2. Metabolic Enzyme/Protease Apoptosis
  3. NAMPT Caspase Apoptosis
  4. AS1604498

AS1604498 is a highly specific competitive inhibitor of human NAMPT, with an IC50 of 44.4 nM. AS1604498 functionally inhibits NAMPT enzymatic activity, reduces nicotinamide mononucleotide production, decreases intracellular NAD levels, activates caspase 3/7 and induces cancer cell apoptosis. AS1604498 is applicable to research related to chronic myeloid leukemia.

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AS1604498

AS1604498 Chemical Structure

CAS No. : 361465-74-9

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Description

AS1604498 is a highly specific competitive inhibitor of human NAMPT, with an IC50 of 44.4 nM. AS1604498 functionally inhibits NAMPT enzymatic activity, reduces nicotinamide mononucleotide production, decreases intracellular NAD levels, activates caspase 3/7 and induces cancer cell apoptosis. AS1604498 is applicable to research related to chronic myeloid leukemia[1].

In Vitro

AS1604498 (0.032-10 μM; 48 h) inhibits THP-1 human leukemia cell growth with an IC50 of 198 nM, and this effect is reversed by 10 mM Nicotinamide (HY-B0150)[1].
AS1604498 (0.032-10 μM; 48 h) inhibits K562 human chronic myelogenous leukemia cell growth with an IC50 of 673 nM, and this effect is reversed by 10 mM Nicotinamide[1].
AS1604498 (10 μM; 48 h) induces delayed caspase 3/7 activation in THP-1 cells, and this activation is reversed by 10 mM Nicotinamide[1].
AS1604498 (0.001-10 μM; 5 h) reduces intracellular NAD levels in K562 cells in a dose-dependent manner, and this effect is reversed by 10 mM Nicotinamide[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AS1604498 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: THP-1 human leukemia cell
Concentration: 0.032, 0.1, 0.32, 1, 3.2, 10 μM
Incubation Time: 48 h
Result: Dose-dependently inhibited THP-1 cell proliferation, with an IC50 of 198 nM (equivalent to 198 nM).
Was completely reversed in growth inhibitory effect by the addition of 10 mM nicotinamide.

Cell Proliferation Assay[1]

Cell Line: K562 human chronic myelogenous leukemia cell
Concentration: 0.032, 0.1, 0.32, 1, 3.2, 10 μM
Incubation Time: 48 h
Result: Dose-dependently inhibited K562 cell proliferation, with an IC50 of 673 nM (equivalent to 673 nM).
Was completely reversed in growth inhibitory effect by the addition of 10 mM nicotinamide.
Molecular Weight

319.36

Formula

C19H17N3O2
CAS No.
SMILES

O=C(NCCCN1C=NC=C1)C=2OC(C#CC=3C=CC=CC3)=CC2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AS1604498 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AS1604498361465-74-9AS 1604498AS-1604498NAMPTCaspaseApoptosisNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorNAMPT dimer interface pocketcancer cellsK562 human chronic myelogenous leukemia cellNAMPT enzyme activitycaspase 3/7human NAMPTchronic myelogenous leukemiaTHP-1 human leukemia cellintracellular NAD levelsnicotinamide mononucleotideInhibitorinhibitorinhibit

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