9A1P9
Based on 1 Customer Validation
9A1P9 is a multi-tail ionizable cationic phospholipid. 9A1P9 induces membrane destabilization. 9A1P9 can be used for mRNA delivery t.
The product specifications provided below refer solely to the active content of 9A1P9.
For research use only. We do not sell to patients.
- Purity : 99.4%
- CAS No.: 2760467-57-8
- Formula: C27H58NO4P
- Molecular Weight:491.73
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Storage:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
9A1P9 shows higher membrane-disruptive activity at the acidic endosomal compartment compared to that of neutral pH[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Preparation of iPLNP[2]:
9A1P9 : Fluc mRNA = 11,622 : 1 (molar ratio).
9A1P9 : MDOA (DODAP or 5A2-SC8) : cholesterol : DMG-PEG2000 = 25 : 30 : 30 : 1 (molar ratio).
9A1P9 : DOPE : cholesterol : DMG-PEG2000 = 55 : 30 : 45 : 0.2 (molar ratio).
9A1P9 : DDAB (or DOTAP) : cholesterol : DMG-PEG2000 = 60 : 30 : 40 : 0.4 (molar ratio).
The weight ratio of 9A1P9 to RNA is 18:1 (w/w).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:female C57BL/6 mice (6-8 weeks)[2]
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Dosage:9A1P9:mRNA weight ratio was fixed at 18:1
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Administration:Intravenous injection (i.v.)
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Result:9A1P9 demonstrates universal applicability to synergistically function with zwitterionic, ionizable cationic and permanently cationic helper lipids to formulate multi-component LNPs for selective organ targeting (SORT) to mediate exclusive transfection in spleen, liver or lungs in mice.
Chemical Information
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CAS No. 2760467-57-8
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Appearance Liquid
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Molecular Weight 491.73
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Formula C27H58NO4P
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Color Colorless to light yellow
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SMILES
O=P(OCCN(CCCCCCCC)CCCCCCCC)(OCCCCCCCCC)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Godbout K, et al. Delivery of RNAs to Specific Organs by Lipid Nanoparticles for Gene Therapy. Pharmaceutics. 2022 Oct 7;14(10):2129. [Content Brief]
[2]. Liu S, et al. Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR-Cas gene editing. Nat Mater. 2021 May;20(5):701-710. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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