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Cat. No.: HY-B0686A

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Eptifibatide monoacetate

9 Cited Publications

Customer Review

Based on 9 publication(s) in Google Scholar

Eptifibatide monoacetate is a cyclic heptapeptide, acts as a competitive antagonist for the activated platelet glycoprotein IIb/IIIa receptor, with anti-platelet activity.

For research use only. We do not sell to patients.

CAS No.: 1248559-53-6
Formula: C₃₇H₅₃N₁₁O₁₁S₂
Molecular Weight:892.01

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Eptifibatide monoacetate Chemical Structure

CAS No.: 1248559-53-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (9)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Eptifibatide monoacetate is a cyclic heptapeptide, acts as a competitive antagonist for the activated platelet glycoprotein IIb/IIIa receptor, with anti-platelet activity^[1].

All Integrin Isoforms :

In Vitro

Eptifibatide monoacetate is a cyclic heptapeptide, acts as a competitive antagonist for the activated platelet glycoprotein IIb/IIIa receptor, with anti-platelet activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1248559-53-6
Molecular Weight 892.01
Formula C₃₇H₅₃N₁₁O₁₁S₂
Sequence

MPA-HAR-Gly-Asp-Trp-Pro-Cys-NH2
Sequence Shortening

MPA-HAR-GDWPC-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (9)

All Bio/Physico-chemical AssayHistological Imaging/StainingIn Vivo Efficacy Study

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Journal Impact Factor

Nat Commun

Protein disulfide isomerase cleaves allosteric disulfides in histidine-rich glycoprotein to regulate thrombosis. [Abstract]

2024 Apr 11;15(1):3129. PMID: 38605050

Eptifibatide monoacetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 11;15(1):3129. [Abstract]

The median fluorescence intensity of HRG and platelets were calculated and plotted over time from mice treated or untreated with Eptifibatide (10 μg/g body weight, repeated every 15-20 min).

Eptifibatide monoacetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 11;15(1):3129. [Abstract]

The scatter plot of pixel intensities of green (HRG) and red (CD31) fluorescence in ROI1 and ROI2 as indicated were presented. The Pearson's correlation coefficients (r) for pixels with intensity above the threshold (indicated by the dashed lines) in the thrombus (ROI2) and in the area without the thrombus (ROI1-ROI2) were inserted. Veh vehicle, Epti eptifibatide.

Eptifibatide monoacetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 11;15(1):3129. [Abstract]

When mice were treated with eptifibatide, an integrin α_IIbβ3 antagonist that eliminated platelet deposition and thus platelet-derived Zn²⁺, HRG accumulation at the site of vessel injury was significantly reduced by 58.3%.
Pharmacol Res

Anti-thrombotic effects mediated by dihydromyricetin involve both platelet inhibition and endothelial protection. [Abstract]

2021 May:167:105540. PMID: 33711433
Life Sci

Mechanistic insights into PPARγ's role in suppressing collagen-driven platelet activation. [Abstract]

2026 Jan 15:385:124138. PMID: 41354414
Int J Mol Sci

A Combined Activity of Thrombin and P-Selectin Is Essential for Platelet Activation by Pancreatic Cancer Cells. [Abstract]

2021 Mar 24;22(7):3323. PMID: 33805059
Am J Respir Cell Mol Biol

GP IIb/IIIa-ICAM-1 Mediated Platelet-Endothelial Adhesion Exacerbates Pulmonary Hypertension. [Abstract]

2025 Feb 28. PMID: 40019848
Platelets

Antiplatelet effects of the CEACAM1-derived peptide QDTT. [Abstract]

2024 Dec;35(1):2308635. PMID: 38345065
J Thromb Thrombolysis

The inhibitory effect of antiplatelet drugs on spontaneous platelet aggregation on glass surfaces: an analysis based on microscopic three-dimensional topography. [Abstract]

2025 Sep 9. PMID: 40924280
University of Bonn

2023 May 31.
Ghent University

2018 May.

Eptifibatide monoacetate purchased from MedChemExpress. Usage Cited in: Ghent University. 2018 May.

Concentration eptifibatide in function of buffer volume eluted from the column.

Eptifibatide monoacetate purchased from MedChemExpress. Usage Cited in: Ghent University. 2018 May.

Calibration curve eptifibatide (0.25 mg/mL-0,00012207 mg/mL).

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gilchrist IC, et al. Platelet glycoprotein IIb/IIIa inhibitors in percutaneous coronary intervention: focus on the pharmacokinetic-pharmacodynamic relationships of eptifibatide. Clin Pharmacokinet. 2003;42(8):703-20. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Eptifibatide monoacetate

9 Cited Publications

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (9)
Purity & Documentation
References

1/16
1/16

Eptifibatide monoacetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 11;15(1):3129. [Abstract]

Customer Validation
The median fluorescence intensity of HRG and platelets were calculated and plotted over time from mice treated or untreated with Eptifibatide (10 μg/g body weight, repeated every 15-20 min).
1/16

Eptifibatide monoacetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 11;15(1):3129. [Abstract]

Customer Validation
The scatter plot of pixel intensities of green (HRG) and red (CD31) fluorescence in ROI1 and ROI2 as indicated were presented. The Pearson's correlation coefficients (r) for pixels with intensity above the threshold (indicated by the dashed lines) in the thrombus (ROI2) and in the area without the thrombus (ROI1-ROI2) were inserted. Veh vehicle, Epti eptifibatide.
1/16

Eptifibatide monoacetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 11;15(1):3129. [Abstract]

Customer Validation
When mice were treated with eptifibatide, an integrin α_IIbβ3 antagonist that eliminated platelet deposition and thus platelet-derived Zn²⁺, HRG accumulation at the site of vessel injury was significantly reduced by 58.3%.
1/16

Eptifibatide monoacetate purchased from MedChemExpress. Usage Cited in: Ghent University. 2018 May.

Customer Validation
Concentration eptifibatide in function of buffer volume eluted from the column.
1/16

Eptifibatide monoacetate purchased from MedChemExpress. Usage Cited in: Ghent University. 2018 May.

Customer Validation
Calibration curve eptifibatide (0.25 mg/mL-0,00012207 mg/mL).

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Eptifibatide monoacetate

Publications Citing Use of MedChemExpress (MCE) Eptifibatide monoacetate

All Integrin Isoforms

Biological Activity

Chemical Information

Publications (9)

Purity & Documentation

References

Calculators

Help & FAQs

Eptifibatide monoacetate Related Classifications

HY-B0686A Related Classifications