2. Immunology/Inflammation
  3. Fc Receptor (FcR)
  4. Nipocalimab

Nipocalimab  (Synonyms: M281)

Cat. No.: HY-P99037 Purity: ≥99.0%
COA
SDS
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Nipocalimab (M281) is a fully humanized, recombinant, and non-glycosylated IgG1 monoclonal antibody. Nipocalimab can bind to the IgG-binding site of FcRn with high affinity and inhibit the transplacental transfer of IgG. Nipocalimab can be used in the research of fetal and neonatal hemolytic disease, myasthenia gravis, and various IgG-mediated autoimmune diseases.

For research use only. We do not sell to patients.

CAS No. : 2211985-36-1

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Customer Review

Based on 3 publication(s) in Google Scholar

Nipocalimab Featured Recommendations:

Nipocalimab Related Antibodies

Top Publications Citing Use of Products

    Nipocalimab purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Nov 3;16(1):9621.

    The structure of FcRn in complex with HAstV1 spike overlayed with the structure of FcRn in complex with the Nipocalimab antigen binding fragment (Fab) (PDB: 9MI6). HAstV1 spike is shown in magenta, FcRn is shown in teal (αFcRn) and gray (β2M), and Nipocalimab Fab is shown in green.

    Nipocalimab purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Nov 3;16(1):9621.

    Competitive ELISA results from mixing biotinylated HAstV1 spike at 125 nM with varying concentrations of Nipocalimab and adding these pre-mixtures to an FcRn-coated ELISA plate at pH 7.0. After washing, HRP-streptavidin was used to detect bound HAstV1 spike. Results are an average of three replicates, and error bars represent standard deviation. Each Nipocalimab concentration was compared to the 0 nM condition using a two-sided Welch's t test. Source data are provided as a source data file.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Nipocalimab (M281) is a fully humanized, recombinant, and non-glycosylated IgG1 monoclonal antibody. Nipocalimab can bind to the IgG-binding site of FcRn with high affinity and inhibit the transplacental transfer of IgG. Nipocalimab can be used in the research of fetal and neonatal hemolytic disease, myasthenia gravis, and various IgG-mediated autoimmune diseases[1][2][3].

    Isotype

    Human IgG1 lambda
    Recommend Isotype Controls
    Species Reactivity

    Human
    IC50 & Target

    FcRn
    In Vitro

    Nipocalimab (4-6 h) inhibits the transfer of IgG from the maternal to the fetal circulation in the human placental perfusion model[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Nipocalimab Related Antibodies
    In Vivo

    Nipocalimab (300 mg/kg; once a week; 6 months) can cause a sustained decrease in IgG without adverse effects in non-human primates[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Gene ID

    2217  [NCBI]

    Accession
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    Molecular Weight

    142.12 kDa

    CAS No.
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Nipocalimab]
    Shipping

    Shipping with dry ice.
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Format
    • Human IgG1 lambda3
    Biological Activity
    • Immobilized Human FcRn/FCGRT&B2M Heterodimer protein, His can bind Nipocalimab. The EC50 for this effect is 8.97 ng/mL.
    • Flow cytometric analysis of 1.5×106 THP-1 cells labeling Nipocalimab (HY-P99037, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 lambda Isotype Control (HY-P99992, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
    Purity & Documentation

    Purity: ≥99.0%

    SDS (251 KB)

    COA (232 KB) SDS-PAGE (102 KB) SEC-HPLC (74 KB)

    Inhibitory Antibodies User Guide (603 KB)
    References
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    Nipocalimab Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Nipocalimab2211985-36-1M281M 281M-281Fc Receptor (FcR)Fc Receptornon-human primatehuman placental perfusion modelInhibitorinhibitorinhibit

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