PI3K-IN-6
Based on 1 publication(s) in Google Scholar
PI3K-IN-6 (compound 20a) is an oral active and highly selective phosphoinositide 3-kinase (PI3K) β/δ inhibitor, with IC50 values of 7.8 nM/5.3 nM for PI3K β/δ, respectively. PI3K-IN-6 (compound 20a) has potential top treat phosphatase and tensin homolog (PTEN) feficient tumors.
For research use only. We do not sell to patients.
- CAS No.: 1842380-77-1
- Formula: C17H14Cl2FN9O
- Molecular Weight:450.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) PI3K-IN-6
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Biological Activity
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PI3Kβ 7.8 nM (IC50) |
PI3Kδ 5.3 nM (IC50) |
PI3Kα 850 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A498 | GI50 |
80 nM
Compound: 20a
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Growth inhibition of human A498 cells harboring PI3Kbeta mutant after 72 hrs by Celltiter-Glo reagent based assay
Growth inhibition of human A498 cells harboring PI3Kbeta mutant after 72 hrs by Celltiter-Glo reagent based assay
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[PMID: 28106991] |
| LNCaP | GI50 |
38 nM
Compound: 20a
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Growth inhibition of PTEN-deficient human LNCAP cells after 72 hrs by Celltiter-Glo reagent based assay
Growth inhibition of PTEN-deficient human LNCAP cells after 72 hrs by Celltiter-Glo reagent based assay
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[PMID: 28106991] |
| MDA-MB-415 | GI50 |
12 nM
Compound: 20a
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Growth inhibition of PTEN-deficient human MDA-MB-415 cells after 72 hrs by Celltiter-Glo reagent based assay
Growth inhibition of PTEN-deficient human MDA-MB-415 cells after 72 hrs by Celltiter-Glo reagent based assay
|
[PMID: 28106991] |
| PC-3 | GI50 |
120 nM
Compound: 20a
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Growth inhibition of PTEN-deficient human PC3 cells after 72 hrs by Celltiter-Glo reagent based assay
Growth inhibition of PTEN-deficient human PC3 cells after 72 hrs by Celltiter-Glo reagent based assay
|
[PMID: 28106991] |
| ZR-75-1 | GI50 |
2 nM
Compound: 20a
|
Growth inhibition of PTEN-deficient human ZR-75-1 cells after 72 hrs by Celltiter-Glo reagent based assay
Growth inhibition of PTEN-deficient human ZR-75-1 cells after 72 hrs by Celltiter-Glo reagent based assay
|
[PMID: 28106991] |
Chemical Information
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CAS No. 1842380-77-1
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Molecular Weight 450.26
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Formula C17H14Cl2FN9O
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SMILES
FC1=CC(Cl)=C(N=C([C@@H](NC2=C(Cl)C(N)=NC(N)=N2)C)N(C3=NNC=C3)C4=O)C4=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Neuropsychiatr Dis Treat
The Impact of Esketamine on Depression: Targeting Oxidative Stress and Neuronal Apoptosis Through BDNF/TrkB/PI3K/AKT Pathway Activation. [Abstract]2025 Aug 25:21:1783-1793. PMID: 40893928
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)