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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
36 Results for "
glycine transporter
" in MedChemExpress (MCE) Product Catalog:
Products (36)
36 Results for "glycine transporter" in MCE Product Catalog:
7
7 Publications Verification
Cat. No.: HY-18638
CAS No.: 30675-13-9
Synonyms: 4,5,6,7-Tetrachloroindan-1,3-dione
Target:
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TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC50 of 0.6 μM . TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons .
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Category:
Natural Products Other disease Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields
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3 Cited Publications
Synonyms: N-Methylglycine; Sarcosin
Category:
Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Disease markers Endocrine diseases Amino acids Endogenous metabolite Disease Research Fields Cancer
Target:
3
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Iclepertin (BI-425809) is a potent, selective and orally active glycine transporter 1 (GlyT1) inhibitor. Iclepertin is inactive against GlyT2. Iclepertin can be used for Alzheimer disease and schizophrenia research .
Synonyms: N-Methylglycine-d3; Sarcosin-d3
Synonyms: VVZ-149 hydrochloride
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Opiranserin (VVZ-149) hydrochloride, a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. Opiranserin hydrochloride shows antagonistic activity on rP2X3 (IC50=0.87 μM). Opiranserin hydrochloride is development as an injectable agent for the treatment of postoperative pain .
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PF-03463275 is a centrally penetrant, orally available, selective, and competitive GlyT1 (glycine transporter-1) reversible inhibitor, with a Ki of 11.6 nM. PF-03463275 has the potential for Schizophrenia research .
Cat. No.: HY-111029A
Purity: 99.83%
ALX-1393 TFA, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model .
Cat. No.: HY-101037R
CAS No.: 107-97-1
Synonyms: N-Methylglycine (Standard); Sarcosin (Standard)
Synonyms: (R)-NFPS hydrochloride
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ALX-5407 ((R)-NFPS) hydrochloride is a selective and orally active glycine transporter GlyT1 inhibitor with an IC50 value of 3 nM. ALX-5407 hydrochloride can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia .
Cat. No.: HY-101037S
Purity: ≥99.0%
Synonyms: N-Methylglycine-15N; Sarcosin-15N
Cat. No.: HY-113329R
CAS No.: 543-18-0
Synonyms: Taurocyamine (Standard)
Cat. No.: HY-109067
CAS No.: 1441000-45-8
Synonyms: VVZ-149
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Research Areas:
Opiranserin (VVZ-149), a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. Opiranserin shows antagonistic activity on rP2X3 (IC50=0.87 μM). Opiranserin is development as an injectable agent for the treatment of postoperative pain .
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Research Areas:
ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease .
Cat. No.: HY-148708
CAS No.: 2240164-55-8
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Oleoyl-D-lysine is a selective Glycine Transporter-2 (GlyT2) inhibitor based on lipid. Oleoyl-D-lysine reverses neuropathic pain in mice，shows antidrowsiness effect on chronic neuropathic pain. Oleoyl-D-lysine is safe and effective without respiratory depression .
Cat. No.: HY-107526
CAS No.: 405225-21-0
Synonyms: (Rac)-NFPS
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NFPS is a selective, non-competitive glycine transporter-1 (GlyT1) inhibitor with IC50s of 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively . NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion .
Cat. No.: HY-10711
CAS No.: 571147-18-7
Synonyms: (R)-NFPS
Target:
Research Areas:
ALX-5407 ((R)-NFPS) is a selective and orally active glycine transporter GlyT1 inhibitor with an IC50 value of 3 nM. ALX-5407 can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia .
Cat. No.: HY-W748519
CAS No.: 2806125-84-6
Synonyms: N-Methylglycine-13C3; Sarcosin-13C3
Cat. No.: HY-114555
CAS No.: 1007109-16-1
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TASP0315003 is a glycine transporter 1 (GlyT1) inhibitor. TASP0315003 potentiates NMDA receptor function by increasing synaptic glycine levels. TASP0315003 can improve cognitive dysfunction and the negative symptoms of schizophrenia without having undesirable central nervous system side effects. TASP0315003 can be used for the research of neurological disease .
Cat. No.: HY-19887
CAS No.: 1000690-85-6
Synonyms: AMG747
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Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1).
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
