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Cat. No.: HY-N11630

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Pinellic acid

Pinellic acid is an orally active adjuvant for intranasal influenza vaccines. Pinellic acid can be extracted from the tubers of Pinellia ternata Breitenbach. When administered intranasally in combination with influenza HA vaccine, Pinellic acid slightly increases the titers of antiviral IgG antibodies in bronchoalveolar lavage fluid and serum. Pinellic acid shows no hemolytic activity. Pinellic acid can be used in studies related to influenza virus infection.

For research use only. We do not sell to patients.

CAS No.: 97134-11-7
Formula: C₁₈H₃₄O₅
Molecular Weight:330.46

Storage:

Solution, -20°C, 2 years

Pinellic acid Chemical Structure

CAS No.: 97134-11-7

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Pinellic acid (up to 200 μg/mL) shows no hemolytic activity against sheep red blood cells at concentrations up to 200 μg/mL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pinellic acid (1 μg per mouse; p.o.) increases the antigen-specific antiviral IgA titer by 5.2-fold in nasal lavage fluid, by 2.5-fold in bronchoalveolar lavage fluid, and elevates the antigen-specific antiviral IgG titer by 3-fold in both bronchoalveolar lavage fluid and serum of BALB/c mice^[2].
Pinellic acid (1 μg per mouse; intranasal administration; mixed with intranasal influenza HA vaccine dose) slightly enhances antigen-specific antiviral IgG titers in bronchoalveolar lavage fluid and serum of BALB/c mice, but does not increase antiviral IgA titers in nasal cavity or bronchoalveolar lavage fluid^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 97134-11-7
Appearance Liquid
Molecular Weight 330.46
Formula C₁₈H₃₄O₅
Color Colorless to light yellow
SMILES

CCCCC[C@H](O)[C@@H](O)/C=C/[C@@H](O)CCCCCCCC(O)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sunazuka T, et al. Total synthesis of pinellic acid, a potent oral adjuvant for nasal influenza vaccine. Determination of the relative and absolute configuration[J]. Tetrahedron Letters, 2002, 43(7): 1265-1268.

[2]. Nagai T, et al. Pinellic acid from the tuber of Pinellia ternata Breitenbach as an effective oral adjuvant for nasal influenza vaccine. Int Immunopharmacol. 2002;2(8):1183-1193. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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