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Results for "

hypoglycaemic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (3) Autophagy (3) Biochemical Assay Reagents (1) Dipeptidyl Peptidase (3) Drug Derivative (1) Endogenous Metabolite (2) Environmental Pollutants (1) GCGR (1) Imidazoline Receptor (3) Insulin Receptor (2) Isotope-Labeled Compounds (2) nAChR (2) Potassium Channel (8) Reference Standards (6)
By Research Areas:	Cancer (2) Cardiovascular Disease (6) Inflammation/Immunology (5) Metabolic Disease (20) Neurological Disease (2)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-77490A

1,3-Butanediol 1 Publications Verification	Environmental Pollutants Endogenous Metabolite	Cardiovascular Disease Neurological Disease
1,3-Butanediol, an orally active ethanol dimer providing a source of calories for human nutrition. 1,3-Butanediol administeration can stimulate the biosynthesis of the ketone body, β-hydroxybutyrate (βHB). 1,3-Butanediol has cerebral protective and hypoglycaemic effect .

HY-117985B

Evogliptin tartrate 1 Publications Verification DA-1229 tartrate	Dipeptidyl Peptidase Autophagy	Metabolic Disease Inflammation/Immunology
Evogliptin (DA-1229) tartrate is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin tartrate also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy. Evogliptin tartrate can be used in studies of type 2 diabetes, osteoporosis, renal impairment and chronic liver inflammation .

HY-N2840

Allitol 1 Publications Verification Allodulcitol	Others	Metabolic Disease
Allitol (Allodulcitol) is an orally active rare sugar alcohol found in Itea virginica L, Tylopilus plumbeoviolaceus. Allitol has anti-obesity and hypoglycaemic activities. Allitol reduces carcass and total body fat mass, increases cecal weight, surface area, and short-chain fatty acid production, and upregulates cecal microbial enzymes linked to butyrate metabolism. Allitol can be used for the researches of obesity and diabetes .

HY-B0881

Acetohexamide 2 Publications Verification	Potassium Channel	Metabolic Disease Cancer
Acetohexamide is an orally active first-generation sulfonylurea agent used in research related to type 2 diabetes and cancer. Acetohexamide exerts reductase activity in human erythrocytes. Acetohexamide stimulates the pancreas to secrete insulin. Acetohexamide inhibits ATP-sensitive potassium channels in the β cells of the pancreas. Acetohexamide can inhibit the formation of circular chemorepellent induced defects (CCIDs) in lymphendothelial cell (LEC) monolayers. Acetohexamide inhibits markers of epithelial-to-mesenchymal-transition and migration. Acetohexamide suppresses the synthesis of 12(S)-HETE. Acetohexamide can potentiate hypoglycaemic action .

HY-N0443

N-Methylcytisine 2 Publications Verification Caulophylline	nAChR	Inflammation/Immunology
N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (K_d = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia .

HY-B0682A

Mitiglinide calcium hydrate 2 Publications Verification KAD-1229; S-21403	Potassium Channel	Metabolic Disease
Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K ⁺ (K_ATP) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell K_ATP channel). Mitiglinide Calcium hydrate can be used for the research of type 2 diabetes .

HY-17398

Mitiglinide calcium 2 Publications Verification KAD-1229 anhydrous; S21403 anhydrous	Potassium Channel	Metabolic Disease
Mitiglinide Calcium (KAD-1229 anhydrous), an insulinotropic agent, is an ATP-sensitive K ⁺ (K_ATP) channel antagonist. Mitiglinide Calcium is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell K_ATP channel). Mitiglinide Calcium can be used for the research of type 2 diabetes .

HY-B1416A

Efaroxan hydrochloride	Adrenergic Receptor Imidazoline Receptor	Cardiovascular Disease Metabolic Disease
Efaroxan hydrochloride is a potent, selective and orally active α2-adrenoceptor antagonist, with antidiabetic activity. Efaroxan hydrochloride is a selective I1-Imidazoline receptor antagonist. Efaroxan hydrochloride can be used for the research of cardiovascular disease .

HY-117985

Evogliptin DA-1229	Dipeptidyl Peptidase Autophagy	Metabolic Disease Inflammation/Immunology
Evogliptin (DA-1229) is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy. Evogliptin can be used in studies of type 2 diabetes, osteoporosis, renal impairment and chronic liver inflammation .

HY-120401

Glybuzole Desaglybuzole	Insulin Receptor GCGR	Metabolic Disease
Glybuzole (Desaglybuzole) is an orally active hypoglycaemic agent that has antidiabetic effect .

HY-B0682

Mitiglinide KAD-1229 free acid anhydrous; S21403 free acid anhydrous	Potassium Channel	Metabolic Disease
Mitiglinide (KAD-1229), an insulinotropic agent, is an ATP-sensitive K ⁺ (K_ATP) channel antagonist. Mitiglinide is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell K_ATP channel). Mitiglinide can be used for the research of type 2 diabetes .

HY-116844

Glymidine Glidiazine	Drug Derivative Insulin Receptor	Metabolic Disease
Glymidine (Glidiazine) is a hypoglycaemic agent. Glymidine is a lipid soluble sulphapyrimidine derivative. Glymidine appears to stimulate insulin release from pancreas. Glymidine is a possible alternative to the sulphonylureas and biguanides for the research of diabetes mellitus .

HY-77490AR

1,3-Butanediol (Standard)	Reference Standards Endogenous Metabolite	Cardiovascular Disease Neurological Disease
1,3-Butanediol (Standard) is the analytical standard of 1,3-Butanediol. This product is intended for research and analytical applications. 1,3-Butanediol, an ethanol dimer providing a source of calories for human nutrition. 1,3-Butanediol is converted in the body to β-hydroxybutyrate and has cerebral protective and hypoglycaemic effect .

HY-U00211

CS476 NSC302998	Potassium Channel	Cardiovascular Disease
CS476 is a potent hypoglycaemic agent.

HY-B1416AR

Efaroxan hydrochloride (Standard)	Adrenergic Receptor Imidazoline Receptor	Cardiovascular Disease Metabolic Disease
Efaroxan (hydrochloride) (Standard) is the analytical standard of Efaroxan (hydrochloride). This product is intended for research and analytical applications. Efaroxan hydrochloride is a potent, selective and orally active α2-adrenoceptor antagonist, with antidiabetic activity. Efaroxan hydrochloride is a selective I1-Imidazoline receptor antagonist. Efaroxan hydrochloride can be used for the research of cardiovascular disease .

HY-17398R

Mitiglinide calcium (Standard) KAD-1229 anhydrous (Standard); S21403 anhydrous (Standard)	Potassium Channel Reference Standards	Metabolic Disease
Mitiglinide (calcium) (Standard) is the analytical standard of Mitiglinide (calcium). This product is intended for research and analytical applications. Mitiglinide Calcium (KAD-1229 anhydrous), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide Calcium is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide Calcium can be used for the research of type 2 diabetes .

HY-B0682AR

Mitiglinide calcium hydrate (Standard) KAD-1229 (Standard); S-21403 (Standard)	Reference Standards Potassium Channel	Metabolic Disease
Mitiglinide (calcium hydrate) (Standard) is the analytical standard of Mitiglinide (calcium hydrate). This product is intended for research and analytical applications. Mitiglinide calcium hydrate (KAD-1229), an insulinotropic agent, is an ATP-sensitive K ⁺ (K_ATP) channel antagonist. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell K_ATP channel). Mitiglinide Calcium hydrate can be used for the research of type 2 diabetes .

HY-W014078

4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid	Biochemical Assay Reagents	Metabolic Disease
4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid has hypoglycaemic activity. 4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid follows a mechanism based on the response to the oral glucose overcharge .

HY-N0443R

N-Methylcytisine (Standard) Caulophylline (Standard)	Reference Standards nAChR	Inflammation/Immunology
N-Methylcytisine (Standard) is the analytical standard of N-Methylcytisine. This product is intended for research and analytical applications. N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia .

HY-N2840S

Allitol-13C Allodulcitol-¹³C	Isotope-Labeled Compounds	Metabolic Disease
Allitol (Allodulcitol)- ¹³C is the ¹³C labeled Allitol (HY-N2840). Allitol is an orally active rare sugar alcohol found in Itea virginica L, Tylopilus plumbeoviolaceus. Allitol has anti-obesity and hypoglycaemic activities. Allitol reduces carcass and total body fat mass, increases cecal weight, surface area, and short-chain fatty acid production, and upregulates cecal microbial enzymes linked to butyrate metabolism. Allitol can be used for the researches of obesity and diabetes .

HY-117985S

Evogliptin-d9 DA-1229-d₉	Isotope-Labeled Compounds Autophagy Dipeptidyl Peptidase	Metabolic Disease Inflammation/Immunology
Evogliptin-d₉ (DA-1229-d₉) is deuterium labeled Evogliptin. Evogliptin (DA-1229) is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy. Evogliptin can be used in studies of type 2 diabetes, osteoporosis, renal impairment and chronic liver inflammation .

HY-N2840R

Allitol (Standard) Allodulcitol (Standard)	Reference Standards	Metabolic Disease
Allitol (Allodulcitol) (Standard) is the analytical standard of Allitol (HY-N2840). This product is intended for research and analytical applications. Allitol is an orally active rare sugar alcohol found in Itea virginica L, Tylopilus plumbeoviolaceus. Allitol has anti-obesity and hypoglycaemic activities. Allitol reduces carcass and total body fat mass, increases cecal weight, surface area, and short-chain fatty acid production, and upregulates cecal microbial enzymes linked to butyrate metabolism. Allitol can be used for the researches of obesity and diabetes .

HY-B0881R

Acetohexamide (Standard)	Reference Standards Potassium Channel	Metabolic Disease Cancer
Acetohexamide (Standard) is the analytical standard of Acetohexamide. This product is intended for research and analytical applications. Acetohexamide is an orally active first-generation sulfonylurea agent used in research related to type 2 diabetes and cancer. Acetohexamide exerts reductase activity in human erythrocytes. Acetohexamide stimulates the pancreas to secrete insulin. Acetohexamide inhibits ATP-sensitive potassium channels in the β cells of the pancreas. Acetohexamide can inhibit the formation of circular chemorepellent induced defects (CCIDs) in lymphendothelial cell (LEC) monolayers. Acetohexamide inhibits markers of epithelial-to-mesenchymal-transition and migration. Acetohexamide suppresses the synthesis of 12(S)-HETE. Acetohexamide can potentiate hypoglycaemic action .

HY-N18176

Atractylic acid	Others	Metabolic Disease
Atractylic acid is a powerful hypoglycaemic agent found in Callilepis laureola. Atractylic acid has nephrotoxicity .

HY-B1416

Efaroxan	Adrenergic Receptor Imidazoline Receptor	Cardiovascular Disease Metabolic Disease
Efaroxan is a potent, selective and orally active α2-adrenoceptor antagonist, with antidiabetic activity. Efaroxan is a selective I1-Imidazoline receptor antagonist. Efaroxan can be used for the research of cardiovascular disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-77490A

1,3-Butanediol 1 Publications Verification	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite
1,3-Butanediol, an orally active ethanol dimer providing a source of calories for human nutrition. 1,3-Butanediol administeration can stimulate the biosynthesis of the ketone body, β-hydroxybutyrate (βHB). 1,3-Butanediol has cerebral protective and hypoglycaemic effect .

HY-N2840

Allitol 1 Publications Verification Allodulcitol	Structural Classification Natural Products Microorganisms Classification of Application Fields Metabolic Disease Disease Research Fields Sweeteners Source Classification Food Research	Others
Allitol (Allodulcitol) is an orally active rare sugar alcohol found in Itea virginica L, Tylopilus plumbeoviolaceus. Allitol has anti-obesity and hypoglycaemic activities. Allitol reduces carcass and total body fat mass, increases cecal weight, surface area, and short-chain fatty acid production, and upregulates cecal microbial enzymes linked to butyrate metabolism. Allitol can be used for the researches of obesity and diabetes .

HY-N0443

N-Methylcytisine 2 Publications Verification Caulophylline	Alkaloids Piperidine Alkaloids Classification of Application Fields Leguminosae Pyridine Alkaloids Sophora flavescens Aiton Plants Inflammation/Immunology Disease Research Fields Source Classification	nAChR
N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (K_d = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia .

HY-77490AR

1,3-Butanediol (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
1,3-Butanediol (Standard) is the analytical standard of 1,3-Butanediol. This product is intended for research and analytical applications. 1,3-Butanediol, an ethanol dimer providing a source of calories for human nutrition. 1,3-Butanediol is converted in the body to β-hydroxybutyrate and has cerebral protective and hypoglycaemic effect .

HY-N0443R

N-Methylcytisine (Standard) Caulophylline (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Leguminosae Pyridine Alkaloids Sophora flavescens Aiton Plants Source Classification	Reference Standards nAChR
N-Methylcytisine (Standard) is the analytical standard of N-Methylcytisine. This product is intended for research and analytical applications. N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia .

HY-N2840R

Allitol (Standard) Allodulcitol (Standard)	Structural Classification Natural Products Microorganisms Source Classification	Reference Standards
Allitol (Allodulcitol) (Standard) is the analytical standard of Allitol (HY-N2840). This product is intended for research and analytical applications. Allitol is an orally active rare sugar alcohol found in Itea virginica L, Tylopilus plumbeoviolaceus. Allitol has anti-obesity and hypoglycaemic activities. Allitol reduces carcass and total body fat mass, increases cecal weight, surface area, and short-chain fatty acid production, and upregulates cecal microbial enzymes linked to butyrate metabolism. Allitol can be used for the researches of obesity and diabetes .

HY-N18176

Atractylic acid	Structural Classification Ketones, Aldehydes, Acids Astragalus caprinus L. Plants Compositae Source Classification	Others
Atractylic acid is a powerful hypoglycaemic agent found in Callilepis laureola. Atractylic acid has nephrotoxicity .

Cat. No.	Product Name	Chemical Structure

HY-N2840S

Allitol-13C
Allitol (Allodulcitol)- ¹³C is the ¹³C labeled Allitol (HY-N2840). Allitol is an orally active rare sugar alcohol found in Itea virginica L, Tylopilus plumbeoviolaceus. Allitol has anti-obesity and hypoglycaemic activities. Allitol reduces carcass and total body fat mass, increases cecal weight, surface area, and short-chain fatty acid production, and upregulates cecal microbial enzymes linked to butyrate metabolism. Allitol can be used for the researches of obesity and diabetes .

Allitol-13C

Allitol (Allodulcitol)- ¹³C is the ¹³C labeled Allitol (HY-N2840). Allitol is an orally active rare sugar alcohol found in Itea virginica L, Tylopilus plumbeoviolaceus. Allitol has anti-obesity and hypoglycaemic activities. Allitol reduces carcass and total body fat mass, increases cecal weight, surface area, and short-chain fatty acid production, and upregulates cecal microbial enzymes linked to butyrate metabolism. Allitol can be used for the researches of obesity and diabetes .

HY-117985S

Evogliptin-d9
Evogliptin-d₉ (DA-1229-d₉) is deuterium labeled Evogliptin. Evogliptin (DA-1229) is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy. Evogliptin can be used in studies of type 2 diabetes, osteoporosis, renal impairment and chronic liver inflammation .

Evogliptin-d9

Evogliptin-d₉ (DA-1229-d₉) is deuterium labeled Evogliptin. Evogliptin (DA-1229) is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy. Evogliptin can be used in studies of type 2 diabetes, osteoporosis, renal impairment and chronic liver inflammation .

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