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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
human chronic myelogenous leukemia
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "human chronic myelogenous leukemia" in MCE Product Catalog:
Category:
Ketones, Aldehydes, Acids Other Diseases Phenols Endogenous metabolite Disease Research Fields
Target:
Cat. No.: HY-162608
CAS No.: 3052553-20-2
PROTAC JAK1 degrader 1 is a JAK1 PROTAC degrader with a DC50 of 214 nM and an IC50 of 5.2 nM. PROTAC JAK1 degrader 1 inhibits the downstream JAK-STAT signaling pathway by degrading JAK1. PROTAC JAK1 degrader 1 exhibits antiproliferative activity in cells. PROTAC JAK1 degrader 1 can be used for research on leukemia .
Cat. No.: HY-147342
CAS No.: 156724-91-3
Target:
Research Areas:
β-Benzamide adenine dinucleotide is a biologically active metabolite of benzamide riboside. β-Benzamide adenine dinucleotide is a competitive inhibitor of human NAD kinase with a Ki value of 90 μM, and inhibits human IMPDH with IC50 values of 0.787 μM and 0.884 μM for type I and type II, respectively. β-Benzamide adenine dinucleotide exhibits inhibitory activities against lactate dehydrogenase, glutamate dehydrogenase, and malate dehydrogenase. β-Benzamide adenine dinucleotide can be used for the study of chronic myelogenous leukemia .
Cat. No.: HY-N6736
CAS No.: 85753-43-1
Target:
Cat. No.: HY-125322
CAS No.: 144860-69-5
Reveromycin C is a polyketide originally isolated from Streptomyces that has antifungal activity against C. albicans (MICs=2.0 and >500 μg/mL at pH 3 and 7.4, respectively). Reveromycin C inhibits EGF-induced mitogenic activity in the Balb/MK mouse epidermal cell line. It also reverses the morphology of sarcoma-virus-transformed NRK rat kidney cells (EC50=1.58 μg/mL) and inhibits proliferation of KB cells and K562 human chronic myelogenous leukemia cells (IC50=2.0 μg/mL for both).
Cat. No.: HY-N18083
CAS No.: 123914-43-2
Target:
Cat. No.: HY-181710
LASSBio-2337 is a dual pan-PI3K/mTOR inhibitor with an mTOR IC50 of 5.8 μM.LASSBio-2337 functionally modulates mTOR and all PI3K isoforms.LASSBio-2337 acts as a cytotoxic agent in leukemia cells, including multidrug-resistant populations.LASSBio-2337 spares nontumor human peripheral blood mononuclear cells.LASSBio-2337 displays moderate PAMPA-GIT permeability.LASSBio-2337 shows low metabolic stability in rat liver microsomes.LASSBio-2337 is aqueous insoluble.LASSBio-2337 can be used for the research of acute lymphoblastic leukemia, chronic myelogenous leukemia, breast cancer .
Cat. No.: HY-N19778
CAS No.: 89946-00-9
Category:
Flavonoids Juglandaceae Flavones Olacaceae Olax mannii Oliv. Cyclocarya paliurus (Batal.) Iljinsk. Plants
Target:
Cat. No.: HY-P701574
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: KBTBD11; Kelch Repeat And BTB (POZ) Domain Containing 11; Kelch Repeat And BTB Domain Containing 11; chronic myelogenous leukemia-Associated Protein; KLHDC7C; Kelch Domain-Containing Protein 7B; KIAA0711; CMLAP; Kelch Repeat And BTB Domain-Containing Prot
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701877
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EXOSC5; Ribosomal RNA-Processing Protein 46; Exosome Component 5; Exosome Complex Component RRP46; RRP46; Exosome Component Rrp46; P12B; MGC12901; HRrp46p; Exosome Complex Exonuclease RRP46; Rrp46p; CABAC; RRP41B; CML28; chronic myelogenous leukemia Tumor
Species:
Human
Source:
E. coli
Cat. No.: HY-D3183
CAS No.: 1623011-10-8
Cat. No.: HY-P701878
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EXOSC5; Ribosomal RNA-Processing Protein 46; Exosome Component 5; Exosome Complex Component RRP46; RRP46; Exosome Component Rrp46; P12B; MGC12901; HRrp46p; Exosome Complex Exonuclease RRP46; Rrp46p; CABAC; RRP41B; CML28; chronic myelogenous leukemia Tumor
Species:
Human
Source:
E. coli
Cat. No.: HY-119159
CAS No.: 361465-74-9
AS1604498 is a highly specific competitive inhibitor of human NAMPT, with an IC50 of 44.4 nM. AS1604498 functionally inhibits NAMPT enzymatic activity, reduces nicotinamide mononucleotide production, decreases intracellular NAD levels, activates caspase 3/7 and induces cancer cell apoptosis. AS1604498 is applicable to research related to chronic myeloid leukemia .
Cat. No.: HY-123113
CAS No.: 65886-71-7
Synonyms: Kymarabine; Ara-AC; NSC 281272
Target:
Research Areas:
Fazarabine (Kymarabine; Ara-AC; NSC 281272) is an orally active, blood-brain barrier permeable DNA polymerase inhibitor and antitumor agent. Fazarabine interferes with DNA synthesis via intracellular activation into a triphosphate nucleotide that directly incorporates into DNA, inducing cytotoxicity, myelosuppression, as well as moderate nausea and vomiting. Fazarabine is resistant to deamination by cytidine-deoxycytidine deaminase and undergoes spontaneous aqueous degradation. Fazarabine exerts time-dependent, broad-spectrum activity against leukemia and solid tumors. Fazarabine can be used in research related to refractory malignancies, acute leukemia, and blast-phase chronic myeloid leukemia .
Cat. No.: HY-183242
CAS No.: 120154-96-3
Research Areas:
Eilatin is a seven-ring pyridoacridine marine alkaloid with anticancer, antibacterial, and antiparasitic activities. Eilatin acts as a DNA intercalator with selectivity for electron-deficient polycyclic purines; it can chelate Ni 2+ ions and cleave DNA via hydroxyl radical generation. Eilatin induces the SOS response in bacteria, inhibits cancer cell proliferation, and induces cancer cell differentiation and reversion of transformation. The IC50 of Eilatin against Trypanosoma brucei brucei is 1.33 μM. Eilatin can be used in research related to colon tumors, neuroblastoma, chronic myeloid leukemia, acute myeloid leukemia, and trypanosome infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
