Search Result

Results for "

leave

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (2) ADC Linker (2) Apoptosis (1) Autophagy (2) Bcl-2 Family (1) Biochemical Assay Reagents (50) CaMK (2) Carboxypeptidase (1) Caspase (1) Drug Derivative (1) Drug Intermediate (1) E3 Ligase Ligand-Linker Conjugates (1) Environmental Pollutants (1) Fluorescent Dye (2) HDAC (1) Histone Methyltransferase (3) Necroptosis (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1)
By Research Areas:	Cancer (8) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (3)
Click Chemistry:	DBCO (1) Azide (4) Alkynes (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-135753

Sethoxydim BAS 9052	Environmental Pollutants Acetyl-CoA Carboxylase	Others
Sethoxydim is a postemergent herbicide. Sethoxydim inhibits plant acetyl-coenzyme A carboxylase (ACCase) activity .

HY-W052066

tert-Butyl (3-chloropropyl)carbamate	Biochemical Assay Reagents	Others
tert-Butyl (3-chloropropyl)carbamate is a compound with a t-butyl and a terminal choloride. The cholorine (Cl) is a good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W591374

DBCO-PEG4-Val-Ala-PAB-PNP	ADC Linker	Cancer
DBCO-PEG4-Val-Ala-PAB-PNP is a cleavable ADC linker. The Val-Ala linkers can be cleaved by Cathepsin B. The DBCO groups is commonly used for Click Chemistry reactions. PEG spacer improves the compound's aqueous solubility. PNP is a good leaving group.

HY-W250928D

Biotin-PEG3400-azide	Fluorescent Dye	Others
Biotin-PEG3400-azide is a biotin labeled PEG derivative. Biotin is an enzyme co-factor, can be used for labeling protein; PEG is a hydrophilic and water-soluble polymer with low toxicity; azide, is a moderately good leaving group, can react with alkyne by Cu-catalyzation, which improve the efficiency of biotin binding targets. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-W250928C

Biotin-PEG2000-azide	Fluorescent Dye	Others
Biotin-PEG2000-azide is a biotin labeled PEG derivative. Biotin is an enzyme co-factor, can be used for labeling protein; PEG is a hydrophilic and water-soluble polymer with low toxicity; azide, is a moderately good leaving group, can react with alkyne by Cu-catalyzation, which improve the efficiency of biotin binding targets. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-W032015

1-Bromooctane n-Octyl Bromide	Biochemical Assay Reagents	Others
1-Bromooctane (n-Octyl Bromide) posesses a terminal bromine. The bromine is a very good leaving group for nucleophilic substitution reactions.

HY-P0271A

Syntide 2 TFA 2 Publications Verification	CaMK	Neurological Disease
Syntide 2 (TFA), a Ca ²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .

HY-W016455

6-Bromo-1-hexanol	Biochemical Assay Reagents	Others
6-Bromo-1-hexanol posesses a terminal bromine and hydroxylic group. The bromine is a very good leaving group for nucleophilic substitution reactions. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

HY-W014159

1-Bromo-2-methyl-3-nitrobenzene	Biochemical Assay Reagents	Others
1-Bromo-2-methyl-3-nitrobenzene is an organic synthesis intermediate. 1-Bromo-2-methyl-3-nitrobenzene participates in chemical reactions such as electrophilic substitution and coupling through the bromine atom and nitro group in the molecule, and acts as a synthetic precursor. 1-Bromo-2-methyl-3-nitrobenzene can construct complex molecular structures by relying on the leaving property of bromine and the electron-withdrawing property of nitro group, and can be used in the synthesis of benzimidazole VISTA inhibitors in medicinal chemistry .

HY-N11166

3,5,7,8,3′,4′-Hexamethoxyflavone	Others	Others
3,5,7,8,3′,4′-Hexamethoxyflavone is a flavonoid. 3,5,7,8,3′,4′-Hexamethoxyflavone can be isolated from the leaves of Melicope triphylla MERR .

HY-W053842

tert-Butyl 3-iodopropylcarbamate	Biochemical Assay Reagents	Others
tert-Butyl 3-iodopropylcarbamate is a compound with a t-butyl and a terminal iodine. The iodine (I) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-W615327

Bis-sulfone NHS ester	Biochemical Assay Reagents	Others
Bis-sulfone NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact.

HY-W190881

N3-PEG11-CH2CH2Br	Biochemical Assay Reagents	Others
N3-PEG11-CH2CH2Br is a PEG linker containing a bromine and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The bromine (Br) is a very good leaving group for nucleophilic substitution reactions.

HY-120137

CMP-5	Histone Methyltransferase	Cancer
CMP-5 is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 prevents Epstein-Barr virus (EBV)-driven B-lymphocyte transformation but leaving normal B cells unaffected .

HY-P0271

Syntide 2	CaMK Autophagy	Neurological Disease
Syntide 2, a Ca ²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .

HY-172291

Mal-amide-PEG8-Val-Cit-PAB-PNP	ADC Linker	Cancer
Mal-amide-PEG8-Val-Cit-PAB-PNP is a cleavable ADC linker featuring a maleimide, a PEG spacer, a Val-Cit dipeptide, a PAB. and a PNP carbonate. Maleimide is a thiol-specific covalent linker which is used to label cysteine residues in proteins while the PNP group acts as a highly activated leaving group. Val-Cit linkers are cleaved by cytoplasmic peptidases.

HY-178380

HDAC8-IN-14	HDAC Reactive Oxygen Species (ROS) Apoptosis Necroptosis Biochemical Assay Reagents Caspase Bcl-2 Family	Inflammation/Immunology Cancer
HDAC8-IN-14, a curcuminoid derivative, is a selective HDAC8 inhibitor with a Ki of 9 nM. HDAC8-IN-14 induces the production of reactive oxygen species (ROS), disrupts mitochondrial membrane potential, and promotes apoptosis. HDAC8-IN-14 can significantly promote the accumulation of cells in the sub-G0/G1 phase, consistent with apoptotic or necrotic cell death. HDAC8-IN-14 induces upregulation of cytochrome c, cleaved caspase-3, and the pro-apoptotic protein Bak while leaving the anti-apoptotic Bcl-2 levels unaltered. HDAC8-IN-14 can be used for the study of leukemia .

HY-135753R

Sethoxydim (Standard) BAS 9052 (Standard)	Reference Standards Acetyl-CoA Carboxylase	Others
Sethoxydim (Standard) is the analytical standard of Sethoxydim. This product is intended for research and analytical applications. Sethoxydim is a postemergent herbicide. Sethoxydim inhibits plant acetyl-coenzyme A carboxylase (ACCase) activity .

HY-N10894

Murrayacarpin B	Others	Others
Murrayacarpin B is a phenolic compound. Murrayacarpin B can be isolated from the leaves and fruits of F. carica .

HY-W395122

Mal-PEG1-PNP-carbonate	Biochemical Assay Reagents	Others
Mal-PEG1-PNP-carbonate is a amine-reactive compound. PNP is a good leaving group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

HY-W878813

Tos-PEG22-Tos	Biochemical Assay Reagents	Others
Tos-PEG22-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

HY-W393115

Diethyl (6-bromohexyl)phosphonate	Biochemical Assay Reagents	Others
Diethyl 6-bromohexylphosphonate is a short linker featuring a bromide and a diethyl phosphonate. The bromide is a good leaving group which can be easily displaced by nucleophiles like alcohols, amines or thiols, while the diethyl phosphonate may be hydrolyzed to allow for esterification.

HY-W190836

N3-PEG2-Tos	Biochemical Assay Reagents	Others
Azide-PEG2-Tos is a small PEG linker featuring an azide and a tosylate. Tosylates are good leaving groups which are easily displaced by nucleophiles while azide is a click chemistry handle which is used to react with terminal alkynes or strained cyclooctynes.

HY-W096068

Propargyl-PEG4-mesyl ester	Biochemical Assay Reagents	Others
Propargyl-PEG5-Ms represents a bifunctional linker possessing a proparygyl group reactive towards azides in copper (I) click chemistry to form stable triazoles with the target compound as well as a mesyl group which is a good leaving group for nucleophilic reactions.

HY-W777866

(Rac)-1-Linoleoyl-2-stearoyl-3-chloropropanediol	Biochemical Assay Reagents	Others
(Rac)-1-Linoleoyl-2-stearoyl-3-chloropropanediol is a diacylglycerol that contains Linoleic acid at the sn-1 position and stearic acid group at the sn-2 position. The chlorine is a good leaving group and can undergo substitution reactions.

HY-W451433

OTs-PEG1-NHCbz	Biochemical Assay Reagents	Others
OTs-PEG1-NHCbz is a PEG linker containing a tosyl group and benzyl (Cbz) protecting group. The hydrophilic PEG spacer increases the water solubility of the compound in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The benzyl protecting group can be removed via hydrogenolysis to form a free amine.

HY-W460133

tert-Butyl (2-(2-(2-iodoethoxy)ethoxy)ethyl)carbamate	Biochemical Assay Reagents	Others
tert-Butyl (2-(2-(2-iodoethoxy)ethoxy)ethyl)carbamate is a PEG linker containing a Boc protected amine and an iodine group. The protected amine can be deprotected under mild acidic conditions. Iodine (I) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

HY-122125

RX 336M	Drug Derivative	Neurological Disease
RX 336M is a dihydrocodeinone analogue. RX 336M induces behaviors consisting of consisting of behavioral activation, rapid forepaw movements, excessive grooming, and whole body "wet-dog" shakes (WDS) (rapid twisting of the head and trunk with the forepaws leaving the ground). RX 336M can be used for the study of neurological disease .

HY-W800760

(S,R,S)-AHPC-PEG6-Tos	E3 Ligase Ligand-Linker Conjugates	Cancer
(S, R, S)-AHPC-PEG6-Tos is a combination of a von Hippel-Lindau (VHL)-recruiting ligand and PEGylated crosslinker with a tosyl group. The tosyl group is a good leaving group for nucleophilic substitution reactions. (S, R, S)-AHPC-PEG2-Tos is useful for synthesis of PROTAC compounds and molecules for targeted protein degradation.

HY-W572763

Tos-PEG6-acid	Biochemical Assay Reagents	Others
Tos-PEG6-acid is a PEG linker containing a tosyl group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. HATU) to form a stable amide bond.

HY-122047

SW063058	Autophagy	Cancer
SW063058 is an autophagy inducer that specifically disrupts the binding of Beclin 1 to Bcl-2 while leaving the interaction between Bcl-2 and pro-apoptotic members like Bax and BIM unaffected. By inhibiting the negative regulatory effects of Bcl-2 on Beclin 1, which is crucial for the initiation of autophagy, SW063058 promotes autophagic activity without triggering cytotoxicity, apoptosis, or other forms of cell death in vitro.

HY-W190952

Bis-sulfone-PEG4-NHS ester	Biochemical Assay Reagents	Others
Bis-sulfone-PEG4-NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. The hydrophilic PEG spacer increases solubility in aqueous media.

HY-113846A

CMP-5 dihydrochloride	Histone Methyltransferase	Cancer
CMP-5 dihydrochloride is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 dihydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 dihydrochloride prevents EBV-driven B-lymphocyte transformation but leaving normal B cells unaffected .

HY-113846

CMP-5 hydrochloride	Histone Methyltransferase	Cancer
CMP-5 hydrochloride is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 hydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 hydrochloride prevents EBV-driven B-lymphocyte transformation but leaving normal B cells unaffected .

HY-W394551

Methyl 3,4-dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate	Biochemical Assay Reagents	Others
Methyl 3,4-dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxylate is a small pyrrolidone molecule which features two bromine atoms and a methyl ester. The unsaturated dibromo motif is a covalent ligand for thiol groups, and may be used to label cysteine residues in proteins. The presence of two leaving groups on this molecule allows this linker to bind two thiols at a time. The methyl ester can be saponified to link this molecule to amines to form larger structures.

HY-W396413

(4-Chlorobutoxy)trimethylsilane	Biochemical Assay Reagents	Others
4-Chlorobutoxy(trimethyl)silane is a silane compound with a terminal cholorine. The cholorine (Cl) is a good leaving group for nucleophilic substitution reactions. The trimethylsilane is commonly used for surface modifications.

HY-W591314

M-PEG11-Ms	Biochemical Assay Reagents	Others
m-PEG11-Ms is a PEG linker featuring a methoxy cap and a mesylate group. The methoxy cap is inert while the mesylate is a good leaving group which is easily displaced by nucleophiles such as alcohols and amines.

HY-W348170

tert-Butyl((5-iodopentyl)oxy)dimethylsilane	Biochemical Assay Reagents	Others
tert-Butyl((5-iodopentyl)oxy)dimethylsilane is a silane compound with a terminal iodine group. The trimethylsilane is commonly used for surface modifications. The iodine (I) is a very good leaving group for nucleophilic substitution reactions.

HY-W800806

Heptyl 8-bromooctanoate	Biochemical Assay Reagents	Others
Heptyl 8-bromooctanoate is an ester compound that has a terminal bromine. Heptyl 8-bromooctanoate is formed by coupling 8-Bromooctanoic acid to Heptanol. The bromine (Br) is a very good leaving group for nucleophilic substitution reactions.

HY-W800678

Bromoacetamido-PEG2-AZD	Biochemical Assay Reagents	Others
Bromoacetamido-PEG2-AZD is a PEG linker containing an AZD group and a bromide group which is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

HY-W800842

1-Ethylnonyl 8-bromooctanoate	Biochemical Assay Reagents	Others
1-Ethylnonyl 8-bromooctanoate is a lipid featuring a bromide along an octanoate chain linking to a C11 chain. 1-Ethylnonyl 8-bromooctanoate can be derivatized via substitution at the bromide leaving group.

HY-W248726

tert-Butyl (6-iodohexyl)carbamate	Biochemical Assay Reagents	Others
tert-Butyl (6-iodohexyl)carbamate is a six carbon linker containing an iodine group and a t-butyl ester. The iodine (I) acts as a good leaving group for nucleophilic substitution reactions. The t-butyl ester groups can be deprotected under acidic conditions.

HY-172720

Azide-PEG5-Ms	Biochemical Assay Reagents	Others
Azide-PEG5-Ms serves as a PEG linker containing an azide that reacts with BCN, DBCO, alkyne via Click Chemistry and mesyl group that is a good leaving group for nucleophilic substitution reactions. The PEG spacer imparts water solubility.

HY-W190738

Azide-PEG8-Tos	Biochemical Assay Reagents	Others
Azide-PEG8-Tos is a small PEG linker featuring an azide and a tosylate. Tosylates are good leaving groups which are easily displaced by nucleophiles while azide is a click chemistry motif which is used to react with terminal alkynes or strained cyclooctynes.

HY-W251756

3-(2-Iodoethoxy)prop-1-yne	Biochemical Assay Reagents	Others
3-(2-Iodoethoxy)prop-1-yne is a crosslinker that can be used in copper catalyzed azide-alkyne Click Chemistry to form a stable triazole linkage with azides. The iodine (I) acts as a good leaving group for nucleophilic substitution reactions.

HY-W591972

6-Hydroxyhexyl 4-methylbenzenesulfonate	Biochemical Assay Reagents	Others
6-Hydroxyhexyl 4-methylbenzenesulfonate is a six carbon linker containing a hydroxyl group and a tosyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

HY-W591971

5-((tert-Butoxycarbonyl)amino)pentyl 4-methylbenzenesulfonate	Biochemical Assay Reagents	Others
5-((tert-Butoxycarbonyl)amino)pentyl 4-methylbenzenesulfonate is a PEG linker containing a Boc protected amine and a tosyl group. The protected amine can be deprotected under mild acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

HY-W800661

Tos-PEG3-methyl ester	Biochemical Assay Reagents	Others
Tos-PEG3-methyl ester is a PEG linker with tosyl and methyl ester moieties. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG linker increases the water solubility of the compound. Methyl ester can be hydrolyzed under strong basic condition.

HY-W800662

Bromo-PEG2-methyl ester	Biochemical Assay Reagents	Others
Bromo-PEG2-methyl ester is a PEG linker containing a bromide moiety and a methyl ester. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media. Methyl ester can be hydrolyzed under strong basic condition.

HY-W591973

OTs-C6-NHBoc	Biochemical Assay Reagents	Others
OTs-C6-NHBoc is a six carbon linker containing a tosyl group and Boc-protected amine group. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form a free amine.

Cat. No.	Product Name

HY-L005M

Epigenetics Compound Library Mini

297 compounds

Epigenetics involves heritable phenotypic changes that occur without alterations to the underlying DNA sequence. Key mechanisms include DNA methylation, histone modifications, and regulation by small non-coding RNAs such as microRNAs. By modifying DNA, histones, or RNA—while leaving their primary sequences intact—these processes influence molecular function and regulation, thereby playing critical roles in cellular differentiation, embryonic development, gene expression control, aging, and diseases such as cancer.

MCE provide a unique collection of 297 epigenetics-related compounds. For each regulatory target and its subtype, 3 to 5 highly specific representative compounds have been retained, which can be used in epigenetic and related disease research.

HY-L011

Membrane Transporter/Ion Channel Compound Library

2,174 compounds

Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development.

MCE designs a unique collection of 2,174 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.

Cat. No.	Product Name	Type

HY-W014159

1-Bromo-2-methyl-3-nitrobenzene

Biochemical Assay Reagents

1-Bromo-2-methyl-3-nitrobenzene is an organic synthesis intermediate. 1-Bromo-2-methyl-3-nitrobenzene participates in chemical reactions such as electrophilic substitution and coupling through the bromine atom and nitro group in the molecule, and acts as a synthetic precursor. 1-Bromo-2-methyl-3-nitrobenzene can construct complex molecular structures by relying on the leaving property of bromine and the electron-withdrawing property of nitro group, and can be used in the synthesis of benzimidazole VISTA inhibitors in medicinal chemistry .

Cat. No.	Product Name	Target	Research Area

HY-P0271A

Syntide 2 TFA 2 Publications Verification	CaMK	Neurological Disease
Syntide 2 (TFA), a Ca ²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .

HY-P0271

Syntide 2	CaMK Autophagy	Neurological Disease
Syntide 2, a Ca ²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .

Cat. No.	Product Name		Classification

HY-W591374

DBCO-PEG4-Val-Ala-PAB-PNP		DBCO
DBCO-PEG4-Val-Ala-PAB-PNP is a cleavable ADC linker. The Val-Ala linkers can be cleaved by Cathepsin B. The DBCO groups is commonly used for Click Chemistry reactions. PEG spacer improves the compound's aqueous solubility. PNP is a good leaving group.

HY-W250928D

Biotin-PEG3400-azide		Azide
Biotin-PEG3400-azide is a biotin labeled PEG derivative. Biotin is an enzyme co-factor, can be used for labeling protein; PEG is a hydrophilic and water-soluble polymer with low toxicity; azide, is a moderately good leaving group, can react with alkyne by Cu-catalyzation, which improve the efficiency of biotin binding targets. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-W250928C

Biotin-PEG2000-azide		Azide
Biotin-PEG2000-azide is a biotin labeled PEG derivative. Biotin is an enzyme co-factor, can be used for labeling protein; PEG is a hydrophilic and water-soluble polymer with low toxicity; azide, is a moderately good leaving group, can react with alkyne by Cu-catalyzation, which improve the efficiency of biotin binding targets. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-W190881

N3-PEG11-CH2CH2Br		Azide
N3-PEG11-CH2CH2Br is a PEG linker containing a bromine and an azide group. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The bromine (Br) is a very good leaving group for nucleophilic substitution reactions.

HY-W190836

N3-PEG2-Tos		Azide
Azide-PEG2-Tos is a small PEG linker featuring an azide and a tosylate. Tosylates are good leaving groups which are easily displaced by nucleophiles while azide is a click chemistry handle which is used to react with terminal alkynes or strained cyclooctynes.

HY-W096068

Propargyl-PEG4-mesyl ester		Alkynes
Propargyl-PEG5-Ms represents a bifunctional linker possessing a proparygyl group reactive towards azides in copper (I) click chemistry to form stable triazoles with the target compound as well as a mesyl group which is a good leaving group for nucleophilic reactions.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

leave

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

NaturalProducts

Click Chemistry

Natural
Products