Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
human PDI
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "human PDI" in MCE Product Catalog:
8
8 Publications Verification
Cat. No.: HY-W107464
CAS No.: 2457232-14-1
Target:
Research Areas:
G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 of 0.07 μM for human G6PD. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells .
1
1
1 Cited Publications
Cat. No.: HY-P71917
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Cellular thyroid hormone binding protein; Cellular thyroid hormone-binding protein; Collagen prolyl 4 hydroxylase beta; Disulphide Isomerase; DSI; EC 5.3.4.1; ER protein 59; ERBA2L; ERp59; GIT; P4HB; P4Hbeta; p55; PDI; PDIA1; PDIA1_human; PDIR; PHDB; PO4DB; PO4HB; PROHB; Protocollagen hydroxylase; Thbp;
Cat. No.: HY-N2163
CAS No.: 172760-03-1
Category:
Other Monoterpenes other families Monophenols Terpenoids Other Diseases Phenols Plants Disease Research Fields
Target:
Cat. No.: HY-110172
CAS No.: 1461648-55-4
PDI-IN-1 is a cell-permeable PDI covalent inhibitor with an IC50 of 1.7 μM against bovine PDI. PDI-IN-1 specifically modifies the Cys397 residue at the active site of human PDI, selectively labels endogenous PDI in living mammalian cancer cells, and effectively inhibits PDI-mediated insulin aggregation in vitro. PDI-IN-1 exhibits significant anti-tumor activity and inhibits the growth of various cancer cell lines .
Cat. No.: HY-170655
Research Areas:
PDI-IN-4 is a highly selective inhibitor of human PDI (IC50=0.48 μM) with no significant cytotoxicity. PDI-IN-4 binds to PDI in a reversible manner, not only forming a covalent bond with the Cys400 residue but also engaging in hydrophobic interactions with other residues. By inhibiting the activation of GPIIb/IIIa, PDI-IN-4 effectively blocks platelet aggregation and thrombus formation. PDI-IN-4 can serve as an important tool reagent for thrombosis-related research .
Cat. No.: HY-163351
Research Areas:
PDI-IN-2 is a highly selective PDI inhibitor. PDI-IN-2 has an IC50 of 0.63-4.01 μM against human PDI, and exhibits higher targeting specificity compared with ERp57 and ERp72. PDI-IN-2 inhibits platelet aggregation induced by U46619, collagen and tumor cells, and also blocks platelet-promoted tumor cell proliferation as well as the growth of multiple myeloma cells. PDI-IN-2 serves as an important tool reagent for research on multiple myeloma and associated thrombosis .
Cat. No.: HY-181573
Research Areas:
TC8026 is an allosteric-covalent inhibitor targeting protein disulfide isomerase (PDI), with an IC50 of 7 μM against human PDI. TC8026 induces endoplasmic reticulum stress-mediated apoptosis. TC8026 is a hit compound with PDI inhibitory activity identified via high-throughput screening, and it can be used for the research of glioblastoma .
Cat. No.: HY-P704834
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PAD1; PDI1
Species:
Source:
Cat. No.: HY-P703022
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PAD1; PDI1
Species:
Source:
Cat. No.: HY-N19464
CAS No.: 16408-78-9
Target:
Cat. No.: HY-138934
CAS No.: 1642375-66-3
Target:
Research Areas:
Bepristat 1a is a reversible, selective protein disulfide isomerase (PDI) inhibitor with an IC50 of 0.7 μM. Bepristat 1a inhibits platelet aggregation in laser-injured mouse arterioles. Bepristat 1a is applicable for research related to thrombosis .
Cat. No.: HY-P704161
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PAD3; PDI3; UHS1; Protein-arginine deiminase type-3
Species:
Source:
Cat. No.: HY-P701030
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Protein-arginine deiminase type-4; HL-60 PAD; HL60 PAD; HL-60; PAD; PAD4; PADI5; PDI5
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
