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replicative DNA polymerase

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15310
    Ivermectin
    Maximum Cited Publications
    48 Publications Verification

    MK-933; CD-5024; K-237

    		 Environmental Pollutants Antibiotic Mitophagy Bacterial Parasite Autophagy Flavivirus HSV HIV SARS-CoV Dengue Virus Infection Cancer
    Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X4 and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .
    Ivermectin
  • HY-13637
    Ganciclovir
    25+ Cited Publications

    BW 759; 2'-Nor-2'-deoxyguanosine

    		 CMV HSV Antibiotic Nucleoside Antimetabolite/Analog Infection Cancer
    Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain .
    Ganciclovir
  • HY-17438
    Cidofovir
    10+ Cited Publications

    GS 0504; HPMPC; (S)-HPMPC

    		 CMV Apoptosis DNA/RNA Synthesis Orthopoxvirus Endogenous Metabolite Infection Cancer
    Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir also has anti-orthopoxvirus and anti-variola activities .
    Cidofovir
  • HY-B0307
    Idoxuridine
    5+ Cited Publications

    5-Iodo-2′-deoxyuridine; 5-IUdR; IdUrd

    		 DNA/RNA Synthesis Phosphatase Orthopoxvirus Infection Cancer
    Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM . Idoxuridine shows anti-orthopoxvirus activity.
    Idoxuridine
  • HY-N0365
    Sennoside A
    5+ Cited Publications

    		 DNA/RNA Synthesis HIV Infection
    Sennoside A is an anthraquinone glycoside found in senna (Cassia angustifolia). Sennoside A is an HIV-1 inhibitor (IC50=3.8 μM) that inhibits HIV-1 replication. Sennoside A also inhibits HIV-1 reverse transcriptase (RT)-related DNA polymerase (RDDP) and ribonuclease H (Ribonuclease H) with IC50s of 1.9 μM and 5.3 μM, respectively .
    Sennoside A
  • HY-W010800
    Cholesteryl hemisuccinate

    		Topoisomerase DNA/RNA Synthesis Apoptosis Necroptosis Cancer
    Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth .
    Cholesteryl hemisuccinate
  • HY-B1318
    Foscarnet sodium
    3 Publications Verification

    Trisodium phosphonoformate; Phosphonoformic acid trisodium salt

    		 DNA/RNA Synthesis Infection
    Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis .
    Foscarnet sodium
  • HY-W010800A
    Cholesterol hemisuccinate Tris salt

    Cholesterol hydrogen succinate Tris salt; CHS-Tris

    		 Biochemical Assay Reagents Topoisomerase DNA/RNA Synthesis Apoptosis Necroptosis Inflammation/Immunology Cancer
    Cholesterol hemisuccinate (Cholesterol hydrogen succinate) Tris salt is a compound with hepatoprotective and anticancer activity. Cholesterol hemisuccinate Tris salt inhibits Acetaminophen (AAP) (HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesterol hemisuccinate Tris salt inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Cholesterol hemisuccinate Tris salt inhibits tumor growth. Cholesterol hemisuccinate Tris salt can be used for buffer preparation .
    Cholesterol hemisuccinate Tris salt
  • HY-100126
    Tubercidin
    5+ Cited Publications

    7-Deazaadenosine

    		 Bacterial DNA/RNA Synthesis Influenza Virus Antibiotic Infection
    Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC50 of 0.02 μM . Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis . Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP . Tubercidin has antiviral activity .
    Tubercidin
  • HY-B0277
    Vidarabine
    5+ Cited Publications

    Ara-A; Adenine Arabinoside; 9-β-D-Arabinofuranosyladenine

    		 Apoptosis Fungal Reactive Oxygen Species (ROS) EBV HSV Antibiotic DNA/RNA Synthesis Drug Metabolite Infection Cancer
    Vidarabine (Ara-A) is a nucleoside antibiotic isolated from Streptomyces, and a metabolite of Vidarabine phosphate (HY-B0277A). Vidarabine selectively inhibits viral DNA polymerase and cellular ribonucleotide reductase, thereby blocking viral replication. Vidarabine phosphate also exhibits antifungal activity, induces late-stage cellular apoptosis, and causes cell cycle arrest. Vidarabine phosphate can be used in research related to severe chronic active Epstein-Barr virus (EBV) infection, herpes infection, and candidiasis .
    Vidarabine
  • HY-17026E
    Gemcitabine triphosphate trisodium

    dFdCTP trisodium

    		 Drug Metabolite DNA/RNA Synthesis Apoptosis Cancer
    Gemcitabine triphosphate (dFdCTP) trisodium is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate trisodium cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate trisodium shows a Ki of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε. Gemcitabine triphosphate trisodium partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate trisodium disrupts DNA and RNA synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate trisodium can be used for the research of pancreatic cancer and non-small cell lung cancer .
    Gemcitabine triphosphate trisodium
  • HY-W011725
    N-6-Methyl-2-deoxyadenosine

    m6dA

    		 Nucleoside Antimetabolite/Analog Mitochondrial Metabolism DNA/RNA Synthesis Neurological Disease Cancer
    N-6-Methyl-2-deoxyadenosine (m6dA) is an adenine nucleoside analogue. N-6-Methyl-2-deoxyadenosine targets nuclear processes and DNA replication machineries including WER, SATB1, TFAM, Jumu, SSBP1, DNA polymerase η and phage polymerase Gp90 exo −. N-6-Methyl-2-deoxyadenosine acts as a multifunctional epigenetic regulator that modulates transcription, DNA damage response, cell cycle, transposon silencing, stress adaptation, epigenetic crosstalk, and nucleosome organization in both prokaryotes and eukaryotes. N-6-Methyl-2-deoxyadenosine regulates mitochondrial epigenetic inheritance and is required for fear extinction memory in mice. N-6-Methyl-2-deoxyadenosine exhibits dysregulated levels in cancers. N-6-Methyl-2-deoxyadenosine can be used for the research of glioblastoma, triple negative breast cancer, and conditioned fear (fear extinction impairment) .
    N-6-Methyl-2-deoxyadenosine
  • HY-W013715A
    Deoxythymidine-5'-triphosphate trisodium solution (100 mM)

    dTTP trisodium solution (100 mM)

    		 DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Endogenous Metabolite Others
    Deoxythymidine-5'-triphosphate (dTTP) (trisodium) solution (100 mM) is one of the raw materials used by DNA polymerase to synthesize long DNA strands during DNA replication. Deoxythymidine-5'-triphosphate (trisodium) solution (100 mM) is used in polymerase chain reaction (PCR) for DNA amplification. This product is supplied as an aqueous solution.
    Deoxythymidine-5'-triphosphate trisodium solution (100 mM)
  • HY-10571A
    Delavirdine mesylate
    3 Publications Verification

    U 90152 mesylate; BHAP-U 90152 mesylate

    		 HIV Reverse Transcriptase Infection
    Delavirdine (U 90152) mesylate is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine mesylate selectively inhibits HIV-1 reverse transcriptase (RT) (IC50=0.26 μM) over DNA polymerase α (IC50=440 μM) and polymerase δ (IC50>550 μM). Delavirdine mesylate is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .
    Delavirdine mesylate
  • HY-10571
    Delavirdine
    3 Publications Verification

    U 90152; BHAP-U 90152

    		 HIV Reverse Transcriptase Infection
    Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC50=0.26 μM) over DNA polymerase α (IC50=440 μM) and polymerase δ (IC50>550 μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .
    Delavirdine
  • HY-109056
    Elsulfavirine
    2 Publications Verification

    R-1206

    		 Drug Intermediate HIV Reverse Transcriptase Carbonic Anhydrase Infection Cancer
    Elsulfavirine (R-1206) is an orally active human carbonic anhydrase (carbonic anhydrase, CA) inhibitor and an allosteric inhibitor of HIV-1 non-nucleoside reverse transcriptase (NNRT). Elsulfavirine also targets and blocks the interaction between adenylosuccinate lyase (ADSL) and insulin-induced gene proteins INSIG1/2, blocks SREBP-1-mediated de novo lipid synthesis, and inhibits the proliferation of liver cancer cells. The combination of Elsulfavirine and Lenvatinib (HY-10981) produces a synergistic anti-tumor effect. Elsulfavirine is converted into the active metabolite VM1500A in vivo, blocks the DNA polymerase activity of reverse transcriptase, and inhibits HIV-1 replication. Elsulfavirine exhibits a Ki of 1960 nM-52400 nM against human carbonic anhydrase isoforms including I, VII, VI, VA, VB, IX, XIII, XIV. Elsulfavirine is used in studies related to HIV-1 infection and liver cancer .
    Elsulfavirine
  • HY-E70094
    T4 UvsX Recombinase

    		DNA/RNA Synthesis Others
    T4 UvsX Recombinase helps initiate DNA replication on a double-stranded DNA template by catalyzing synapsis between the template and a homologous DNA single strand that serves as primer. T4 UvsX Recombinase greatly amplifies the snap-back (hairpin-primed) DNA synthesis that is catalyzed by the T4 DNA polymerase holoenzyme on linear, single-stranded DNA templates .
    T4 UvsX Recombinase
  • HY-136648A
    2'-Deoxyadenosine-5'-triphosphate trisodium

    dATP trisodium

    		 Endogenous Metabolite DNA/RNA Synthesis Cancer
    2'-Deoxyadenosine-5'-triphosphate (dATP) trisodium is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. 2'-Deoxyadenosine-5'-triphosphate is promising for research of genetic immunodeficiency diseases adenosine deaminase deficiency and purine nucleotide phosphorylase deficiency .
    2'-Deoxyadenosine-5'-triphosphate trisodium
  • HY-17026A
    Gemcitabine triphosphate

    dFdCTP

    		 Drug Metabolite DNA/RNA Synthesis Apoptosis Cancer
    Gemcitabine triphosphate (dFdCTP) is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate shows a Ki of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε. Gemcitabine triphosphate partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate disrupts DNA and RNA synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate can be used for the research of pancreatic cancer and non-small cell lung cancer .
    Gemcitabine triphosphate
  • HY-B0277A
    Vidarabine phosphate

    ara-AMP; ara-A 5'-monophosphate

    		 EBV HSV Fungal DNA/RNA Synthesis Apoptosis Drug Intermediate Reactive Oxygen Species (ROS) Infection
    Vidarabine phosphate (ara-AMP; ara-A 5'-monophosphate) is a purine nucleoside antiviral agent and a prodrug of Vidarabine (HY-B0277). Vidarabine phosphate is rapidly converted into the antiviral active Vidarabine in vivo, which selectively inhibits viral DNA polymerase and cellular ribonucleotide reductase, thereby blocking viral replication. Vidarabine phosphate also exhibits antifungal activity, induces late-stage cellular apoptosis, and causes cell cycle arrest. Vidarabine phosphate can be used in research related to severe chronic active Epstein-Barr virus (EBV) infection, herpes infection, and candidiasis .
    Vidarabine phosphate
  • HY-W013256
    Foscarnet trisodium hexahydrate
    3 Publications Verification

    Trisodium phosphonoformate hexahydrate; Phosphonoformic acid trisodium salt hexahydrate

    		 DNA/RNA Synthesis Infection
    Foscarnet trisodium hexahydrate (Trisodium phosphonatoformate hexahydrate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet trisodium hexahydrate is an antiherpesvirus agent used in cytomegalovirus retinitis .
    Foscarnet trisodium hexahydrate
  • HY-137697D
    ddCTP trisodium solution (100 mM)

    		HIV DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Drug Metabolite HIV Protease Infection
    ddCTP trilithium solution (100 mM) is a chain-terminating dideoxynucleotide. ddCTP trilithium is a type of chain-terminating deoxynucleotide. ddCTP trilithium can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP trilithium can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP trilithium is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication .
    ddCTP trisodium solution (100 mM)
  • HY-W013403
    2'-Deoxy-2'-fluorouridine

    		IFNAR Infection
    2'-Deoxy-2'-fluorouridine is a derivative of the pyrimidine nucleoside uridine. 2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. Hepatitis C polyU/UC RNA strands containing 2'-Deoxy-2'-fluorouridine, bind to RIG-I but do not activate RIG-I signaling in a reporter assay using Huh7 cells. 2'-Deoxy-2'-fluorouridine also has been used as a starting material in the synthesis of respiratory syncytial virus (RSV) polymerase inhibitors. 2'-Deoxy-2'-fluorouridine can incorporate into DNA and RNA in rat and woodchuck model upon administration. 2'-Deoxy-2'-fluorouridine can be studied in anti-viral research .
    2'-Deoxy-2'-fluorouridine
  • HY-136648
    2'-Deoxyadenosine-5'-triphosphate

    dATP

    		 Endogenous Metabolite DNA/RNA Synthesis Others
    2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase .
    2'-Deoxyadenosine-5'-triphosphate
  • HY-136648B
    2'-Deoxyadenosine-5'-triphosphate trisodium,100 mM Solution,PCR Grade

    dATP trisodium,100 mM Solution,PCR Grade

    		 Biochemical Assay Reagents Others
    2'-Deoxyadenosine-5'-triphosphate (dATP) trisodium, 100 mM Solution, PCR Gradeis one of the raw materials used by DNA polymerase to synthesize long DNA strands during DNA replication. 2'-Deoxyadenosine-5'-triphosphate trisodium,100 mM Solution,PCR Grade is used in reverse transcription polymerase chain reaction (RT-PCR) for DNA amplification. This product is supplied in the form of an aqueous solution .
    2'-Deoxyadenosine-5'-triphosphate trisodium,100 mM Solution,PCR Grade
  • HY-116364B
    AZT triphosphate tetraammonium

    3'-Azido-3'-deoxythymidine-5'-triphosphate tetraammonium

    		 HIV DNA/RNA Synthesis HBV Reactive Oxygen Species (ROS) Apoptosis Infection
    AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) tetraammonium is an active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate tetraammonium exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate tetraammonium also inhibits the DNA polymerase of HBV. AZT triphosphate tetraammonium activates the mitochondria-mediated apoptosis pathway .
    AZT triphosphate tetraammonium
  • HY-N12540
    Monogalactosyldiacylglycerol

    MGDG

    		 DNA/RNA Synthesis Apoptosis Others
    Monogalactosyldiacylglycerol (MGDG) is a galactolipid with anti-inflammatory and anticancer activities, which is found in photosynthetic organisms. Monogalactosyldiacylglycerol is a potent DNA polymerase inhibitor with pro-apoptotic activity. Monogalactosyldiacylglycerol inhibits the synthesis of LPS (HY-D1056)-induced inflammation-related proteins (Ex-FABP, Avidin, Serum Amyloid A). Monogalactosyldiacylglycerol exerts an anti-proliferative effect on chicken articular chondrocytes . Monogalactosyldiacylglycerol can be used in research related to osteoarthritis, cancer and inflammatory diseases .
    Monogalactosyldiacylglycerol
  • HY-W008661A
    Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade

    dGTP trisodium,100 mM Solution,PCR Grade; 2'-Deoxyguanosine-5'-triphosphate trisodium,100 mM Solution,PCR Grade

    		 DNA/RNA Synthesis Others
    Deoxyguanosine triphosphate (dGTP) trisodium,100 mM Solution,PCR Grade is one of the raw materials used by DNA polymerases to synthesize long DNA strands during DNA replication. Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade is used in polymerase chain reaction (PCR) for DNA amplification. This product is supplied in the form of an aqueous solution .
    Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade
  • HY-W013715B
    Deoxythymidine-5'-triphosphate trisodium,100 mM Solution,PCR Grade

    dTTP trisodium,100 mM Solution,PCR Grade

    		 DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Endogenous Metabolite Others
    Deoxythymidine-5'-triphosphate (dTTP) trisodium, 100 mM Solution, PCR Grade is one of the raw materials used by DNA polymerase to synthesize long DNA strands during DNA replication. Deoxythymidine-5'-triphosphate trisodium, 100 mM Solution, PCR Grade is used in polymerase chain reaction (PCR) for DNA amplification. This product is supplied as an aqueous solution.
    Deoxythymidine-5'-triphosphate trisodium,100 mM Solution,PCR Grade
  • HY-W010800R
    Cholesteryl hemisuccinate (Standard)

    		Reference Standards Topoisomerase DNA/RNA Synthesis Apoptosis Necroptosis Cancer
    Cholesteryl hemisuccinate (Standard) is the analytical standard of Cholesteryl hemisuccinate. This product is intended for research and analytical applications. Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth[1][2].
    Cholesteryl hemisuccinate (Standard)
  • HY-136648AR
    2'-Deoxyadenosine-5'-triphosphate trisodium (Standard)

    dATP trisodium (Standard)

    		 Reference Standards Endogenous Metabolite DNA/RNA Synthesis Metabolic Disease
    2'-Deoxyadenosine-5'-triphosphate trisodium (Standard) (dATP trisodium (Standard)) is the analytical standard of 2'-Deoxyadenosine-5'-triphosphate trisodium (HY-136648A). This product is intended for research and analytical applications. 2'-Deoxyadenosine-5'-triphosphate trisodium (dATP trisodium) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase .
    2'-Deoxyadenosine-5'-triphosphate trisodium (Standard)
  • HY-131605B
    Ganciclovir triphosphate disodium

    GCV-TP disodium

    		 CMV DNA/RNA Synthesis Infection Cancer
    Ganciclovir triphosphate (GCV-TP) disodium is a synthetic 2'-deoxyguanosine analog with activity in inhibiting human cytomegalovirus (CMV) replication. Ganciclovir triphosphate disodium is effective against CMV infection by binding to viral DNA polymerase and interfering with viral DNA synthesis. Ganciclovir triphosphate disodium has an IC50 of 0.01 μM against CMV strains from humans, monkeys, mice, and guinea pigs. Ganciclovir triphosphate disodium has also been used in gene-directed enzyme prodrug inhibition for cancer inhibition .
    Ganciclovir triphosphate disodium
  • HY-13637A
    Ganciclovir sodium
    25+ Cited Publications

    BW 759 sodium; 2'-Nor-2'-deoxyguanosine sodium

    		 CMV HSV Antibiotic Nucleoside Antimetabolite/Analog Infection Cancer
    Ganciclovir (BW 759) sodium, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain .
    Ganciclovir sodium
  • HY-13637R
    Ganciclovir (Standard)

    BW 759 (Standard); 2'-Nor-2'-deoxyguanosine (Standard)

    		 Reference Standards CMV HSV Antibiotic Nucleoside Antimetabolite/Analog Infection Cancer
    Ganciclovir (Standard) is the analytical standard of Ganciclovir. This product is intended for research and analytical applications. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain .
    Ganciclovir (Standard)
  • HY-137697
    ddCTP

    		Nucleoside Antimetabolite/Analog DNA/RNA Synthesis HIV Protease HIV Drug Metabolite Infection
    ddCTP is a type of chain-terminating deoxynucleotide. ddCTP can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication .
    ddCTP
  • HY-136648S5
    2'-Deoxyadenosine-5'-triphosphate-13C10 dilithium

    dATP-13C10 dilithium

    		 Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis Others
    2'-Deoxyadenosine-5'-triphosphate- 13C10 (dATP- 13C10) dilithium is 13C-labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.
    2'-Deoxyadenosine-5'-triphosphate-13C10 dilithium
  • HY-W013256R
    Foscarnet trisodium hexahydrate (Standard)

    Trisodium phosphonoformate hexahydrate (Standard); Phosphonoformic acid trisodium salt hexahydrate (Standard)

    		 Reference Standards DNA/RNA Synthesis Infection
    Foscarnet (trisodium hexahydrate) (Standard) is the analytical standard of Foscarnet (trisodium hexahydrate). This product is intended for research and analytical applications. Foscarnet trisodium hexahydrate (Trisodium phosphonatoformate hexahydrate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet trisodium hexahydrate is an antiherpesvirus agent used in cytomegalovirus retinitis .
    Foscarnet trisodium hexahydrate (Standard)
  • HY-116364
    AZT triphosphate

    3'-Azido-3'-deoxythymidine-5'-triphosphate

    		 HIV DNA/RNA Synthesis HBV Reactive Oxygen Species (ROS) Apoptosis Infection
    AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate also inhibits the DNA polymerase of HBV. AZT triphosphate activates the mitochondria-mediated apoptosis pathway .
    AZT triphosphate
  • HY-136648S1
    2'-Deoxyadenosine-5'-triphosphate-13C10,15N5 dilithium

    dATP-13C10,15N5 dilithium

    		 Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis Others
    2'-Deoxyadenosine-5'-triphosphate- 13C10, 15N5 (dATP- 13C10, 15N5) dilithium is 13C and 15N-labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.
    2'-Deoxyadenosine-5'-triphosphate-13C10,15N5 dilithium
  • HY-131605
    Ganciclovir triphosphate

    GCV-TP

    		 Endogenous Metabolite CMV DNA/RNA Synthesis Infection Cancer
    Ganciclovir triphosphate (GCV-TP) is a synthetic 2'-deoxyguanosine analog with activity in inhibiting human cytomegalovirus (CMV) replication. Ganciclovir triphosphate is effective against CMV infection by binding to viral DNA polymerase and interfering with viral DNA synthesis. Ganciclovir triphosphate has an IC50 of 0.01 μM against CMV strains from humans, monkeys, mice, and guinea pigs. Ganciclovir triphosphate has also been used in gene-directed enzyme prodrug inhibition for cancer inhibition .
    Ganciclovir triphosphate
  • HY-17438A
    Cidofovir dihydrate

    GS 0504 dihydrate; HPMPC dihydrate; (S)-HPMPC dihydrate

    		 CMV DNA/RNA Synthesis Orthopoxvirus Apoptosis Endogenous Metabolite Infection Cancer
    Cidofovir (GS 0504; HPMPC; (S)-HPMPC) dihydrate is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir dihydrate inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir dihydrate induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir dihydrate also has anti-orthopoxvirus and anti-variola activities .
    Cidofovir dihydrate
  • HY-170547
    DNA polymerase-IN-6

    		DNA/RNA Synthesis HSV EBV CMV Infection
    DNA polymerase-IN-6 is an antiviral agent and a DNA polymerase inhibitor. DNA polymerase-IN-6 inhibits the replication of HCMV, HSV-1, HSV-2 and EBV. DNA polymerase-IN-6 exhibits low cytotoxicity in mammalian cells. DNA polymerase-IN-6 can be used in research related to viral infections .
    DNA polymerase-IN-6
  • HY-116364A
    AZT triphosphate TEA

    3'-Azido-3'-deoxythymidine-5'-triphosphate TEA

    		 HIV DNA/RNA Synthesis HBV Reactive Oxygen Species (ROS) Apoptosis Infection
    AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) TEA is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TEA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TEA also inhibits the DNA polymerase of HBV. AZT triphosphate TEA activates the mitochondria-mediated apoptosis pathway .
    AZT triphosphate TEA
  • HY-17438R
    Cidofovir (Standard)

    GS 0504 (Standard); HPMPC (Standard); (S)-HPMPC (Standard)

    		 Reference Standards CMV Apoptosis DNA/RNA Synthesis Orthopoxvirus Endogenous Metabolite Infection Cancer
    Cidofovir (Standard) is the analytical standard of Cidofovir. This product is intended for research and analytical applications. Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir also has anti-orthopoxvirus and anti-variola activities .
    Cidofovir (Standard)
  • HY-13637B
    Ganciclovir hydrate

    BW-759 hydrate; 2'-Nor-2'-deoxyguanosine hydrate

    		 CMV HSV Antibiotic Nucleoside Antimetabolite/Analog Infection Cancer
    Ganciclovir (BW 759) hydrate, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir hydrate also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir hydrate inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir hydrate has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain .
    Ganciclovir hydrate
  • HY-B0307R
    Idoxuridine (Standard)

    5-Iodo-2′-deoxyuridine (Standard); 5-IUdR (Standard); IdUrd (Standard)

    		 Reference Standards Phosphatase Orthopoxvirus Infection Cancer
    Idoxuridine (Standard) is the analytical standard of Idoxuridine. This product is intended for research and analytical applications. Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM . Idoxuridine shows anti-orthopoxvirus activity.
    Idoxuridine (Standard)
  • HY-B0277R
    Vidarabine (Standard)

    Ara-A (Standard); Adenine Arabinoside (Standard); 9-β-D-Arabinofuranosyladenine (Standard)

    		 Reference Standards Apoptosis Fungal Reactive Oxygen Species (ROS) EBV HSV Antibiotic DNA/RNA Synthesis Drug Metabolite Infection
    Vidarabine (Ara-A) (Standard) is the analytical standard of Vidarabine. This product is intended for research and analytical applications. Vidarabine is a nucleoside antibiotic isolated from Streptomyces, and a metabolite of Vidarabine phosphate (HY-B0277A). Vidarabine selectively inhibits viral DNA polymerase and cellular ribonucleotide reductase, thereby blocking viral replication. Vidarabine phosphate also exhibits antifungal activity, induces late-stage cellular apoptosis, and causes cell cycle arrest. Vidarabine phosphate can be used in research related to severe chronic active Epstein-Barr virus (EBV) infection, herpes infection, and candidiasis .
    Vidarabine (Standard)
  • HY-137697B
    ddCTP trilithium

    		HIV DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Drug Metabolite HIV Protease Infection
    ddCTP trilithium is a type of chain-terminating deoxynucleotide. ddCTP trilithium can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP trilithium can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP trilithium is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication .
    ddCTP trilithium
  • HY-156998
    Troxacitabine triphosphate

    TRX-TP

    		 Nucleoside Antimetabolite/Analog Cancer
    Troxacitabine triphosphate (TRX-TP) is a good substrate for replicative and repair DNA polymerases in vitro .
    Troxacitabine triphosphate
  • HY-B1318R
    Foscarnet sodium (Standard)

    Trisodium phosphonoformate (Standard); Phosphonoformic acid trisodium salt (Standard)

    		 DNA/RNA Synthesis Reference Standards Infection
    Foscarnet (sodium) (Standard) is the analytical standard of Foscarnet (sodium). This product is intended for research and analytical applications. Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis .
    Foscarnet sodium (Standard)

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