18 Results for "

human CCR8

" in MedChemExpress (MCE) Product Catalog:
Products (18)

18 Results for "human CCR8" in MCE Product Catalog:

  • Targets Recommended:
Cat. No.: HY-P990914
CAS No.: 2865822-82-6
Synonyms: GS-1811; JTX-1811

Target:  

CCR

Research Areas:  

Inflammation/Immunology Cancer

Denikitug (GS-1811; JTX-1811) is a humanized monoclonal antibody against CCR8 receptor with a KD of 16.8 pM. Denikitug specifically binds to human CCR8, inhibits CCL1-induced downstream CCR8 signaling. Denikitug selectively depletes cells expressing CCR8 via antibody-dependent cellular cytotoxicity (ADCC). Denikitug promotes anti-tumor immunity and can be used for the research of cancer and immunology .
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Cat. No.: HY-P991061
CAS No.: 3024486-14-1
Synonyms: CHS-114; SRF-114

Target:  

CCR

Research Areas:  

Cancer

Tagmokitug (CHS-114; SRF-114) is a fully human IgG1 antibody targeting CCR8. Tagmokitug selectively binds to human CCR8 (Kd = 502 pM) and mediates the death of CCR8-expressing cells via antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis. Tagmokitug selectively eliminates intratumoral regulatory T cells, induces tumor growth inhibition, remodels the tumor immune microenvironment, and promotes the differentiation of cytotoxic CD8 + T cell subsets. Tagmokitug can be used for the research of solid tumors .
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Cat. No.: HY-144197
CAS No.: 723304-76-5
Purity:  99.50%
Target:  

CCR

Research Areas:  

Neurological Disease

CCR8 antagonist 1 (Compound 15) is a potente human CCR8 antagonist with a Ki of 1.6 nM. CCR8 antagonist 1 has high safety and metabolic stability. CCR8 antagonist 1 can be used to study diseases such as asthma and multiple sclerosis .
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Cat. No.: HY-P990904
CAS No.: 2837169-12-5
Synonyms: PR-1925514

Target:  

CCR

Research Areas:  

Inflammation/Immunology

HY-P990904 is an CCR8-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-P990908
CAS No.: 2851855-89-3
Synonyms: LM-108

Target:  

CCR

Research Areas:  

Inflammation/Immunology

HY-P990908 is an CCR8-targeting IgG1κ type chimeric antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) .
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Cat. No.: HY-159692
CAS No.: 2603457-08-3
Synonyms: IONIS-1063734
Target:  

FOXP

Research Areas:  

Cancer

AZD8701 (IONIS-1063734) is an antisense oligonucleotide targeting FOXP3 in regulatory T cells (Tregs), with a human IC50 of 65.2 nM. AZD8701 binds to intronic sites of all FOXP3 pre-mRNA isoforms and mediates dose-dependent FOXP3 knockdown via free uptake. AZD8701 can be used in cancer-related research .
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Cat. No.: HY-P991481

Target:  

CCR

Research Areas:  

Inflammation/Immunology Cancer

S-531011 is a high-affinity, selective, and reversible CCR8 ligand with antibody-dependent cellular cytotoxicity (ADCC) against CCR8-expressing cells. S-531011 induces the death of tumor-infiltrating CCR8 + regulatory T cells while preserving regulatory T cells in peripheral blood, thereby reinvigorating anti-tumor immunity. The combination of S-531011 with anti-PD-1 antibody effectively inhibits tumor growth, and S-531011 can be used for research on advanced solid tumors and various cancers including non-small cell lung cancer, ovarian cancer, colon cancer, breast cancer, and pancreatic ductal adenocarcinoma .
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Cat. No.: HY-174741
Target:  

mRNA

Research Areas:  

Inflammation/Immunology

Human CCR8 mRNA encodes the human C-C motif chemokine receptor 8 (CCR8) protein, a member of the beta chemokine receptor family. CCR8 plays a role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues.
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Cat. No.: HY-RS02169
Research Areas:  

Others

CCR8 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-153669
CAS No.: 935262-95-6
Target:  

CCR

Research Areas:  

Inflammation/Immunology

SB-649701 is a potent human CCR8 antagonist, with a pIC50 of 7.7. AZ084 can be used for the research of asthma .
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Cat. No.: HY-P991135
CAS No.: 2999644-88-9
Synonyms: RO-7502175; RG-6411

Target:  

CCR

Research Areas:  

Cancer

Enzelkitug is a humanized immunoglobulin G1-κ monoclonal antibody targeting the human C-C motif chemokine receptor 8 (CCR8). Enzelkitug is promising for research of various solid tumors and hematological malignancies .
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Cat. No.: HY-160647
CAS No.: 912463-57-1
Target:  

CCR

Research Areas:  

Inflammation/Immunology

CCR8 antagonist 3 (compound 2) is a CCR8 antagonist with an IC50 value of 0.062 µM. CCR8 antagonist 3 shows human microsomal stability .
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Cat. No.: HY-P991941

Target:  

CCR

Research Areas:  

Inflammation/Immunology

ABT-182 is an antibody against human CCR8.
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Cat. No.: HY-P991942
Synonyms: BAY3375968; TPP-23411

Target:  

CCR

Research Areas:  

Inflammation/Immunology Cancer

Lanerkitug (BAY3375968) is a fully human monoclonal IgG1 anti-human CCR8 antibody. Lanerkitug selectively depletes human CCR8 + Tregs via antibody dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP). Lanerkitug can be used in the research of solid tumors .
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Cat. No.: HY-P991942A
Synonyms: BAY3375968 (FUT8-KO); TPP-23411 (FUT8-KO)

Target:  

CCR

Research Areas:  

Cancer

Lanerkitug (FUT8-KO) (BAY3375968 (FUT8-KO)) is an anti-CCR8 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out. Fucose deficiency enhances the ADCC effect of the antibody. Lanerkitug (HY-P991942) selectively depletes human CCR8+Tregs via antibody dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP). Lanerkitug can be used in the research of solid tumors .
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Cat. No.: HY-P992365

Target:  

CCR

Research Areas:  

Cancer

HFB101110 is a human-derived inhibitor and Treg depleter that specifically targets CCR8. It does not bind to the homologous CCR4 receptor and is mainly used in research on solid tumors, renal cell carcinoma and colorectal cancer. HFB101110 blocks hCCL1 binding by interacting with the N-terminal extracellular domain of hCCR8, thereby inhibiting hCCL1-induced calcium influx, chemotaxis and downstream signaling pathways. Meanwhile, HFB101110 can mediate ADCC effects to specifically deplete CCR8-positive cells, including intratumoral Tregs. HFB101110 exhibits favorable anti-tumor activity and pharmacokinetic properties .
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Cat. No.: HY-P77882
Purity:  ≥ 95%, as determined by HPLC.
Synonyms: C-C CKR-8; CC-CKR-8; CCR-8; CC chemokine receptor CHEMR1; CMKBRL2; CKR-L1; GPR-CY6; GPRCY6; TER1; CCR8; CKRL1; CMKBR8; CD198; ChemR1; CKR-L1; CY6; TER-1; CDw198
Species:  
Source:  
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Cat. No.: HY-P700543
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CCR8; chemokine (C-C motif) receptor 8; CMKBR8, CMKBRL2; C-C chemokine receptor type 8; CDw198; CKR L1; CY6; GPR CY6; TER1; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor chemr1; chemokine (C-C) receptor-like 2; CCR-8; CKRL1; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8; MGC129966; MGC129973
Species:  
Source:  
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