV-2; EDPF1; enterocyte Differentiation-Associated Factor 1; enterocyte Differentiation-Promoting Factor 1; Vitamin D3-Ind
Species:
Human
Source:
E. coli
Cat. No.: HY-P704082
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: UBE2V2; Ubiquitin Conjugating Enzyme E2 V2; Ubiquitin-Conjugating Enzyme E2 Variant 2; EDPF-1; EDAF-1; MMS2; UEV2; DDVit-1; DDVIT1; UEV-2; EDPF1; enterocyte Differentiation-Associated Factor 1; enterocyte Differentiation-Promoting Factor 1; Vitamin D3-Inducible Protein; MMS2 Homolog; DDVit 1; CDNA,FLJ93989,Homo Sapiens Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2),MRNA; Methyl Methanesulfonate Sensitive 2,S.Cerevisiae,Homolog Of; Ubiquitin-Conjugating Enzyme E2 Variant 2,Isoform CRA_a; enterocyte Differentiation-Associated Factor EDAF-1; enterocyte Differentiation Promoting Factor 1 Alpha,25-Dihydroxyvitamin D3-Inducible
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
