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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
38 Results for "
phosphoinositide 3-kinase
" in MedChemExpress (MCE) Product Catalog:
Products (38)
38 Results for "phosphoinositide 3-kinase" in MCE Product Catalog:
7
7 Publications Verification
Cat. No.: HY-P81211
Synonyms: PI3-kinase p110 subunit beta; p-PI3Kβ(Ser1070); PI 3-kinase C2β; p110 BETA; p110Beta; Phosphatidylinositol 3 kinase catalytic beta polypeptide; Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit beta; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit beta isoform; Phosphatidylinositol-4; phosphoinositide 3 kinase catalytic beta polypeptide; PI3 kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K beta; PI3K-beta; PI3Kbeta; PI3KCB; PIK3C1; Pik3cb; PK3CB_HUMAN; PtdIns 3 kinase p110; PtdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; 5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; 5-bisphosphate 3-kinase catalytic subunit beta isoform.
1
1 Cited Publications
Cat. No.: HY-P701744
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PIK3R3; PI3-kinase Regulatory Subunit Gamma; phosphoinositide-3-kinase Regulatory Subunit 3; PI3K Regulatory Subunit Gamma; Phosphatidylinositol 3-kinase 55 KDa Regulatory Subunit Gamma; PI3-kinase Subunit P55-Gamma; Phosphatidylinositol 3-kinase Regulato
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-N4246
CAS No.: 382148-47-2
Cat. No.: HY-P5433
CAS No.: 865778-50-3
Target:
Research Areas:
Cat. No.: HY-161366
CAS No.: 3033806-03-7
OMS14 is exhibits inhibitory activity for phosphoinositide 3-kinase γ (PI3Kγ) and PIK3CD/PIK3R1, which inhibits 19% PI3Kγ and 65% PIK3CD/PIK3R1 activity at 100 μM. OMS14 exhibits anticancer efficacy in various cancer cells .
FD223 is a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor. FD223 displays high potency (IC50=1 nM) and good selectivity over other isoforms (IC50s of 51 nM, 29 nM and 37 nM, respectively for α, β and γ). FD223 exhibits efficient inhibition of the proliferation of acute myeloid leukemia (AML) cell lines by suppressing p-AKT Ser473 thus causing G1 phase arrest during the cell cycle. FD223 has potential for the research of leukemia such as AML .
Cat. No.: HY-115814
CAS No.: 1975263-74-1
Target:
Research Areas:
AM-1430 is an efficient, highly selective and orally active small molecule inhibitor of PI3Kδ with an IC50 of 4.6 nM. AM-1430 exhibits IC50s for PI3Kα, PI3Kβ and PI3Kγ of 14.18, 2.2 and 3.22 μM, respectively. AM-1430 inhibits B cell proliferation and exhibits excellent in vivo activity in pAKT inhibition models and the hemoglobin (KLH) immune response model. AM-1430 can be used for the study of inflammation and autoimmune diseases .
Cat. No.: HY-139880
CAS No.: 2566569-31-9
PI3Kγ inhibitor 5 is an inhibitor of phosphoinositide 3-kinase γ (PI3Kγ) with an IC50 value of 34 nM.
Cat. No.: HY-P991842
Target:
Research Areas:
Cat. No.: HY-101115
CAS No.: 1842380-77-1
PI3K-IN-6 (compound 20a) is an oral active and highly selective phosphoinositide 3-kinase (PI3K) β/δ inhibitor, with IC50 values of 7.8 nM/5.3 nM for PI3K β/δ, respectively. PI3K-IN-6 (compound 20a) has potential top treat phosphatase and tensin homolog (PTEN) feficient tumors .
Cat. No.: HY-171558
CAS No.: 2633645-58-4
PI3K-IN-56 (Compound 1) is an orally active, potent and selective irreversible inhibitor of phosphoinositide 3-kinase (PI3K). PI3K-IN-56 irreversibly blocks the phosphatidylinositol-3,4,5-triphosphate (PIP3) production and downstream AKT signaling pathway. PI3K-IN-56 is promising for research of PI3Kα-driven cancers, such as breast and ovarian cancers .
Cat. No.: HY-163360
CAS No.: 885692-56-8
PI3Kα-IN-19 (Compound 1) is a PI3Kα inhibitor with a targeted binding site at the p110α catalytic subunit. PI3Kα is one of the most common dysregulated kinases used in cancer research .
Cat. No.: HY-107387
CAS No.: 851757-93-2
Target:
Research Areas:
PF-376304 is an orally active non-specific class I phosphoinositide 3-kinase (PI3K) inhibitor with an IC50 of 0.197 μM against PI3Kγ. PF-376304 induces dose-dependent glucose and lipid metabolic disorders in rats, causes rapid death at high doses, and leads to metabolic abnormalities that are self-reversible at low doses. PF-376304 is applicable to the research of metabolic and inflammatory diseases .
Cat. No.: HY-158688
CAS No.: 3048633-11-7
Target:
Research Areas:
PI3Kδ-IN-21 (Compound 31) is a selective inhibitor for phosphoinositide 3-kinases δ (PI3Kδ), with an IC50 of 13.6 nM. PI3Kδ-IN-21 inhibits proliferation and differentation of T cells through PI3K/AKT/mTOR signaling pathway. PI3Kδ-IN-21 exhibits good pharmacokinetic characters in rat model, and attenuates the experimental autoimmune encephalomyelitis in myelin oligodendrocyte glycoprotein (MOG)-induced EAE model .
Cat. No.: HY-P85585
Synonyms: p85; p85 beta; p85-BETA; P85B; P85B_HUMAN; Phosphatidylinositol 3 kinase; Phosphatidylinositol 3 kinase regulatory beta subunit; Phosphatidylinositol 3 kinase regulatory subunit beta; Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2; Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2; p85 beta; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; phosphatidylinositol 3-kinase; Phosphatidylinositol 3-kinase regulatory beta subunit; Phosphatidylinositol 3-kinase regulatory subunit beta; phosphoinositide 3 kinase regulatory subunit 2; beta; phosphoinositide 3 kinase regulatory subunit 2; phosphoinositide 3 kinase regulatory subunit polypeptide 2; p85 beta; phosphoinositide 3 kinase regulatory subunit polypeptide 2; phosphoinositide 3 kinase, regulatory subunit 2; beta; phosphoinositide 3 kinase, regulatory subunit 2; p85 beta; PI3 kinase p85 beta subunit; PI3 kinase p85 subunit beta; PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PI3K; PI3K regulatory subunit beta; PIK3R 2; PIK3R2; polypeptide 2; p85 beta; PtdIns 3 kinase p85 beta; PtdIns-3-kinase p85-beta; PtdIns-3-kinase regulatory subunit beta; PtdIns-3-kinase regulatory subunit p85-beta.
Cat. No.: HY-P701752
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PIK3C3; PtdIns-3-kinase Type 3; Phosphatidylinositol 3-kinase Catalytic Subunit Type 3; PI3-kinase Type 3; HVps34; PI3K Type 3; Vps34; Phosphatidylinositol 3-kinase, Catalytic Subunit Type 3; Phosphatidylinositol 3-kinase P100 Subunit; phosphoinositide-3-
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P83044
Synonyms: Phosphatidylinositol 3-kinase catalytic subunit type 3 (EC:2.7.1.137); PI3-kinase type 3; PI3K type 3; PtdIns-3-kinase type 3; Phosphatidylinositol 3-kinase p100 subunit; phosphoinositide-3-kinase class 3; hVps34; VPS34 antibodyPIK3C3;
Cat. No.: HY-P703466
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PIK3R1; PI3-kinase Subunit P85-Alpha; phosphoinositide-3-kinase Regulatory Subunit 1; PI3 kinase-Associated P85; GRB1; CDNA FLJ44373 Fis, Clone TRACH3009455, Highly Similar To Phosphatidylinositol 3-kinase Regulatory Subunit Alpha; Phosphatidylinositol 3-kinase 85 KDa Regulatory Subunit Alpha; Phosphatidylinositol 3-kinase, Regulatory Subunit, Polypeptide 1 (P85 Alpha); Phosphatidylinositol 3-kinase Regulatory Subunit Alpha; Phosphatidylinositol 3-kinase-Associated P-85 Alpha; P85-ALPHA; PtdIns-3-kinase Regulatory Subunit P85-Alpha; P85alpha; phosphoinositide-3-kinase Regulatory Subunit; P85; PI3-kinase Regulatory Subunit Alpha; phosphoinositide-3-kinase, Regulatory Subunit 1 (Alpha); PIK3R1/NR4A3 Fusion Protein; phosphoinositide-3-kinase Regulatory Subunit Alpha; NR4A3 Fusion; PtdIns-3-kinase Regulatory Subunit Alpha; IMD36; Growth Factor Receptor Bound 1; AGM7; PI3K Regulatory Subunit Alpha; MHC class I antigen; MHC class I protein; Mamu-A1; Mamu-A
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703469
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: PIK3R1; PI3-kinase Subunit P85-Alpha; phosphoinositide-3-kinase Regulatory Subunit 1; PI3 kinase-Associated P85; GRB1; CDNA FLJ44373 Fis, Clone TRACH3009455, Highly Similar To Phosphatidylinositol 3-kinase Regulatory Subunit Alpha; Phosphatidylinositol 3-kinase 85 KDa Regulatory Subunit Alpha; Phosphatidylinositol 3-kinase, Regulatory Subunit, Polypeptide 1 (P85 Alpha); Phosphatidylinositol 3-kinase Regulatory Subunit Alpha; Phosphatidylinositol 3-kinase-Associated P-85 Alpha; P85-ALPHA; PtdIns-3-kinase Regulatory Subunit P85-Alpha; P85alpha; phosphoinositide-3-kinase Regulatory Subunit; P85; PI3-kinase Regulatory Subunit Alpha; phosphoinositide-3-kinase, Regulatory Subunit 1 (Alpha); PIK3R1/NR4A3 Fusion Protein; phosphoinositide-3-kinase Regulatory Subunit Alpha; NR4A3 Fusion; PtdIns-3-kinase Regulatory Subunit Alpha; IMD36; Growth Factor Receptor Bound 1; AGM7; PI3K Regulatory Subunit Alpha; MHC class I antigen; MHC class I protein; Mamu-A1; Mamu-A
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P706085
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: MHC class I antigen; MHC class I protein; Mamu-A1; Mamu-A; PIK3R1; PI3-kinase Subunit P85-Alpha; phosphoinositide-3-kinase Regulatory Subunit 1; PI3 kinase-Associated P85; GRB1; CDNA FLJ44373 Fis, Clone TRACH3009455, Highly Similar To Phosphatidylinositol 3-kinase Regulatory Subunit Alpha; Phosphatidylinositol 3-kinase 85 KDa Regulatory Subunit Alpha; Phosphatidylinositol 3-kinase, Regulatory Subunit, Polypeptide 1 (P85 Alpha); Phosphatidylinositol 3-kinase Regulatory Subunit Alpha; Phosphatidylinositol 3-kinase-Associated P-85 Alpha; P85-ALPHA; PtdIns-3-kinase Regulatory Subunit P85-Alpha; P85alpha; phosphoinositide-3-kinase Regulatory Subunit; P85; PI3-kinase Regulatory Subunit Alpha; phosphoinositide-3-kinase, Regulatory Subunit 1 (Alpha); PIK3R1/NR4A3 Fusion Protein; phosphoinositide-3-kinase Regulatory Subunit Alpha; NR4A3 Fusion; PtdIns-3-kinase Regulatory Subunit Alpha; IMD36; Growth Factor Receptor Bound 1; AGM7; PI3K Regulatory Subunit Alpha
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
