3052553-20-2
3052553-20-2
Chemical Structure
PROTAC JAK1 degrader 1
- CAS No.: 3052553-20-2
- Formula:C44H41N9O6
- Molecular Weight:791.85
InChIKey: ZIYSEBHHSBKGIO-UHFFFAOYSA-N
SMILES: O=C(NCC#N)C1=CC=C(C2=NC(NC3=CC=C(N4CCC(C(NCCCCC#CC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)=O)CC4)C=C3)=NC=C2)C=C1
Biological Activity: PROTAC JAK1 degrader 1 is a JAK1 PROTAC degrader with a DC50 of 214 nM and an IC50 of 5.2 nM. PROTAC JAK1 degrader 1 inhibits the downstream JAK-STAT signaling pathway by degrading JAK1. PROTAC JAK1 degrader 1 exhibits antiproliferative activity in cells. PROTAC JAK1 degrader 1 can be used for research on leukemia[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
PROTAC JAK1 degrader 1 | 99.97% | PROTAC JAK1 degrader 1 is a JAK1 PROTAC degrader with a DC50 of 214 nM and an IC50 of 5.2 nM. PROTAC JAK1 degrader 1 inhibits the downstream JAK-STAT signaling pathway by degrading JAK1. PROTAC JAK1 degrader 1 exhibits antiproliferative activity in cells. PROTAC JAK1 degrader 1 can be used for research on leukemia. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.59
HY-153415PROTAC BCR-ABL Degrader-1 -
Similarity Score 0.58
HY-151902SJ988497 -
Similarity Score 0.57
HY-139972PROTAC(H-PGDS)-7 -
Similarity Score 0.57
HY-157767Abd110 -
Similarity Score 0.56
HY-171770dAurAB5 -
Similarity Score 0.55
HY-169861PROTAC SMARCA2/4 degrader-37 -
Similarity Score 0.55
HY-143458FAK PROTAC B5 -
Similarity Score 0.55
HY-162538LC-MI-3 -
Similarity Score 0.54
HY-161615PROTAC ATR degrader-2 -
Explore the MedChemAI to find more analogs
