21 Results for "

fully humanized monoclonal antibody

" in MedChemExpress (MCE) Product Catalog:
Products (21)

21 Results for "fully humanized monoclonal antibody" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-P99037
CAS No.: 2211985-36-1
Synonyms: M281

Target:  

Fc Receptor (FcR)

Research Areas:  

Inflammation/Immunology

Nipocalimab (M281) is a fully humanized, recombinant, and non-glycosylated IgG1 monoclonal antibody. Nipocalimab can bind to the IgG-binding site of FcRn with high affinity and inhibit the transplacental transfer of IgG. Nipocalimab can be used in the research of fetal and neonatal hemolytic disease, myasthenia gravis, and various IgG-mediated autoimmune diseases .
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2
2 Cited Publications
Cat. No.: HY-P99395
CAS No.: 1826831-79-1
Synonyms: JNJ 56022473; CSL 362

Target:  

Interleukin Related

Research Areas:  

Cancer

Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123-neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has KDs of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models .
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1
1 Cited Publications
Cat. No.: HY-P9929
CAS No.: 1246264-45-8
Synonyms: BLA761046; MBL-CDB1; MDX-1388

Target:  

Bacterial

Research Areas:  

Infection

Bezlotoxumab (BLA761046; MBL-CDB1; MDX-1388) is a fully humanized IgG1/kappa monoclonal antibody directed against Clostridium difficile toxin B. Bezlotoxumab mediates the early reconstitution of gut microbiota to reduce the risk of recurrent Clostridium difficile infection (CDI). Bezlotoxumab can be used for the study of recurrent Clostridium difficile infection prevention .
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Cat. No.: HY-P99022
CAS No.: 1043556-46-2
Synonyms: R-04909832; RG-1450

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Gantenerumab is a fully humanized anti-Aβ IgG1 monoclonal antibody. Gantenerumab can specifically bind to Aβ fibrils and plaques and can be used in Alzheimer's disease research .
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Cat. No.: HY-P99009
CAS No.: 2187430-05-1
Synonyms: RVT-1401; HBM9161; IMVT-1401

Target:  

Fc Receptor (FcR)

Research Areas:  

Inflammation/Immunology

Batoclimab (RVT-1401) is a fully humanized IgG1 monoclonal antibody targeting FcRn. Batoclimab has high affinity for the IgG-binding site on FcRn. By competitively binding to the IgG binding site on FcRn, Batoclimab blocks FcRn-mediated recycling of IgG, resulting in enhanced degradation and subsequent reductions in IgG levels. Batoclimab can be used in the research of autoimmune diseases such as myasthenia gravis and thyroid eye disease .
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Cat. No.: HY-P99379
CAS No.: 2171061-85-9
Synonyms: CAN04; Anti-IL-1RAP/IL-1R3 Reference antibody (nidanilimab)

Target:  

Interleukin Related

Research Areas:  

Cancer

Nidanilimab (CAN04) is a fully humanized monoclonal anti-IL1RAP antibody with a Kd value of 1.10 pM. Nidanilimab blocks IL1α and IL1β signaling and stimulates the immune system to destroy tumour cells. Nidanilimab can be used in research of non-small lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC) .
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Cat. No.: HY-P99166
CAS No.: 2329669-72-7
Synonyms: XMAB-20717

Target:  

PD-1/PD-L1 CTLA-4

Research Areas:  

Inflammation/Immunology Cancer

Vudalimab is a potent dual PD-1 and CTLA-4 inhibitor as a fully humanized bispecific monoclonal antibody. Vudalimab targets immune checkpoint receptors PD-1 and CTLA-4 and promotes tumor-selective T-cell activation .
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Cat. No.: HY-P99899
CAS No.: 2052591-32-7
Synonyms: PR-1498487

Target:  

ADC Antibodies

Research Areas:  

Cancer

Samrotamab (PR-1498487) is a humanized IgG1-κ chimeric monoclonal antibody targeting LRRC15, with a Kd of 5.42 nM for human LRRC15. Samrotamab can be used to synthesize antibody-drug conjugates (ADC). Samrotamab disrupts the LRRC15-SCG5 signaling module, binds to a membrane-proximal conformational epitope within the C-terminal leucine-rich repeat region of LRRC15, and binds to the lateral edge of the LRR solenoid while leaving the canonical concave β-sheet surface fully exposed. Samrotamab reduces the viability of bladder cancer cells, inhibits clonogenic growth, impairs cell migration, and compromises cell invasion. Samrotamab induces compensatory upregulation of LRRC15 transcripts while suppressing the expression of SCG5 mRNA. Samrotamab is applicable to research related to urothelial carcinoma, sarcoma, osteosarcoma, and undifferentiated pleomorphic sarcoma .
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Cat. No.: HY-P990937
CAS No.: 2948444-06-0
Synonyms: PF-04236921; TOUR-006

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Pacibekitug (PF-04236921; TOUR-006) is a fully humanized IgG2 monoclonal antibody targeting IL-6. Pacibekitug binds to and neutralizes IL-6 signaling, thereby inhibiting the pathophysiological role of this pro-inflammatory cytokine in autoimmune diseases (such as rheumatoid arthritis, Crohn's disease, and systemic lupus erythematosus) [1][2].
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Cat. No.: HY-P99835
CAS No.: 1095207-05-8
Synonyms: MABT 5102A; RG 7412

Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Crenezumab (MABT 5102A; RG 7412) is a fully humanized anti-Aβ monoclonal antibody that binds multiple forms of Aβ, such as soluble, oligomeric and fibrillar, for use in Alzheimer's disease research .
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Cat. No.: HY-P990635

Target:  

TGF-β Receptor

Research Areas:  

Cancer

NGM-120 is a fully humanized IgG1 monoclonal antibody targeting GFRAL, which functions by blocking the GDF15-GFRAL axis. NGM-120 reduces serum GDF15 levels, increases body weight, expands central memory and proliferative CD8 + T cell populations, and decreases immunosuppressive and naive regulatory T cell populations. NGM-120 can be used for research on advanced prostate cancer .
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Cat. No.: HY-P991040
Synonyms: Gamsitabart; M3554 antibody

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

hu14.18 (K322A) is a humanized anti-disialoganglioside GD2 monoclonal antibody that contains fully human amino acid sequences for immunoglobulin G1 heavy and kappa light chains. hu14.18 (K322A) has antibody-dependent cellular cytotoxicity (ADCC). hu14.18 (K322A) can be used for the study of high-risk neuroblastoma .
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Cat. No.: HY-P99702
CAS No.: 2035008-70-7
Synonyms: BCD-089

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Levilimab (BCD-089) is a fully humanized anti-interleukin-6 receptor (IL-6R) monoclonal antibody. Levilimab is an inflammation-alleviating antibody. Levilimab can be used for the research of rheumatoid .
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Cat. No.: HY-P991230
Target:  

Others

Research Areas:  

Cancer

MK-4830 is a fully humanized monoclonal antibody of the immunoglobulin G4 subclass that specifically binds to ILT4 and blocks its interaction with HLA-G and other ligands. MK-4830 inhibits tumor growth in humanized mouse cancer models .
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Cat. No.: HY-P991178

Target:  

TNF Receptor

Research Areas:  

Cancer

BMS-986156 is a fully humanized IgG1 agonist monoclonal antibody agonist corticosteroid-induced tumor necrosis factor receptor-related protein (GITR). BMS-986156 binds to GITR and promotes activation of T effector cells and inactivates T regulatory cells. BMS-986156 is indicated for use in advanced solid tumor studies .
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Cat. No.: HY-P99525
CAS No.: 1610010-60-0
Synonyms: R 84 (antibody); GNR-011

Target:  

VEGFR

Research Areas:  

Cancer

Varisacumab (R 84; GNR-011) is a fully humanized IgG1 monoclonal antibody targeting VEGF. Varisacumab specifically blocks the interaction between VEGF and VEGFR2, but does not interfere with the interaction between VEGF and VEGFR1. Varisacumab achieves effective anti-tumor and anti-angiogenic effects and can be used in the research of non-small cell lung cancer and pancreatic cancer.
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Cat. No.: HY-P991507
Synonyms: Demupitamab

Target:  

EGFR

Research Areas:  

Cancer

SCT200 is a fully humanized IgG1 anti-EGFR monoclonal antibody with a Kd of 0.08 nM. SCT200 can kill tumor cells by complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC) through the Fc. SCT200 can be used for the study of refractory RAS and BRAF wild-type metastatic colorectal cancer .
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Cat. No.: HY-P992480

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

VAK-694 is a fully humanized anti-IL-4 monoclonal antibody. VAK-694 can be used for the research of seasonal allergic rhinitis .
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Cat. No.: HY-P992463

Target:  

Ser/Thr Protease

Research Areas:  

Endocrinology

SHR-2010 is a fully humanized monoclonal antibody targeting MASP-2. SHR-2010 selectively inhibits lectin pathway activation without affecting classical or alternative complement pathways. SHR-2010 can be used for the research of IgA nephropathy .
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Cat. No.: HY-P991957

Target:  

Prion Protein

Research Areas:  

Neurological Disease

PRN100 is a fully humanized anti-prion protein (PrPᶜ) monoclonal antibody belonging to the IgG4κ isotype. By binding to and stabilizing cellular prion protein, PRN100 aims to prevent the recruitment and conversion of cellular prion protein into pathogenic, self-propagating prion (PrPˢᶜ) aggregates. PRN100 can be used for the research of Creutzfeldt-Jakob disease.
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