28 Results for "

murine monoclonal antibody

" in MedChemExpress (MCE) Product Catalog:
Products (28)

28 Results for "murine monoclonal antibody" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-P99008
CAS No.: 2417175-94-9
Synonyms: IC14
Atibuclimab (IC14), is a chimeric monoclonal antibody directed against CD14 and is composed of murine variable and human IgG4 Fc regions. Atibuclimab attenuates Lipopolysaccharides (HY-D1056) (LPS)-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist. Atibuclimab can be used for the research of amyotrophic lateral sclerosis, sepsis, community-acquired pneumonia, or acute lung injury .
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1
1 Cited Publications
Cat. No.: HY-P99294
CAS No.: 905703-97-1
Synonyms: AMG 479; Human Anti-IGF1R Recombinant antibody

Target:  

IGF-1R

Research Areas:  

Cancer

Ganitumab (AMG 479) is a recombinant human monoclonal antibody to the human type 1 insulin-like growth factor receptor (IGF1R). Ganitumab recognizes murine IGF1R with sub-nanomolar affinity (KD=0.22 nM) and inhibits the interaction of murine IGF1R with IGF1 and IGF2. Ganitumab can be used in research of cancer .
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1
1 Cited Publications
Cat. No.: HY-P99732
CAS No.: 195189-17-4
Synonyms: CC-49

Target:  

Mucin

Research Areas:  

Cancer

Minretumomab (CC-49) is a murine monoclonal antibody against TAG-72 (tumor-associated glycoprotein 72). Minretumomab is used in cancer and immunity research .
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Cat. No.: HY-P9948
CAS No.: 216503-57-0
Synonyms: Campath-IH

Target:  

Apoptosis

Research Areas:  

Cancer

Alemtuzumab (Campath-IH) is a humanized monoclonal antibody against CD52. Alemtuzumab does not cross-react with murine CD52. Alemtuzumab selectively targets the CD52 antigen to induce profound lymphocyte depletion, followed by recovery of T and B cells with regulatory phenotypes. Alemtuzumab is capable of complement-dependent cytotoxicity and antibody-dependent cell-mediated cytotoxicity (ADCC), as well as induction of apoptosis. Alemtuzumab has the potential for B-cell chronic lymphocytic leukaemia research .
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Cat. No.: HY-P9964
CAS No.: 906805-06-9
Synonyms: 11F8; IMC-11F8; LY3012211

Target:  

EGFR

Research Areas:  

Cancer

Necitumumab (11F8; IMC-11F8; LY3012211) is a human IgG monoclonal antibody directed against EGFR. Necitumumab binds to the EGF binding site of EGFR, blocks ligand binding, neutralizes ligand-induced EGFR phosphorylation and downstream signaling, induces EGFR internalization and degradation, and mediates antibody-dependent cellular cytotoxicity (ADCC) in EGFR-expressing cells. Necitumumab enhances antitumour activity in combination with Gemcitabine (HY-17026) and Cisplatin (HY-17394) in murine non-small-cell lung cancer xenograft models. Necitumumab can be used in research on cancers such as non-small cell lung cancer and colorectal cancer .
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Cat. No.: HY-108852
CAS No.: 179045-86-4
Purity:  99.73%
Synonyms: CHI 621
Basiliximab (CHI 621) is a recombinant chimeric murine/human IgG1 monoclonal anti-interleukin-2 receptor antibody. Basiliximab can be used for the research of renal transplantation .
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Cat. No.: HY-P99231
CAS No.: 156586-89-9
Synonyms: Panorex; CO17-1A

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Edrecolomab (Panorex) is a murine monoclonal antibody to the cell-surface glycoprotein 17-1A, expressed on epithelial tissues and on various carcinomas. Edrecolomab shows anti-tumor activity and can be used in colorectal carcinoma research .
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Cat. No.: HY-P99336
CAS No.: 142864-19-5
Synonyms: BI-RR 0001; Anti-Human IL6 Recombinant antibody

Target:  

Integrin

Enlimomab (BI-RR 0001), a murine IgG2a monoclonal antibody to the human ICAM-1, inhibits leukocyte adhesion to the vascular endothelium, thereby decreasing leukocyte extravasation and inflammatory tissue injury. Enlimomab has anti-inflammatory effects, and can be used for stroke research .
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Cat. No.: HY-P991319

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

TAB-004 is a murine IgG1 monoclonal antibody that specifically binds to the tumor-associated hypoglycosylated mucin 1 (tMUC1), with high selectivity for human tMUC1. TAB-004 can be conjugated with Indocyanine green (ICG) (HY-D0711) for in vivo targeted imaging. TAB-004 can be used for the research of early detection, tumor progression monitoring and cancer stem cell targeting in breast cancer and pancreatic cancer.
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Cat. No.: HY-P99906
CAS No.: 2414962-49-3
Synonyms: DKN-01; LY-2812176

Target:  

β-catenin Wnt

Research Areas:  

Cancer

Sirexatamab (DKN-01; LY-2812176) is a humanized IgG4 monoclonal antibody targeting DKK1, with Kd values of 3.3 pM and 20 pM for human and murine (mDKN-01) forms, respectively. Sirexatamab binds to DKK1 to neutralize its activity and reverse the inhibition of the canonical Wnt/β-catenin signaling pathway. Sirexatamab can be used in research related to cancers such as non-small cell lung cancer, endometrial cancer, and ovarian cancer .
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Cat. No.: HY-P99566
CAS No.: 1412891-40-7
Synonyms: ST2146

Research Areas:  

Cancer

Tenatumomab (ST2146) is a murine monoclonal antibody against tenascin-C. And tenascin-C, the large extracellular glycoprotein, is overexpressed in cancer. Tenatumomab has been used for Pretargeted Antibody Guided Radioimmunoresearch (PAGRIT), and delivering radionuclides to tumors via PAGRIT and direct 131Iodine labeling approach .
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Cat. No.: HY-P99409
CAS No.: 213327-37-8
Synonyms: Alt-2 monoclonal antibody; MAB-B43.13; Oregovamab

Research Areas:  

Cancer

Oregovomab (Alt-2 monoclonal antibody) is a murine mAb targeting CA125. Oregovomab induces cytotoxic immune response against CA125 expressing tumor cells .
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Cat. No.: HY-P99726
CAS No.: 127757-92-0

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Maslimomab is a murine monoclonal antibody targeting T-cell receptor. Maslimomab is an immunosuppressive agent .
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Cat. No.: HY-P99707
CAS No.: 1453362-55-4
Synonyms: HH1

Target:  

Apoptosis

Research Areas:  

Cancer

Lilotomab (HH1) is a murine anti-CD37 monoclonal antibody. Lilotomab reduces clonogenic survival. Lilotomab shows anti-tumor activity .
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Cat. No.: HY-P99691
CAS No.: 250242-54-7
Synonyms: IMMU-MN3
Lemalesomab (IMMU-MN3) is a Fab' fragment of a murine anti-granulocyte monoclonal antibody targeting NCA-90 (CEACAM6). Lemalesomab binds strongly to NCA-90 on the surface of granulocytes, cross-reacts with epitopes of other CEA family members, and blocks the binding between human colon adenocarcinoma cells and CEA. When labeled with 99mTc, Lemalesomab can be used for radionuclide imaging of soft tissue infections and osteomyelitis .
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Cat. No.: HY-P991618

Research Areas:  

Cancer

ST2485 is a monoclonal antitenascin antibody. ST2485 shows additivity in tenascin C binding in vitro as well as in a xenograft model. ST2485 binds human tenascin at an epitope partially shared with BC2. ST2485 cross-reacts with murine tenascin. ST2485 can be studied in antitumor research .
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Cat. No.: HY-P9937
CAS No.: 154361-48-5
Synonyms: IMMU-4

Research Areas:  

Cancer

Arcitumomab is a murine anti-carcinoembryonic antigen (CEA) monoclonal antibody Fab’ fragment. Arcitumomab can be labeled with technetium-99m and can be used for single-photon emission computed tomography (SPECT) imaging .
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Cat. No.: HY-P991608
Synonyms: 7F11C7

Target:  

Mucin

Research Areas:  

Cancer

CTM01 is a murine IgG1 (or humanized IgG4) monoclonal antibody inhibitor targeting MUC1. CTM01 has a broad spectrum anticancer activity against solid tumors of epithelial origin, such as breast, lung and ovarian cancer .
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Cat. No.: HY-P9942
CAS No.: 167747-19-5

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Sulesomab (IMMU-MN3) is a murine monoclonal antibody fragment of the IgG1 class that binds to Normal Cross-Reactive Antigen-90 present on leukocytes. Sulesomab is cleared into infection nonspecifically through increased capillary membrane permeability .
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Cat. No.: HY-P991601

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Anti-IL6 Antibody (MH166) is a murine anti-hIL-6 monoclonal antibody. Anti-IL6 Antibody (MH166) can completely neutralize the activity of hIL-6 in vitro, but when used in combination with hIL-6 in vivo, Anti-IL6 Antibody (MH166) can enhance the activity and prolong the half-life of hIL-6, and increase the production of antigen-specific antibodies .
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