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toxic metal ions

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By Targets:	Bacterial (1) Biochemical Assay Reagents (6) Endogenous Metabolite (1) Fluorescent Dye (1) Reference Standards (1)
By Research Areas:	Cancer (3) Infection (1) Metabolic Disease (2)

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Biochemical Assay Reagents

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Targets Recommended: MOFs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W129633

2,6-Dichlorophenolindophenol sodium hydrate 1 Publications Verification DCIP sodium hydrate; DPIP sodium hydrate	Biochemical Assay Reagents	Others
2,6-Dichlorophenolindophenol (DCIP; DPIP) sodium hydrate is a redox chromogenic indicator with a redox potential of +217 mV relative to SHE, and it acts as a substrate for reduction reactions. During the metabolic process of nutrient consumption by Saccharomyces cerevisiae, 2,6-Dichlorophenolindophenol sodium hydrate is reduced from dark blue to colorless, resulting in a decrease in absorbance. 2,6-Dichlorophenolindophenol sodium hydrate is widely used in spectrophotometric biochemical oxygen demand determination and preclinical colorimetric toxicity analysis for heavy metal ion detection based on Saccharomyces cerevisiae .

HY-W012683

Iminodiacetic acid	Biochemical Assay Reagents	Cancer
Iminodiacetic acid is a metal ion chelator targeting Cr ⁶⁺, Cd ²⁺, Ni ²⁺, and Pb ²⁺. Iminodiacetic acid selectively and irreversibly binds metal ions through the coordination of carboxyl and imino groups, reduces the toxicity of metal ions and promotes their adsorption and separation. Iminodiacetic acid has the functions of heavy metal ion removal and coordination complex stabilization. Iminodiacetic acid is often used in environmental pollution control (such as heavy metal adsorption in water) and coordination chemistry (such as metal ion detection and separation) research .

HY-W110793

Dithizone Diphenylthiocarbazone	Biochemical Assay Reagents	Metabolic Disease
Dithizone can be toxic to pancreatic islet cells and cause experimental diabetes. Dithizone can be used for in vitro in vivo staining of transplanted islets and cytoplasmic granules of bone marrow cells. Dithizone can be used as a chelating agent and colorimetric indicator for the detection and extraction of various heavy metals, including lead and mercury, in analytical and biochemical applications. Dithizone forms stable colored complexes with metal ions and can be quantitatively analyzed by methods such as spectrophotometry .

HY-W008992

Quinolin-8-ol sulfate hydrate 8-Hydroxyquinoline sulfate hydrate	Biochemical Assay Reagents	Others
Quinolin-8-ol sulfate hydrate is an organic compound commonly used in dyes and as a raw material for chemical analysis. It can cooperate with metal ions to form dyes, and is widely used in the fields of dyes, printing and textile manufacturing. In addition, the compound also has good toxicity and biocompatibility, and is also used in some medical fields.

HY-W012683R

Iminodiacetic acid (Standard)	Biochemical Assay Reagents Reference Standards	Cancer
Iminodiacetic acid is a metal ion chelator targeting Cr6+, Cd2+, Ni2+, and Pb2+. Iminodiacetic acid selectively and irreversibly binds metal ions through the coordination of carboxyl and imino groups, reduces the toxicity of metal ions and promotes their adsorption and separation. Iminodiacetic acid has the functions of heavy metal ion removal and coordination complex stabilization. Iminodiacetic acid is often used in environmental pollution control (such as heavy metal adsorption in water) and coordination chemistry (such as metal ion detection and separation) research .

HY-156939

ZnDTPA	Biochemical Assay Reagents	Cancer
ZnDTPA is an orally effective chelating agent, which belongs to the class of amino carboxylic acid chelating agents and is mainly used to form stable complexes with metal ions. DTPA (diethylenetriaminepentaacetic acid) itself is a polydentate ligand that can form stable cyclic or chain-like complexes with a variety of metal ions. ZnDTPA can be used to reduce the long-term toxicity of ²³⁹Pu to rats and reduce the incidence of osteosarcoma, breast cancer, etc. in rats .

HY-W722245

Pyochelin	Endogenous Metabolite Bacterial	Infection
Pyochelin is a salicylate-based nonribosomal peptide siderophore produced by Pseudomonas aeruginosa. Pyochelin chelates Fe ³⁺ and transports it back into bacterial cells, providing the iron essential for bacterial survival. Pyochelin can also chelate other metals such as Zn ²⁺, Co ²⁺, and Ni ²⁺, which helps bacteria maintain intracellular metal ion homeostasis by chelating and excreting excess metals in response to toxic metal stress. Pyochelin can be used in studies related to Pseudomonas aeruginosa infection .

HY-W783351

CS790AM Coppersensor 790 acetoxymethyl ester	Fluorescent Dye	Metabolic Disease
CS790AM (Coppersensor 790 acetoxymethyl ester) is a cell-permeable, Cu ⁺-targeted near-infrared fluorescent probe (λ_abs=760 nm, λ_em=790 nm) applicable to live cells. CS790AM can cross lipophilic cell membranes, and is converted into negatively charged CS790 under the action of intracellular esterases to be retained, thus enabling highly sensitive, reversible "turn-on" detection of labile Cu ⁺ pools in live cells and mice. CS790AM possesses excellent biocompatibility and selectivity, avoids interference from other metal ions, shows no obvious toxicity, and can be rapidly cleared. CS790AM allows long-term longitudinal monitoring of individual mice, visualizes copper levels in internal organs and isolated livers, and effectively evaluates abnormal copper accumulation in Wilson's disease models (Atp7b ^-/-) as well as dynamic changes after chelator treatment. CS790AM can be used for research on Wilson's disease and related copper metabolic disorders .

Cat. No.	Product Name	Type

HY-W129633

2,6-Dichlorophenolindophenol sodium hydrate 1 Publications Verification DCIP sodium hydrate; DPIP sodium hydrate	Biochemical Assay Reagents
2,6-Dichlorophenolindophenol (DCIP; DPIP) sodium hydrate is a redox chromogenic indicator with a redox potential of +217 mV relative to SHE, and it acts as a substrate for reduction reactions. During the metabolic process of nutrient consumption by Saccharomyces cerevisiae, 2,6-Dichlorophenolindophenol sodium hydrate is reduced from dark blue to colorless, resulting in a decrease in absorbance. 2,6-Dichlorophenolindophenol sodium hydrate is widely used in spectrophotometric biochemical oxygen demand determination and preclinical colorimetric toxicity analysis for heavy metal ion detection based on Saccharomyces cerevisiae .

2,6-Dichlorophenolindophenol sodium hydrate

1 Publications Verification

DCIP sodium hydrate; DPIP sodium hydrate

Biochemical Assay Reagents

2,6-Dichlorophenolindophenol (DCIP; DPIP) sodium hydrate is a redox chromogenic indicator with a redox potential of +217 mV relative to SHE, and it acts as a substrate for reduction reactions. During the metabolic process of nutrient consumption by Saccharomyces cerevisiae, 2,6-Dichlorophenolindophenol sodium hydrate is reduced from dark blue to colorless, resulting in a decrease in absorbance. 2,6-Dichlorophenolindophenol sodium hydrate is widely used in spectrophotometric biochemical oxygen demand determination and preclinical colorimetric toxicity analysis for heavy metal ion detection based on Saccharomyces cerevisiae .

HY-W110793

Dithizone Diphenylthiocarbazone	Biochemical Assay Reagents
Dithizone can be toxic to pancreatic islet cells and cause experimental diabetes. Dithizone can be used for in vitro in vivo staining of transplanted islets and cytoplasmic granules of bone marrow cells. Dithizone can be used as a chelating agent and colorimetric indicator for the detection and extraction of various heavy metals, including lead and mercury, in analytical and biochemical applications. Dithizone forms stable colored complexes with metal ions and can be quantitatively analyzed by methods such as spectrophotometry .

Dithizone

Diphenylthiocarbazone

Biochemical Assay Reagents

Dithizone can be toxic to pancreatic islet cells and cause experimental diabetes. Dithizone can be used for in vitro in vivo staining of transplanted islets and cytoplasmic granules of bone marrow cells. Dithizone can be used as a chelating agent and colorimetric indicator for the detection and extraction of various heavy metals, including lead and mercury, in analytical and biochemical applications. Dithizone forms stable colored complexes with metal ions and can be quantitatively analyzed by methods such as spectrophotometry .

HY-W008992

Quinolin-8-ol sulfate hydrate 8-Hydroxyquinoline sulfate hydrate	Biochemical Assay Reagents
Quinolin-8-ol sulfate hydrate is an organic compound commonly used in dyes and as a raw material for chemical analysis. It can cooperate with metal ions to form dyes, and is widely used in the fields of dyes, printing and textile manufacturing. In addition, the compound also has good toxicity and biocompatibility, and is also used in some medical fields.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W012683

Iminodiacetic acid	Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	Biochemical Assay Reagents
Iminodiacetic acid is a metal ion chelator targeting Cr ⁶⁺, Cd ²⁺, Ni ²⁺, and Pb ²⁺. Iminodiacetic acid selectively and irreversibly binds metal ions through the coordination of carboxyl and imino groups, reduces the toxicity of metal ions and promotes their adsorption and separation. Iminodiacetic acid has the functions of heavy metal ion removal and coordination complex stabilization. Iminodiacetic acid is often used in environmental pollution control (such as heavy metal adsorption in water) and coordination chemistry (such as metal ion detection and separation) research .

HY-W012683R

Iminodiacetic acid (Standard)	Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Biochemical Assay Reagents Reference Standards
Iminodiacetic acid is a metal ion chelator targeting Cr6+, Cd2+, Ni2+, and Pb2+. Iminodiacetic acid selectively and irreversibly binds metal ions through the coordination of carboxyl and imino groups, reduces the toxicity of metal ions and promotes their adsorption and separation. Iminodiacetic acid has the functions of heavy metal ion removal and coordination complex stabilization. Iminodiacetic acid is often used in environmental pollution control (such as heavy metal adsorption in water) and coordination chemistry (such as metal ion detection and separation) research .

HY-W722245

Pyochelin	Structural Classification Monophenols Microorganisms Ketones, Aldehydes, Acids Phenols Source Classification	Endogenous Metabolite Bacterial
Pyochelin is a salicylate-based nonribosomal peptide siderophore produced by Pseudomonas aeruginosa. Pyochelin chelates Fe ³⁺ and transports it back into bacterial cells, providing the iron essential for bacterial survival. Pyochelin can also chelate other metals such as Zn ²⁺, Co ²⁺, and Ni ²⁺, which helps bacteria maintain intracellular metal ion homeostasis by chelating and excreting excess metals in response to toxic metal stress. Pyochelin can be used in studies related to Pseudomonas aeruginosa infection .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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toxic metal ions

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Biochemical Assay Reagents

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