83 Results for "

glycosaminoglycans

" in MedChemExpress (MCE) Product Catalog:
Products (83)

83 Results for "glycosaminoglycans" in MCE Product Catalog:

13
13 Publications Verification
Cat. No.: HY-B1125
CAS No.: 3416-24-8
Synonyms: D-Glucosamine; Chitosamine
Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
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13
13 Publications Verification
Cat. No.: HY-N0733
CAS No.: 66-84-2
Synonyms: D-(+)-Glucosamine hydrochloride; Chitosamine hydrochloride
Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
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13
13 Publications Verification
Cat. No.: HY-N0487
CAS No.: 29031-19-4
Synonyms: D-Glucosamine sulfate
Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
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11
11 Cited Publications
Cat. No.: HY-17567
CAS No.: 9005-49-6
Heparin is a highly sulfated glycosaminoglycan,that is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. Heparin significantly inhibits exosome-cell interactions.
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8
8 Cited Publications
Cat. No.: HY-B2162
CAS No.: 9007-28-7
Synonyms: Chondroitin polysulfate
Chondroitin sulfate, one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and MMPs.
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8
8 Cited Publications
Cat. No.: HY-B2162A
CAS No.: 9082-07-9
Synonyms: Chondroitin polysulfate sodium (from shark cartilage)
Chondroitin sulfate sodium (from shark cartilage), one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and MMPs .
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5
5 Cited Publications
Cat. No.: HY-116282
CAS No.: 9011-18-1
Purity:  99.20%
Synonyms: DSS (MW 5000); DXS (MW 5000)
Dextran sulfate sodium salt (DSS) (MW 5000) is a polymer of dehydrated glucose with a molecular weight of approximately 5000. Dextran sulfate sodium salt (DSS) with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 5000) is an inhibitor of complement and coagulation pathways, and belongs to the glycosaminoglycans (GAG) family. Dextran sulfate sodium salt (MW 5000) acts as an anticoagulant, antiviral, and anti-lipemic agent. Dextran sulfate sodium salt (DSS) stops HIV-1 virus adsorption to host cells. Dextran sulfate sodium salt (MW 5000) prevents NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 5000) inhibits instant blood-mediated inflammatory reaction (IBMIR) .
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4
4 Cited Publications
Cat. No.: HY-D0001
CAS No.: 33864-99-2
Alcian Blue 8GX is a commonly used phthalocyanine dye that binds to glycoproteins and glycosaminoglycans. Alcian Blue 8GX has a wide range of applications in biological staining, including proteins in brain tumors and DNA in cells and tissues .
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4
4 Cited Publications
Cat. No.: HY-P2336A
Target:  

Melanocortin Receptor

Research Areas:  

Cancer

CCZ01048 TFA, a α-MSH analogue, exhibits high binding affinity to melanocortin 1 receptor (MC1R) with a Ki of 0.31 nM. CCZ01048 TFA shows rapid internalization into B16F10 melanoma cells and high in vivo stability. CCZ01048 TFA is a promising candidate for PET imaging of malignant melanoma .
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2
2 Cited Publications
Cat. No.: HY-122704A
CAS No.: 5424-37-3
Synonyms: Aminoquinuride dihydrochloride
Surfen dihydrochloride is a potent heparan sulfate antagonist. Surfen inhibits FGF2 binding and signal transduction. Surfen binds to glycosaminoglycans and reduces tau hyperphosphorylation. Surfen dihydrochloride inhibits the activity of recombinant uronyl 2-O-sulfotransferase with an IC50 of approximately 2 μM. Surfen dihydrochloride inhibits HSV-1 viral infection. Surfen dihydrochloride inhibits neural differentiation, delays remyelination, and alleviates EAE .
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2
2 Cited Publications
Cat. No.: HY-P2727
CAS No.: 9024-13-9
Synonyms: ChABC
Research Areas:  

Neurological Disease

Chondroitinase ABC (ChABC) is an enzyme that degrades glycosaminoglycan side-chains of chondroitin sulfate (CS-GAG) from the chondroitin sulfate proteoglycan (CSPG) core protein. Chondroitinase ABC facilitates reinnervation by degrading CS-GAGs around motoneurons. Chondroitinase ABC has the potential for the research of spinal injury .
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1
1 Cited Publications
Cat. No.: HY-P0063
CAS No.: 89030-95-5
Synonyms: GHK-Cu
Copper tripeptide (GHK-Cu) is a tripeptide. During wound healing, Copper tripeptide may be freed from existing extracellular proteins via proteolysis and serves as a chemoattractant for inflammatory and endothelial cells. Copper tripeptide has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. Copper tripeptide is a natural modulator of multiple cllular pathways in skin regeneration .
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1
1 Cited Publications
Cat. No.: HY-P2803
CAS No.: 9001-45-0
Target:  

β-glucuronidase

Research Areas:  

Metabolic Disease

Beta-glucuronidase is a glycosyl hydrolase that hydrolyzes β-glucuronic acid and sulfate esters in urine and other biological fluids, and then releases β-glucuronate .
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1
1 Cited Publications
Cat. No.: HY-N8278
CAS No.: 54328-33-5
Dermatan sulphate sodium is an oral active glycosaminoglycan and thrombin inactivator with antithrombotic activity. It selectively catalyzes the heparin cofactor II-mediated inactivation of thrombin without interacting with antithrombin III. Dermatan sulphate sodium promotes stem cell differentiation, exhibits high bioavailability, and alleviates pulmonary fibrosis injury induced by Bleomycin (HY-108345). Dermatan sulphate sodium can be used in research related to cardiovascular diseases, inflammation, and stem cell differentiation .
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1
1 Cited Publications
Cat. No.: HY-108036
CAS No.: 439685-79-7
Purity:  ≥98.0%
Synonyms: Hydroxypropyl tetrahydropyrantriol (30% in water)
Research Areas:  

Metabolic Disease

Pro-xylane (30% in water) (Hydroxypropyl tetrahydropyrantriol) is a bioactive C-glycoside that targets the biosynthesis pathway of glycosaminoglycans/mucopolysaccharides (GAGs) in the skin matrix and can be absorbed transdermally. Pro-xylane (30% in water) stimulates the biosynthesis of GAGs in fibroblasts, enhances the structural stability of the skin extracellular matrix, improves skin elasticity and moisturizing ability, and delays wrinkle formation. Pro-xylane (30% in water) can effectively promote the synthesis of collagen fibers and hyaluronic acid in the dermis. Pro-xylane (30% in water) is used in the field of anti-aging cosmetics to improve skin hydration and elasticity. Pro-xylane (30% in water) is eco-friendly and biodegradable .
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1
1 Cited Publications
Cat. No.: HY-105055
CAS No.: 77327-05-0
Purity:  99.95%
Didemnin B is a depsipeptide extracted from the marine tunicate Trididemnin cyanophorum. Didemnin B can be used for the research of cancer .
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1
1 Cited Publications
Cat. No.: HY-108036B
CAS No.: 439685-79-7
Purity:  ≥98.0%
Synonyms: Hydroxypropyl tetrahydropyrantriol
Research Areas:  

Metabolic Disease

Pro-xylane (Hydroxypropyl tetrahydropyrantriol) is a bioactive C-glycoside that targets the biosynthesis pathway of glycosaminoglycans/mucopolysaccharides (GAGs) in the skin matrix and can be absorbed transdermally. Pro-xylane stimulates the biosynthesis of GAGs in fibroblasts, enhances the structural stability of the skin extracellular matrix, improves skin elasticity and moisturizing ability, and delays wrinkle formation. Pro-xylane can effectively promote the synthesis of collagen fibers and hyaluronic acid in the dermis. Pro-xylane is used in the field of anti-aging cosmetics to improve skin hydration and elasticity. Pro-xylane is eco-friendly and biodegradable .
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1
1 Cited Publications
Cat. No.: HY-124704
CAS No.: 2158198-77-5
Purity:  98.09%
Target:  

SULT

Research Areas:  

Neurological Disease

Chst15-IN-1 is a potent reversible covalent Chst15 inhibitor. Chst15-IN-1 effectively inhibits chondroitin sulfate-E (CS-E) sulfation levels and other closely related glycosaminoglycans (GAG) sulfotransferases. Chst15-IN-1, as a selective sulfotransferase inhibitor, can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs), and can be used for the stimulation of neuronal repair .
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Cat. No.: HY-N7033
CAS No.: 63700-19-6
Synonyms: Uridine 5'-diphosphoglucuronic acid trisodium salt
Target:  

Drug Intermediate

Research Areas:  

Metabolic Disease

UDP-​glucuronic acid trisodium (Uridine-5'-diphosphoglucuronic acid trisodium salt) is a critical precursor for essential glycoconjugates across biological kingdoms, ranging from mammalian glycosaminoglycans and plant cell wall polysaccharides to bacterial capsule glycoglycerolipids.
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Cat. No.: HY-W751238
CAS No.: 931418-92-7
Synonyms: DMMB
Dimethyl methylene blue zinc chloride double salt (DMMB) is a cationic dye. Dimethyl methylene blue zinc chloride double salt competitively binds to the active site of the PANI-Benz-Ag nanocomposite with endotoxin, releasing DMMB and increasing the fluorescence intensity. Dimethyl methylene blue zinc chloride double salt can be used as a fluorescent probe for the detection of bacteria (such as E. Coli) endotoxin . Dimethyl methylene blue zinc chloride double salt can be used for the quantification of sulfated glycosaminoglycans .
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