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histone H2AX

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By Targets:	HDAC (1) Histone Methyltransferase (1) Apoptosis (5) ATM/ATR (1) Casein Kinase (1) Caspase (1) DNA/RNA Synthesis (1) ERK (1) FLAP (1) Fluorescent Dye (1) HSV (1) JNK (1) MDM-2/p53 (1) PARP (1) PI3K (2) Polo-like Kinase (PLK) (2) Topoisomerase (1) VRK (1)
By Research Areas:	Cancer (8) Infection (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Targets Recommended: Histone Methyltransferase Histone Demethylase HDAC Histone Acetyltransferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12037A

Rigosertib 5+ Cited Publications ON-01910	Polo-like Kinase (PLK) PI3K Apoptosis	Cancer
Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle . Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 with an IC₅₀ of 9 nM .

HY-123834

FEN1-IN-1 Maximum Cited Publications 8 Publications Verification	FLAP ATM/ATR	Cancer
FEN1-IN-1 (compound 1) is a small molecule flap endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-1 binds to the active site of FEN1 and partly achieves inhibition by the co-ordination of Mg ²⁺ ions. FEN1-IN-1 initiaties a DNA damage response and activates the ATM checkpoint signalling pathway, the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is promising for research of cancers .

HY-12037

Rigosertib sodium 5+ Cited Publications ON-01910 sodium	Polo-like Kinase (PLK) PI3K Apoptosis	Cancer
Rigosertib sodium (ON-01910 sodium) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3K/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle . Rigosertib sodium is a selective and non-ATP-competitive inhibitor of PLK1 with an IC₅₀ of 9 nM .

HY-122182

OTS193320	Histone Methyltransferase Apoptosis	Cancer
OTS193320, a imidazo[1,2-a]pyridine compound, is a SUV39H2 methyltransferase activity inhibitor. OTS193320 decreases global histone H3 lysine 9 tri-methylation levels in breast cancer cells and triggers apoptotic cell death. Combination of OTS193320 with Doxorubicin (HY-15142A) results in reduction of γ-H2AX levels as well as cancer cell viability compared to a single agent OTS193320 or DOX .

HY-158975

VRK1/CK1-IN-1	Casein Kinase VRK	Cancer
VRK1/CK1-IN-1 (compound 36) is a dual VRK1 and CK1 family inhibitor, with a K_i of 37.9 nM against human VRK1, 8.3 nM against human CK1δ, and 7.8 nM against human CK1ε. VRK1/CK1-IN-1 exhibits extremely low activity against VRK2. VRK1/CK1-IN-1 can be used in studies related to p53-deficient tumors .

HY-113041

Prostaglandin A2 PGA2; Medullin	Apoptosis Caspase PARP ERK MDM-2/p53 JNK HSV	Infection Cancer
Prostaglandin A2 (PGA2) is a Cyclopentenone prostaglandin. Prostaglandin A2 induces Caspase-dependent Apoptosis, activates p53. Prostaglandin A2 activates ERK2 and JNK1/SAPK. Prostaglandin A2 shows antiviral activity against HSV-1. Prostaglandin A2 has anti-tumor effects. Prostaglandin A2 can be used for the research of colorectal cancer, colorectal carcinoma, breast carcinoma, and herpetic keratitis .

HY-117688

WJ35435	HDAC Topoisomerase Apoptosis	Cancer
WJ35435 is a dual-targeted anticancer hybrid that induces anti-HDAC (in particular HDAC1 and HDAC6) and anti-topoisomerase I activities that causes DNA damage associated with a low DNA repair capability and induces cell cycle arrest at G1- and G2-phase to apoptosis. WJ35435 induces histone H3 acetylation and phosphorylation, α-tubulin acetylation and γ-H2AX formation to achieve anti-HDAC effect. WJ35435 is promising for research of cancer .

HY-W414334

ICR-191 dihydrochloride	DNA/RNA Synthesis Fluorescent Dye	Cancer
ICR-191 dihydrochloride enhances Cisplatin (HY-17394)- DNA binding and sensitizes cells to cisplatin. ICR-191 dihydrochloride induces a significant increase in the expression of phosphorylated H2AX (γH2AX), particularly in DNA-replicating cells. ICR-191 dihydrochloride can be used for the study of leukemia .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705951

	H2AX Protein, Human (GST) H2A histone family member X ; H2A histone family member X; H2A.FX; H2A.X; H2a/x; H2AFX; H2AX; H2AX_HUMAN; histone H2A.X	Human	E. coli

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Host:	Mouse (2) Rabbit (6)
Reactivity:	Xenopus (1) Human (7) C. elegans (1) Rat (5) Mouse (7) broad mammalian (1) Drosophila (1) Monkey (1) Zebrafish (1)
Application:	IHC-P (3) ICC/IF (6) IF-Tissue (2) IP (6) WB (8) ELISA (1)
Isotype:	IgG (6) IgG1 (2)
Conjugation:	Non-conjugated (8)
Clonality:	Monoclonal (5) Recombinant (3)
Modification:	Phosphorylated (4) Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86516

	Phospho-Histone H2A.X(Ser139) Antibody (YA6208) H2AFX; H2AX; histone H2A.x; H2a/x	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-Histone H2A.X(Ser139) Antibody (YA6208) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Histone H2A.X(Ser139).

HY-P810603

	Histone H2A Acetyl Antibody H2A histone family member X; H2A histone family member X; H2A.FX; H2A.X; H2a/x; H2AFX; H2AX; H2AX_HUMAN; histone H2A.X	WB, IP, IF-Tissue, ICC/IF, IP	broad mammalian, Zebrafish, Drosophila, Xenopus, C. elegans
	Histone H2A Acetyl Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Histone H2A Acetyl.

HY-P80941

	*Phospho-Histone* H2A.X (Ser139) Antibody (YA844)** 1 Publications Verification H2A.X; H2AFX; H2a/x; HIST5-2AX; histone H2A.X; gamma H2A.X	WB, ICC/IF	Human, Mouse
	Phospho-Histone H2A.X (Ser139) Antibody (YA844) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Phospho-Histone H2A.X (Ser139).

HY-P80941A

	*Phospho-Histone* H2A.X (Ser139) Antibody (YA844)(PBS only)** H2A.X; H2AFX; H2a/x; HIST5-2AX; histone H2A.X; gamma H2A.X	WB, ICC/IF	Human, Mouse
	Phospho-Histone H2A.X (Ser139) Antibody (YA844) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Phospho-Histone H2A.X (Ser139).

HY-P80821

	*Phospho-Histone* H2A.X (Ser139) Antibody (YA191)** 2 Publications Verification H2A.X; H2AFX; H2a/x; HIST5-2AX; histone H2A.X; gamma H2A.X	WB, IP	Human, Mouse, Rat
	Phospho-Histone H2A.X (Ser139) Antibody (YA191) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Histone H2A.X (Ser139).

HY-P80821A

	*Phospho-Histone* H2A.X (Ser139) Antibody (YA191)(PBS only)** H2A.X; H2AFX; H2a/x; HIST5-2AX; histone H2A.X; gamma H2A.X	WB, IP	Human, Mouse, Rat
	Phospho-Histone H2A.X (Ser139) Antibody (YA191) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Histone H2A.X (Ser139).

HY-P80161

	Histone H2A.X Antibody (YA380) 2 Publications Verification	WB, ICC/IF, IHC-P, IP	Human, Mouse, Rat
	Histone H2A.X Antibody (YA380) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Histone H2A.X.

HY-P80463

	*Phospho-Histone* H2A.X (Ser139) Antibody (YA190)**	WB, IHC-P, ICC/IF, IF-Tissue	Human, Mouse, Rat, Monkey
	Phospho-Histone H2A.X (Ser139) Antibody (YA190) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Histone H2A.X (Ser139).

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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