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Cat. No.: HY-B0686B

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Eptifibatide acetate

9 Cited Publications

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Based on 9 publication(s) in Google Scholar

Eptifibatide acetate is a cyclic heptapeptide, acts as a competitive antagonist for the activated platelet glycoprotein IIb/IIIa receptor, with anti-platelet activity.

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Pureté: 99.67%
CAS No.: 881997-86-0
Formule: C₃₅H₄₉N₁₁O₉S₂.xC₂H₄O₂
Masse moléculaire:831.96 (free base)

Stockage:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Eptifibatide acetate Chemical Structure

CAS No.: 881997-86-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Eptifibatide acetate is a cyclic heptapeptide, acts as a competitive antagonist for the activated platelet glycoprotein IIb/IIIa receptor, with anti-platelet activity^[1].

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Chemical Information

CAS No. 881997-86-0
Appearance Solid
Masse moléculaire 831.96 (free base)
Formule C₃₅H₄₉N₁₁O₉S₂.xC₂H₄O₂
Color White to off-white
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (9)

All Bio/Physico-chemical AssayHistological Imaging/StainingIn Vivo Efficacy Study

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Journal Impact Factor

Nat Commun

Protein disulfide isomerase cleaves allosteric disulfides in histidine-rich glycoprotein to regulate thrombosis. [Abstract]

2024 Apr 11;15(1):3129. PMID: 38605050

Eptifibatide acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 11;15(1):3129. [Abstract]

The median fluorescence intensity of HRG and platelets were calculated and plotted over time from mice treated or untreated with Eptifibatide (10 μg/g body weight, repeated every 15-20 min).

Eptifibatide acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 11;15(1):3129. [Abstract]

The scatter plot of pixel intensities of green (HRG) and red (CD31) fluorescence in ROI1 and ROI2 as indicated were presented. The Pearson's correlation coefficients (r) for pixels with intensity above the threshold (indicated by the dashed lines) in the thrombus (ROI2) and in the area without the thrombus (ROI1-ROI2) were inserted. Veh vehicle, Epti eptifibatide.

Eptifibatide acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 11;15(1):3129. [Abstract]

When mice were treated with eptifibatide, an integrin α_IIbβ3 antagonist that eliminated platelet deposition and thus platelet-derived Zn²⁺, HRG accumulation at the site of vessel injury was significantly reduced by 58.3%.
Pharmacol Res

Anti-thrombotic effects mediated by dihydromyricetin involve both platelet inhibition and endothelial protection. [Abstract]

2021 May:167:105540. PMID: 33711433
Life Sci

Mechanistic insights into PPARγ's role in suppressing collagen-driven platelet activation. [Abstract]

2026 Jan 15:385:124138. PMID: 41354414
Int J Mol Sci

A Combined Activity of Thrombin and P-Selectin Is Essential for Platelet Activation by Pancreatic Cancer Cells. [Abstract]

2021 Mar 24;22(7):3323. PMID: 33805059
Am J Respir Cell Mol Biol

GP IIb/IIIa-ICAM-1 Mediated Platelet-Endothelial Adhesion Exacerbates Pulmonary Hypertension. [Abstract]

2025 Feb 28. PMID: 40019848
Platelets

Antiplatelet effects of the CEACAM1-derived peptide QDTT. [Abstract]

2024 Dec;35(1):2308635. PMID: 38345065
J Thromb Thrombolysis

The inhibitory effect of antiplatelet drugs on spontaneous platelet aggregation on glass surfaces: an analysis based on microscopic three-dimensional topography. [Abstract]

2025 Sep 9. PMID: 40924280
University of Bonn

2023 May 31.
Ghent University

2018 May.

Eptifibatide acetate purchased from MedChemExpress. Usage Cited in: Ghent University. 2018 May.

Concentration eptifibatide in function of buffer volume eluted from the column.

Eptifibatide acetate purchased from MedChemExpress. Usage Cited in: Ghent University. 2018 May.

Calibration curve eptifibatide (0.25 mg/mL-0,00012207 mg/mL).

Solvant et solubilité

In Vitro:

DMSO : 125 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (275 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Gilchrist IC, et al. Platelet glycoprotein IIb/IIIa inhibitors in percutaneous coronary intervention: focus on the pharmacokinetic-pharmacodynamic relationships of eptifibatide. Clin Pharmacokinet. 2003;42(8):703-20. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Eptifibatide acetate

9 Cited Publications

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Eptifibatide acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 11;15(1):3129. [Abstract]

Customer Validation
The median fluorescence intensity of HRG and platelets were calculated and plotted over time from mice treated or untreated with Eptifibatide (10 μg/g body weight, repeated every 15-20 min).
1/16

Eptifibatide acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 11;15(1):3129. [Abstract]

Customer Validation
The scatter plot of pixel intensities of green (HRG) and red (CD31) fluorescence in ROI1 and ROI2 as indicated were presented. The Pearson's correlation coefficients (r) for pixels with intensity above the threshold (indicated by the dashed lines) in the thrombus (ROI2) and in the area without the thrombus (ROI1-ROI2) were inserted. Veh vehicle, Epti eptifibatide.
1/16

Eptifibatide acetate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Apr 11;15(1):3129. [Abstract]

Customer Validation
When mice were treated with eptifibatide, an integrin α_IIbβ3 antagonist that eliminated platelet deposition and thus platelet-derived Zn²⁺, HRG accumulation at the site of vessel injury was significantly reduced by 58.3%.
1/16

Eptifibatide acetate purchased from MedChemExpress. Usage Cited in: Ghent University. 2018 May.

Customer Validation
Concentration eptifibatide in function of buffer volume eluted from the column.
1/16

Eptifibatide acetate purchased from MedChemExpress. Usage Cited in: Ghent University. 2018 May.

Customer Validation
Calibration curve eptifibatide (0.25 mg/mL-0,00012207 mg/mL).

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Eptifibatide acetate

Peptide Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

Publications Citing Use of MedChemExpress (MCE) Eptifibatide acetate

Voir tous les produits spécifiques à Isoform Integrin

Activité biologique

Chemical Information

Publications (9)

Solvant et solubilité

Pureté et documentation

Références

Calculators

Help & FAQs

Eptifibatide acetate

Peptide Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

Publications Citing Use of MedChemExpress (MCE) Eptifibatide acetate

Voir tous les produits spécifiques à Isoform Integrin

Activité biologique

Chemical Information

Publications (9)

Solvant et solubilité

Pureté et documentation

Références

Calculators

Help & FAQs

Eptifibatide acetate Related Classifications

HY-B0686B Related Classifications