Oleoyl-D-lysine

Cat. No.: HY-148708: FAQs
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Oleoyl-D-lysine is a selective Glycine Transporter-2 (GlyT2) inhibitor based on lipid. Oleoyl-D-lysine reverses neuropathic pain in mice, shows antidrowsiness effect on chronic neuropathic pain. Oleoyl-D-lysine is safe and effective without respiratory depression.

For research use only. We do not sell to patients.

Oleoyl-D-lysine Chemical Structure

CAS No. : 2240164-55-8

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Description	Oleoyl-D-lysine is a selective Glycine Transporter-2 (GlyT2) inhibitor based on lipid. Oleoyl-D-lysine reverses neuropathic pain in mice, shows antidrowsiness effect on chronic neuropathic pain. Oleoyl-D-lysine is safe and effective without respiratory depression^[1].
IC₅₀ & Target	Glycine Transporter-2 (GlyT2)^[1]
In Vivo	Oleoyl-D-lysine (30 mg/kg, 50 mg/kg, 100 mg/kg; i.p.; ) 在慢性神经性（慢性收缩性损伤）疼痛的小鼠模型中，有效地逆转小鼠神经性疼痛，在 30 mg/kg 达到峰值镇痛剂量，同时不引起呼吸抑制；在 100 mg/kg 出现轻度副作用，但不引起抽搐^[1]。 MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	410.63
Formula	C₂₄H₄₆N₂O₃
CAS No.	2240164-55-8
SMILES	CCCCCCCC/C=C\CCCCCCCC(N[C@@H](C(O)=O)CCCCN)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (262 KB) Handling Instructions (2659 KB)
References	[1]. Wilson BS, et al. Peripheral Administration of Selective Glycine Transporter-2 Inhibitor, Oleoyl-D-Lysine, Reverses Chronic Neuropathic Pain but Not Acute or Inflammatory Pain in Male Mice. J Pharmacol Exp Ther. 2022 Sep;382(3):246-255. [Content Brief]

Oleoyl-D-lysine Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oleoyl-D-lysine2240164-55-8iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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Oleoyl-D-lysine

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