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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
hAR
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "hAR" in MCE Product Catalog:
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Darolutamide (ODM-201) is an orally active competitive androgen receptor (AR) antagonist. Darolutamide has a Ki of 11 nM for rat wild-type AR (wtAR) and IC50 of 26 nM for human wild-type AR (hAR)-mediated transcriptional activation . Darolutamide inhibits testosterone-induced AR nuclear translocation and transcriptional activation . Darolutamide exerts selective effects on AR-positive cells by inhibiting AR-dependent signaling pathways, and its active metabolite retains full antagonistic activity against AR mutants . Darolutamide can be used for the research of prostate cancer, including androgen receptor-dependent prostate cancer .
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9 Publications Verification
Cat. No.: HY-B0686
CAS No.: 188627-80-7
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Cat. No.: HY-P990782
CAS No.: 2566615-11-8
Synonyms: ATYR-1923; KRP-R120
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Cat. No.: HY-16985S
CAS No.: 2484757-20-0
Synonyms: ODM-201-d4; BAY-1841788-d4
Cat. No.: HY-16985R
CAS No.: 1297538-32-9
Synonyms: ODM-201 (Standard); BAY-1841788 (Standard)
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Darolutamide (Standard) is the analytical standard of Darolutamide (HY-16985). This product is intended for research and analytical applications. Darolutamide (ODM-201) is an orally active competitive androgen receptor (AR) antagonist, with a Ki of 11 nM for rat wild-type AR (wtAR) and an IC50 of 26 nM for human wild-type AR (hAR)-mediated transcriptional activation . Darolutamide inhibits testosterone-induced AR nuclear translocation and transcriptional activation . Darolutamide exerts selective effects on AR-positive cells by inhibiting AR-dependent signaling pathways, and its active metabolite retains full antagonistic activity against AR mutants . Darolutamide can be used for the research of prostate cancer, including androgen receptor-dependent prostate cancer .
Cat. No.: HY-B0686A
CAS No.: 1248559-53-6
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Cat. No.: HY-RS06005
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HARS2 Human Pre-designed siRNA Set A contains three designed siRNAs for HARS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS26928
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Hars2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hars2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS07929
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LYVE1 Human Pre-designed siRNA Set A contains three designed siRNAs for LYVE1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-183518
CAS No.: 179894-84-9
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LG-120753 is an orally active nonsteroidal progesterone receptor (PR) antagonist, with an IC50 of 38 nM against hPR-B, a Ki of 19 nM against hPR-A, an IC50 of 227 nM against hAR, and IC50 values greater than 1000 nM against hGR, hER and hMR. LG-120753 blocks the action of progesterone, binds to and antagonizes hPR-A, and shows limited cross-reactivity with other steroid receptors. LG-120753 blocks blastocyst implantation, prevents the establishment of pregnancy, exhibits dose-dependent antiprogestogenic activity in vivo, and induces reversible antifertility effects .
Cat. No.: HY-RS20419
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Hars2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hars2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P70161
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rHuLymphatic vessel endothelial hyaluronic acid receptor 1/LYVE-1, His; Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1; LYVE-1; Cell Surface Retention Sequence-Binding Protein 1; CRSBP-1; Extracellular Link Domain-Containing Protein 1; Hyaluronic Acid Receptor; LYVE1; CRSBP1; hAR; XLKD1
Cat. No.: HY-180409
CAS No.: 262295-11-4
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YM580 is a potent, orally active and selective Androgen Receptor (AR) antagonist (IC50 = 0.11 μM, hAR Ki = 4.6 nM, rAR Ki = 6.2 nM). YM580 exhibits good selectivity over PR, GR, and ERα (Kis > 3300 nM). YM580 decreases ventral prostate weight in mature intact rats dose-dependently without affecting serum testosterone levels. YM580 can be used for the research of prostate cancer .
Cat. No.: HY-179476
CAS No.: 847232-54-6
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3-Oxochol-5-en-24-oic acid is a rare bile acid produced by the intestinal microbiota. 3-Oxochol-5-en-24-oic acid is a potent antagonist of the human androgen receptor (hAR), with an IC50 of 119.4 nM. 3-Oxochol-5-en-24-oic acid has no significant agonistic or antagonistic effects on estrogen receptors (ER) or glucocorticoid receptors (GR). 3-Oxochol-5-en-24-oic acid effectively inhibits the growth of prostate cancer cells. In animal models, it enhances the efficacy of anti-PD-1 therapy by regulating the differentiation of CD8 + T cells. 3-Oxochol-5-en-24-oic acid can be used for research on regulating host immunity and anti-tumor studies .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
