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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
69 Results for "
peptidylprolyl isomerase
" in MedChemExpress (MCE) Product Catalog:
Products (69)
69 Results for "peptidylprolyl isomerase" in MCE Product Catalog:
Cat. No.: HY-P2930
CAS No.: 95076-93-0
Target:
Research Areas:
Peptidylprolyl isomerase is an enzyme that catalyzes the cis-trans isomerization of peptidylprolyl amino groups. Peptidylprolyl isomerase may be involved in cellulase modification. Peptidylprolyl isomerase also functions as a chaperone protein .
3
Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17 nM. Sulfopin blocks Myc-driven tumors in vivo. The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors .
2
2 Cited Publications
Cat. No.: HY-P70007A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPIA; Epididymis Secretory Sperm Binding Protein Li 69p; peptidylprolyl isomerase A; peptidylprolyl isomerase A (Cyclophilin A); CYPA; Peptidyl-Prolyl Cis-Trans isomerase; Peptidyl-Prolyl Cis-Trans isomerase A; T Cell Cyclophilin; Cyclosporin A-Binding Pr
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC50 of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development .
1
1 Cited Publications
Cat. No.: HY-P71224
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PPID; PPIase D; peptidylprolyl isomerase D; 40 KDa Peptidyl-Prolyl Cis-Trans isomerase D; CYP-40; peptidylprolyl isomerase D (Cyclophilin D); Peptidyl-Prolyl Cis-Trans isomerase D; Peptidyl-Prolyl Cis-Trans isomerase; Rotamase D; Testicular Tissue Protein
Species:
Human
Source:
E. coli
Cat. No.: HY-P4202
CAS No.: 128802-76-6
Synonyms: Suc-AEPF-pNA
Target:
Research Areas:
Cat. No.: HY-P4581
CAS No.: 128802-78-8
Synonyms: Suc-ALPF-pNA
Cat. No.: HY-P4202A
Synonyms: Suc-AEPF-pNA TFA
Target:
Research Areas:
Cat. No.: HY-P3480
CAS No.: 202739-41-1
Target:
Research Areas:
Cat. No.: HY-143903
CAS No.: 2883498-73-3
ZL-Pin13 is a high potent cell-active covalent inhibitor targeting the Pin1 (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) with an IC50 of 67 nM. ZL-Pin13 effectively inhibits the proliferation and downregulated the Pin1 substrates in MDA-MB-231 cells .
Cat. No.: HY-P10411
CAS No.: 2396407-35-3
Cat. No.: HY-125182
CAS No.: 2649904-85-6
Target:
Research Areas:
SMCypI C31 is a non-peptidic cyclophilin inhibitor with potent peptidyl-prolyl cis/trans isomerases (PPIase) inhibitory activity (IC50 of 0.1 µM). SMCypI C31 shows pangenotype anti-HCV activity with EC50s ranging from 1.20 to 7.76 μM for genotype 1a, 1b, 2a, 3a, and 5a HCV subgenomic replicons (HCV-SGRs) and chimeric genotype 2a/4a HCV-SGRs. SMCypI C31 disrupts the cyclophilin A-NS5A interaction .
Cat. No.: HY-12135
CAS No.: 1239513-63-3
Target:
Research Areas:
Poloxipan is a pan-specific polo-like kinase (PLK) inhibitor that can inhibit a non-catalytic region at the C-terminus called the Polo-box domain (PBD) found in kinases. The IC50 values for Poloxipan against the PBDs of PLK-1/2/3 are 3.2 μM, 1.7 μM, and 3.0 μM, respectively. Poloxipan also inhibits other phospho-tyrosine binding domains, such as the forkhead-associated (FHA) domain of CHK-2, the WW domain of peptidyl-prolyl cis/trans isomerase (PIN1), and the phospho-tyrosine binding domains of STAT1/3/5 and lymphocyte-specific protein tyrosine kinase's SH2 domain. Poloxipan can be used in cancer research .
Cat. No.: HY-183450
CAS No.: 71458-51-0
Supradamal is a peptidyl-prolyl cis-trans isomerase (PPIase) inhibitor with an IC50 of 83 nM against *Plasmodium falciparum* and an IC50 of 75 nM against *Plasmodium vivax*. Supradamal inhibits the development, maturation and in vitro growth of *Plasmodium falciparum* trophozoites. Supradamal is applicable to malaria-related research .
Cat. No.: HY-P71224A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPID; PPIase D; peptidylprolyl isomerase D; 40 KDa Peptidyl-Prolyl Cis-Trans isomerase D; CYP-40; peptidylprolyl isomerase D (Cyclophilin D); Peptidyl-Prolyl Cis-Trans isomerase D; Peptidyl-Prolyl Cis-Trans isomerase; Rotamase D; Testicular Tissue Protein
Species:
Human
Source:
E. coli
Cat. No.: HY-P70047A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPIA; Epididymis Secretory Sperm Binding Protein Li 69p; peptidylprolyl isomerase A; peptidylprolyl isomerase A (Cyclophilin A); CYPA; Peptidyl-Prolyl Cis-Trans isomerase; Peptidyl-Prolyl Cis-Trans isomerase A; T Cell Cyclophilin; Cyclosporin A-Binding Pr
Species:
Human
Source:
E. coli
Cat. No.: HY-P74211A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PPIF; HCyP3; peptidylprolyl isomerase F; CyP-M; CypD; CYP3; Cyclophilin D; Peptidyl-Prolyl Cis-Trans isomerase, Mitochondrial; Cyp-D; peptidylprolyl isomerase F (Cyclophilin F); Peptidyl-Prolyl Cis-Trans isomerase F, Mitochondrial; Peptidyl-Prolyl Cis-Tra
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
