mouse tyrosinase

By Targets:	Tyrosinase (9) AMPK (1) Apoptosis (2) Bacterial (1) Cholinesterase (ChE) (1) Fluorescent Dye (1) Glycosidase (1) Heme Oxygenase (HO) (1) HSP (1) JNK (1) MHC (1) MMP (1) NF-κB (1) p38 MAPK (2) PERK (1) Phosphatase (1) Reactive Oxygen Species (ROS) (1) SARS-CoV (1) TGF-beta/Smad (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (5) Metabolic Disease (3) Neurological Disease (1)

Targets Recommended: Tyrosinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N3266

Methyl rosmarinate	Tyrosinase Phosphatase Cholinesterase (ChE) SARS-CoV PERK JNK p38 MAPK TGF-beta/Smad Apoptosis Reactive Oxygen Species (ROS) AMPK MMP	Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology Cancer
Methyl rosmarinate is an orally active hydroxycinnamic acid. Methyl rosmarinate exhibits an IC₅₀ of 24.70 μM and a K_i of 15.29 μM against PTP1B, an IC₅₀ of 41.46 μg/mL against BChE, a K_i of 0.61 mM against mushroom tyrosinase, and an IC₅₀ of 2.50 μM against SARS-CoV-2 3CLpro. Methyl rosmarinate downregulates the phosphorylation levels of ERK, JNK, p38, Smad2 and Smad3. Methyl rosmarinate activates erythrocyte BPGM and promotes the production of 2,3-BPG. Methyl rosmarinate induces apoptosis of fibroblasts. Methyl rosmarinate prolongs the survival time of hypoxic mice. Methyl rosmarinate improves insulin sensitivity. Methyl rosmarinate binds to SARS-CoV-2 3CLpro and inhibits viral replication. Methyl rosmarinate induces glioblastoma cell death. Methyl rosmarinate activates the TGR5/AMPK axis and reduces the levels of ROS and MDA. Methyl rosmarinate shows inhibitory activity against MMP-1. Methyl rosmarinate can be used in research related to pulmonary fibrosis, hypoxia-induced injury, type 2 diabetes, Alzheimer's disease, hyperpigmentation disorders, COVID-19, glioblastoma and myocardial ischemia-reperfusion injury .

HY-B1461

Deoxyarbutin	Tyrosinase Apoptosis	Cancer
Deoxyarbutin is an orally active *tyrosinase* inhibitor that can promote apoptosis of melanoma cells, enhance the vitality of mouse acinar cells, and has skin whitening and anti-tumor activity ^[1][2][3].

HY-N6606

Delphinidin-3-O-galactoside chloride 1 Publications Verification	Glycosidase Tyrosinase Heme Oxygenase (HO) HSP	Metabolic Disease Inflammation/Immunology
Delphinidin-3-O-galactoside chloride is an anthocyanin found in abbiteye blueberry. Delphinidin-3-O-galactoside chloride show inhibitory activitiesagainst α-glucosidase with an IC₅₀ of 68.33 μM, and tyrosinase with an IC₅₀ of 34.14 μM. Delphinidin-3-O-galactoside chloride attenuates HO-1 and HSP70 messenger RNA down-regulation, suppresses cytotoxicity, reduces endoplasmic reticulum stress responses, scavenges free radicals, reduces intracellular triglyceride levels and lipid droplet accumulation. Delphinidin-3-O-galactoside chloride can be used for the researches of diabesity, melanoma and inflammation .

HY-N1098

Velutin	Tyrosinase p38 MAPK NF-κB Bacterial	Infection Metabolic Disease Inflammation/Immunology
Velutin is a flavonoid. Velutin can be extracted from mistletoe. Velutin inhibits mushroom Tyrosinase activity with an IC₅₀ of 910.1 μM. Velutin inhibits p38 phosphorylation, the NF-κB pathway and the MAPK pathway. Velutin prevents articular cartilage degeneration and subchondral bone loss. Velutin slows down the progression of intervertebral disc degeneration. Velutin exhibits inhibitory effects on melanogenesis, skin whitening, anti-inflammatory, anti-allergic, anti-oxidant and antibacterial activities. Velutin can be used in studies related to pigmented diseases, osteoarthritis and intervertebral disc degeneration .

HY-P3742

**Tyrosinase (192-200), human mouse**	Tyrosinase MHC	Cancer
Tyrosinase (192-200), human mouse is a *HLA-B4403*-restricted tyrosinase* epitope with affinity for HLA-B4403 and HLA-B4402. Tyrosinase (192-200), human mouse binds to *HLA-B4403** to form a complex, which is recognized by the autologous cytotoxic T lymphocyte clone 22/31 derived from melanoma. Tyrosinase (192-200), human mouse binds to HLA-B4402 to form a complex, which is recognized by the CTL clone 329B/5 derived from healthy HLA-B4402 donors. Tyrosinase (192-200), human mouse is applicable to melanoma-related research .

HY-139430

4-Isopropylcatechol 4-IPC	Tyrosinase	Inflammation/Immunology
4-Isopropylcatechol is a potent and irreversible cutaneous depigmenting agent. 4-Isopropylcatechol significantly inhibits protein biosynthesis in mouse melanoma cells containing high levels of tyrosinase. 4-Isopropylcatechol can be use to study hyperpigmentation of skins .

HY-P990149

Anti-Mouse/Human TYRP1 Antibody (TA99)	Tyrosinase	Cancer
Anti-Mouse/Human TYRP1 Antibody (TA99) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/human TYRP1. Anti-Mouse/Human TYRP1 Antibody (TA99) binds to Tyrp1 (tyrosinase related protein-1) on tumor. Anti-Mouse/Human TYRP1 Antibody (TA99) enhances infiltration of the tumor by CD8 ⁺ T cells. Anti-Mouse/Human TYRP1 Antibody (TA99) can be used for the research of melanoma .

HY-D3140

MB-m-borate	Fluorescent Dye Tyrosinase	Cancer
MB-m-borate is a double-locked near-infrared fluorescence-activated probe (Ex/Em ≈ 647 nm/684 nm). MB-m-borate undergoes cascade activation by hydrogen peroxide and tyrosinase to release the fluorophore methylene blue, thereby generating a fluorescence activation response. MB-m-borate enables precise detection of melanoma in melanoma cells and mouse models. MB-m-borate can be used for melanoma research .

HY-D3141

DR probe		Cancer
DR probe is a "dual-key-and-lock" fluorescent probe designed based on the Resorufin (HY-123533) scaffold (Ex/Em = 647 nm/663-738 nm). DR probe can be sequentially activated by hydrogen peroxide to form the intermediate SR, which acts as a tyrosinase substrate to trigger a fluorescence turn-on signal. DR probe can distinguish normal melanocytes from melanoma cells. DR probe supports cell imaging and can be applied to mouse melanoma models to achieve melanoma diagnosis with higher accuracy and lower false-positive rates. DR probe is applicable to relevant research on melanoma .

HY-182989

Tyrosinase-IN-50	Tyrosinase	Metabolic Disease Inflammation/Immunology
Tyrosinase-IN-50 (Compound 14) is a Tyrosinase inhibitor (IC₅₀ is 0.06 μM or 0.16 μM). Tyrosinase-IN-50 inhibits melanogenesis in multiple cell types. Tyrosinase-IN-50 can be used for the research of hyperpigmentation-related diseases and inflammatory diseases .

Cat. No.	Product Name	Type

HY-D3140

MB-m-borate	Fluorescent Dyes
MB-m-borate is a double-locked near-infrared fluorescence-activated probe (Ex/Em ≈ 647 nm/684 nm). MB-m-borate undergoes cascade activation by hydrogen peroxide and tyrosinase to release the fluorophore methylene blue, thereby generating a fluorescence activation response. MB-m-borate enables precise detection of melanoma in melanoma cells and mouse models. MB-m-borate can be used for melanoma research .

MB-m-borate

Fluorescent Dyes

MB-m-borate is a double-locked near-infrared fluorescence-activated probe (Ex/Em ≈ 647 nm/684 nm). MB-m-borate undergoes cascade activation by hydrogen peroxide and tyrosinase to release the fluorophore methylene blue, thereby generating a fluorescence activation response. MB-m-borate enables precise detection of melanoma in melanoma cells and mouse models. MB-m-borate can be used for melanoma research .

HY-D3141

DR probe	Fluorescent Dyes
DR probe is a "dual-key-and-lock" fluorescent probe designed based on the Resorufin (HY-123533) scaffold (Ex/Em = 647 nm/663-738 nm). DR probe can be sequentially activated by hydrogen peroxide to form the intermediate SR, which acts as a tyrosinase substrate to trigger a fluorescence turn-on signal. DR probe can distinguish normal melanocytes from melanoma cells. DR probe supports cell imaging and can be applied to mouse melanoma models to achieve melanoma diagnosis with higher accuracy and lower false-positive rates. DR probe is applicable to relevant research on melanoma .

DR probe

Fluorescent Dyes

DR probe is a "dual-key-and-lock" fluorescent probe designed based on the Resorufin (HY-123533) scaffold (Ex/Em = 647 nm/663-738 nm). DR probe can be sequentially activated by hydrogen peroxide to form the intermediate SR, which acts as a tyrosinase substrate to trigger a fluorescence turn-on signal. DR probe can distinguish normal melanocytes from melanoma cells. DR probe supports cell imaging and can be applied to mouse melanoma models to achieve melanoma diagnosis with higher accuracy and lower false-positive rates. DR probe is applicable to relevant research on melanoma .

Cat. No.	Product Name	Target	Research Area

HY-P3742

**Tyrosinase (192-200), human mouse**	Tyrosinase MHC	Cancer
Tyrosinase (192-200), human mouse is a *HLA-B4403*-restricted tyrosinase* epitope with affinity for HLA-B4403 and HLA-B4402. Tyrosinase (192-200), human mouse binds to *HLA-B4403** to form a complex, which is recognized by the autologous cytotoxic T lymphocyte clone 22/31 derived from melanoma. Tyrosinase (192-200), human mouse binds to HLA-B4402 to form a complex, which is recognized by the CTL clone 329B/5 derived from healthy HLA-B4402 donors. Tyrosinase (192-200), human mouse is applicable to melanoma-related research .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990149

Anti-Mouse/Human TYRP1 Antibody (TA99)	Tyrosinase	Cancer
Anti-Mouse/Human TYRP1 Antibody (TA99) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/human TYRP1. Anti-Mouse/Human TYRP1 Antibody (TA99) binds to Tyrp1 (tyrosinase related protein-1) on tumor. Anti-Mouse/Human TYRP1 Antibody (TA99) enhances infiltration of the tumor by CD8 ⁺ T cells. Anti-Mouse/Human TYRP1 Antibody (TA99) can be used for the research of melanoma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3266

Methyl rosmarinate	Structural Classification Classification of Application Fields Simple Phenylpropanols Adenocarpus cincinnatus (Ball) Maire Labiatae Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification Cancer	Tyrosinase Phosphatase Cholinesterase (ChE) SARS-CoV PERK JNK p38 MAPK TGF-beta/Smad Apoptosis Reactive Oxygen Species (ROS) AMPK MMP
Methyl rosmarinate is an orally active hydroxycinnamic acid. Methyl rosmarinate exhibits an IC₅₀ of 24.70 μM and a K_i of 15.29 μM against PTP1B, an IC₅₀ of 41.46 μg/mL against BChE, a K_i of 0.61 mM against mushroom tyrosinase, and an IC₅₀ of 2.50 μM against SARS-CoV-2 3CLpro. Methyl rosmarinate downregulates the phosphorylation levels of ERK, JNK, p38, Smad2 and Smad3. Methyl rosmarinate activates erythrocyte BPGM and promotes the production of 2,3-BPG. Methyl rosmarinate induces apoptosis of fibroblasts. Methyl rosmarinate prolongs the survival time of hypoxic mice. Methyl rosmarinate improves insulin sensitivity. Methyl rosmarinate binds to SARS-CoV-2 3CLpro and inhibits viral replication. Methyl rosmarinate induces glioblastoma cell death. Methyl rosmarinate activates the TGR5/AMPK axis and reduces the levels of ROS and MDA. Methyl rosmarinate shows inhibitory activity against MMP-1. Methyl rosmarinate can be used in research related to pulmonary fibrosis, hypoxia-induced injury, type 2 diabetes, Alzheimer's disease, hyperpigmentation disorders, COVID-19, glioblastoma and myocardial ischemia-reperfusion injury .

HY-B1461

Deoxyarbutin	Natural Products Monophenols other families Classification of Application Fields Other Diseases Phenols Plants Disease Research Fields Source Classification	Tyrosinase Apoptosis
Deoxyarbutin is an orally active *tyrosinase* inhibitor that can promote apoptosis of melanoma cells, enhance the vitality of mouse acinar cells, and has skin whitening and anti-tumor activity ^[1][2][3].

HY-N6606

Delphinidin-3-O-galactoside chloride 1 Publications Verification	Structural Classification Anthocyans Flavonoids Cornaceae Classification of Application Fields Cornus officinalis Sieb. et Zucc. Other Diseases Phenols Polyphenols Plants Disease Research Fields Source Classification	Glycosidase Tyrosinase Heme Oxygenase (HO) HSP
Delphinidin-3-O-galactoside chloride is an anthocyanin found in abbiteye blueberry. Delphinidin-3-O-galactoside chloride show inhibitory activitiesagainst α-glucosidase with an IC₅₀ of 68.33 μM, and tyrosinase with an IC₅₀ of 34.14 μM. Delphinidin-3-O-galactoside chloride attenuates HO-1 and HSP70 messenger RNA down-regulation, suppresses cytotoxicity, reduces endoplasmic reticulum stress responses, scavenges free radicals, reduces intracellular triglyceride levels and lipid droplet accumulation. Delphinidin-3-O-galactoside chloride can be used for the researches of diabesity, melanoma and inflammation .

HY-N1098

Velutin	Structural Classification Flavonoids Microorganisms other families Classification of Application Fields Flavones Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Tyrosinase p38 MAPK NF-κB Bacterial
Velutin is a flavonoid. Velutin can be extracted from mistletoe. Velutin inhibits mushroom Tyrosinase activity with an IC₅₀ of 910.1 μM. Velutin inhibits p38 phosphorylation, the NF-κB pathway and the MAPK pathway. Velutin prevents articular cartilage degeneration and subchondral bone loss. Velutin slows down the progression of intervertebral disc degeneration. Velutin exhibits inhibitory effects on melanogenesis, skin whitening, anti-inflammatory, anti-allergic, anti-oxidant and antibacterial activities. Velutin can be used in studies related to pigmented diseases, osteoarthritis and intervertebral disc degeneration .

Species:	Mouse (2)
Tag:	SUMO (1) His (2)
Source:	E. coli Cell-free (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702479

	*TYR/Tyrosinase* Protein, Mouse (Cell-Free, His)** tyrosinase; Albino locus protein; Monophenol monooxygenase	Mouse	E. coli Cell-free
	TYR/Tyrosinase Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived TYR/Tyrosinase protein, expressed by E. coli Cell-free, with N-10*His labeled tag., has molecular weight of 61.3 kDa.

HY-P72169

	DCT Protein, Mouse (His-SUMO) Dct; Tyrp-2; Tyrp2; L-dopachrome tautomerase; DCT; DT; EC 5.3.3.12; DOPAchrome conversion factor; DOPAchrome isomerase; DOPAchrome oxidoreductase; L-dopachrome Delta-isomerase; SLATY locus protein; tyrosinase-related protein 2; TRP-2; TRP2	Mouse	E. coli
	DCT (Dopachrome tautomerase) is pivotal in melanin biosynthesis, catalyzing the conversion of L-dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA), a critical step in melanin synthesis. DCT's enzymatic activity is integral to the complex processes governing melanin production, emphasizing its role in skin pigmentation and the regulation of melanin-related functions. DCT Protein, Mouse (His-SUMO) is the recombinant mouse-derived DCT protein, expressed by E. coli , with N-10*His, N-SUMO labeled tag.

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mouse tyrosinase

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