GR 82334
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats.
For research use only. We do not sell to patients.
- CAS No.: 129623-01-4
- Formula: C69H91N15O16
- Molecular Weight:1386.55
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:3-6 month-old, male C57BL/6 mice and 6-18 month-old naked mole-rats[2]
-
Dosage:10 nM, 100 nM, and 1 µM
-
Administration:Lntrathecal injection between vertebrae L4 and L5
-
Result:Increased heat-induced foot withdrawal latency in mice.
Chemical Information
-
CAS No. 129623-01-4
-
Molecular Weight 1386.55
-
Formula C69H91N15O16
-
Sequence
{Glp}-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-{d-Pro(spiro-γ-lactam)Leu}-Trp-NH2
-
Sequence Shortening
{Glp}-ADPNKFY-{d-Pro(spiro-γ-lactam)Leu}-W-NH2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. A Lecci,et al.Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions. Life Sci [Content Brief]
[2]. Antje Brand, et al. Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat.PLoS One. 2010 Dec 21;5(12):e15162. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GR 82334 Related Classifications
HY-P1193 Related Classifications
Powered by Bioz