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primers

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43

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7

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5

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10

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1

Isotope-Labeled Compounds

3

Click Chemistry

8

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-43520
    BODIPY-FL

    		Fluorescent Dye Others
    BODIPY-FL is a green fluorescent dye that can be used to label probes or primers. BODIPY-FL fluorescence can be quenched after interacting with uniquely positioned guanine, making it useful for quantifying specific DNA or RNA molecules. The maximum absorption wavelength of BODIPY-FL is 505 nm, and the maximum emission wavelength is 513 nm .
    BODIPY-FL
  • HY-D1725
    Cy3-dCTP

    		Fluorescent Dye DNA Stain Others
    Cy3-dCTP is a directly fluorescently labeled deoxyribonucleotide, in which Cy3 is a cyanine fluorescent dye. Cy3-dCTP is used for direct enzymatic labeling of DNA and cDNA: with the aid of DNA polymerases, this modified nucleotide is incorporated into the extending DNA strand during processes such as reverse transcription, PCR, nick translation or random primer labeling .
    Cy3-dCTP
  • HY-E70094
    T4 UvsX Recombinase

    		DNA/RNA Synthesis Others
    T4 UvsX Recombinase helps initiate DNA replication on a double-stranded DNA template by catalyzing synapsis between the template and a homologous DNA single strand that serves as primer. T4 UvsX Recombinase greatly amplifies the snap-back (hairpin-primed) DNA synthesis that is catalyzed by the T4 DNA polymerase holoenzyme on linear, single-stranded DNA templates .
    T4 UvsX Recombinase
  • HY-D1668
    Biotin-11-dCTP

    		DNA Stain Reverse Transcriptase Infection Neurological Disease Cancer
    Biotin-11-dCTP is a biotinylated deoxynucleoside triphosphate and an important DNA labeling reagent. In random primer DNA labeling reactions, Biotin-11-dCTP incorporates into newly synthesized DNA strands to generate labeled DNA probes suitable for hybridization applications. In addition, Biotin-11-dCTP can serve as a substrate for terminal deoxynucleotidyl transferase to end-label oligonucleotides for telomere sequence detection, or to label the cut ends of linearized DNA molecules, thereby supporting streptavidin-based electron microscopy analysis. For example, Biotin-11-dCTP can label the cut ends of linearized DNA molecules under the action of dGTP and avian myeloblastosis virus reverse transcriptase .
    Biotin-11-dCTP
  • HY-132142
    5-Propargylamino-dCTP

    		DNA/RNA Synthesis Others
    5-Propargylamino-dCTP is a sustrate for DNA polymerases. 5-Propargylamino-dCTP can conjugate to molecular markers for use in nucleic acid labeling or sequence analysis. 5-Propargylamino-dCTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .
    5-Propargylamino-dCTP
  • HY-D1720
    Cy5-dATP

    		DNA/RNA Synthesis Others
    Cy5-dATP is a Cy5?(HY-D0821)-labeled dATP?(HY-136648). Cy5-dATP can be incorporated into a DNA primer .
    Cy5-dATP
  • HY-137697D
    ddCTP trisodium solution (100 mM)

    		HIV DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Drug Metabolite HIV Protease Infection
    ddCTP trilithium solution (100 mM) is a chain-terminating dideoxynucleotide. ddCTP trilithium is a type of chain-terminating deoxynucleotide. ddCTP trilithium can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP trilithium can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP trilithium is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication .
    ddCTP trisodium solution (100 mM)
  • HY-D1090
    ​JOE

    		DNA Stain Fluorescent Dye Others
    JOE is a xanthene fluorophore (i.e., 4′,5′-dichloro-2′,7′-dimethoxy-5 (6)-carboxyfluorescein; 2',7'-dimethoxy-4',5'-dichloro-6-carboxyfluorescein) with an absorption wavelength of approximately 525 nm and an emission wavelength of approximately 550 nm. The fluorescence quantum yield of JOE correlates with the rigidity of the linker arm and the distance to dG nucleoside. JOE is commonly used as a fluorescent label for oligonucleotides and molecular beacon probes, and also serves as the acceptor fluorophore in fluorescence energy transfer primers for DNA sequencing .
    ​JOE
  • HY-W719041
    1,6-Di-O-galloyl-β-D-glucose

    		HIV Reverse Transcriptase Infection
    1,6-Di-O-galloyl-β-D-glucose is a compound found in the fruit of Phyllanthus emblica. 1,6-Di-O-galloyl-β-D-glucose has HIV-1 reverse transcriptase (RT) inhibitory activity with an IC50 value of 270 μM. The inhibitory mechanism of 1,6-Di-O-galloyl-β-D-glucose is competitive inhibition of the template primer and non-competitive inhibition of the substrate (dTTP). 1,6-Di-O-galloyl-β-D-glucose can be used in anti-HIV research .
    1,6-Di-O-galloyl-β-D-glucose
  • HY-136650A
    Fludarabine triphosphate trisodium
    1 Publications Verification

    F-ara-ATP trisodium

    		 Nucleoside Antimetabolite/Analog Drug Metabolite DNA/RNA Synthesis Apoptosis Cancer
    Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis .
    Fludarabine triphosphate trisodium
  • HY-13247
    Setrobuvir

    ANA598

    		 DNA/RNA Synthesis HCV SARS-CoV Infection
    Setrobuvir (ANA598) is an orally active non-nucleosidic HCV NS5B polymerase inhibitor. ANA-598 inhibits both de novo RNA synthesis and primer extension, with IC50s between 4 and 5 nM. Setrobuvir also shows excellent binding affinity to SARS-CoV-2 RdRp and induces RdRp inhibition .
    Setrobuvir
  • HY-137697
    ddCTP

    		Nucleoside Antimetabolite/Analog DNA/RNA Synthesis HIV Protease HIV Drug Metabolite Infection
    ddCTP is a type of chain-terminating deoxynucleotide. ddCTP can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication .
    ddCTP
  • HY-W048513
    7-Deaza-2'-deoxyadenosine

    		DNA/RNA Synthesis Cancer
    7-Deaza-2'-deoxyadenosine is an isosteric dATP analog of 2'-deoxyadenosine. 7-Deaza-2'-deoxyadenosine is recognized by various DNA polymerases and incorporated into DNA strands as a substrate. 7-Deaza-2'-deoxyadenosine undergoes a bioorthogonal inverse electron demand Diels-Alder reaction with tetrazine-modified molecules, enabling site-specific labeling of DNA, surface antibody immobilization and intracellular fluorescent labeling. 7-Deaza-2'-deoxyadenosine reduces the DNA curvature of d(A6)·d(T6) fragments and the stability of DNA/RNA double helices, and leads to decreased antisense activity against SV40 T Antigen. 7-Deaza-2'-deoxyadenosine finds application in the research field of SV40 T Antigen-related cancers .
    7-Deaza-2'-deoxyadenosine
  • HY-137868
    Decanoyl coenzyme A

    Decanoyl-coa

    		 Endogenous Metabolite Endocrinology
    Decanoyl coenzyme A (Decanoyl CoA) is a primer for the fatty acid elongation system in Mycobacterium smegmat .
    Decanoyl coenzyme A
  • HY-15349
    Trovirdine
    1 Publications Verification

    LY300046

    		 HIV Infection
    Trovirdine inhibits HIV-1 RT with an IC50 of 7 nM when employing heteropolymeric primer/template (oligo-DNA/ribosomal RNA)and dGTP as substrate.
    Trovirdine
  • HY-163529
    HN0037

    		HSV Cytochrome P450 Infection
    HN0037 is a selective, orally active Helicase-primase inhibitor. HN0037 is mainly metabolized by CYP3A4. HN0037 inhibits HSV replication by targeting the viral helicase-primase complex, which consists of three proteins encoded by UL5 (helicase), UL52 (primase), and UL8 (scaffold protein that promotes primer synthesis) .
    HN0037
  • HY-100513
    (±)-Dehydroaltenusin

    		DNA/RNA Synthesis Apoptosis Antibiotic Cancer
    (±)-Dehydroaltenusin, an antibiotic, is a selective eukaryotic DNA polymerase α (pol α) inhibitor with an IC50 of 0.68 μM. (±)-Dehydroaltenusin can be isolated from fungus Alternaria tenuis. (±)-Dehydroaltenusin competitively inhibits the DNA template primer (Ki: 0.23 μM) and non-competitively suppresses the 2'-deoxyribonucleoside 5'-triphosphate substrate (Ki: 0.18 μM). (±)-Dehydroaltenusin induces the cancer cell S-phase cycle arrest and apoptosis. (±)-Dehydroaltenusin can be used for cancers like human adenocarcinoma research .
    (±)-Dehydroaltenusin
  • HY-151682
    H-L-Lys(Norbornene-methoxycarbonyl)-OH

    		Amino Acid Derivatives Others
    H-L-Lys(Norbornene-methoxycarbonyl)-OH is a Norbornene (HY-W013021)-derivatized lysine that can be click-functionalized. H-L-Lys(Norbornene-methoxycarbonyl)-OH can be used for the mild and selective modification of proteins in a copper-free click reaction .
    H-L-Lys(Norbornene-methoxycarbonyl)-OH
  • HY-W048492
    7-Iodo-7-deaza-2'-deoxyguanosine

    7-Deaza-7-Iodo-2'-deoxyguanosine

    		 DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Others
    7-Iodo-7-deaza-2'-deoxyguanosine (7-Deaza-7-Iodo-2'-deoxyguanosine) is a modified deoxyguanosine nucleoside. 7-Iodo-7-deaza-2'-deoxyguanosine is used in DNA synthesis and sequencing reactions .
    7-Iodo-7-deaza-2'-deoxyguanosine
  • HY-136650
    Fludarabine triphosphate

    F-ara-ATP

    		 Nucleoside Antimetabolite/Analog Drug Metabolite DNA/RNA Synthesis Apoptosis Cancer
    Fludarabine triphosphate (F-ara-ATP), the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis .
    Fludarabine triphosphate
  • HY-W001974
    7-Nitroindole

    		DNA/RNA Synthesis Bacterial Others
    7-Nitroindole is a cleavable base analog and Antibacterial agent. 7-Nitroindole inhibits the growth of Lactobacillus arabinosus. 7-Nitroindole is used in studies of light-controlled DNA cleavage and Lactobacillus arabinosus infection .
    7-Nitroindole
  • HY-137697B
    ddCTP trilithium

    		HIV DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Drug Metabolite HIV Protease Infection
    ddCTP trilithium is a type of chain-terminating deoxynucleotide. ddCTP trilithium can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP trilithium can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP trilithium is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication .
    ddCTP trilithium
  • HY-155869
    5-fluoro-dCTP

    5-Fluoro-2′-deoxycytidine 5′-triphosphate

    		 DNA/RNA Synthesis Others
    5-fluoro-dCTP is a fluorinated pyrimidine dNTP that can be used as a substrate for the incorporation of fluorine modification into specific DNA sequences by primer extension (PEX) catalyzed by Pwo polymerase .
    5-fluoro-dCTP
  • HY-174252
    HSV-1/HSV-2-IN-3

    		DNA/RNA Synthesis HSV Infection
    HSV-1/HSV-2-IN-3 inhibits the herpes-simplex-virus (HSV) helicase-primase complex, blocking the coordinated DNA-unwinding and primer-synthesis steps required for viral genome replication. HSV-1/HSV-2-IN-3 exhibits an EC50 of 7.0 nM against HSV-2 in a gD-immunofluorescence cell assay containing 2 % FBS and 57.5 nM when 10 % human serum is present. HSV-1/HSV-2-IN-3 achieves an EC50 of 1.1 nM in a qPCR replication assay. HSV-1/HSV-2-IN-3 shows strong selectivity over human carbonic-anhydrase off-targets (IC50 ≈ 2.9 µM for hCA II and > 35 µM for hCA I). HSV-1/HSV-2-IN-3 can be studied in anti-HSV research .
    HSV-1/HSV-2-IN-3
  • HY-131817
    5'-GMPS

    		DNA/RNA Synthesis Others
    5'-GMPS is an analogue of 5'-GMP and a substrate, competitive inhibitor or regulator of enzymes that interact with 5'-GMP. 5'-GMPS is suitable as a primer of RNA synthesis by T7 RNA polymerase .
    5'-GMPS
  • HY-E70253
    Tridecanoyl-CoA triammonium

    		Biochemical Assay Reagents Others
    Tridecanoyl-CoA triammonium, a coenzyme, is used as a primer .
    Tridecanoyl-CoA triammonium
  • HY-137868A
    Decanoyl coenzyme A triammonium

    Decanoyl-COA triammonium

    		 Endogenous Metabolite Endocrinology
    Decanoyl coenzyme A (Decanoyl CoA) triammonium is a primer for the fatty acid elongation system in Mycobacterium smegmat .
    Decanoyl coenzyme A triammonium
  • HY-124592
    BMT-052

    		HCV Infection
    BMT-052 is a pan-genotypic hepatitis C (HCV) NS5B polymerase primer grip inhibitor .
    BMT-052
  • HY-155869A
    5-fluoro-dCTP sodium

    5-Fluoro-2′-deoxycytidine 5′-triphosphate sodium

    		 DNA/RNA Synthesis Others
    5-fluoro-dCTP sodium is a fluorinated pyrimidine dNTP that can be used as a substrate for the incorporation of fluorine modification into specific DNA sequences by primer extension (PEX) catalyzed by Pwo polymerase .
    5-fluoro-dCTP sodium
  • HY-172452
    RSV L-protein-6

    		RSV Infection
    RSV L-protein-6 (Compound 19a) is a respiratory syncytial virus polymerase inhibitor, with an IC50 of 13 nM in SPA primer extensions enzymatic assay. RSV L-protein-6 can inhibit RSV replication in Hela cells .
    RSV L-protein-6
  • HY-19143
    L-697639

    		HIV Infection
    L-697639 is an inhibitor for HIV-1 reverse transcriptase (HIV-1 RT) with IC50 of 20-400 nM (in a template-primer-dependent manner). L-697639 exhibits antiviral activity, that inhibits 95% HIV-1 infection at concentrations of 12-200 nM in human T lymphocyte cultures .
    L-697639
  • HY-N7232
    Limocrocin

    		Reverse Transcriptase Infection
    Limochromin is a pigment produced by Streptomyces limosus that strongly inhibits the reverse transcriptase of avian myeloid leukemia virus (AMV). The inhibitory activity of limochromin is not affected by changes in the concentration of template-primer, substrate or carrier protein, but its inhibitory effect is significantly reduced when the concentration of AMV reverse transcriptase increases. Limochromin can be used to develop antiviral treatments .
    Limocrocin
  • HY-122532
    Fagaronine chloride

    		Histone Methyltransferase Cancer
    Fagaronine chloride is an alkaloid with inhibitory activity against reverse transcriptase and topoisomerase I. Fagaronine chloride can effectively inhibit the reverse transcriptase of RSii tumor virus at a concentration of 6-60 μg/mL. Fagaronine chloride rapidly blocks the synthesis of DNA polymerase by interacting with the template primer. Fagaronine chloride has shown anti-tumor potential, especially in the study of retroviral infection .
    Fagaronine chloride
  • HY-168473
    13-TP

    		SARS-CoV DNA/RNA Synthesis Infection
    13-TP is an inhibitor of SARS-CoV-2. 13-TP effectively inhibits the SARS-CoV-2 central replication transcription complex (C-RTC, nsp12-nsp7-nsp82) catalyzed in vitro RNA synthesis. 13-TP completely inhibits the RdRp polymerization activity. 13-TP blocks the full extension of some of the primer RNA .
    13-TP
  • HY-154871
    α-D-Glucosamine 1-phosphate

    		Drug Derivative Biochemical Assay Reagents Others
    α-D-Glucosamine 1-phosphate is a glycosyl donor analog of Glc-1-P. α-D-Glucosamine 1-phosphate acts as a glycosyl donor to produce α(1→4)-linked glucosamine chains in the enzyme-catalyzed polymerization reaction mediated by thermostable α-glucan phosphorylase. α-D-Glucosamine 1-phosphate serves as a glycosyl donor analog to generate a pentasaccharide with a glucosamine residue at the non-reducing end in the maltotetraose glucosamination reaction catalyzed by potato α-glucan phosphorylase. α-D-Glucosamine 1-phosphate is used for the synthesis of amphiphilic block polysaccharides with pH-responsive assembly/disassembly properties .
    α-D-Glucosamine 1-phosphate
  • HY-W998694
    6-CR, 6G

    		Fluorescent Dye Others
    6-CR, 6G is an acceptor chromophore commonly used in energy transfer (ET) fluorescent primers .
    6-CR, 6G
  • HY-D3310
    Fluorescein-12-dGTP

    		Fluorescent Dye Others
    Fluorescein-12-dGTP is a fluorescein-labeled deoxyguanosine triphosphate. Fluorescein-12-dGTP incorporates into complementary allele-specific primers at SNP sites, enabling FRET with cationic conjugated polymer PFP via DNA-PFP electrostatic interactions. Fluorescein-12-dGTP incorporates into G-allele-specific primers for homozygous G/G SNP genotypes to enable genotype discrimination. Fluorescein-12-dGTP serves as a fluorescently labeled nucleotide for homogeneous solution-based SNP and FRET genotyping assays (Ex/Em = 498/517 nm) .
    Fluorescein-12-dGTP
  • HY-185272
    3'-O-(2-Nitrobenzyl)-dCTP

    		DNA/RNA Synthesis Others
    3'-O-(2-Nitrobenzyl)-dCTP is a reversible terminator. 3'-O-(2-Nitrobenzyl)-dCTP can be recognized and incorporated by polymerases, thereby temporarily terminating primer extension during DNA synthesis. After incorporation into the extending DNA strand, 3'-O-(2-Nitrobenzyl)-dCTP temporarily halts the DNA polymerase extension reaction, and its 3'-O-(2-nitrobenzyl) blocking group can be removed by laser irradiation to regenerate a free 3'-OH for subsequent primer extension cycles. 3'-O-(2-Nitrobenzyl)-dCTP is applicable for resolving homopolymeric regions in DNA templates .
    3'-O-(2-Nitrobenzyl)-dCTP
  • HY-185273
    3'-O-(2-Nitrobenzyl)-dGTP

    		DNA/RNA Synthesis Others
    3'-O-(2-Nitrobenzyl)-dGTP is a reversible terminator. 3'-O-(2-Nitrobenzyl)-dGTP can be recognized and incorporated by DNA polymerases, thereby temporarily terminating DNA primer extension; after the 2-nitrobenzyl blocking group is removed via laser irradiation, a free 3'-OH can be regenerated to allow subsequent polymerase-mediated extension. 3'-O-(2-Nitrobenzyl)-dGTP can be used in DNA sequencing studies .
    3'-O-(2-Nitrobenzyl)-dGTP
  • HY-137697A
    ddCTP tetrasodium

    		Drug Metabolite HIV Nucleoside Antimetabolite/Analog HIV Protease DNA/RNA Synthesis Infection
    ddCTP tetrasodium is a type of chain-terminating deoxynucleotide. ddCTP tetrasodium can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP tetrasodium can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP tetrasodium is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication .
    ddCTP tetrasodium
  • HY-185129
    Headpiece

    		Biochemical Assay Reagents Others
    Headpiece is a short, covalently linked double-stranded DNA (dsDNA). It is designed as the starting point of DNA-Encoded Libraries (DELs) synthesis. In each chemical synthesis step, the compounds are encoded by enzymatically ligating the respective DNA tags to the Headpiece. Finally, a closing primer containing the distal primer-binding site for PCR amplification is added to complete the library synthesis/encoding.
    Headpiece
  • HY-157264
    dTPT3TP

    		DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Others
    dTPT3TP is a non-natural nucleoside triphosphate. dTPT3TP can be used by TdT to extend ssDNA primers .
    dTPT3TP
  • HY-E71209
    α-1,3-Glucan synthase

    		Biochemical Assay Reagents Others
    α-1,3-Glucan synthase (EC 2.4.1.183) requires a dextran primer to initiate the reaction, which leads to the elongation of the dextran chain.
    α-1,3-Glucan synthase

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