41 Results for "

pH-responsive

" in MedChemExpress (MCE) Product Catalog:
Products (41)

41 Results for "pH-responsive" in MCE Product Catalog:

Cat. No.: HY-W008034
CAS No.: 143824-78-6
Synonyms: Fmoc-L-Trp(Boc)-OH
Fmoc-Trp(Boc)-OH (Fmoc-L-Trp(Boc)-OH) is an amino acid derivative with protective groups. Fmoc-Trp(Boc)-OH can self-assemble into stable and pH-responsive spherical nanoparticles, which can load and release bioactive molecules, with good biocompatibility and high cell uptake rate. Fmoc-Trp(Boc)-OH can be used in research on drug delivery .
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Cat. No.: HY-P5423
CAS No.: 107658-43-5
Target:  

Exosomes Liposome

Research Areas:  

Cancer

GALA is a pH-responsive amphipathic peptide consisting of 30 amino acids, which acts as a lung endothelium-targeting ligand. GALA undergoes a conformational transition from random coil to α-helix in an acidic environment at pH 5.0, thereby inducing endosomal membrane destabilization and fusion. GALA-modified liposomes traverse lung endothelial cells via clathrin-dependent endocytosis and transcytosis, and specifically accumulate in the lungs after intravenous injection. GALA significantly promotes the cytosolic release of cargos carried by exosomes, plasmids and liposomes, effectively enhances gene transfection efficiency, and drives gene knockdown of functional macromolecules (such as siRNA) in alveolar epithelial cells (with no significant cytotoxicity at effective concentrations). GALA serves as a critical tool for studies on lung cancer metastasis (e.g., melanoma lung metastasis) and lung-targeted drug delivery systems .
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Cat. No.: HY-145795
CAS No.: 1883431-67-1
Purity:  ≥98.0%
OF-02 is an ionizable lipid for mRNA delivery and a key component of lipid nanoparticles (LNPs). OF-02 is protonated in the acidic endosomal environment to promote endosomal escape of mRNA and efficiently induce protein expression in target cells. OF-02 relies on the pH-responsive membrane fusion properties to form a complex with mRNA and destroy the endosomal membrane structure to achieve mRNA release in the cytoplasm. OF-02 is mainly used in the development of mRNA vaccines, gene editing, and protein replacement therapy[1][2][3].
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Cat. No.: HY-P4116
CAS No.: 2293160-09-3
Synonyms: pHLIP
Target:  

Peptides

Research Areas:  

Metabolic Disease Cancer

pH-Low Insertion Peptide (pHLIP) is a short, pH-responsive peptide capable of inserting across a cell membrane to form a transmembrane helix at acidic pH. pH-Low Insertion Peptide targets the acidic tumor microenvironment for tumors at early and metastatic stages with high specificity, used as a specific ligand. pH-Low Insertion Peptide successfully modify polylysine polymers to have the pH-responsive capability. pH-Low Insertion Peptide-based targeting of cancer presents an opportunity to monitor metabolic changes, and to selectively deliver imaging and therapeutic agents to tumors .
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Cat. No.: HY-W923198
CAS No.: 480439-15-4
Synonyms: Methacryloyloxy fluorescein
Fluorescein O-methacrylate (Methacryloyloxy fluorescein) is a pH-responsive fluorescent monomeric dye. Fluorescein O-methacrylate exhibits pH-responsive fluorescence properties: its fluorescence is activated under alkaline conditions and quenched under neutral or acidic conditions; reversible switching of fluorescence is achievable by adjusting the pH of the solution. Fluorescein O-methacrylate can be used as a monomer for the synthesis of amphiphilic fluorescein polymers. These polymers can self-assemble into stable polymer nanoparticles with enhanced aqueous-phase fluorescence, and also enable the conjugation of nanoparticles with amine-containing biomolecules to support sensitive optical detection of biomarkers (Ex/Em = 490/520 nm) .
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Cat. No.: HY-W127770
CAS No.: 569-61-9
Synonyms: Basic red 9
Target:  

Fluorescent Dye

Research Areas:  

Infection

Pararosaniline hydrochloride (Basic red 9) is a pH-responsive basic dye, as a biological stain to track certain proteins. The pH of the acidified Pararosaniline hydrochloride reagent has a significant effect on the color and the maximum absorption wavelength (λmax) of the reaction system, with its optimum pH 0.48 and a λmax at 549 nm. Pararosaniline hydrochloride is also a strong modifier of RNA splicing. Pararosaniline hydrochloride has been used in the analysis of SO2 and formaldehyde and staining of bacteria or other organisms. Pararosaniline hydrochloride is extensively used in industries like textile, printing, paper, cosmetic, and leather .
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Cat. No.: HY-P5284
CAS No.: 1613231-49-4
Target:  

Peptides

Research Areas:  

Others

RALA peptide is a cationic amphiphilic delivery agent targeting cell membranes, which forms nanoparticles through electrostatic interactions with anionic drugs. RALA peptide has pH-responsive binding properties, which can enhance the α-helical conformation in an acidic environment and destroy the endosomal membrane, promote the release of drugs into the cytoplasm, and exert efficient intracellular delivery activity. RALA peptide can be used in cancer research (enhancing the activity of bisphosphonates against prostate cancer and breast cancer cells) and bone tissue engineering (promoting osteoblast collagen deposition and extracellular matrix mineralization) .
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Cat. No.: HY-W243303J
CAS No.: 9003-01-4
Poly(acrylic acid) (MW 250000) is a synthetic cationic electrolyte containing abundant carboxyl groups (-COOH), which exhibits excellent water absorption and retention properties and is often cross-linked to form hydrogels. Poly(acrylic acid) (with a molecular weight of 250,000). Poly(acrylic acid) (MW 250000) can be used as a non-collagenous analog in the biomimetic mineralization research of type I collagen. Poly(acrylic acid) (MW 250000) has pH responsiveness and biocompatibility and is often used as a drug carrier, surface modifier and functional material .
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Cat. No.: HY-118924
CAS No.: 1558079-49-4
Purity:  98.27%
IR-825 is a near infrared fluorescent dye.the end of IR-825 has carboxyl COOH active group, and can participate in the reaction to connect other molecules. IR-825 can be widely used in tumor photothermal study. .
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Cat. No.: HY-P4116A
Synonyms: pHLIP TFA
Target:  

Peptides

Research Areas:  

Metabolic Disease Cancer

pH-Low Insertion Peptide TFA (pHLIP TFA) is a short, pH-responsive peptide capable of inserting across a cell membrane to form a transmembrane helix at acidic pH. pH-Low Insertion Peptide TFA targets the acidic tumor microenvironment for tumors at early and metastatic stages with high specificity, used as a specific ligand. pH-Low Insertion Peptide TFA successfully modifys polylysine polymers to have the pH-responsive capability. pH-Low Insertion Peptide TFA -based targeting of cancer presents an opportunity to monitor metabolic changes and to selectively deliver imaging and therapeutic agents to tumors .
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Cat. No.: HY-W243303N
CAS No.: 9003-01-4
Poly(acrylic acid) (Mv 500000) is an anionic polyacrylic acid. Poly(acrylic acid) (Mv 500000) possesses thickening, dispersing, and pH-responsive gelling properties. Poly(acrylic acid) (Mv 500000) can be used in biochemical, cosmetic, and various industrial formulations .
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Cat. No.: HY-D1463
CAS No.: 699018-10-5
Nile Blue Methacrylamide is a pH-responsive probe. Nile Blue Methacrylamide exhibits pH-sensitive absorption and fluorescence emission in the physiological pH range, with spectral shifts occurring between acidic and near-physiological pH conditions . (Ex/Em = 590/670-700 nm)
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Cat. No.: HY-P11353
CAS No.: 117138-19-9
Research Areas:  

Cancer

HA2 peptide is a potent pH-responsive fusogenic peptide derived from hemagglutinin (HA). HA2 peptide is anionic and can be conjugated to cationic peptides for siRNA condensation. HA2 peptide can be used for the research of cancer .
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Cat. No.: HY-P11055
CAS No.: 2169935-95-7
Target:  

Bacterial

Research Areas:  

Infection

IKFQFHFD is a pH-responsive and self-assembling peptide. IKFQFHFD is biocompatible at neutral pH and becomes an antimicrobial peptide-like molecular structure only at acidic pH. IKFQFHFD can be used for chronic wounds (venous ulcers, diabetic ulcers, and pressure ulcers) induced by biofilm infections research .
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Cat. No.: HY-172403
CAS No.: 25608-40-6
Research Areas:  

Others

Poly-L-aspartic acid is an acidic polypeptide that functions via pH-dependent conformational changes. Poly-L-aspartic acid is promising for research of pH-responsive structural transitions in biological systems .
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Cat. No.: HY-172692
Target:  

Liposome

Research Areas:  

Cancer

DSPE-PEG1000-TH is a PEG compound which composed of DSPE and a pH-responsive cell penetrating peptide (TH). TH is activated in an acidic environment (such as the tumor microenvironment) and can selectively carry small molecules, oligonucleotides, proteins, etc. into tumor cells .
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Cat. No.: HY-172693
DSPE-PEG2000-TH is a PEG compound which composed of DSPE and a pH-responsive cell penetrating peptide (TH). TH is activated in an acidic environment (such as the tumor microenvironment) and can selectively carry small molecules, oligonucleotides, proteins, etc. into tumor cells .
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Cat. No.: HY-177344
CAS No.: 2857089-36-0
Research Areas:  

Cancer

IAJD-97 is a single-component ionizable amphiphilic Janus dendrimer carrier targeting mRNA delivery, which self-assembles into dendrimersomes (DNPs) via pH-responsive mechanisms to efficiently encapsulate and protect mRNA, while facilitating cellular uptake and endosomal escape through ionizable amine groups. IAJD-97 is promising for research of cancers .
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Cat. No.: HY-W008034S
CAS No.: 1325307-52-5
Synonyms: Fmoc-L-Trp(Boc)-OH-13C11,15N2
Fmoc-Trp(Boc)-OH- 13C11, 15N2 (Fmoc-L-Trp(Boc)-OH- 13C11, 15N2) is the 13C-labeled and 15N-labeled Fmoc-Trp(Boc)-OH (HY-W008034). Fmoc-Trp(Boc)-OH (Fmoc-L-Trp(Boc)-OH) is an amino acid derivative with protective groups. Fmoc-Trp(Boc)-OH can self-assemble into stable and pH-responsive spherical nanoparticles, which can load and release bioactive molecules, with good biocompatibility and high cell uptake rate. Fmoc-Trp(Boc)-OH can be used in research on drug delivery .
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Cat. No.: HY-172710
DSPE-PEG1000-R6H4 is a PEG compound which composed of DSPE and pH responsive membrane-penetrating peptide (R6H4). R6H4 can be used for pH responsive anticancer drug delivery purposes. DSPE-PEG1000-R6H4 can be used for drug delivery .
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