Eptifibatide acetate

Cat. No.: HY-B0686B Purity: 99.67%: Data Sheet
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Eptifibatide acetate is a cyclic heptapeptide, acts as a competitive antagonist for the activated platelet glycoprotein IIb/IIIa receptor, with anti-platelet activity.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CAS No. : 881997-86-0

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of Eptifibatide acetate:

Eptifibatide In-stock
Eptifibatide monoacetate Get quote
Eptifibatide acetate (Standard) Get quote

9 Publications Citing Use of MCE Eptifibatide acetate

Bio/Physico-chemical Assay

Histological Imaging/Staining

In Vivo Efficacy Study

: Eptifibatide acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 11;15(1):3129. [Abstract]; The median fluorescence intensity of HRG and platelets were calculated and plotted over time from mice treated or untreated with Eptifibatide (10 μg/g body weight, repeated every 15-20 min).

: Eptifibatide acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 11;15(1):3129. [Abstract]; The scatter plot of pixel intensities of green (HRG) and red (CD31) fluorescence in ROI1 and ROI2 as indicated were presented. The Pearson's correlation coefficients (r) for pixels with intensity above the threshold (indicated by the dashed lines) in the thrombus (ROI2) and in the area without the thrombus (ROI1-ROI2) were inserted. Veh vehicle, Epti eptifibatide.

: Eptifibatide acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 11;15(1):3129. [Abstract]; When mice were treated with eptifibatide, an integrin α_IIbβ3 antagonist that eliminated platelet deposition and thus platelet-derived Zn²⁺, HRG accumulation at the site of vessel injury was significantly reduced by 58.3%.

: Eptifibatide acetate purchased from MedChemExpress. Usage Cited in: Ghent University. 2018 May.; Concentration eptifibatide in function of buffer volume eluted from the column.

: Eptifibatide acetate purchased from MedChemExpress. Usage Cited in: Ghent University. 2018 May.; Calibration curve eptifibatide (0.25 mg/mL-0,00012207 mg/mL).

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Eptifibatide acetate is a cyclic heptapeptide, acts as a competitive antagonist for the activated platelet glycoprotein IIb/IIIa receptor, with anti-platelet activity^[1].

Molecular Weight

831.96 (free base)

Formula

C₃₅H₄₉N₁₁O₉S₂.xC₂H₄O₂

CAS No.

881997-86-0

Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.67%

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Data Sheet (275 KB) SDS (419 KB)

COA (257 KB) HNMR (296 KB) RP-HPLC (258 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Gilchrist IC, et al. Platelet glycoprotein IIb/IIIa inhibitors in percutaneous coronary intervention: focus on the pharmacokinetic-pharmacodynamic relationships of eptifibatide. Clin Pharmacokinet. 2003;42(8):703-20. [Content Brief]