1. PI3K/Akt/mTOR
  2. PI3K
  3. PI3K-IN-6

PI3K-IN-6 (compound 20a) is an oral active and highly selective phosphoinositide 3-kinase (PI3K) β/δ inhibitor, with IC50 values of 7.8 nM/5.3 nM for PI3K β/δ, respectively. PI3K-IN-6 (compound 20a) has potential top treat phosphatase and tensin homolog (PTEN) feficient tumors.

For research use only. We do not sell to patients.

PI3K-IN-6 Chemical Structure

PI3K-IN-6 Chemical Structure

CAS No. : 1842380-77-1

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Description

PI3K-IN-6 (compound 20a) is an oral active and highly selective phosphoinositide 3-kinase (PI3K) β/δ inhibitor, with IC50 values of 7.8 nM/5.3 nM for PI3K β/δ, respectively. PI3K-IN-6 (compound 20a) has potential top treat phosphatase and tensin homolog (PTEN) feficient tumors[1].

IC50 & Target

PI3Kβ

7.8 nM (IC50)

PI3Kδ

5.3 nM (IC50)

PI3Kα

850 nM (IC50)

Molecular Weight

450.26

Formula

C17H14Cl2FN9O

CAS No.
SMILES

FC1=CC(Cl)=C(N=C([C@@H](NC2=C(Cl)C(N)=NC(N)=N2)C)N(C3=NNC=C3)C4=O)C4=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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PI3K-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PI3K-IN-6
Cat. No.:
HY-101115
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